Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 849364 | Hyaluronic acid production by irradiated human synovial fibroblasts. | 1977 Mar | Radioactive particles as well as X-irradiation from an external source have been used in the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. In order to clarify effects of ionizing irradiation on synovial cells, radioactive gold (198Au) and yttrium (90Y) were added to fibroblast cultures derived from human synovial membranes. Other cultures were irradiated by a Picker X-ray machine. Fibroblast growth and hyaluronic acid production were measured. Radioactive gold and yttrium particles induced a significant increase of hyaluronic acid synthesis rate (pg/cell/day) and inhibited fibroblast growth. Fibroblasts continued to overproduce hyaluronic acid and to show growth inhibition 3 weeds after irradiation with radioactive gold. Hydrocortisone inhibited hyaluronic acid overproduction induced by radioactive gold. Overproduction of hyaluronic acid induced by the X-ray machine was inhibited by hydrocortisone, actinomycin-D, and cycloheximide. Fibroblasts derived from normal and rheumatoid patients responded similarly to ionizing irradiation. | |
| 7073343 | The articular manifestations of progressive systemic sclerosis (scleroderma). | 1982 Apr | The articular manifestations of progressive systemic sclerosis (PSS) were studied in 38 patients. Of these, 66% experienced joint pain and 61% had signs of joint inflammation. Limitation of joint movement was seen in 45%. Radiological abnormalities included periarticular osteoporosis (42%), joint space narrowing (34%), and erosions (40%). Erosive disease did not correlate with disease duration, presence of rheumatoid factor, antinuclear antibodies, distal tuft resorption, or the extent of the scleroderma skin changes. Calcinosis was seen more frequently in those patients with articular erosions (67%). Erosive osteoarthritis of the distal interphalangeal joints (7 patients) was associated with impaired finger flexion. Joint involvement in PSS occurs frequently and may resemble rheumatoid arthritis in the early stages but is less destructive. The occurrence of unrelated arthropathy, such as primary osteoarthritis, is not uncommon, and its differentiation from true PSS joint disease can be difficult. | |
| 6916753 | Besides the liver, what does the virus of hepatitis attack? | 1982 Mar | I have reviewed some of the clinical and pathogenetic features of the extrahepatic syndromes of viral hepatitis B. They are important for three reasons: First, it is important to be able to reassure the patient with acute viral hepatitis that the troubling symptoms which he frequently fears are due to rheumatoid arthritis, are self-limited, are benign, and will disappear. Second, these syndromes will occur with occult liver disease or with no active liver disease. Frequently, patients will consult a dermatologist for a rash or a rheumatologist for arthritis. They will see a clinical immunologist for a severe vasculitis or a nephrologist for nephritis. They will have no apparent evidence of liver disease, and the etiologic agent will not be discovered unless it is searched for, that is, unless one is aware that an occult infection with the hepatitis B virus can cause these syndromes. The third important reason is that all of these syndromes previously have been thought to be idiopathic; several of them have been rather severe and even fatal. Now, with the advent of potential antiviral therapy for viral hepatitis, it becomes important to make a correct diagnosis because now, for the first time, one can think about antiviral therapy for some of these serious syndromes. | |
| 6573872 | Histocompatibility antigens in psoriasis, psoriatic arthropathy, and ankylosing spondyliti | 1983 Apr | Patients with ankylosing spondylitis, psoriatic arthritis, and psoriasis alone were typed for HLA A, B, Cw, and DR antigens, and the antigen frequencies were compared with those in a normal control population and in patients with rheumatoid arthritis. Patients with psoriasis had a significantly raised frequency of Cw6. Those with arthritis in addition to their psoriasis also had raised frequencies of B27 and DR7. Patients with ankylosing spondylitis were characterised by the expected high frequency of HLA B27. Again, those with peripheral arthritis had a higher B27 and DR7 frequency than those without. DR3 is associated with the development of erosions in psoriatic arthritis. | |
| 7169301 | Sulindac in the treatment of acute gout arthritis. | 1982 | Sulindac is a new non-steroidal drug which is currently available for the treatment of rheumatoid arthritis, osteo-arthritis and ankylosing spondylitis throughout the world. We have recently assessed on open trial of this drug in acute gout arthritis of 26 patients (16 men and ten women). Their ages ranged from 40 to 62 years. All the patients entered in the study provided the fulfilled rigid criteria. Patients received 400 mg in two separate doses in the morning and evening for seven days. There was a dramatic improvement in the joint pain in 15 patients in the first 24 hours and only one after 48 hours, swelling and tenderness improved after four days. No significant side-effects and no significant changes in any of the laboratory tests were observed. Our conclusion is that sulindac is a very useful drug in the treatment of acute gout arthritis. | |
| 6232999 | T-suppressor cell chronic lymphocytic leukemia. Phenotypic characterization by monoclonal | 1984 Jul 15 | A patient with long standing seropositive rheumatoid arthritis developed lymphocytosis which phenotypically involved the cytotoxic/suppressor T-lymphocyte population. There are 10 reported instances of this new disease entity described as "chronic T-cell lymphocytosis with neutropenia" or "chronic suppressor T-cell lymphocytic leukemia." The disease is characterized by hepatosplenomegaly, neutropenia, and the frequent presence of rheumatoid factor without clinical evidence of rheumatoid arthritis. Splenectomy in our patient, as well as in other instances where undertaken, has been ineffective in alleviating the neutropenia. The peripheral blood lymphocytes in our patient were OKT-3+, OKT-5+, OKT-8+, OKT-11+, cALL-, OKT-6-, TdT-. They possessed ADCC but no NK activity and did not suppress PWM-induced B-cell differentiation in spite of the presence of Fc receptor for IgG. Since the lymphocytosis of OKT-8+ cells appears to be clonal, it is suggested that the disease be designated chronic suppressor T-cell lymphocytic leukemia. | |
| 3875721 | HLA-B27 related arthritis and bowel inflammation. Part 2. Ileocolonoscopy and bowel histol | 1985 Apr | Ileocolonoscopy and microscopic examination of ileum biopsies were performed on 35 patients with reactive arthritis, with asymmetrical pauciarticular arthritis and enthesopathies. Ileocolonoscopy was also performed on 26 patients with ankylosing spondylitis (AS) and on 19 control patients with rheumatoid arthritis, juvenile chronic arthritis, systemic lupus erythematosus and psoriatic arthritis. In the reactive group, ileocolonoscopy showed macroscopic inflammation in 16 cases and abnormal microscopic examination in all but 2 cases, even in patients without gastrointestinal disorders. In the 2 patients with sexually acquired disease, the gut was normal. In the AS group, inflammation was observed in the B27 negative and positive patients with peripheral joint involvement. Occasionally, ileal signs were seen in the HLA-B27 positive patients without peripheral joint involvement. None of the controls showed signs of gut inflammation. Ilecolonoscopy may be of value in detecting subclinical forms of bowel inflammation. | |
| 3973335 | Septic arthritis in the elderly. | 1985 Mar | The clinical and microbiologic features of septic arthritis in 23 elderly patients are reviewed. Fifteen patients had pre-existing joint diseases, predominantly osteoarthritis and rheumatoid arthritis. Eight patients had underlying systemic illnesses, and eight patients were receiving systemic corticosteroid therapy prior to the development of septic arthritis. The knee was the joint most commonly infected. Although Staphylococcus aureus was the major pathogen (52.2 per cent of patients), enteric gram-negative bacilli were found in seven of 23 patients (30.4 per cent). Five patients died (21.7 per cent mortality), two as a result of their infection and three of nosocomial Pseudomonas sepsis. Eight of the 18 survivors (44.4 per cent) developed osteomyelitis in the contiguous bone. Return of joint function was slow in all patients. Septic arthritis in the elderly is difficult to treat and has a poor outcome, possibly because pre-existing joint disease is very common and enteric gram-negative bacilli are often the causative organisms. | |
| 3864425 | A report of three cases of Yersinia reactive arthritis. | 1985 Jun | Three cases of reactive arthritis associated with Yersinia enterocolitica bowel infection are reported. In one case Y. enterocolitica was cultured from stools while all three exhibited a significant increase in serum antibody titres to Y. enterocolitica. These are believed to be the first reports of Yersinia reactive arthritis in Australia. Synovial membrane biopsy in one case revealed a mixed inflammatory cell infiltrate the appearance of which was quite dissimilar to that of rheumatoid arthritis (RA). Mononuclear cells of the peripheral blood, but not the synovial fluid from another patient had reduced functional activity compared to RA patients as determined by response to phytohemagglutinin stimulation and allogeneic responses. Large numbers of HLA-DR and acid phosphatase positive macrophages were also found in the synovial fluid of this patient. The reason for joint involvement in Y. enterocolitica reactive arthritis is unknown and further work is necessary. | |
| 7134741 | Group G streptococcal arthritis. | 1982 Nov | Six cases of Lancefield Group G streptococcocal arthritis are described. Two cases had pre-existing chronic arthritis (one rheumatoid) with infection of a joint prosthesis. Three cases had neoplastic disease before or at the same time as septic arthritis. Skin reactions, including cellulitis and scarlatiniform rash were prominent in five cases. One patient may have acquired a Group G streptococcus from her dog. Five cases responded well to penicillin and the sixth who was allergic to that drug was cured by erythromycin. This unusual cause of septic arthritis is being recognized more frequently in the United Kingdom. | |
| 6811033 | Pyoderma gangrenosum associated with primary thrombocythaemia. | 1982 Sep 25 | Pyoderma gangrenosum is most commonly associated with inflammatory bowel disease and rheumatoid arthritis, but it has been associated with various haematological malignancies. A 54-year-old man with no history of bowel disease or arthritis presented with a leg ulcer, which healed after treatment. Results of bone marrow aspiration were compatible with primary thrombocythaemia. Seven weeks later there were pronounced recurrence of the ulceration and pyoderma gangrenosum was diagnosed. The appearance of pyoderma gangrenosum associated with blood disorders may differ from that associated with bowel and joint disease. | |
| 7174285 | The spherocentric knee prosthesis (long term results in 18 cases). | 1982 Mar | The authors report the clinical and radiographic results at from six months to two years after the insertion of spherocentric knee prostheses in fourteen patients with rheumatoid arthritis and four patients with arthrosis of the knee. The results were satisfactory and there were no complications. This type of prosthesis has therefore become the treatment of choice in cases of varus or valgus deformity in excess of 30 degrees and those involving extreme instability. It is also an alternative after failures with other types of prosthesis. | |
| 7065736 | Sideroblastic anaemia with iron overload presenting as an arthropathy. | 1982 Feb | We report on 2 patients with sideroblastic anaemia an secondary iron overload whose presenting symptom was an arthropathy of small an large joints. One patient had marked spinal symptoms which were severe enough to suggest ankylosing spondylitis, and the pattern of arthritis in the other resembled seronegative rheumatoid arthritis. We believe these to be the first cases described of an arthropathy associated with iron overload secondary to sideroblastic anaemia. | |
| 7223076 | Joint inflammations as complications in intestinal inflammations. | 1981 Jan | Ulcerative colitis and regional ileitis may be accompanied by articular involvement as extraintestinal complications, and were observed in 11 and 4 patients respectively. The temporal connection between the intestinal diseases and the appearance of subsidence of these complications in the majority of the cases suggest an etiologic relationship, regardless of the fact that the etiology of the intestinal diseases has not yet been elucidated. The clinical picture and course as well as the laboratory findings indicate that the joint involvement in question differs from rheumatoid arthritis. | |
| 928239 | Chronic disease and short stature. | 1977 Dec | Careful graphing of the anthropometric measurements of children with chronic disease and short stature should be done to determine height and weight growth velocities. In addition, a detailed history can provide information helpful in determining the expected growth curve. If the chronic disease can be effectively treated (eg, malnutrition, emotional deprivation, celiac disease, asthma, rheumatoid arthritis), a period of rapid "catch-up" growth can be anticipated. The prognosis with regard to adult stature depends on the timing, duration, and severity of the growth-inhibiting influence. | |
| 24822905 | Preliminary experience with a noncemented nonconstrained total joint arthroplasty for the | 1983 Aug 1 | A nonconstrained, nonarticulated ball-and-socket-type stemmed resurfacing implant for the metacarpophalangeal joints of the fingers has been developed. The prosthesis is inserted with a press fit, and is made of a carbon material that allows appositional bone growth and biologic fixation. Preliminary experience in 15 patients (43 joints) with up to two years followup has demonstrated satisfactory clinical results and biologic acceptance of the device. A few complications have occurred, including recurrent deformity and subluxation of the prostheses. The device is indicated in patients with traumatic arthritis, and in younger patients with rheumatoid arthritis who have minimal soft-tissue disease and deformity. | |
| 6824513 | Separation and characterization of immune complexes containing 19S IgM rheumatoid factor-I | 1983 Feb | Sera from 10 patients with juvenile arthritis (JA), 2 seropositive and 8 with hidden rheumatoid factor (RF), were subjected to affinity chromatography on a rabbit anti-human IgM column. Material retained by the column was eluted sequentially by 1M NH3 and 0.1M glycine-HCl buffer, pH 3.0. The affinity fractions contained both 19S IgM RF and IgG, while corresponding fractions from healthy controls contained neither. Sera from 15 patients with JA, 1 seropositive and 11 with hidden RF, were subjected to 4% polyethylene glycol precipitation followed by acid dissociation of the precipitate. Ten of 15 resultant fractions contained both IgM RF and IgG, while corresponding fractions from healthy controls contained only traces of IgG. Sera from 7 of these JA patients were subjected to sucrose density gradient centrifugation and the resultant fractions analyzed for the presence of immune complexes by the C1q solid-phase assay. Immune complexes were detected at and ahead of the IgM marker, as expected for IgM RF-IgG complexes. These combined data show that the majority of JA patients with classic or hidden 19S IgM RF have immune complexes containing IgM RF and IgG in their sera. | |
| 4012148 | [Recurrent multiple paralysis of cranial nerves. Gougerot-Sjögren syndrome]. | 1985 | A 53 year-old woman presented with 6 episodes of recurrent cranial nerve palsies over seven years, each episode lasting several weeks. She had three episodes of diplopia, one of difficulty with swallowing, a left facial paralysis and two episodes of trigeminal sensory neuropathy. Sjögren's syndrome was diagnosed when the patient developed dryness of the eyes and mouth, 7 years after the first episode. The diagnosis was proved by biopsy of the accessory salivary glands, the presence of a hypergammaglobulinaemia and anti-tissue antibodies. | |
| 933695 | Sjögren's syndrome and serous otitis media. | 1976 Jul | Extrasalivary lymphoid abnormalities in Sjögren's syndrome are well described. Patients have been found to have lymphoid infiltration of many organ systems. The nature of the lymphoid abnormalities constitutes a spectrum ranging from benign to malignant disease. A case of an elderly patient with long standing Sjögren's syndrome is presented because of the unusual manifestation of a benign lymphoid mass in the nasopharynx producing unilateral eustachian tube obstruction and serous otitis media. Serous otitis media associated with Sjögren's syndrome is recognized, but to our knowledge in previous cases an extrasalivary lymphoid abnormality has not been implicated as the underlying pathology. | |
| 866898 | Pulmonary disorders associated with Sjogren's syndrome. | 1977 Apr | Pulmonary disorders occur in 25 to 47 per cent of the patients with Sjogren's Syndrome. These are of two types: 1. related to the major connective tissue disorders which commonly accompany this syndrome, and 2. secondary to the peculiar underlying pathology of Sjogren's Syndrome i.e. sicca disorders of the lung. The latter is the more frequent type, occurring mainly in patients with protected sicca complex unaccompanied by a systemic connective tissue disorder, and consists of chronic bronchitis, subsegmental atelectasis, pneumonia, bronchiectasis, lymphoproliferative pulmonary infiltrates and chronic interstitial pneumonitis which may lead to pulmonary fibrosis. 21 cases of Sjogren's Syndrome, 9 of whom had evidence of pulmonary abnormality, are presented, including a case of interstitial pneumonitis leading to diffuse interstitial pulmonary fibrosis. A review of the literature is included. |