Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6539545 | Felty's and Sjögren's syndromes and hypertrophic obstructive cardiomyopathy (case report) | 1984 Mar | Our findings refer to a female patient with Felty's and Sjögren's syndromes and hypertrophic obstructive cardiomyopathy. The rheumatoid granuloma found in the left ventricle at autopsy and the absence of other conditions which may be manifested by hypertrophic obstructive cardiomyopathy suggest that the case studied, probably represents an extraarticular manifestation of Felty's and Sjögren's syndromes. | |
| 6655777 | Quinidine induced sicca syndrome. | 1983 Jun | Two weeks after initiation of therapy with 1.2 gm/day quinidine sulphate, a 67 year old patient developed clinical and laboratory features of sicca syndrome. These subsided upon discontinuation of the treatment, but reappeared on a second challenge with this drug. Sicca syndrome represents a previously undescribed hypersensitivity reaction to quinidine. | |
| 452603 | [Cerebral manifestation in a case of Sjögren's syndrome (author's transl)]. | 1979 May 11 | A case of Sjögren's disease is described in which isolated cerebellar symptoms were prominent. Serological investigations gave no evidence of disseminated immune vasculitis, systemic lupus erythematosus or any other autoimmune disease. The cerebrospinal fluid protein changes, which were diagnostic of an autoimmune process in the CNS and suggestive of Sjögren's syndrome are discussed. | |
| 6607495 | [Anti-SS-B antibody : marker of Gougerot-Sjögren's connective tissue disease independent | 1983 Dec | We studied the predictive value of anti-SS-B antibody on 48 patients having this antibody and no other antinuclear antibody. 25 patients had a typical Sjögren syndrome and the rest had no sicca syndrome but generally an unclassified disease. Between these two groups of patients we observed an identity of clinical and biological manifestations except for the sicca syndrome. We conclude that anti-SS-B antibody is not a marker for Sjögren syndrome, but is correlated with the presence of an autoimmune disorder inconstantly associated with the sicca syndrome. This auto-immune disorder has the clinical and biological features of systemic Sjögren syndrome but the sicca syndrome. | |
| 7032383 | [Gougerot-Sjögren's syndrome in two univitelline twin sisters (author's transl)]. | 1981 | Two univitelline twin sisters developed Gougerot-Sjögren's syndrome at 30 years of age. Immunity disorders were more significant in the sister with the more severe disorder, as demonstrated by sialography and scintigraphy. Among the immunological tests practiced, emphasis is placed on antinuclear antibody assay in the saliva, the authors finding no mention of this test in the published literature. Of particular interest is the negative result of histological examination of the accessory salivary glands, this contrasting with the close relationship between immunity and sialographic disturbances. The identical nature of the two sisters was confirmed by a study of the HLA systems, but this did not demonstrate the presence of the B8 marker, classically correlated with Gougerot-Sjögren's syndrome. | |
| 865947 | Sjögren's syndrome in children. | 1977 Jun | Sjögren's syndrome is a relatively uncommon condition in the pediatric age group. The clinical and immunological features of this disease in childhood have not been adequately described in the literature. Herein, we present details of the clinical features and results of laboratory investigations including minor salivary gland biopsy, parotid scintigraphy, and renal biopsy on two children with Sjögren's syndrome associated with systemic lupus erythematosus. | |
| 6271449 | Production of collagenase and inhibitor (TIMP) by normal, rheumatoid and osteoarthritic sy | 1981 Dec | 1. The amounts of latent and active collagenase and of collagenase inhibitor (TIMP) produced by two normal, three rheumatoid and two osteoarthritic synovial specimens in culture were compared. Normal synovia produced TIMP, but little latent enzyme. Rheumatoid synovia produced higher levels of total collagenase activity than normal, of which up to 50% in one sample was present in the medium in an active form, whereas no specific inhibitory activity due to TIMP was detectable. The amounts of collagenase and TIMP produced by osteoarthritic synovia were more variable and appeared to reflect the degree of inflammation in the tissue at the time of initiating the cultures. 2. Concentrations of TIMP were usually higher in the culture media of normal, rheumatoid and osteoarthritic synovia when hydrocortisone was present. Correspondingly, amounts of total collagenase were reduced. Production of prostaglandin E (PGE) were inhibited in a dose-dependent manner by hydrocortisone. 3. Indomethacin had no consistent effect on the production of TIMP by rheumatoid and osteoarthritic synovia, although it tended to depress production of collagenase. The production of TIMP by normal synovia was depressed by indomethacin. No PGE was detectable in the media when indomethacin was present. 4. These results are consistent with those from previous animal studies, and we conclude that the balance between production of collagenase and TIMP may be critical in determining the extent of the destructive processes in arthritis. The ability of hydrocortisone to suppress production of collagenase and to increase free TIMP concentration, as well as to inhibit synthesis of prostaglandin, may explain in part how the drug exerts its therapeutic effects in patients with rheumatoid arthritis. | |
| 580268 | Pilot study of d-penicillamine, vitamins and minerals in multiple sclerosis. | 1978 Feb | A pilot study of the effect of D-penicillamine in multiple sclerosis (MS) was undertaken because of D-penicillamine's activity against RNA neurotropic viruses, because it is effective against the auto-immune disease, rheumatoid arthritis, and because both viruses and autoimmunity have been implicated in multiple sclerosis. We have treated 16 patients with advanced MS, nine on full doses (2-2.25 grams/day) and seven whose treatment was permanently stopped for reasons other than adverse reactions. There has been some improvement in most of those whose treatment was not withdrawn, and no change or deterioration in those not continued on the therapeutic regimen. Despite use of a high dosage regimen, such as has evoked intolerable side effects in a high percentage of patients with rheumatoid arthritis, we have experienced few side effects in a total of 48 patients suffering from diseases with auto-immune components, a finding we speculate is due to replacement of nutrients inactivated or removed by D-penicillamine, and to supplementation with selected nutrients. | |
| 4048878 | Dilatation of cerebral ventricles in patients with rheumatoid vertical atlanto-axial sublu | 1985 | Twenty-four patients with seropositive rheumatoid arthritis, 12 of them with anterior atlanto-axial subluxation alone and 12 with vertical atlanto-axial subluxation, were examined by echo-encephalographic measurement of the width of third and lateral cerebral ventricles. The 12 patients with anterior atlanto-axial subluxation showed normal values for the third and the lateral ventricles. Ten of the 12 patients with vertical atlanto-axial subluxation had increased width of third and lateral ventricles, indicating hydrocephalus. | |
| 153144 | Survey for immune complexes in disseminated gonococcal arthritis-dermatitis syndrome. | 1979 Jan | Seventeen patients with characteristic disseminated gonococcal arthritis-dermatitis syndrome were studied for the presence of immune complexes, and circulating gonococcal antigen and antibody. The two immune complex techniques, monoclonal rheumatoid factor assay and cryoglobulin survey, did not reveal any consistent abnormalities. Complement levels (CH50, C'3, C'4) were not consistent with peripheral consumption except in 2 patients with coinciding systemic lupus erythematosus. Gonococcal antibody was detected in 47% of patients when they presented with the syndrome. However, gonococcal antigen was not found in either serum or synovial fluid. These results do not support the hypothesis that circulating immune complexes are involved in the pathogenesis of disseminated gonococcal arthritis-dermatitis syndrome. | |
| 1243805 | [Side effects in immunosuppressive therapy]. | 1975 | 61 patients with rheumatoid arthritis received a total of 80 courses of immunosuppressive therapy with one or more of the following substances: azathioprine, chlorambucil, mannitolmustard, cyclophosphamide, procarbazine. The overall results were excellent or good in 50% of the patients. There was a significant correlation between the efficacy of the different substances and the rate of side effects. Azathioprine was best tolerated, but gave only medium results whereas procarbazine, as a very potent drug, had the highest rate of side effects (especially depression of bone marrow, infections, gastrointestinal manifestations etc.). Serious immediate side effects of the immunosuppressive therapy according to our experience and in literature are infections and leucopenia, whereas the most important late risk is the possibility of an occurrence of malignancy. In our series, which had been followed up to five years, no malignancies have been thus far detected. Also, in the literature, there are only very few patients with malignancies published. Therefore the risk of immunosuppressive therapy in rheumatoid arthritis with regards the incidence of malignancies, seems to be relatively small in contrast to the findings in patients with kidney transplants. | |
| 6773455 | Pneumonitis caused by gold salt therapy: evidence for the role of cell-mediated immunity i | 1980 Jul | Gold salt-related pneumonitis is now an established clinical entity, but the mechanism for the induction of the pulmonary disease is not known. In 2 patients with this disorder, we observed elaboration of the lymphokines, migration inhibition factor (MIF) and macrophage chemotactic factor (MCF), by peripheral blood lymphocytes after incubation with gold salt. Incorporation of [3H]thymidine was not seen with several different dosages of gold salt. Control lymphocytes from normal subjects, from patients with rheumatoid arthritis but not receiving gold salt, and from patients with rheumatoid arthritis receiving gold salt but without hypersensitivity manifestations, were all unresponsive to the drug. These results suggested that the pneumonitis associated with chrysotherapy is also associated with a specific cellular immune response to the drug. Further, they point to the necessity of evaluating multiple parameters of cellular immunity, because in these patients there was a dissociation between blast transformation and mediator production. In addition, they underscored the need for further observations of cellular responsiveness in patients receiving gold salt therapy with and without overt pulmonary disease. | |
| 6301051 | [Wissler-Fanconi syndrome and Still's disease in adults. Nosological and etiological probl | 1983 Jan 27 | In both Still disease and Wissler-Fanconi syndrome, onset may occur in adulthood and the clinical picture includes acute, often migratory, polyarthritis, polymorphic exanthema and a major inflammatory syndrome with fever (often intermittent) and high polymorphonuclear leukocyte counts. The grounds for this double designation are not clearly stated in the medical literature: does it refer to two separate entities or not? Some authors plainly stand for a unitary opinion. We report on seven cases in adults, five of which recovered without sequellae, while two developed respectively into rheumatoid arthritis and seronegative polyarthritis. We therefore propound a dualistic concept although, in the present state of our knowledge, there is no means of predicting at onset whether the disease will resolve or progress towards polyarthritis. We suggest that the term Still disease be used only when chronic and/or destructive arthritis develops. Among the forms which are neither chronic nor destructive, there seems to be a number of cases in allergic patients with poor tolerance of chrysotherapy. Some of these patients could recover after the cure of an often latent focal infection, usually of the upper respiratory tract, ear or oral cavity, resistant to antibiotics. In the other cases, corticosteroid therapy is usually very effective in arresting an exacerbation of the disease. | |
| 7150374 | Cytotoxic activity of sera from scleroderma and other connective tissue diseases. Lack of | 1982 Dec | It has been suggested that serum-mediated endothelial cell injury in scleroderma might contribute to disease pathogenesis. We compared the effect of serum from 28 scleroderma patients on human umbilical cord vein endothelial cell and human foreskin fibroblast proliferation with sera from 28 healthy controls, 13 patients with isolated Raynaud's disease, 22 patients with systemic lupus erythematosus, 19 patients with rheumatoid arthritis, and 15 patients with other connective tissue diseases. Five sera (2 scleroderma, 1 morphea, 12 rheumatoid arthritis, 1 systemic lupus erythematosus) markedly suppressed 3H-thymidine incorporation into both endothelial cells and fibroblasts (to greater than 3 SD below the mean of the control group). These sera were also cytotoxic to endothelial cells and fibroblasts in a 51Cr release assay. Three additional sera (1 Raynaud's, 2 controls) suppressed endothelial cell proliferation moderately (greater than 2 SD but less than 3 SD from control mean) but did not affect fibroblasts. Mean 3H-thymidine incorporation by endothelial cells and fibroblasts in scleroderma serum was comparable to that of the other disease and control groups. In contrast to previous studies, we found serum-mediated endothelial cell cytotoxicity occurred infrequently in scleroderma, occurred also in other connective tissue diseases, and was without target cell specificity. Furthermore, scleroderma serum did not appear to stimulate fibroblast proliferation. | |
| 7114925 | Nephelometry compared with differential antibody titre in routine rheumatoid factor measur | 1982 Aug | The comparative merits of agglutination techniques (differential agglutination titre (DAT)/latex slide test) and nephelometry for the routine measurements of IgM rheumatoid factors have been studied in this 2-part paper. The first part investigates the errors inherent in standard DAT measurements, and the second determines the rate of false positive results in an elderly nonrheumatoid population. It was found that the errors in agglutination techniques are due to differences in setting up the tests rather than in interpreting the results, and that the coefficient of variance was consistently around 20%. Approximately 1 in 5 of DAT results have such a high error as to be clinically valueless. The false positive rate in the elderly nonrheumatoid population was only 2% with nephelometry compared with 9% on the latex slide test. A previous study had demonstrated the advantages of nephelometry over DAT in routine rheumatological use, showing not only greater reproducibility but also a more accurate positive detection rate than the DAT in rheumatoid arthritis. The results also suggest that the traditional spectrum of rheumatoid factors of low titre detectable in the general population is probably an artefact inherent in agglutination techniques and that a definitive cut-off point is more likely. As nephelometers are generally available in biochemistry laboratories there is much to recommended their routine use for the measurement of IgM rheumatoid factors. | |
| 12280147 | Connective tissue diseases, arthritis require special patient counseling. | 1985 Jul | ||
| 656158 | Total hip replacement in children with arthritis. | 1978 May | Fourteen children with juvenile rheumatoid arthritis and two with ankylosing spondylitis received 29 total hip replacements (THR). The ages at THR were 12 to 18 years, the median duration of prior hip disease was 7.1 years, and the minimum followup was one year (range 1--4 years, median 2.2 years). The primary indication for THR was pain in 5 hips and severe malposition or flexion contractures in 24 hips. (Sixteen of these also had some degree of pain.) All 29 hips demonstrated improved postoperative range of motion, and all were free of pain. In children, active rheumatic disease in other joints, prosthesis longevity, and possible lack of adequate motivation all merit special consideration prior to THR, but the results are encouraging. | |
| 4073068 | Attitudes of patients with hypertension or arthritis toward the frequency of medication ad | 1985 Nov | The attitudes of patients with a nonpainful chronic illness (hypertension) and the attitudes of patients with a painful chronic illness (arthritis) toward the frequency of medication administration were compared. Hospitalized patients with rheumatoid arthritis (n = 83) and hypertension (n = 117) were interviewed by study monitors. Multiple-daily dosing was preferred by 70% of the arthritis patients and 61% of the hypertension patients for pain medications. The majority of patients in both groups preferred single-daily dosing for nonpainful conditions. The majority of patients in both groups believed that there was no difference between the dosing regimens in terms of the number of side effects. Thirty-five percent of the patients with arthritis and 19% of the patients with hypertension stated that they would consider increasing or decreasing the number of daily doses of their medication. A single daily dose might not be the optimal dosing regimen for all medications for all patients. Clinicians should consider the nature of the patient's illness and its potential influence on compliance when selecting a dosing regimen. | |
| 806697 | Acute tropical polyarthritis in Sri Lanka patients. | 1975 Feb | This paper described the clinical manifestations and laboratory findings in 20 patients with an unusual form of arthritis. All but two were above the age of 20 years (range 14-79). There were eight males and 12 females. The majority of them had fever. All had multi-joint involvement. The erythrocyte sedimentation rate was elevated (mean 74 mm./hr.). All recovered completely with penicillin and salicylates; there were recurrences in two, but no tendency to chronicity. | |
| 6235815 | Arthropathy of Down's syndrome. | 1984 Aug | Down's syndrome (trisomy 21) is associated with a variety of skeletal abnormalities and an increased incidence of joint hypermobility. Children with Down's syndrome are known to have a number of immunologic abnormalities and an increased incidence of autoimmune phenomena. We report 7 patients with Down's syndrome and arthritis. Four children had polyarticular disease and 3 had pauciarticular disease at onset. Only 1 child had significant cardiac disease. HLA typing in 5 children did not show specific correlations. Mean duration of followup was 3 years and 7 months. All children responded to nonsteroidal antiinflammatory drugs, but only 1 child is in clinical remission. Two children have died: 1 secondary to cervical spine instability and the other secondary to cardiac compromise. Arthropathy associated with Down's syndrome should be an additional exclusion for the diagnosis of juvenile rheumatoid arthritis. Further investigation of this association may give clues to the relationship between genetic and immunologic factors in the pathogenesis of joint inflammation. |