Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7358951 | The hand in the child with juvenile rheumatoid arthritis. | 1980 Mar | Clinical examination of 100 children showed frequent loss of wrist extension and ulnar deviation. Loss of flexion and radial deviation in the metacarpophalangeal joint is more frequent than in the adult. Statistical review of charts and roentgenograms of 200 patients showed all had ulnar shortening up to 9 mm but there was no correlation with ulnar deviation or netacarpophalangeal radial deviation. Conservative treatment is reviewed; surgery is rarely indicated. | |
| 6859215 | Reversible glaucomatous cupping of the disc. | 1983 Apr | A nine-year-old girl under medical treatment for uveitis was brought for optometrical examination. In addition to a low grade anterior uveitis she was found to have high intraocular pressures, a reduced light sense, pulsation of the arteries on the disc and extensive optic disc cupping. The most probable diagnosis was juvenile rheumatoid arthritis. Photographs show reversal of the cupping over a four-month period during which intraocular pressures were brought into the normal range. Optometrists are cautioned that they should assess not only the progress of treatment of an established eye disease but should also review the entire ocular status of patients coming under their care. | |
| 27094 | Granulomatous ileocolitis preceded by three years of pauciarticular arthritis. | 1978 Mar | The case of a 12-year old male is presented in whom pauciarticular arthritis preceded the clinical onset of granulomatous ileocolitis by three years. Before the onset of gastrointestinal symptoms, the patients' clinical diagnosis was juvenile rheumatoid arthritis. This case stresses the importance of including inflammatory bowel disease in the differential diagnosis of pauciarticular arthritis in children. | |
| 7061721 | 111Indium-labelled white blood cells in the diagnosis of Felty's syndrome. | 1982 Jan | The use of isotope scanning of the spleen in conjunction with 51Cr-labelled red blood cells has become an established technique in the evaluation of patients with hypersplenism. As far as we are aware the similar technique using labelled white blood cells to demonstrate splenic sequestration in a neutropenic patient has not been described. We report a case where this technique proved valuable in confirming the diagnosis and in predicting a favourable response to splenectomy. | |
| 7281097 | Pulmonary function abnormalities in Sjögren's syndrome and the sicca complex. | 1981 Apr | The frequency of pulmonary involvement in a group of 20 patients with Sjögren's syndrome or the sicca complex was evaluated with pulmonary function studies. In 12 patients pulmonary functional abnormalities were demonstrated. The most common abnormality was airway obstruction. Nine out of 13 patients with the limited variant of the disease (sicca complex) and three out of seven patients with the complete syndrome had abnormal pulmonary function. | |
| 6774673 | Gold in psoriatic arthopathy. | 1980 Jun | It has been suggested that gold is not effective in psoriatic arthropathy. We did not agree and therefore did a retrospective study of 98 patients. Gold had been given to 27 and was effective in 22, 14 of whom are still receiving it. The incidence of side effects was low and comparable to those in rheumatoid arthritis. | |
| 4017677 | Respiratory manifestations in primary Sjögren's syndrome. A clinical, functional, and his | 1985 Aug | Thirty-six patients with primary Sjögren's syndrome were evaluated for respiratory manifestations using clinical, roentgenologic, functional, and in five cases, histologic criteria. Twenty seven patients (75 percent) had evidence of respiratory involvement, usually occurring early in the course of the disease. Diffuse interstitial lung disease was most common (25 percent) followed by small airways disease (22 percent), desiccation of upper respiratory tract (17 percent) and large airways obstruction (8 percent). There was no patient with pleural effusion. Transbronchial lung biopsy of five patients studied revealed interstitial pathology ranging from dense lymphocytic infiltrates to interstitial fibrosis. Roentgenologic evaluation was often suggestive of interstitial lung disease but did not correlate with functional or histologic findings. | |
| 3866299 | [Godwin's tumor and Gougerot-Sjögren syndrome. Apropos of 2 cases]. | 1985 | Two new cases of pseudo-tumoral parotid benign lymphoepithelial lesion serve as the basis for a review of the clinical aspects of "Godwin tumour". This is a pseudo-tumoral parotid swelling of non-characteristic clinical appearance which has the radiological findings of a systemic type sialogram ("punctate marks" and diffuse parenchymatous spots). Histopathological examination shows lesions affecting the whole gland but predominant in the swollen area, sometimes surrounded by a connective tissue pseudo-capsule. These lesions are the same as those seen in Sjögren's syndrome. There are virtually no humoral immunological abnormalities such as auto-antibodies nor inflammatory laboratory abnormalities. Whilst the diagnosis of this rare condition may be considered in the presence of any isolated parotid swelling with a sialogram of systemic type, the diagnosis of a benign lymphoepithelial lesion, eliminating a lymphoma, can be made only by histopathological examination of the parotidectomy specimen. These lesions could be the pseudo-tumoral form of isolated, so-called primary, Sjögren's syndrome. Some of these isolated syndromes become more complete after several years with the appearance of auto-antibodies. Clinical, immunological and haematological surveillance of these benign lymphoepithelial lesions is thus necessary during the years following parotidectomy. | |
| 7462277 | Leg-length discrepancies in monoarticular and pauciarticular juvenile rheumatoid arthritis | 1981 Feb | A retrospective study was performed to determine the course of limb-length discrepancies occurring in patients with monoarticular and pauciarticular juvenile rheumatoid arthritis. Data were assessed on thirty-six patients followed to skeletal maturity, on fifteen patients who had not reached skeletal maturity but who had been followed for four years or more, and on forty-nine patients followed for three years or less. In seventy-two of the total of 100 patients the onset of the disease occurred before they were five years old, and ninety patients had involvement of the knee. All patients in whom the disease developed before the age of nine had overgrowth of the involved extremity, but that overgrowth never exceeded 3.0 centimeters. The major discrepancy developed within the first three or four years and either increased very slowly thereafter, remained level, or decreased. Of the thirty-six patients who were followed to skeletal maturity, in twenty-nine a discrepancy of 1.5 centimeters or more developed at some time during the period of assessment. Twelve of the thirty-six patients had diminution of the discrepancy to the extent that epiphyseal arrest was not required. Fifteen eventually had an epiphyseal arrest. Rapid premature closure of the epiphyseal growth plate occurred only in those patients in whom the disease developed after the age of nine years. This led to immediate shortening of the involved side and on occasion to marked limb-length discrepancies. | |
| 21283473 | The rheumatoid hand and preventive surgery. | 1983 Nov | Preventive surgery in rheumatoid arthritis of the hand is aimed at avoiding or at least delaying deformity and disability and at alleviating symptoms, especially pain. This can be successfully accomplished only in the disease's early phases. The family physician is in a position to assess his rheumatoid patients and to develop a good sense of the disease's progression. He can therefore make timely referrals to a hand surgeon, before major deformity and disability are present and the optimum time for preventive surgery has passed. The common surgical procedures-including excision of rheumatoid nodules; release of nerve entrapments; tenosynovectomy; synovectomy, and resection and reconstruction of the ulnar head-are discussed, as are their indications. | |
| 501727 | Altered responsiveness to mitogens in subgroups of patients with juvenile rheumatoid arthr | 1979 Feb | Thirty patients with juvenile rheumatoid arthritis (JRA) were compared to an age-matched control population with respect to lymphocyte transformation by the mitogens Concanavalin A, Phytohemagglutinin-P, Pokeweed and Lipopolysaccharide, as well as for the relative frequency of E-rosette and Ig-bearing cells in peripheral blood. The data were analysed according to sex, age of onset, mode of onset and disease activity. Lymphocytes from patients with a pauciarticular pattern of onset of JRA responded to mitogens in a similar fashion as normal volunteers, whereas lymphocytes from patients with both a polyarticular and Still's mode of onset had a diminished response to the mitogens. However, this reduction was noteworthy only during periods of disease activity; during periods of remission, lymphocytes from the patients responded similarly to lymphocytes from normals. In contrast to this reduction in mitogen stimulation in these subgroups of patients with JRA, all patients with JRA--irrespective of disease activity or mode of onset--were similar to controls with respect to the percentage of E-rosette and Ig-bearing cells. These alterations in mitogen responsiveness could not be attributed to therapy. Finally, the abnormalities of lymphocyte transformation in patients with polyarticular and Still's mode of onset represent secondary features of disease and are not due to a generalized predisposition or abnormality of cell mediated immunity. | |
| 6333875 | Use of the HEp-2 cell substrate in the detection of antinuclear antibodies in juvenile rhe | 1984 Nov | Presence and titer of antinuclear antibodies (ANA) were determined in 217 juvenile rheumatoid arthritis (JRA) patients, by indirect immunofluorescence using HEp-2 cells as substrate. Positive ANA titers (greater than or equal to 1:40) were present in 131 (60%) of the JRA patients. All 3 JRA onset types demonstrated increased percentages of ANA positivity compared with healthy children. Sixty-seven percent of the patients in the polyarticular onset group had positive titers; titers were positive in 62% of the pauciarticular onset group and in 32% of the systemic onset group. ANA were also found in 45% of control patients with other connective tissue diseases. In JRA patients, the speckled pattern occurred most commonly (72%). Fourteen patients (8 with pauciarticular onset and 6 with polyarticular onset) had iridocyclitis; all of them had high titers (greater than or equal to 1:80) of ANA. The use of HEp-2 cells provided a sensitive substrate for detecting ANA in JRA. It proved to be of value in differentiating JRA patients from healthy controls, but not from patients with other connective tissue diseases. | |
| 263904 | Prognosis of juvenile rheumatoid arthritis. | 1977 Mar | The true prognosis of JRA is unknown. The best interpretation of reports to this date may be that at any given time of examination between 5 and 15 years after onset, 30-50% of children will have grossly active disease and that 70-90% of patients will be in class I-II functional status. Published studies, however, are not comparable because of differing criteria and selection of support data to be reported. Close analysis of four cases of JRA illustrate some of the difficulties in utilizing loosely defined criteria. A preliminary plan for improving the precision of reporting course and prognosis of JRA has been outlined. | |
| 7102892 | Incidence and nature of primary granulomatous inflammation in surgically removed material. | 1982 Mar | A large number of cases (303) of primary granulomatous inflammation, present in surgically removed specimens from a broad range of locations, were reviewed and examined in detail. The granulomas were characterized as to morphology, location, and etiology. Epithelioid granulomas without necrosis were most frequently due to sarcoidosis and mycobacterial infection, while epithelioid granulomas with necrosis were most commonly due to mycobacterial infection, fungal infection, rheumatoid arthritis and sarcoidosis. Mature granulomas, most of which did not contain necrosis, were generally due to foreign bodies. The responsible etiologic agents were generally identified in granulomas due to fungi, bacteria, or foreign bodies (92%). However, mycobacteria were infrequently identified in granulomas, even when the lesions were examined by the auramine-O technique (31%). Overall, the majority of the granulomas (76%), were due to five causes: sarcoidosis, mycobacterial infection, particulate inclusions, fungal infection, and rheumatoid arthritis. The frequency of a given etiology, however, varied widely depending on the location of the lesion. By classifying granulomas morphologically and knowing their location, useful predictive information concerning the etiology of a given granuloma, beyond that obtained by histochemical stains, could be derived. | |
| 6980281 | Mucha-Habermann disease in children -- the association with rheumatic diseases. | 1982 Mar | Two children are described who developed Mucha-Habermann disease as infants. One boy had juvenile rheumatoid arthritis that ran a progressive course over 10 years, although his skin disease responded to a low dose of corticosteroids. One girl had polyarthritis associated with onset of her rash but both resolved over several years without treatment. She has since developed scleroderma followed by a reappearance of her skin lesions. | |
| 4020546 | Hypercalciuria in children with juvenile rheumatoid arthritis: association with hematuria. | 1985 Aug | After discovering juvenile rheumatoid arthritis (JRA), hematuria, and urolithiasis associated with hypercalciuria in two children, urinary calcium excretion was examined in 38 patients with JRA. Fasting urine calcium/creatinine (mg/mg) (UCa/UCr) ratios were increased (greater than 0.21) in 12 patients, who had a mean UCa/UCr ratio of 0.34 +/- 0.14, compared with 0.09 +/- 0.06 in 26 normocalciuric patients with JRA. Increased UCa/UCr ratios were found more frequently in patients with systemic JRA (P less than 0.05); however, no relationship between UCa/UCr ratios and either functional classification or drug therapy was observed. Four children with increased urine calcium to creatinine ratios were examined more extensively. Twenty-four-hour urine calcium excretion ranged from 4.0 to 7.2 mg/kg/24 hours. An orally administered calcium loading test demonstrated fasting hypercalciuria after dietary calcium restriction in these four patients. Serum calcium, bicarbonate, phosphorus, and parathyroid hormone values were normal. Hematuria was found in six of 12 hypercalciuric patients with JRA but in only three of 26 normocalciuric patients (P less than 0.016). We conclude that urinary calcium excretion is frequently increased in patients with JRA and that hypercalciuria may be related to the pathogenesis of hematuria in some of them. | |
| 83707 | A complex of HLA-D specificities detected by HTC typing: Dw7, Dw11, and TMo. | 1978 Dec | Homozygous typing cells defining HLA-D antigens related to Dw7 appear to identify a complex of partially overlapping structures. The relationships between these specificities were analyzed using 7th Workshop cells and other cells sent to the reference laboratory. The local cells JLe and KA seem to fit the antigen Dw11, which is in large part included in Dw7. TMo defines a component that is rare in normal whites and frequently observed in children with rheumatoid arthritis. | |
| 950805 | Joint imaging in polymyalgia rheumatica. | 1976 Aug | Technetium pertechnetate joint scintigrams were abnormal in 24 of 25 patients with polymyalgia rheumatica, in all 16 with rheumatoid arthritis, in 4 of 13 with nonarticular rheumatism, but in none of 26 control patients. Abnormal uptake in polymyalgia patients was commonest in shoulders and was less likely to be symmetric than in patients with rheumatoid arthritis, in whom distal joint abnormalities predominated. The pattern of abnormal uptake in polymyalgia rheumatica was not different in those with biopsy-proved giant cell arteritis. Correlation between symptoms and abnormal scintigrams was 72%, and abnormal uptake was present in 81% of joints of patients having physical abnormalities. Biopsy showed lymphocytic synovitis in the knee of one patient. After treatment the number of abnormal joints declined. These findings suggest that synovitis is common in polymyalgia rheumatica, and that it may account for some or most of the symptoms in this condition. | |
| 3902298 | Coexistent gout and septic arthritis: a report of two cases and literature review. | 1985 Jul | Two cases of coexistent gout and septic arthritis are presented. The known increased incidence of joint injections in patients with rheumatoid arthritis is contrasted with the relative rarity of this complication in persons with gouty arthritis. The reason for this dichotomy is not clear but it is suggested that an important factor may be the more episodic nature of the gouty process. For patients presenting with acute arthritis the possible concurrence of sepsis and gout should be considered. | |
| 871735 | Mycoplasma pneumoniae infection and arthritis in man. | 1977 Jul 2 | Seven patients developed arthritis after Mycoplasma pneumoniae infection. Their joint symptoms persisted for up to one year. One patient developed an articular erosion and in another rheumatoid factor was present in serum transiently. Mycoplasma infection often causes ill-defined arthralgias and myalgias, but the migratory polyarthropathy of middle-sized joints that occurred in these patients is much less common. The prognosis seems to be good. |