Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7034456 | Anti-IgG antibodies in juvenile rheumatoid arthritis. | 1981 Sep | Sixty-two patients, 48 children and 14 adults, with juvenile rheumatoid arthritis (JRA) and 62 age and sex matched controls were studied for anti-IgG antibodies of the classes IgG, IgM and IgA by an indirect immunofluorescence method. IgG anti-IgG occurred in 88% of 48 children less than or equal to 16 years and in 64% of 14 patients greater than 16 years with JRA against 2% of the controls. IgM anti-IgG occurred in 4% of the children, in 24% of the adults and in 2% of the controls. IgA anti-IgG occurred in 2% of the patients and in none of the controls. The prevalence of IgG anti-IgG was the same in pauciarticular, polyarticular and systemic cases, whereas the titres were higher in polyarticular than in pauciarticular cases, and higher in children with a disease duration of more than 5 years. Higher titres were related to higher ESR and lower hemoglobin values. The relationship of higher titres to clinically active disease was not statistically significant. No relationship was found to age, sex, age at onset, or to the duration of disease. The titres were not related to the concentrations of serum IgG or to the titres of antinuclear antibodies. IgG anti-IgG are common to all the clinical types of JRA, whereas antinuclear antibodies separate the systemic type from pauci- and polyarthritis. Their possible pathogenic significance must therefore be different. | |
| 6335307 | [Possibilities for using the analytical ultracentrifugation method for determining circula | 1984 | Analytical ultracentrifugation was used to study circulating immune complexes in 78 patients suffering from different rheumatic diseases. Using this method immune complexes were mostly detectable in patients with rheumatoid arthritis. This correlated with the disease activity, roentgenological stage of articular involvement, development of the systemic manifestations associated with rheumatoid vasculitis. Demonstration of immune complexes by analytical ultracentrifugation was found to correlate on the whole with the presence in sera of high titers of rheumatoid factors and immune complexes according to the PEG method data. | |
| 7203370 | Prevalence of liver disease in patients taking salicylates for arthropathy. | 1980 Oct | 110 patients with various arthropathies, mostly rheumatoid arthritis, treated with salicylates, were investigated for the presence of signs of liver disease attributable to this drug. An increased serum alkaline phosphatase level was observed in 9 of 96 ASA-treated patients with rheumatoid arthritis. However, this alteration could not be related to the use of salicylates, nor to the ingestion of any other antirheumatic drug. The hyperphosphatasemia persisted during a three-year follow-up in five of the nine patients. | |
| 21274227 | Surgery for the arthritic knee. | 1985 Mar | The optimal surgical procedure for the arthritic knee depends upon the type of arthritis and the patient. If the patient is 'high demand' (i.e., relatively active and young), and has incongruous arthritis (in either the medial or lateral compartments but not both), then realignment by osteotomy transfers the weight to the healthy compartment. If the osteotomy is successful, the patient may continue a physically demanding lifestyle. Knee replacement is indicated if the patient is 'low demand' (i.e., elderly or suffering from multiple joint disease) and has congruous arthritis, with destruction of both weight-bearing compartments. Knee replacement does not allow the same activity level as realignment but, fortunately, the low demand patient tends to have congruous disease (e.g., rheumatoid arthritis) and the high demand patient incongruous disease (e.g., osteoarthritis). | |
| 3981379 | Bilateral acquired inflammatory Brown's syndrome. | 1985 Jan | An 11-year-old boy presented with fever, skin rash, joint pains and vertical diplopia, and was found to have a right Brown's syndrome and systemic onset Juvenile Rheumatoid Arthritis (JRA). Later in the course of his illness, he developed a left Brown's syndrome. Acquired Brown's syndrome may occur as a complication of JRA during exacerbations of the systemic inflammatory disease. | |
| 6702788 | Eosinophilic fasciitis in a child. | 1984 Apr | A 13-year-old boy with a three-year history of an illness characterized by stiff hands, arthralgias in the metacarpophalangeal joints, flexion contractures in all fingers, and thickened skin over his hands, arms, and thighs had an initial diagnosis of juvenile rheumatoid arthritis with dry synovitis. Eosinophilia and a deep-fascial biopsy led to a diagnosis of eosinophilic fasciitis. Prednisone therapy resulted in sustained subjective and objective improvement. | |
| 7441664 | Interlaboratory salicylate variability. | 1980 Sep | Nineteen patients with juvenile rheumatoid arthritis had salicylate concentration determination by 2 different methods in 2 laboratories. Differences in the results from these laboratories prompted testing at 4 laboratories with known samples of salicylates. Significant variation was shown between spectrofluorometric and Trinder methods. We feel that it is imperative that physicians and clinical pharmacists determine the reliability of salicylate determinations performed in their laboratories prior to making recommendations for changes in patients' drug regimens. | |
| 6451160 | [Lymphocyte transformation using anti-lymphocyte globulin in child patients (author's tran | 1980 | In normal children about under PHA 67% of the lymphocytes, but only 8% under AHLG show a blast transformation. Children with juvenile rheumatoid arthritis reveal (in autologeous serum) a PHA-reactivity of the normal range, whereas the transformation rate under AHLG is increased on more than 60%. In immune proliferative disease the results are different. Further investigations have to show, if these results are of importance for diagnosis and therapy of the above mentioned diseases. | |
| 856067 | Measurement of pain in juvenile chronic polyarthritis. | 1977 Apr | Pain can be measured using a visual analogue scale in children with juvenile chronic polyarthritis. In a study of 100 children failures were uncommon after the age of 5. Pain severity was strikingly lower than in a group of adults with rheumatoid arthritis and correlated poorly with other measures of disease severity and activity. Because of the low scores, measurement of pain is likely to be less useful in children for assessing the effects of treatment than it is adults. | |
| 608274 | Ankylosing spondylitis and its variants. A review of recent developments for orthopedic su | 1977 Nov | Recent developments in genetic tissue typing have altered concepts of ankylosing spondylitis (AS) or variants of this spondylitic arthritis. It is now apparent that AS is separate and distinct from rheumatoid arthritis; and the term "rheumatoid" should be avoided except as it applies to the latter, usually characterized by rheumatoid factor or nodules and symmetrical arthritis of peripheral joints. Classical definitions of AS require X-ray evidence of sacroiliitis and/or restriction of chest expansion. Recent studies suggest that many patients, especially women, may have symptoms of AS without typical roentgenographic or clinical findings. Use of the HL-A B27 genetic test is useful for identifying AS patients. Radioisotope bone or joint scanning techniques further augment present diagnostic capabilities. Atypical AS may be a very common form of morbidity among patients with back pain in the United States. Since patients have a tendency to form osseous reankylosis after total hip replacement, it is especially important for orthopedic surgeons to identify incipient AS and related disorders. Inappropriate treatment or procedures may be avoided by use of these newer clinical tools in the evaluation of patients with chronic back or skeletal pain. | |
| 7352872 | Corneal ulceration and perforation associated with Sjögren's syndrome. | 1980 Jan | Sterile corneal ulcerations and perforations associated with Sjögren's syndrome affected 18 eyes in 14 patients. Seven of the 18 eyes were perforated on presentation. Nine of the 18 eyes had received topical steroid treatment prior to referral. Two of the eyes had undergone recent anterior segment surgery and suffered perforated corneas postoperatively while receiving topical steroid treatment. All 14 patients had successful management of their corneal ulceration or management of their corneal ulceration or perforation (reepithelialization of the corneal defect, restoration or maintenance of the anterior chamber, and stromal scarring with visual acuity equal to or better than on presentation). Two of the 18 eyes had sterile infiltrated ulcers. We believe that this type of ulcer responds less predictably to therapy than the noninfiltrated lesions. | |
| 6847084 | Silicone-induced human adjuvant disease? | 1983 Apr | Human adjuvant disease is an immunologically mediated disorder manifested by arthritis, arthralgias, skin lesions, malaise, pyrexia, and weight loss. Clinically, it often resembles rheumatoid arthritis and Reiter's syndrome. While scattered cases of adjuvant disease have been reported following injections with silicone fluid of unknown purity, paraffin, and petroleum jelly, no cases of adjuvant disease following silicone gel implant mammaplasty have been reported. We present such a case, discuss the pertinent biology of silicone, and review the literature describing adjuvant disease. | |
| 6273765 | Sjögren syndrome: central nervous system manifestations. | 1981 Nov | We studied eight patients who had primary Sjögren syndrome and central nervous system (CNS) disorders that were not attributable to other causes. Focal cerebral deficits were observed in five patients. Aseptic meningoencephalitis was seen in five patients, recurrent in one. Spinal cord manifestations in three patients took several forms: acute transverse myelitis, chronic progressive myelopathy, and spinal subarachnoid hemorrhage. Precipitating antibodies to the Ro(SSA) cytoplasmic antigen were detected in the sera of seven of eight patients. This may be relevant to the pathogenesis of CNS disease in Sjögren syndrome, because there is a strong correlation between vasculitis and the presence of anti-Ro(SSA) antibodies in this connective tissue disorder. | |
| 7386505 | Lysozyme determination in parotid saliva from patients with Sjögren's syndrome. | 1980 Jul | Lysozyme and total protein concentrations in parotid saliva were measured in 17 patients with primary Sjögren's syndrome, in six patients with Sjögren's syndrome secondary to hyperlipoproteinemia and in 14 age- and sex-matched healthy control subjects. Increased lysozyme concentrations were found only in patients with primary Sjögren's syndrome and correlated well with the presence of parotid gland enlargement. The total protein concentration in the saliva of patients with Sjögren's syndrome was not different from that of the control subjects. Parotid saliva lysozyme determination may be useful as an early adjunctive diagnostic test of primary Sjögren's syndrome. | |
| 220713 | [Systematic screening for Sjögren's syndrome in patients with various blood diseases]. | 1978 Oct 18 | A Sjögren's syndrom was looked for systematically in 154 hematological patients, half of them with lymphoproliferative disorders, by means of three current diagnosis methods: the Schirmer's test, the tear lysozyme assay, and the salivary immunoglobulin assay. These tests, poorly specific, are frequently abnormal, but the coexistence of the three abnormalities in the same patient makes the diagnosis highly probable. This corresponded to 4 patients. Taking into account the other diagnostic methods, the diagnosis was considered as possible or probable in 7 patients, and certain in 3 of them. This rate of 2% is discussed but the frequency of latent Sjögren's syndrome in hematologic patients and mainly in lymphoproliferative disease cannot be considered as high. | |
| 6644698 | Still's arthritis in adults: disease or syndrome? | 1983 Oct | Seven adults with a syndrome similar to systemic-onset (Still's) juvenile rheumatoid arthritis are reported. In addition to characteristic fever, rash, and arthritis prominent features included pharyngitis (7), lymphadenopathy (6), pleuropericarditis (4) and progression to joint damage (5). Three were over 50-years-old. Previous reports are reviewed. Symptoms, laboratory and physical findings are broadly comparable to the childhood disease. However findings may be quite variable in individual patients and the diagnosis remains a clinical one. Recognition of the variable presentations of this syndrome will assist in the differential diagnosis of fever of unknown origin. | |
| 6250422 | Feline chronic progressive polyarthritis. | 1980 Apr | Twenty cats with a chronic progressive polyarthritis were studied. The disorder occurred exclusively in male cats, and all but six of the cats were between 1.5 and 5.0 years of age. There were two forms of the disease as determined by radiographic changes: joint instability and deformity, and clinical course. The most prevalent form of the disease was characterized by osteopenia and periosteal new bone formation surrounding affected joints. Marginal periarticular erosions and collapse of the joint spaces with fibrous ankylosis occurred with time, but joint instability and deformities were not seen. The second form of the disease was characterized by severe subchondral marginal erosions, joint instability, and deformities. The periosteal proliferative form resembled Reiter's arthritis of man, and the deforming type resembled human rheumatoid arthritis. The disease began as tenosynovitis and synovitis, with subsequent changes in the articular cartilage and periosteal bone. Histopathologic changes in these cats were similar to those occurring in both chronic Reiter's and rheumatoid arthritis of man. Chronic progressive polyarthritis of cats was not caused by identifiable bacteria or mycoplasma, but was etiologically linked to feline leukemia virus (FeLV) and feline syncytia-forming virus (FeSFV) infections. The FeSFV was isolated from the blood or was detected by a serologic test in all of the cats with the disease, whereas FeLV was isolated or identified by immunofluorescence technique in 60% of the cats. The arthritis could not be reproduced by inoculation of cell-free cynovial tissue from diseased cats or with tissue culture fluid containing FeSFV and FeLV isolates. It was postulated that arthritis was an uncommon manifestation of FeSFV infection that occurred in predisposed male cats. Feline leukemia virus may not have been directly involved in the disease, but may have acted in some way to potentiate the pathogenic effects of FeSFV. | |
| 7174271 | Adult Still's disease associated with pregnancy. | 1982 Oct | A 23-yr-old woman in her sixth month of pregnancy presented with the systemic variant of juvenile rheumatoid arthritis (Still's disease). The symptoms included high fever, erythematous evanescent maculopapular rash, hepatosplenomegaly and asymmetric arthritis. During a follow-up period of 1 yr, anti-inflammatory drugs (both steroidal and nonsteroidal) were administered, leading to the eventual disappearance of the patient's complaints. Adult-onset Still's disease reported in the literature is reviewed, and the association of Still's disease with pregnancy is discussed. | |
| 7171185 | [Destructive arthritis and Behçet's syndrome]. | 1982 | The arthritis of Behçet's syndrome is not usually responsible for articular destructions, so that the presence of destructive lesions makes the diagnosis of Behçet's syndrome doubtful. Here is presented the observation of a 29 years old man (his illness beginning at twelve), with a typical Behçet's syndrome, who developed a destructive arthritis. Arthritic and systemic flares showed a parallel evolution. Destructive lesions involved wrists, hands, feet and elbows. The search for another cause of destructive arthritis (mainly juvenile rheumatoid arthritis and ankylosing spondylitis) was negative. The occurrence of destructive arthropathies in Behçet's syndrome has been exceptionally reported. | |
| 139092 | [Demonstration of antigens of bone and articular connective tissue in the blood of rats wi | 1976 | The results reported in this paper clearly indicate the release of osteal antigens of articular connective tissue in response to inflammatory alterations and injuries to the region immediately adjacent to an articulation. Further studies will have to be performed in an effort to find out whether these antigens are of pathological importance and if there is a relationship between the liberation of antigens and the intensity of inflammatory alterations or if the different and often difficult-to-interpret results of the determination of antibodies in the sera of patients with rheumatoid arthritis can be more easily explained by a simultaneous antigen analysis of the corresponding sera. |