Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6880720 | Cardiac involvement in juvenile rheumatoid arthritis. A follow-up study. | 1983 May | Cardiac involvement was diagnosed in 15 of 320 cases of JRA (4.7%) and was most frequent in children with active systemic disease. Ten children had pericarditis, 2 had myocarditis, 2 had peri-myocarditis and 1 had aortic valvulitis. The highest risk of heart involvement was found during the first three years but it could occur at any time. Recurrent episodes were seen in 60% of cases. The prognosis in pericarditis seems to be good since no patient developed cardiac tamponade or constrictive pericarditis and cardiac function evaluated by echocardiography was normal in all patients at follow-up. In patients with myocarditis and peri-myocarditis, a dilated left ventricle was found in 2 of 4 patients and 1 patient who died, had severe cardiac changes at autopsy. The prognosis in myocarditis thus seems to be worse. In valvulitis the prognosis depends on which valve is involved. The benefit of early treatment with corticosteroids is discussed. | |
| 392987 | [Experimental study on erysipeloid arthritis in the rabbit after blockage of lymph drainag | 1979 Sep | The lymph drainage was radically blocked in 29 rabbits. One to three days after the operation Erysipelothrix rhusiopathiae was inoculated subcutaneously into the animals. Some control animals were injected with agents of erysipelas and some only with the sterile solution without additional blockade of the lymph drainage. Light and electron microscopy as well as immuno-histological tests showed that the erysipelas arthritis developing in rabbits closely resembles human rheumatoid arthritis with exsudative-necrotising changes of the synovial membrane, proliferation of synovial cells and subsynovial, perivascular plasmacell, and lymphocyte infiltration. The changes were not intensified by the additional blockade of the lymph drainage, when comparing the side with lymph drainage blockade and the non-operated side. The results may be explained by a marked pathogenetic importance of the erysipelas infection in comparison to the relatively mild, lymphostate dependent alterations as well as by mobilisation of macrophages on the operated side. | |
| 6155424 | Evidence for a subset of rheumatoid factors that cross-react with DNA-histone and have a d | 1980 Jun 1 | Cross-reactivity of a monoclonal rheumatoid factor with an antigen present on IgG and DNA-nucleoprotein was demonstrated, and evidence presented that the combining site of the antibody was involved in the reaction. The antigen on the DNA-nucleoprotein was shown to involve both DNA and histone fraction H2A + H2B and was trypsin sensitive. The relative binding affinity of the antibody appeared to be greater for IgG than the DNA-histone antigen. Similar polyclonal cross-reactive rheumatoid factors were found in a variety of diseases. A high incidence was found among patients with rheumatoid arthritis and mixed connective tissue disease. None were detected in patients with systemic lupus erythematosus and idiopathic cryoglobulinemia. Studies on one representative isolated polyclonal rheumatoid factor demonstrated the same reactivity with DNA-histone H2A + H2B as the monoclonal antibody. Cross-idiotype studies using antigen-binding inhibition methods demonstrated the same cross-idiotype on the polyclonal and the monoclonal rheumatoid factor which reacted with DNA-histone. This cross-idiotype was shown to be distinct from the cross-idiotypes previously demonstrated on monoclonal IgM proteins with anti-gamma-globulin activity. | |
| 6361986 | Treatment of juvenile rheumatoid arthritis with diclofenac sodium. | 1983 | Diclofenac sodium was investigated in the treatment of juvenile rheumatoid arthritis (JRA). The pharmacokinetics of diclofenac in children aged 2-7 was assessed. Seven patients were included in a single-dose trial to determine plasma levels and renal elimination of diclofenac sodium. Venous blood samples were taken at 0, 0.5, 1, 2, 4 and 6 hours after administration of a 25 mg enteric-coated Voltaren tablet. Urine was collected before and 0-6 and 6-12 hours after tablet ingestion. Maximum concentrations ranged from 0.79 to 4.25 micrograms/ml, and were found between 0.5 and 2 hours. Renal elimination of total diclofenac ranged from 5.4 to 10.2% of the oral dose in 6 of the 7 patients. The youngest patient (2 years) had a lower elimination rate (2.25%) during the 12 hours observed. The values for children over 2 years corresponded to the range measured in adults. The pharmacokinetic study was followed by a placebo-controlled study with diclofenac sodium and acetylsalicylic acid (ASA) for 2 weeks in 45 hospitalized patients aged 3-15 years. The patients were randomly assigned to either: DS 2-3 mg/kg/day, microcrystallized ASA 50-100 mg/kg/day, or placebo matching diclofenac. Global evaluation of therapeutic efficacy showed improvement in 73% of the patients in the diclofenac group, in 50% of the ASA group and in 27% of the placebo group. A statistically significant difference between these groups was found (p less than 0.05). The sum of grades of joint tenderness decreased during the 2 weeks in 67% of patients in the diclofenac group, in 56% of the ASA group and in 36% of the placebo group.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 6499392 | Rotatory subluxation of the scaphoid. | 1984 Nov | Rotatory subluxation of the scaphoid is an uncommon abnormality which is not widely understood. It can be difficult to diagnose and, if incorrectly managed, can lead to a severe and disabling radio-carpal arthritis. While complicating many forms of wrist trauma, its place in the lunate-perilunate dislocation spectrum being especially important, the abnormality may occur in the absence of trauma, such as with rheumatoid arthritis; its association with Kienböck's disease is documented in this paper. The mechanisms underlying the subluxation are discussed and the importance of early diagnosis is stressed. Eight cases of rotatory subluxation of the scaphoid are reported to illustrate the presentations, symptomatology and complexities of diagnosis. | |
| 729254 | Current concepts in synovial fluid analysis. | 1978 Jul | The systematic examination of synovial fluid confirms the noninflammatory nature of degenerative joint disease, is diagnostic of gout, pseudogout, and septic arthritis, and will usually allow the identification of rheumatoid arthritis, systemic lupus erythematosus and Reiter's syndrome. | |
| 6524979 | Synovitis with non-specific histological changes in synovium in chronic sarcoidosis. | 1984 Dec | Polyarthritic episodes in seven patients during the course of chronic sarcoidosis involved the knees and less frequently other joints. Synovial effusions were non-inflammatory or mildly inflammatory. Needle synovial biopsies 10 days to seven weeks after the onset of joint symptoms have revealed varying patterns, including mild lining cell proliferation, occasional vascular congestion, diffuse infiltrates with lymphocytes and histiocytes, but no granulomas. These studies show distinctly less inflammation than in rheumatoid arthritis. Granulomas need not be identifiable in synovium in all chronic sarcoidosis with arthritis. | |
| 594372 | Prostaglandin A2 and 35S uptake in connective tissue. | 1977 Oct | Rats deficient in essential fatty acids (EFA) incorporated lesser amounts of radioactive sulfate into lung, kidney, spleen, heart, costal cartilage, long bone and skull bone than did normal control animals. Administration of prostaglandin A2 stimulated 35S uptake by lung, kidney and aorta while 35S levels in costal cartilage, tibial cap and long bone were strikingly reduced. Comments are presented suggesting that this metabolic mechanism may explain, in part, cartilage and bone resorption in areas of inflammation, such as arthritis, both rheumatoid arthritis and osteoarthritis. | |
| 6246904 | Elevated levels of collagenase and prostaglandin E2 from synovium associated with erosion | 1980 May | A patient with chronic Lyme arthritis and roentgenographic evidence of bony erosion underwent a synovectomy; proliferative synovium (pannus), containing aggregates of small lymphocytes, was found adherent to eroded cartilage and bone. During 8 days in tissue culture, the synovial cells produced large amounts of collagenase and prostaglandin E2, but only low levels of both neutral and acid proteinases. Sixty-seven percent of the lymphocytes from the synovium were T cells; 19% were B cells. Attempts to identify agent/antigen in the synovial cells were unsuccessful. Thus, the synovium of this patient, whose disease appears to be tick-transmitted, resembles that of rheumatoid arthritis. This finding further supports the hypothesis that many possible agents, including infectious ones, trigger a common pathway in synovium, which leads to joint destruction. | |
| 6966599 | [Physical therapy in rheumatic diseases]. | 1980 Feb 28 | Physicotherapy is of rather high importance for many rheumatic diseases. Cold as well as warm applications will be positively effecting alleviation of distress and pain if close observation of the various stages is guaranteed. Indications for the different electrotherapeutic proceedings, however, have to some extent not been put up yet. Medical gymnastics is so far representing the only causally active therapy. The present study is demonstrating physicotherapeutic methods in relation to stages of rheumatic disease, as for instance in rheumatoid arthritis, ankylosing spondylitis, during some forms of non-articular rheumatism and--only fleetingly--arthrosis. | |
| 7353815 | Amyloid arthropathy in myelomatosis--intracytoplasmic synovial deposition. | 1980 Jan | An unusual case is described of a West Indian man who presented with symptoms of an acute polyarthritis and who was found to have myelomatosis. At necropsy, generalized amyloidosis was found with particular involvement of synovial tissue. Myelomatosis presenting as an acute polyarthritis resembling rheumatoid arthritis is an uncommon, although well recognized entity, whereas an arthritic picture produced by amyloidosis is exceptional. The occurrence of joint pathology in myelomatosis and amyloidosis is discussed and the unique feature of intracytoplasmic amyloid deposition seen in this case is stressed. | |
| 3919139 | Characterization of an epibody. An antiidiotype that reacts with both the idiotype of rheu | 1985 Feb 1 | Recently, an antiidiotype to human monoclonal IgM anti-IgG autoantibodies (rheumatoid factors) was found to react also with human IgG. This peculiar antiidiotype was called an 'epibody'. We describe the induction of a similar epibody by immunization with a synthetic peptide (corresponding to one hypervariable region of the IgM-RF Glo). The results confirm the existence of epibodies, and provide the possible molecular basis of the epibody phenomenon. | |
| 7332374 | Clinical features of 53 cases with pustulotic arthro-osteitis. | 1981 Dec | We have described clinical features of 53 cases with pustulotic arthro-osteitis. Anterior chest wall symptoms such as intersterno-costoclavicular or manubriosternal lesions were observed in all of 53 cases. Spondylitis or spondylodiscitis was found in 18 cases. Sacroiliitis resembling ankylosing spondylitis was seen in 7 cases. Peripheral inflammatory arthritis was seen in 14 cases, which were of nonerosive, of oligoarthritis type, and cured within 1 to 2 months, leaving no residue. HLA B27 was never found, and RAW factor was negative. Histological examinations revealed nonspecific chronic inflammation of bone and soft tissue. Pustulotic arthro-osteitis is apparently distinct from known rheumatic diseases such as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and Reiter's disease. We have proposed that this condition should be classified as a member of the "seronegative spondylo-arthritis' group as designated by Wright and Moll. | |
| 410740 | Clinical studies of the interaction between tolmetin and glibenclamide. | 1977 Sep | Forty patients with diabetes mellitus and rheumatic disorders (rheumatoid arthritis, osteoarthritis, soft-tissue rheumatism) were included in a double-blind trial with the purpose of investigating whether the concomitant administration of tolmetin and glibenclamide leads to an interaction. No significant alterations of blood and urine glucose values could be found in comparison to placebo. Therefore it can be assumed that there is no interaction between these two substances. | |
| 21307997 | The rheumatoid arthritic at home. | 1977 Jan | Most management of rheumatoid arthritis must take place in the patient's own home with only intermittent professional help. With good planning and instruction it is possible to create in the home a milieu appropriate not only for possible inducement of remission, but also for continuing care during even protracted disability.The mainstay of treatment in all stages of this disease is the achievement of a right balance between rest and activity. In the initial stages, proper rest and support, including splinting of the joints with other simple measures, will greatly relieve pain and help control the inflammatory process. A variety of therapeutic exercises can reduce the likelihood of secondary immobility and promote restoration of strength and function.For the patient in whom the disease has become chronic and disabling a wide variety of self-help devices can be prescribed, together with appropriate home modifications. | |
| 6792316 | Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) | 1981 Sep 1 | A model of arthritis was established by the injection of type II collagen into mice. Only mice bearing the H-2q haplotype were susceptible to the disease. Susceptibility was further mapped by the use of recombinant strains on the Iq locus. Type II collagen arthritis was observed in the (resistant X susceptible) F1 cross. Mice strains were designated high, intermediate, or low responders with respect to the anti-type II antibody levels measured by radioimmunoassay. Arthritis-susceptible strains were all classified as high antibody responders. The clinical and histological appearance of type II collagen arthritis in the mouse indicates that it may be a good animal model for the investigation of various immunogenetic traits in rheumatoid arthritis. | |
| 2995797 | [Treatment of juvenile rheumatoid arthritis]. | 1985 Jul | Recently interest in pediatric rheumatology has increased. This review tries to summarize our knowledge about pharmacological mechanisms, as well as practical application and adverse of antirheumatic drugs. In addition, forms of treatment which sofar lack any scientific backing are mentioned and discussed. Various data about efficacy and side effects in children are poor or lacking, and current treatment in children is based on analogy conclusions derived from experiences with adult RA. The therapeutic concept presented in this article offers a good chance to improve the functional status of the rheumatic child. However, one should be aware that several controlled trials with antirheumatic drugs in children still have to be performed. Uncertainties have to be replaced by knowledge. This is true also for the surgical treatment mentioned. | |
| 1225510 | Antirheumatic drugs: clinical pharmacological and therapeutic aspects. | 1975 | There are many current concepts of the pathogenesis of rheumatic diseases which incorporate immunological, infectious and hereditary factors. Rheumatic diseases may sometimes become apparent after trauma, be associated with certain diseases and may be induced by nerve damage and serum sickness. Systemic lupuserythematosus may result from the use of a variety of drugs. At present the body of evidence tends to incriminate immunological factors as well as infectious agents as principal factors in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus. Just as there is uncertainty regarding the pathogenesis of rheumatic diseases, knowledge of the mechanism of action of the various drugs used to treat these diseases is also incomplete. Recent progress indicates that inhibition of prostaglandin biosynthesis and possibly lysosomal membrane stabilization are primary modes of action of the anti-inflammatory agents. Certain antirheumatic drugs have also been shown to exert some of their therapeutic effect by interfering with the kallikrein-kinin-kininase system... | |
| 24833620 | Acid hydrolase activity following allografting. | 1982 Jul | The synovium of dogs receiving an osteochondral allograft of the distal femur has similar characteristics to a rheumatoid synovium. Since it is generally believed that the cartilage destruction in rheumatoid arthritis is related to the release of hydrolases from lysosomes, the following study was performed to determine whether a similar phenomenon is responsible for the destruction of transplanted articular cartilage. Host synovium revealed an almost threefold increase in acid phosphatase activity at 26 and 52 weeks after transplantation when compared to controls. Electron microscopy studies showed a marked increase in the number of lysosomes seen in the type A synovial cells at 26 weeks, degradation of the cartilage matrix, and the presence of enzyme reaction product when treated for cytochemical demonstration of acid phosphatase activity. It is concluded that the host synovium destroys the allograft by the release of lysosomal enzymes. | |
| 20120568 | Clinical and ergonomic factors in prolonged shoulder pain among industrial workers. | 1979 Sep | Twenty male patients who were attending an occupational health care center because of prolonged (more than three months) shoulder pain were subjected to extensive rheumatological and laboratory examinations. Ergonomic and anthropometric data were compared with those of matched referents. Inflammatory rheumatic diseases were diagnosed for three patients (rheumatoid arthritis for one and reactive arthritis to urinary infections for two). No definite diagnosis was possible with regard to the other 17 patients. Their ages were significantly higher than the mean age of workers at their respective factories and that of industrial workers in Sweden. The anthropometric measurements for these patients did not differ from those of the matched referents or from other Swedish males of the same age. Shoulder load, estimated as work with hands at or above acromion height, was significantly heavier among the patient group than among the referents. Neither the evaluated physical load of their current work nor previous hard work was found to be a significant factor. A follow-up two years later showed a definite deterioration, the majority being on pension or still on sick leave. |