Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6631997 | Pulmonary nodular amyloidosis presenting as Sjögren's syndrome. | 1983 Sep | A case of nodular pulmonary amyloidosis with Sjögren's syndrome is presented. A search of the literature failed to reveal any such case in which pulmonary nodules progressively calcify. | |
| 7079605 | Immunological changes in canine cruciate ligament rupture. | 1982 Mar | Samples of sera (39) and synovial fluid (36) from 58 dogs suffering from inflammatory arthropathy of the stifle joints, 47 of them in combination with unilateral or bilateral rupture of the anterior cruciate ligaments (CLR), were investigated for C1q-binding immune complexes (IC) using a solid phase radioimmunoassay. In 31 out of 39 sera (79 per cent) and 25 out of 36 synovial fluids (69 per cent) significant IC concentrations could be detected. As controls 21 healthy dogs were used. The radioimmunoassay was standardised with aggregated dog gamma globulin. The sera of the dogs were also investigated for anticollagen antibodies to denaturated type 1 or type 2 dog collagens. No evidence of the presence of these antibodies could be obtained. In a small percentage of sera and, or, synovial fluids rheumatoid factor could be demonstrated. These results indicate that the CLR in dogs is accompanied by immunological mechanisms. | |
| 962970 | Rheumatoid factor in acute bacterial endocarditis. | 1976 Sep | Sera from 55 parenteral drug abusers with endocarditis due to Staphylococcus aureus were assayed for the presence and titer of rheumatoid factor. Thirteen (24%) of the 55 patients with endocarditis had sera positive for rheumatoid factor at one point or another in their courses; only 2 (7%) of 30 noninfected drug users were found to be positive. It appeared that more severe cases, as evidenced by duration of fever after initiation of antibiotic therapy, were more likely to develop rheumatoid factor. | |
| 6170754 | Antitrypsin activity and enzyme inhibitors in the rheumatoid joint. | 1981 Jul | Proteolytic enzyme inhibitor activity has been measured in the rheumatoid knee by 2 different techniques. The inactivation rate of trypsin injected into the joint in 13 patients was compared with synovial fluid levels of alpha-1-antitrypsin (apha 1AT), alpha-2-macroglobulin (alpha 2M) and trypsin inhibitory capacity (TIC). The lack of correlation and the fact that an inverse relationship was shown between the T1/2 to inactivation and joint damage suggests that additional mechanisms are involved in the inactivation of destructive enzymes. Serum levels of alpha 1AT and TIC were elevated in 36 rheumatoid arthritis (RA) patients when compared with control values and RA synovial fluid inhibitor levels elevated by comparison with osteoarthritic figures. The synovial fluid alpha 1AT and TIC correlated with the activity of the lysosomal enzyme beta-acetyl glucosaminidase (beta AGA) but only trace amount of neutral protease activity was detected probably because of the large concentration of inhibitors present. The deficient Pi phenotype MZ was rarely encountered. | |
| 4014226 | Treatment of hemophilic arthritis with D-penicillamine: a preliminary report. | 1985 Jul | Current medical management programs for established joint diseases in hemophiliacs are unsatisfactory and do not modify the eventual outcome. D-penicillamine, a drug effective in the proliferative synovitis of rheumatoid arthritis, was evaluated in a rabbit model of hemarthroses-induced arthritis and in four hemophiliacs with chronic synovitis. The animals had intra-articular injections of citrate (left knees) and autologous citrated whole blood (right knees). Eight weeks later, the rabbits were divided into two groups: no treatment and D-penicillamine (50 mg/kg/day, IM) until sacrificed at 6 months. The saline-injected joints showed no inflammation and no iron deposition. The blood-injected knees showed iron deposition in both groups, the D-penicillamine animals had marked suppression of chronic inflammation. Of the four patients treated, three had clinical responses (reduction in synovial thickness, reduction in number of bleeds in the affected joint). One patient, who did not respond, developed mild-moderate proteinuria. Those patients who responded received between 5.3 and 7.1 mg/kg/day of the drug. Mild abnormalities in platelet aggregation were seen in the responders. This preliminary study suggests that D-penicillamine is beneficial in the chronic synovitis/arthritis induced by hemarthroses. Further trials are recommended. | |
| 4013750 | Complexed autoantibodies in patients with juvenile connective tissue diseases, isolated by | 1985 Apr | Selected sera from one patient with systemic lupus erythematosus, two with mixed connective tissue disease, one with dermatomyositis, one with progressive systemic sclerosis and one with juvenile rheumatoid arthritis were investigated for autoantibodies after fractionation by computerized rate-zonal ultracentrifugation. Anti-Smith antibodies sedimented in an area from 6-11 S and anti-ribonucleoprotein from 6-13 S. IgG anti-IgG and IgG antinuclear antibodies (ANA) were present in free or complexed form in the 6-13 S area. IgM ANA occurred as 7 S IgM in patients with systemic lupus erythematosus and mixed connective tissue disease, whereas IgM ANA sedimented in the 19 S area in patients with dermatomyositis and progressive systemic sclerosis. Complexes containing IgG anti-IgG and ANA, positioned in the 6-13 S area are likely to play a significant role in the pathogenesis of systemic lupus erythematosus and mixed connective tissue disease. | |
| 7045360 | Aspirin and fenoprofen (Nalfon) in the treatment of juvenile rheumatoid arthritis results | 1982 Jan | We compared efficacy and safety of aspirin (ASA) and fenoprofen in the treatment of JRA. Ninety-nine children with JRA were given ASA or fenoprofen in a 12-wk, multicentered, double-blind, parallel study. Initial fenoprofen dosage was 900 mg/m2/d increased to 1800 mg/m2/d (3200 mg/d-max). Initial ASA dosage was 1500 mg/m2/d increased to 3000 mg/m2/d (5450 mg/d-max). Adverse reactions forced removal of 14% of ASA treated patients from the trial, whereas no fenoprofen patient was removed for this reason. Forty of 50 ASA patients, and 47 of 49 fenoprofen patients completed at least 10 wk of therapy and analysis showed that the 2 drugs were nearly identical in efficacy, but toxicity was considerably less among fenoprofen treated patients. | |
| 835940 | Aspirin hepatotoxicity and disseminated intravascular coagulation. | 1977 Feb | A 17-year-old girl with a clinical diagnosis of adult-type juvenile rheumatoid arthritis developed a severe hepatotoxic reaction to 3.6 g of aspirin per day. This was associated with a microangiopathic anemia and transient congestive cardiac failure. She responded well to steroids, and when all laboratory test findings were back to normal, she was "challenged" with five divided doses of aspirin (total, 3.0 g). This produced a salicylate level of 9.1 g/dl and was associated with an immediate deterioration in liver function test findings and a return of microangiopathic blood features with elevation of fibrin split products and a prolonged prothrombin time. These changes were again reversed by promptly starting steroid therapy. This case suggests that disseminated intravascular coagulation, and its rare association with hepatotoxicity, is a potentially fatal side effect of aspirin therapy. | |
| 6358589 | Immunopharmacologic studies of D-penicillamine-L-cysteine disulfide. | 1983 Oct | Effects of D-penicillamine-L-cysteine disulfide (P-C) on some immunological parameters were examined in normal and immunity-impaired mice and rats. P-C enhanced the DNA synthesis in concanavalin A-stimulated mouse spleen cell cultures in vitro. In vivo, administration of P-C produced either enhancement or depression of plaque forming cell (PFC) response and delayed type hypersensitivity (DTH) to sheep red blood cells (SRBC) in low responder mice to SRBC, depending on the dose of P-C. P-C restored the impaired PFC response in hydrocortisone-pretreated mice. The enhancing effect of P-C was not shown in high responder mice to SRBC, but an inhibiting effect was observed. P-C inhibited the suppressor cell induction on PFC response in mice immunized with a supraoptimum dose of antigen. In adjuvant arthritic rats, P-C induced severe arthritis by eliminating the suppressor cells regulating this disease process. The relevance of these findings and mode of action of D-penicillamine in rheumatoid arthritis is discussed. | |
| 7441652 | Antigen-induced arthritis: an immunohistologic study of articular tissue and synovial flui | 1980 Sep | Articular tissue and synovial fluid from rabbits with antigen-induced arthritis were stained for localization of immunoglobulin (Ig) and egg albumin (EA) using the immunoperoxidase technique. Discrete granules containing Ig and EA were initially observed within vascular synovial tissue with later occurrence in synovial fluid and dense connective tissue. Homogeneous staining for Ig was not always associated with the presence of antigen and, therefore, cannot be used alone as evidence of the presence of immune complexes. Discrete granules of Ig and EA are formed in dense connective tissue during the period of maximal inflammation and persist for at least 30 days. These granules presumably represent precipitated immune complexes of Ig and EA but can be stained for Ig alone longer than for EA. Insoluble, particulate immune complexes of Ig and EA appeared in synovial fluid within 2 h after injection and remained at least 24 h. These were identical in appearance to the Ig precipitates occurring in synovial fluids from human rheumatoid arthritis. | |
| 6977496 | Association of anti-F (ab')2 antibodies (pepsin agglutinators) with immune complexes as de | 1982 | A solid-phase assay for the detection of anti-F(ab')2 antibodies is described. Wells of microtiter plates are coated with F(ab')2, dilutions of sera are added, and IgG bound to the solid phase is detected using peroxidase-labeled Protein A. Anti-F(ab')2 antibodies were found in 61% of sera from patients with rheumatoid arthritis, 77% with subacute bacterial endocarditis , and 34% with systemic lupus erythematosus. Simultaneous analysis of these sera for immune complexes (IC), using modified Clq and monoclonal rheumatoid factor assays, showed that a correlation existed between anti-F(ab')2 antibodies and the levels of IC. Characterization of anti-F(ab')2 antibodies by inhibition and absorption experiments and by immunological and physical means indicated that they were similar to serum proteins described in the 1960s and designated pepsin agglutinators. | |
| 7086770 | Sodium meclofenamate (Meclomen) in the treatment of juvenile rheumatoid arthritis. A segme | 1982 Jan | Thirty-nine patients with JRA were treated with sodium meclofenamate (Meclomen) during a 4-wk open-labeled, non-controlled trial. Increasing doses started at 3 mg/kg/d qid, up to 7.5 mg/kg/d, not to exceed 300 mg/d. Seven patients dropped out due to adverse side effects, and 1 from inefficacy. Efficacy analysis showed statistically significant decreases in several disease indices, in particular the duration of morning stiffness. Twenty-one patients who completed the 4-wk study entered an extended open-labeled study. Nine patients completed at least 9 months of sodium meclofenamate therapy. At 9 months, these 19 showed mean decreases in all rheumatologic disease indices measured. The drug has recently been approved by the Food and Drug Administration for use in adults. | |
| 6738376 | The oral ecology of patients with severe Sjögren's syndrome. | 1984 | An investigation of the commensal microflora, salivary flow rate, pH, and the degree of atrophy of the oral mucosa in ten patients with severe Sjögren's syndrome and ten control subjects, revealed a number of differences. The numbers of Streptococcus salivarius, Neisseria pharyngis, Veillonella species and Micrococcus mucilagenosus isolated from patients with Sjögren's syndrome were significantly reduced, while the numbers of Candida spp. and Staphylococcus aureus were significantly increased when compared with control subjects. In addition the salivary pH of the Sjögren's group was significantly reduced and the degree of mucosal atrophy increased compared with controls. | |
| 6395620 | Bone grafting in total hip replacement for acetabular protrusion. | 1984 Dec | Total hip replacement combined with acetabuloplasty was performed in 43 hips in 40 patients with protrusion secondary to arthrosis, rheumatoid arthritis or trauma. Depending on the acetabular defect, the acetabuloplasty encompassed reinforcement of the medial wall with bone grafts, vitallium meshes, protrusion rings and cups. The clinical and radiographic results were uniformly good on average 2 years postoperatively. All grafts appeared to be united and incorporated, without evidence of resorption. The only patient suffering from pain had radiographic signs of progressive varus migration of the femoral component. | |
| 6344810 | Polymyalgia rheumatica: an arthroscopic study of the shoulder joint. | 1983 Jun | A careful selection of 19 patients fitting the classical description of polymyalgia rheumatica have been examined by arthroscopy and thoroughly screened and followed up to exclude rheumatoid arthritis and other disease processes. Synovitis of the shoulder joint has been observed through the arthroscope in 17 and synovitis of varying degrees noted histologically, 4 of whom were studied by immunofluorescence. Five patients had radioactive joint scans. | |
| 756133 | [Serum ferritin- diagnostic and clinical significance]. | 1978 | The immunoradiometric measurement of ferritin--a major iron storage protein, in serum, provides a new precise method for determination of storage iron with good clinical evaluation. There is a positive correlation between serum ferritin and other direct or indirect parameters of storage iron. In clinical practice determination of serum ferritin is important in patients undergoing regular dialysis treatment, for rheumatoid arthritis, normal and pathological pregnancy and as controls for therapy in iron deficiency, or iron overload. | |
| 144653 | [The radiographic appearances of the acromio-clavicular joints in old age (author's transl | 1977 Oct | The author studied 200 shoulders in 100 normal persons over the age of 60 and found the following changes in the acromioclavicular joint due to old age: simple sclerosis of the joint surfaces, some new bone formation, hypertrophy of the acromial end of the clavicle, uneveness of the acromion and caudal dislocation of the clavicle. Marginal changes of the clavicle at the point of attachment of the coraco-clavicular ligament are also due to old age and are not a sign of rheumatoid arthritis. | |
| 1200423 | The probable role of interferon in allergy. | 1975 Dec | Sera from 35 patients suffering from autoimmune or allergic diseases such as bronchial asthma, lupus erythematosus, rheumatoid arthritis, Werlhoff disease (autoimmune form), hemorrhagic vasculitis and neurodermatitis and sera from 70 donors were examined for the presence of interferon. Interferon was found in the sera of 17 of the patients but not in any one of the donors' sera. It is suggested that anit-interferon immunoglobulins against human leucocyte interferon should be employed in the treatment of autoimmune or allergic diseases because of the positive clinical results that were obtained. The different hypotheses describing the role of interferon in immunity and allergy are discussed. | |
| 6241440 | [Skin manifestations observed during treatment with penicillamine and its derivatives]. | 1984 | Many forms of toxidermia are observed during D-penicillamine therapy. The exact type seems to depend on the pathology for which the drug was prescribed; pemphigus during rheumatoid arthritis, perforating serpiginous elastoma in Wilson's disease, cystinuria... The two physiopathogenic mechanisms discussed, an autoimmune reaction and a direct action of D-penicillamine on the skin, would seem to be complementary. | |
| 6971536 | [Clinical significance of complement values in rheumatic diseases]. | 1981 Jan 1 | The more than 10-year experiences with complement examinations in rheumatic diseases are described: Manifold determinations of the complement in the course of the disease may be valuable diagnostic means, taking into consideration acknowledged criteria of the diagnosis in forms of rheumatic diseases with increasing immune pathogenesis. Particularly important are repeated determinations in the synovial fluid with references to a rheumatoid arthritis and in the serum in systemic lupus erythematodes as well as for the limitation of the earliest manifestations of a systemic sclerodermia with positive proof of antinuclear factors. |