Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6689382 | The association of Mycoplasma hominis with arthritis. | 1983 Oct | The facts that mycoplasmal arthritis occurs naturally in various animal species and can be induced experimentally have been the main reasons for searching for evidence of mycoplasmal infection in the joints of patients with rheumatoid arthritis. There is, however, no evidence that Mycoplasma hominis is involved in this disease. On the other hand, M. hominis and other mycoplasmas, including Ureaplasma urealyticum, have been isolated from the arthritic joints of several hypogammaglobulinemic patients, and there is some evidence to indicate that the organisms are responsible for the disease. Furthermore, on rare occasions M. hominis has caused arthritis in mothers after childbirth. The relationship between this agent and sexually acquired reactive arthritis (SARA) has been the subject of recent investigation. Sera from 27 patients with nongonococcal urethritis and 25 patients with SARA, all tested previously for antibody to Chlamydia trachomatis, were examined by a metabolism-inhibition technique for antibody to M. hominis. Interpretation of the first tests was difficult because tetracyclines given to some of the patients caused their sera to inhibit metabolism. This problem was overcome by use of a tetracycline-resistant strain of M. hominis. Antibody was found in the sera of only a few patients and not in those of SARA patients whose disease was considered to be nonchlamydial. The initiating factor in nonchlamydial SARA therefore remains an enigma. | |
| 5085241 | A study of clofazimine in the rat. | 1972 Aug | 1. Clofazimine, an anti-mycobacterial agent used in the treatment of leprosy, has been reported to be particularly effective in the treatment of acute erythema nodosum leprosum reactions.2. The present experiments were designed to study in the rat this apparent anti-inflammatory activity.3. In doses relatively non-toxic to the animals clofazimine inhibited both rat adjuvant arthritis and the inflammatory paw swelling following an adjuvant injection.4. Clofamizine failed to inhibit both the primary antibody response to sheep erythrocytes and the tuberculin skin response.5. It is concluded that clofazimine exhibits definite anti-inflammatory (but not immunosuppressive) activity, and that it should be tested in patients with rheumatoid arthritis. | |
| 751309 | Selected autoimmune diseases in the dog. | 1978 Nov | In summary, previous attempts to explain the role of inheritance in autoimmune disorders through family studies have been hampered by the variable degree of phenotypic expression. Our evidence utilizing dogs in family studies is consistent with the concept that genetic factors play some role in determining disease susceptibility. Recognizing the complexity of the genetic components involved in these studies, we have proposed a hypothesis of two classes of genes, one that relates to immunoregulation and another that specifies pathologic lesions (and thus the clinical signs). This dual system of interacting genes provides a rational explanation for many of the observations previously encountered in both human and canine studies. | |
| 278133 | [Variations in salivary immunoglobulins in Sjögren's syndrome (author's transl)]. | 1978 | A study of salivary immunoglobulins (IgA, IgG, IgM) was made in 74 subjects with or without Sjögren's syndrome. In the normal subjects, only IgA could be detected by classical immunodiffusion techniques. A correlation was sought between the presence of IgG and/or IgM in the saliva, and various clinical or objective clinical examinations, as well as with accessory salivary gland biopsy. This study indicates that in Sjögren's syndrome the detection of IgG and/or IgM is strongly correlated with sialography which is the surest examination used clinically. Thus the detection and estimation of salivary immunoglobulins is thus a simple and specific complementary examination in Sjögren's syndrome. | |
| 6972557 | Protease inhibitor phenotypes and pulmonary disease in patients with Sjögren's syndrome. | 1981 | The incidence of pulmonary emphysema in patients with alpha-1-antitrypsin (alpha-1-AT) deficiency associated with the protease inhibitor (Pi) phenotype ZZ is increased. To determine whether less severe deficiency states of alpha-1-AT (i.e. Pi phenotypes other than ZZ and MM) might predispose to the development of pulmonary disease, Pi phenotypes were determined in a group of patients in whom the incidence of chronic pulmonary disease is high. The proportion of 52 patients with Sjögren's syndrome who had Pi phenotypes other than ZZ and MM was not significantly greater than that for populations of normal subjects. Mean values for tests of pulmonary function, including estimates of both restrictive lung disease and airway obstruction in patients with the MM phenotype were not significantly different from corresponding means for patients with non-MM phenotypes. These findings suggest that the increased susceptibility of patients with Sjögren's syndrome to develop chronic obstructive pulmonary disease is not attributable to an abnormally high frequency of non-MM phenotypes and associated moderately reduced serum levels of alpha-1-AT. | |
| 6422532 | Reiter's disease in northern India. A clinical and immunogenetic study. | 1983 | Thirty-six patients fulfilling the criteria for Reiter's disease were studied (29 men and 7 women; 4:1). The mean age of onset was 23.8 years; in 75% of patients the onset was in the second and third decades. Clinical manifestations included low back pain and stiffness (69%), non specific urethritis (53%), heel pain (44%), radiographic sacroiliitis (42%), conjunctivitis (39%), dysentery and diarrhoea (33%), mucosal ulcerations (17%) kidney disease (14%), anterior uveitis (19%), and keratoderma blennorrhagicum (8%). Peripheral arthritis was mono or oligoarthritis in 58% of patients, mainly affecting the large joints of lower extremities, and it was often asymmetric (mean degree of asymmetry = 0.37). HLA-B27 antigen was detected in 83% of 36 patients compared with 5.9% of 118 controls (relative risk 79, corrected Fisher's P = 7.719E-18). | |
| 6388322 | Nonsteroidal anti-inflammatory drugs and modulation of cartilaginous changes in osteoarthr | 1984 Oct 15 | Nonsteroidal anti-inflammatory drugs have a potential for modifying the complex pathophysiologic events leading to cartilage destruction in various forms of arthritis. Following an evaluation of basic mechanisms in the pathogenesis of cartilaginous destructive lesions, the effects of nonsteroidal anti-inflammatory drugs on normal chondrocyte metabolism are discussed. Their capacity to modulate cartilage and bone lesions in experimental forms of arthritis is addressed, as is the manner in which they may modify the pathophysiology of cartilage destruction in human forms of arthritis. Different classes of nonsteroidal anti-inflammatory drugs produce different effects in certain in vivo or in vitro settings. | |
| 6606406 | Primary amyloidosis presenting as Sjögren's syndrome. | 1983 Dec | A patient had severe sicca complex. Histopathologic and immunologic examination of the salivary glands showed amyloid fibril infiltration, type A lambda VI. To our knowledge, this is the first documentation of immunologically characterized primary amyloidosis causing the sicca complex. The sicca complex is usually associated with Sjögren's syndrome and the presence of autoantibodies to SSA and SSB. These antibodies were absent in our patient, despite the severity of the sicca syndrome. The clinician should consider more unusual causes of the sicca complex, eg, amyloidosis, particularly if the serologic markers of antibodies to SSA and SSB are absent. Tissue typing the amyloid protein diagnosed primary amyloidosis, obviating the need to search for underlying disease. | |
| 3930111 | An idiotypic complementarity between rheumatoid factor and anti-peptidoglycan antibodies? | 1985 Aug | Groups of BALB/c mice have been repeatedly immunized with sterile affinity-purified human rheumatoid factor (RF) preparations from high-titred seropositive rheumatoid arthritis sera. In all cases, there was an antibody response reactive with Streptococcus pyogenes cell wall peptidoglycan-polysaccharide (PG-PS) polymer in both immunodiffusion and ELISA. This antibody could be absorbed by either excess RF or PG-PS, but not by isolated human non-RF IgG or IgM preparations. Groups of mice similarly immunized with non-RF IgG or IgM produced no significant anti-PG-PS antibody response compared with pre-immune sera. All immunogens lacked detectable PG-PS. Thus, anti-PG-PS antibody may be produced by RF immunization in the absence of PG-PS. This suggests some idiotypic complementarity between RF and anti-PG-PS antibodies. | |
| 23944696 | Identifying leisure interests. | 1984 | Helping adults learn to live with arthritis is a major responsibility for occupational therapists. There are a variety of instruments for therapists to use in evaluating the self-care and work components of occupational performance, however there are no instruments for assessing the leisure interests of persons with arthritis. The purpose of this investigation was to develop an instrument for assessing the leisure interests of adults with rheumatoid arthritis or degenerative joint disease. The instrument is patterned after Knowles self-diagnostic competency model. Following Knowles' procedure of developing such a model, a literature review and a panel of occupational therapists with expertise in the treatment of rheumatic disease were used to identify a list of leisure activities. The list was categorized and applied to Knowles' suggested format for a self-diagnostic competency model. Strategies for using the instrument with the targeted population are presented. | |
| 6772782 | Oligohydramnios and transient neonatal anuria: a possible association with the maternal us | 1980 May | The chronic use of prostaglandin synthetase inhibitors is reported in a pregnant patient with severe juvenile rheumatoid arthritis. Aspirin and indomethacin, along with corticosteroids, were required to prevent significant progression of the disease. Pregnancy was complicated by oligohydramnios and intrauterine growth retardation. The infant suffered transient anuria. The effects of prostaglandin synthetase inhibitors on renal vascular function is reviewed, and a possible association between the chronic ingestion of these drugs and compromised renal function in the newborn is pointed out. | |
| 565281 | [Visceral kala-azar disease in a child (author's transl)]. | 1978 Mar 10 | Repeated blood cultures were negative in a six-year-old boy with high septic temperature. Rheumatoid arthritis, typhoid and brucellosis were excluded. There was no evidence of leukaemia (bone-marrow tests). There was hepatomegaly with increased transaminase activity. Cortisone treatment was begun for suspected collagen disease. Several liver needle biopsies at first revelaed increasingly severe necrotising changes, predominantly in the centres of the acini. There were no parasites demonstrable histologically. The spleen was increased in the isotope scan but, covered by the liver, not definitely palpable. Diagnosis of mediterranean Kala-Azar disease was then suspected (the parents reporting a camping holiday in Yugoslavia) and finally proven serologically. The previously treatment-resistant disease improved dramatically after administration of trivalent antimony (Fuadin). | |
| 849879 | The binding constants of IgM rheumatoid factors and their univalent fragments for native a | 1977 Mar | IgM rheumatoid factors (RF) were isolated from the sera of patients with rheumatoid arthritis and a serologically active Fabmicron RF fragment prepared by papain digestion. A radioimmunoassay was developed for the determination of interaction of 19S IgM RF and Fabmicron RF with human 7S IgG, heat-aggregated IgG, rabbit 7S IgG, and human pFc'. RF isolated under neutral conditions had a very low binding constant for human 7S IgG (of the order of 10(2) to 10(3) 1 mole-1) and a considerably higher value (ca. 10(5)) for the aggregated protein and monomeric rabbit IgG. RF obtained under acid conditions which dissociate the complexes with endogenous Ig, had a higher avidity for human IgG monomer as expected and also a comparable reactivity with rabbit IgG. Monovalent Fabmicron fragments of 'acid' RF had closely similar affinities for 7S and aggregated IgG suggesting that the enhanced binding with the aggregated protein is essentially dependent on its multivalency rather than the exposure of a new determinant lacking in the native molecule. | |
| 6975369 | Adjuvant polyarthritis. VI. Effect of oxonate-induced hyperuricemia on the development of | 1981 Dec | In humans, there is a negative correlation between gout and rheumatoid arthritis. Similarly, rats rendered hyperuricemic by an oxonate diet appeared resistant to develop adjuvant arthritis. These animals exhibited a normal inflammatory response to a subplantar injection of carrageenin and normal humoral and cell-mediated immune responses to a sensitizing dose of EL4 cells. However, unlike that of normal animals, the cell-mediated immune system of the oxonate-treated rats was found to be unable to respond to adjuvant stimulation, which may be the basis for their resistance to develop adjuvant disease. | |
| 6451634 | Autoantibody to an immunoregulatory inducer population in patients with juvenile rheumatoi | 1981 Mar | The human inducer (T4(+)) and reciprocal cytotoxic/suppressor (T5(+)/T8(+)) subsets have been defined by monoclonal antibodies. In the present study, we examined the relationship of naturally occurring anti-T cell autoantibodies found in patients with active juvenile rheumatoid arthritis (JRA) to these subsets. In one approach, normal T cells were treated with anti-T4 or anti-T8 to eliminate the corresponding subset of cells and then analyzed for reactivity with JRA sera. It was found that JRA sera were reactive with only 15% of an enriched cytotoxic/suppressor population, whereas they reacted with 37% of an enriched inducer population. In reciprocal studies, JRA(+) T cells were eliminated with JRA sera and complement and the residual T cells (JRA(-)) reacted with monoclonal antibodies and indirect immunofluorescence on a fluorescence-activated cell sorter. As expected, the JRA sera and complement treatment of unfractionated T cells markedly diminished the T4(+) subset, whereas there was a concomitant increase in T cells reactive with anti-T5 and anti-T8. A similar diminution in T4(+) T cells was found in the circulating peripheral T cell compartment of patients with active JRA who possessed the JRA antibody. Functional studies demonstrated that removal of the JRA(+) population of T cells diminished phytohemagglutinin and soluble antigen proliferative responses, both of which were previously shown to be functions of T4(+) T cells. More importantly, in the absence of JRA(+) T cells, pokeweed mitogen-stimulated immunoglobulin production was markedly enhanced, despite the concomitant increase in T5(+)/T8(+) cytotoxic/suppressor cells. These results suggest that the JRA serum may define a Qal-like antigen found predominantly on the human inducer population which could activate suppressor and/or other feedback regulatory cells. | |
| 24822879 | Intrapelvic complications of hip surgery: a case report of obturator nerve entrapment. | 1979 Sep 1 | A case is presented in which a patient had persistent pain in one hip after bilateral total hip replacement for rheumatoid arthritis. The diagnosis was elusive until at intrapelvic exploration the obturator nerve was found to be markedly stretched over a large bolus of intrapelvic methylmethacrylate. The patient was completely relieved postoperatively after the cement mass was removed. | |
| 6610259 | [Serum uric acid levels in disorders of the rheumatic type]. | 1984 Mar | Serum uric acid levels were investigated in a series of 1715 subjects. Of these 596 were patients suffering from inflammatory rheumatic disorders, 162 patients with gout, 236 with osteoarthrosis and 79 with systemic lupus erythematosus or diffuse scleroderma. 642 healthy subjects completed the series. On analyzing the results, very high uricemia values were found in patients with gout. Increased average uricemia values were observed in patients with psoriatic arthritis and diffuse connective tissue disorders (systemic lupus erythematosus and diffuse scleroderma). Hyperuricemia was found in psoriatic arthritis, rheumatoid arthritis, and in nosologic units classified under diffuse connective tissue disorders in 5.6 to 10.1% of patients. In the healthy subjects examined, hyperuricemia was recorded in 3.8% of cases. | |
| 6595464 | [Differentiation of juvenile chronic arthritis--diagnostic significance of HLA association | 1984 Nov | From January 1980 to June 1982, 150 children with primary onset of a joint disease during the previous 6 months were entered into a prospective non-randomized observation study. 106 of the 150 children were diagnosed as juvenile chronic arthritis cases according to the EULAR-criteria. Nine children of this group belonged to the systemic subgroup (7 girls, 2 boys). HLA-typing was performed in 100 of the 106 children: HLA-B27 was evident in the total patient group with significantly increased 41% versus 8.9% of the control group. This antigen is significantly evident in all subgroups with variously increased frequency, except in the systemic and early-onset (pauciarticular) subgroups; the frequency in the rheumatoid-factor-negative polyarticular type of juvenile chronic arthritis (JCA) was 37.9%, in the rheumatoid-factor-positive polyarticular form 33.3%, and in the oligoarthritis/sacroiliitis-group 72.2%. DR5 was significantly present in the total patient group with 32% (control group 13.4%) and in the early-onset oligoarthritis group (43.7%). The rheumatoid-factor-positive (50%) and negative polyarticular group (31%) showed a pronounced slightly significant increase. | |
| 7289428 | [Unusually long post-initial remission in case of steroid-diabetes (author's transl)]. | 1981 Sep | The case of a girl, aged 12, is reported, in whom for juvenile rheumatoid arthritis--concomitant with uveitis--a short steroid treatment was performed. After steroid treatment the diabetes became with the symptoms of a diabetic coma manifest. After the beginning of the insulin administration an unusually long remission period followed,--therefore the insulin was temporarily stopped. On the basis of the known relationship between the juvenile diabetes and autoimmune diseases it is advisable--before the beginning of steroid treatment of auto-immune diseases--to perform intensive sugar metabolism examinations (glucose tolerance test). | |
| 7424194 | [Clinical effects of anti-human lymphocyte globulin in the treatment of collagenoses in ch | 1980 Jan | 9 children with collagenoses were first treated with AHLG "Dessau" in combination with corticosteroids and then with Imurek (azathioprine). The children seemed to be vitally endangered and suffered from panarteritis, dermatomyositis, polyserositis or corticosteroid-resistent systemic juvenile rheumatoid arthritis. As assessed by decrease of inflammation and clinical symptoms the treatment appeared in one case to be very good and in another good; in four other children it was good for a short period; in three children there was no effect at all. Side effects occurred relatively frequently (thrombocytopenia, anaphylactoid reactions). The justification of an immuno-suppressive treatment together with anti-human-lymphocyte-globulin is discussed in relation to todays knowledge of the pathogenesis of collagenoses and of the mechanisms behind the effects of the AHLG. |