Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 4073112 | Accelerated recovery from immune-mediated thrombocytopenia with plasmapheresis. | 1985 Dec | Autoimmune thrombocytopenia unresponsive to corticosteroid therapy developed in a 16-year-old female with long-standing Sjögren's syndrome. Serial plasma exchange caused a linear decrease in platelet antibody titer associated with a concomitant rise in platelet count. Statistical analysis of sequential platelet counts revealed an increase with plasmapheresis and immunosuppression that was significantly greater than that achieved with immunosuppression alone (p less than 0.005). | |
| 488025 | Gastric involvement in Sjögren's syndrome simulating early gastric carcinoma. | 1979 Nov | The case of a 42-year-old woman with Sjögren's syndrome accompanied by severe gastric infiltration and interstitial nephritis is reported. Presentation was with finger stiffness, Raynaud's phenomenon and abdominal discomfort. There were endoscopic and radiological features of early cancer, type IIc (depressed type). Resected stomach showed atrophic gastritis with erosion. Histology showed focal to relatively diffuse destruction of the gastric glands with minimal intestinal metaplasia and dense collections of lymphoid cells with occasional germinal centers in the interstitium of the gastric mucosa. Renal biopsy revealed similar severe diffuse interstitial infiltration of lymphoid cells. Distal renal tubular acidosis was confirmed by sodium bicarbonate and ammonium chloride loading test. Satisfactory improvement in xerostomia, keratoconjunctivitis sicca and other laboratory data occurred on prolonged administration of adrenal steroids and cyclophosphamide. | |
| 22307 | Scleroderma, Sjögren-like syndrome, and chronic graft-versus-host disease. | 1977 Dec | A patient with acute myelogenous leukemia treated with an allogeneic bone marrow transplant developed acute graft-versus-host disease manifested by severe diarrhea, hepatitis, and a cutaneous eruption. As the graft-versus-host disease progressed to the chronic phase, the patient developed marked cutaneous sclerosis and symptoms of xerophthalmia and xerostomia. Biopsy of his indurated skin showed features of both graft-versus-host disease and scleroderma. Results of Schirmer's tests, corneal fluorescent studies, parotid flow-rate testing, and a lip biopsy were consistent with Sjögren's syndrome. Possibly, activated lymphocytes may have a role in the pathogenesis of graft-versus-host disease, scleroderma, and Sjögren's syndrome. | |
| 999741 | Serum antibody levels against T mycoplasmas in two North American Indian populations predi | 1976 Nov | Serum antibody levels against T mycoplasmas (Ureaplasma urealyticum) were determined by the metabolic inhibition method in several populations. A higher prevalence of antibody was found in Haida Indians and Bella Coola Indians than in blood donors, patients with rheumatoid arthritis, and patients attending a VD clinic. Antibody levels did not correlate with the presence of spodylitis or the histocompatibility antigen HLA-B27, although both these Indian populations have a high prevalence of spondylitis and HLA-B27. | |
| 1259801 | Antigenic profile of the rat chondrocyte. | 1976 Mar | Hetero- and alloantisera were obtained following hyperimmunization of nonsensitized New Zealand rabbits and dark agouti (DA) rats with washed chondrocytes which had been enzymatically isolated from the long bone cartilage of 17-19-day-old rat fetuses of the Fischer strain. Analyses of these antisera by PVP hemagglutination, dye-exclusion cytotoxicity, and indirect immunofluorescence indicated the presence of major histocompatibility antigens, as well as tissue-specific antigens on chronrocytes. Serologic specificity of reactions was demonstrated by serum absorptions and appropriate controls. These findings supprot previous work suggesting that chrondrocytes are endowed with major histocompatibility antigens. The significance of these findings in relation to rheumatoid arthritis is discussed. | |
| 6463590 | Preparative isolation of immune complexes from serum by sucrose gradient ultracentrifugati | 1984 Jul | Immune complexes were isolated by ultracentrifugation in sucrose gradients (20-65% (w/w]. the centrifugation procedure was demonstrated to be isopycnic. The banding density of the complexes was influenced by the chemical nature and molecular size of the antigen and by the antigen to antibody ratio. The method was applied for preparative isolation of immune complexes from patients with systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and uncomplicated psoriasis. | |
| 465099 | Quantitative sacroiliac joint scintigraphy. A critical assessment. | 1979 Aug | With quantitative sacroiliac joint scintigraphy (QSS), sacroiliac joint-to-sacrum (SIS) ratios greater than or equal to 1.40 are abnormal for our method. High SIS ratios are associated with roentgenographically appreciated sacroiliitis and with early clinically evident sacroiliitis. Although highly sensitive, QSS abnormalities are not specific for inflammatory sacroiliac (SI) joint disease. High SIS ratios are also seen in rheumatoid arthritis, degenerative abnormalities of the lumbosacral spine, and metabolic bone disorder. Other disorders with roentgenographic SI joint abnormalities must be studied scintigraphically before QSS can be employed as a useful diagnostic test. | |
| 6391495 | Outcome assessment in clinical trials. Evidence for the sensitivity of a health status mea | 1984 Dec | Health status measures are conceptually relevant to the assessment of clinical outcome in the rheumatic diseases, but their ability to detect meaningful changes in health has not been clearly demonstrated. This report describes the performance of a self-administered health status questionnaire in a randomized, double-blind, 21-week comparison of placebo, oral gold, and injectable gold in rheumatoid arthritis patients. Outcome was assessed by standard clinical measures, including joint count, grip strength, and laboratory tests, and by the Arthritis Impact Measurement Scales, a reliable and valid health status measure that assesses physical disability, psychological status, and pain. Data from the clinical and health status measures produced highly similar conclusions: injectable and oral gold are more effective than placebo for rheumatoid arthritis, and injections are slightly more effective than oral gold. The health status measure was thus quite sensitive to clinically meaningful drug-induced improvements. These findings provide justification for the further application of health status measures to clinical trials of chronic disease. | |
| 7089505 | Erythrocyte sedimentation rate in women with different manifestations of joint disease. | 1982 | A comprehensive population study of women aged 44-46 was carried out in Göteborg, Sweden in 1974-75. The mean erythrocyte sedimentation rate (ESR) and the rate of high ESR values (defined as ESR greater than or equal to 30 mm) were higher in women with manifestations of joint diseases than in other women, the differences being statistically significant for women with swollen or deformed finger joints and symptoms from the wrists. Women with manifestations of active joint disease at the time of the examination had even higher ESR values, the differences being statistically significant also for women with symptoms from the finger joints. High ESR values were more common in women with a positive serological test for rheumatoid factor and joint manifestations indicating arthritis and osteoarthrosis. The "arthritis" and "osteoarthrosis" groups each included about one-third of the subjects with rheumatoid factor. It is concluded that although ESR values are moderately increased in subjects with different manifestations of joint disease, the vast majority of such subjects have ESR values less than 30 mm. | |
| 7126288 | A syndrome of seronegative enthesopathy and arthropathy in children. | 1982 Sep | Thirty-nine children with a syndrome of seronegative enthesopathy and arthropathy were evaluated. The group included 25 patients with no apparent underlying primary disease and 13 with either ankylosing spondylitis, inflammatory bowel disease, reactive arthritis, or Reiter's syndrome. Significant distinguishing characteristics of the group included male predominance, late age at onset, positive family histories of arthritis, oligoarthropathy, axial skeleton involvement, and the presence of the B27 histocompatibility antigen. This syndrome is distinguishable from other childhood rheumatic disorders, including juvenile rheumatoid arthritis. Its recognition may reliably identify children with the prodromal manifestations of seronegative spondylarthropathies. | |
| 3918155 | Oral lesion in a patient with calcinosis and arthritis: case report and differential diagn | 1985 Jan | Calcinosis, the process whereby calcium salts are deposited in soft tissues, may be idiopathic, metastatic or dystrophic. Metastatic calcinosis develops in a variety of systemic diseases characterized by either hypercalcemia, hyperphosphatemia, or both. Dystrophic calcinosis refers to calcification of previously damaged or necrotic tissue. It may be found accompanying inflammatory or degenerative conditions and is frequently associated with connective tissue diseases. When pathologic calcification is widespread, an attempt must be made to determine the underlying cause. A case is presented in which there was multifocal calcium deposition in soft tissues, including an intra-oral site. The patient also exhibited severe arthritis, sicca syndrome, focal alopecia and vitiligo. In view of this clinical spectrum, one of the "collagen diseases" (dermatomyositis, lupus erythematosus, rheumatoid arthritis, and scleroderma) was suspected as a predisposing factor for disseminated calcinosis. When diagnostic workup failed to reveal a specific connective tissue disease, it was concluded that "undifferentiated connective tissue disease" was responsible for dystrophic calcinosis. | |
| 438245 | The semiconstrained total shoulder arthroplasty. | 1979 Jun | In a two-year follow-up on sixteen total shoulder arthroplasties done with the semiconstrained Stanmore prosthesis, we found that patients with rheumatoid arthritis or osteoarthritis of the glenohumeral joint noted a greater relief of pain, were more satisfied with their surgery, used fewer analgesics, and had a greater increase in range of motion than patients with traumatic arthritis. Patients with irreparable rotator-cuff injury demonstrated the poorest range of motion postoperatively. Younger patients gained significantly more motion than older patients. All patients continued to have difficulty with lifting heavy loads. Complications consisted of one patient with a chronically dislocating prosthesis, one patient with a deep wound infection, and one with a postoperative wound dehiscence. The average follow-up was 31.4 months, ranging from twenty-four to fifty-three months. | |
| 837596 | Management of arthritis of the ankle. An alternative of arthrodesis. | 1977 Jan | Twenty-eight patients treated by total ankle arthroplasty at the University of California, Irvine, were evaluated on a 100-point ankle analysis scale preoperatively and postoperatively. The average preoperative score was 35 and the average postoperative score was 74. Significant improvement occurred in function, pain relief and range of motion. The average follow-up period for these patients was 9 months. Although the number in each group is small, it does not appear that the procedure has merit for the treatment of ankle arthritis from such diverse causes as trauma, rheumatoid arthritis, aseptic necrosis of the talus and talectomy. Complications included wound healing problems in 3 patients. Malalignment of the prosthesis occurred in 2 other patients; one required revision. Ankle replacement failed in 2 patients. One patient required a fusion; the other an amputation following occlusion of the posterior tibial artery after surgery. At the present time, ankle replacement appears to be an acceptable alternative to ankle arthrodesis. | |
| 912991 | Etiological factors in the pathogenesis of femoral trabecular fatigue fractures. | 1977 | Detailed histological evaluation of 72 femoral heads in terms of bone density, cartilagenous integrity and number of stress fractures in 3 different clinical groups of patients suggest that femoral trabecular fatigue fractures are largely determined by the degree of osteoporosis in all clinical states. The state of the hyaline cartilage also contibutes to the development of these fractures but only when the cartilage is degenerated to a severe degree as seen in rheumatoid arthritis. Both bone density and cartilage viability may be determining factors in the pathogenesis of trabecular stress fractures in rheumatoid hips. | |
| 4019675 | Determination of proquazone and its m-hydroxy metabolite by high-performance liquid chroma | 1985 May 31 | A method for the determination of proquazone and its m-hydroxy metabolite in serum and urine by reversed-phase high-performance liquid chromatography is described. The technique is based on a single extraction of the unchanged drug, its metabolite and an internal standard from serum or urine with chloroform. The column was packed with mu Bondapak C18 and the mobile phase was acetonitrile--water (50:50) (pH 3). The detection limits for proquazone and its metabolite were 0.02 mumol/l using 500 microliters of sample. For the determination of the total m-hydroxy metabolite only 100 microliters of sample are needed. The method described is suitable for routine clinical and pharmacokinetic studies. The clinical application of this method suggests that the pharmacokinetics of proquazone in adults and children are similar. | |
| 6442050 | [Mechanism of action of gold compounds]. | 1984 | The mechanisms of action of gold salts are still poorly understood. While Auranofin (AF) has a direct anti-inflammatory action in animal models, Myochrysin (MC) has not. Both gold compounds inhibit various enzymes. Among these, lysosomal enzymes are of particular interest. Gold is known to accumulate in the lysosomes, and gold salts modulate certain macrophage functions in the immune system. The role of organic gold salt ligands containing, like D-penicillamine, a thiol group is still unclear. Positive data characterizing responders versus nonresponders are not yet available. As in other clinically heterogeneous diseases, medical action has mainly been based on clinical empiricism which, although resting on false premises, has helped to find a comparatively efficacious treatment. In fact, the proposals for further studies to shed light on the mode of action presented here may equally be ill conceived. However, these studies would at least expand our understanding of rheumatoid arthritis and thus be beneficial in the long run. | |
| 311007 | Direct evidence for loss of human suppressor cells during active autoimmune disease. | 1978 Oct | These studies indicate that a regulatory subset of lymphocytes is missing in patients with juvenile rheumatoid arthritis but these patients have antibodies in their serum that react with normal T cells. This regulatory subset of T cells is, however, present in patients whose serum shows little or no reactivity with normal T cells. In addition, patients who are deficient in this regulatory subset of lymphocytes significantly higher numbers of cells secreting Ig as measured by a hemolytic plaque assay. The significance of these observations is twofold: first, they represent a positive relationship among the loss of regulation overproduction of immunoglobulin, and the presence of anti-T cell antibodies and second and perhaps of equal importance, is the indication that serum from patients with autoimmune diseases may give us a readily available reagent with which to dissect further functionally distinct subsets of normal T cells in man. | |
| 7086772 | Pirprofen (Rengasil) in the treatment of juvenile rheumatoid arthritis. A segment I study. | 1982 Jan | Thirty-two patients with JRA were enrolled in a 4-wk open-labeled, non-controlled multicentre trial of pirprofen. An initial dose of about 300 mg/m2/d (range 250-330) was gradually increased to a maximum of 600 mg/m2/d (range 413-761). The medication was provided as an aqueous suspension (10 mg/ml), and was given 4 times/d. Efficacy analysis showed significant decreases occurred in the DMS, travel time, grip strength, and the severity of swelling score (in all cases p less than 0.05 based on the paired Student t test, 2-tailed). Nineteen patients reported a total of 27 adverse experiences; 6 of which were attributable to pirprofen. At the study dosages used pirprofen seems to be very similar in efficacy and safety to other nonsteroidal antiinflammatory drugs investigated in children with JRA. | |
| 6630564 | Drug handling and patient compliance in an outpatient paediatric trial. | 1983 Sep | New routines for drug handling were used in a 24-week outpatient double-blind trial of naproxen versus acetylsalicylic acid in 80 patients with juvenile rheumatoid arthritis. The clinician ordered tablets from the pharmacy for each patient by stating name, weight and randomization number. The pharmacy dispensed the drugs in sealed and labelled 1-week medication containers. Totally, 2176 containers were packed and distributed to the patients. Two errors in ordering of drugs were detected. Patient compliance was studied by tablet count in used containers returned by 25 of the patients. The calculated compliance was 95%. The procedures for drug handling seem useful and may increase the validity of clinical trials. The staff at the local pharmacy can be valuable partners in the planning and performance of clinical drug trials. | |
| 3877091 | Contrasting mandibular growth and facial development in long face syndrome, juvenile rheum | 1985 | The complex rotation process of the mandible during growth is elucidated by longitudinal roentgencephalometric analyses, using metallic implants as fixed references. Contrasting development of face and mandibular shape is described in three subjects. In the so-called long face syndrome, development is characterized by increasing inclination of the mandible during growth with only moderate remodeling. In the subjects with juvenile rheumatoid polyarthritis and mandibulofacial dysostosis, the increase in mandibular inclination is moderate. However, the mandibular corpus rotates backward to an extreme extent within the more stable soft tissue matrix, giving rise to the characteristic development of angular notching with an extended angular process at the lower border. |