Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6611138 | Ankylosing spondylitis in North India: a clinical and immunogenetic study. | 1984 Jun | Fifty-one North Indian patients with ankylosing spondylitis (AS) are described with mean age of onset 21.2 years and male to female ratio of 16:1. AS began with peripheral arthritis in 47%, low back pain in 41%, acute anterior uveitis in 10%, and heel pain in 2% of the patients. 76% of 51 patients had one of the extra-axial features of AS: peripheral arthritis (61%), heel pain (24%), anterior uveitis (22%), urethritis (12%), kidney disease (10%), mucosal ulcerations (6%), aortic incompetence (4%), and apical pulmonary fibrosis (4%). A majority (71%) of the patients with peripheral arthritis had mono- or oligoarthritis affecting mainly the lower limb joints. Two patients had coexistent rheumatoid arthritis also. HLA-B27 antigen was detected in 48 (94%) of 51 patients compared with 7 (6%) of 118 controls (relative risk 254; Fisher's exact p = 3.49(-29]. On comparing patients with juvenile onset AS and patients with adult onset disease we found peripheral arthritis to be more frequent at the beginning and during the course of disease in the former. | |
| 6659736 | Rheumatoid factor-negative arthritis, especially ankylosing spondylitis, and infections of | 1983 Nov | 146 men with rheumatoid factor-negative (sero-negative) arthritis, i.e., 97 patients with ankylosing spondylitis, 36 patients with Reiter's syndrome, and 13 patients with reactive arthritis, were examined for infections of the urogenital tract by following recently established criteria. 74 patients (50.7%) had infections of the male adnexes: 3 patients suffered from balanitis, 14 patients from urethritis, 49 patients from prostatitis, 1 patient from epididymitis, and 7 patients from urinary tract infection. Balanitis and urethritis were almost exclusively associated with Reiter's syndrome. In 37 of 97 patients with ankylosing spondylitis, a urogenital tract infection, mainly a prostatitis (31 patients), was detected. The microorganisms isolated most frequently from patients suffering from urethritis and prostatitis, were Chlamydia trachomatis and Ureaplasma urealyticum. | |
| 6681123 | Inhibition of neutrophil phagocytosis and enzyme release by hyaluronic acid. | 1983 Jan | Hyaluronic acid at a concentration found in normal joints (4 mg/ml) inhibited the uptake of aggregated IgG by human peripheral blood polymorphonuclear leukocytes, but concentrations of hyaluronic acid found in inflammatory joints (1 mg/ml) did not. Similarly, hyaluronic acid at 4 mg/ml, but not 1 mg/ml, inhibited the release of lysozyme from aggregated IgG stimulated polymorphonuclear leukocytes. beta-Glucuronidase release was inhibited by both concentrations of hyaluronic acid. Physiological concentrations of hyaluronic acid inhibit this model system for the fluid phase of rheumatoid arthritis and hyaluronic acid may be an important immunomodulating substance in the rheumatoid joint. | |
| 518145 | Metabolic alterations in human synovial lining cells in pigmented villonodular synovitis. | 1979 Oct | Synovial tissue from 3 patients with villonodular synovitis has been examined by quantitative cytochemistry. Considerable changes in the metabolism of the synoviocytes have been observed. These included a massive rise in the activity of glucose 6-phosphate dehydrogenase to levels even greater than those found in rheumatoid arthritis, and a significant rise in the activity of 2 glycolytic enzymes, glyceraldehyde 3-phosphate and lactate dehydrogenase. Lysosomal napthhylamidase showed raised activity with no latency. The sulphydryl content in the synoviocytes was raised, as was the amount of available phospholipid. This pattern of metabolic alterations is similar to that found in human rheumatoid synoviocytes. | |
| 6461446 | Enumeration of T lymphocytes subsets in autoimmune disease using monoclonal antibodies. | 1981 Sep | The numbers of T lymphocytes, B lymphocytes, helper and suppressor T lymphocytes were measured in peripheral blood of patients with autoimmune disease (rheumatoid arthritis, erythema nodosum, Sjögren's disease, Wegener's disease, idiopathic thrombocytopenia, pernicious anaemia and Hashimoto's disease). B lymphocytes were enumerated by direct immunofluorescence and T lymphocytes by E rosette tests and by indirect immunofluorescence with OKT3.PAN Helper and suppressor T lymphocytes were determined by indirect immunofluorescence with OKT4.IND and OKT8.SUP respectively. The numbers of T lymphocytes, B lymphocytes and helper T lymphocytes in patients with autoimmune disease were normal, but the numbers of suppressor T lymphocytes were significantly lower. | |
| 607387 | Long-term follow-up of 90Yttrium-treated knee-joint arthritis. | 1977 | The results are reported of the treatment of 33 patients with long-standing, therapy-resistant synovitis and effusion of the knee by intra-articular injection of 90Yttrium. In 25 patients with bilateral gonitis the effect of the treatment was compared with the effect of local corticosteroid therapy to the contralateral knee. The irradiated group showed statistically significantly better therapeutic results at 3, 6, and 12 months and the effect weakened in proportion to the length of the follow-up period. At the final check-up at 3.5 years, 52% of this group showed improvement, as against 26% of the controls. The difference in radiological deterioration at the end of the observation period between the two groups was not significant. Local remission in the treated joint in spite of high general activity was recorded in 7 patients. In 4 patients, in whom the results were unsatisfactory, severe articular destruction and instability were noted prior to therapy. Assessment of the correlation between clinical diagnosis and therapeutic results shows that the treatment seems to be most successful in patients with rheumatoid arthritis and unsatisfactory in patients with psoriatic arthritis. General reactions were observed in 1, and local reactions in 2 patients. Irradiation therapy seems to be the treatment of choice in patients over 40, with long-standing knee arthritis of rheumatic origin. | |
| 16796 | The use of psychotropic drugs in rheumatology. | 1976 | The possible role of various psychotropic drugs in the management of rheumatic diseases is considered--tranquillizers, sedatives, tricyclic antidepressants and monoamine oxidase inhibitors. The dilemma of which anti-depressant for which patient is considered. The possible association between rheumatoid disease and disorders of the brain, brain-stem and autonomic nervous system is discussed. Psychotropic drugs may effect the disease itself as well as the patient's mood. The author is opposed, however, to the idea that rheumatoid arthritis may be regarded as a psychosomatic disease. | |
| 1122010 | [Experimental erysipelas in different species as a model for systemic connective tissue di | 1975 | INTRODUCTION: In part I of this paper (Schulz et al., 1975) it was shown that in the initial phase of experimental erysipelas a transition from the vascular processes to a systemic connective tissue reaction can be demonstrated in different species. It is the purpose of this paper to describe the chronic phase of the disease with special emphasis on polyarthritis. MATERIALS AND METHODS: 12 spontaneously diseased and 22 experimentally infected pigs were used in experiments to study the pathogenesis of the disease. In addition, 74 Wistar rats and 148 Sprague-Dawley rats were used in the experiments. All experimental animals were specific-pathogen-free and were parenterally infected with the standardized E. insidiosa serotype B strain T 28. The observation period for the pigs was up to 2 years, for the rats up to 11 months. The methods used for pathohistological and electron microscopical studies are described in part I. Immunihistological studies were carried out on synovial tissue with peroxidase-conjugates of goat-anti-pig-IgG, goat-anti-pig-IgM, pig-collagen, E. insidiosa-homogenate and heat-aggregated-pig-IgG. Furthermore, goat-anti-pig-IgG and rabbit-anti-pig-C3 conjugated with FITC were used. Passive hemagglutination tests and Latex agglutination test (Singer and Plotz) were performed to demonstrate rheumatoid factors and collagen antibodies. RESULTS: Polyarthritis occurred in pigs between the 4th and 10th day p.i. and between the 4th and 8th day p.i. in nearly 100% of the infected rats. Fibrinous exudation, proliferation and destruction with pannus formation are marked in most of the joints examined during the first three months. Fibrosis begins 30 days p.i. in the rats' joints and is most severe in both species between the 5th and 8th month. 3 types of lining cells may be differentiated electron microscopically: A (M) cells, B (F) cells and an intermediate form which is found in both species most frequently. Swelling of the endothelial cells together with constriction of the lumen and thickening of the basal membrane occurs in the capillaries. DISCUSSION: A comparison of chronic erysipelas polyarthritis in pigs and rats with rheumatoid arthritis of men reveals many morphological and immunological similarities between the two diseases. Systemic connective tissue activation manifests itself in organs predilected for rheumatic changes, such as heart valves, endocardium and joints. The possible prepetuation of the processes by specific or nonspecific immunomechanisms or by deposits of fibrin is discussed. In addition, experimental erysipelas is reproducible in nearly 100% of the animals given one single subcutaneous application of one defined bacteria strain. Therefore too, erysipelas is suited as an animal model for human rheumatic diseases. | |
| 6731043 | Adenosine deaminase in the diagnosis of pleural effusions. | 1984 | The activity of adenosine deaminase (ADA) was determined in serum and pleural fluid of 90 patients with pleural effusions of various aetiology. Tuberculous pleural effusions, empyemas and rheumatoid pleural effusions demonstrated significantly higher activities of ADA than parapneumonic , nonspecific and malignant pleural effusions and effusions in systemic lupus erythematosus and congestive heart failure. In tuberculosis, empyema and rheumatoid arthritis ADA activity was significantly higher in pleural fluid than in serum, indicating a local synthesis of ADA by cells within the pleural cavity in these diseases. | |
| 4086648 | Antibody responses in arthritic and uncomplicated Yersinia enterocolitica infections. | 1985 Nov | Concentrations of antiyersinia antibody isotypes IgG1, IgG2, IgG3, IgG4, IgA and IgM were measured in 33 patients with yersiniosis using a solid-phase radioimmunoassay. Sixteen patients had a complicating reactive arthritis. Throughout the observation period IgG1 and IgM antibodies both constituted approximately one-third of the total antibodies, while IgA accounted for 10%, IgG3 accounted for 1%, and IgG4 antibodies could not be detected. IgG1, IgM, and IgA antibodies (and the total titer) had reached their peak at the beginning of the observation period (ca. day 20 after the onset of symptoms). The levels then gradually decreased; the total titers averaged 40 times the background at the beginning of the observation period and 4 times the background on day 350. IgM antibodies could be detected as late as a year after the infection. The concentration of IgG2 antibodies varied greatly from patient to patient. In most patients it increased until a plateau was reached approximately 2 months after the onset of symptoms. A decline was observed later. Five arthritic but no nonarthritic patients had a pronounced IgG2 response (more than half of the IgG antibodies were IgG2 in one or several samples). | |
| 6764224 | Immunopharmacological profile of TEI-3096: a new immunomodulator. | 1982 | TEI-3096 [6-p-chlorobenzyl-5H-2,3,6,7-terahydro-5,7-dioxothiazolo (3,2-a) pyrimidine], a novel thiazolopyrimidine compound has been shown to suppress adjuvant arthritis in rats without any effect on conventional inflammation. We examined the immuno-pharmacological profile of TEI-3096 in murine lymphocytes. The blastformation induced by Con A or LPS was inhibited by addition of 50-500 microM concentrations of TEI-3096. This compound suppressed elevated plaque-forming cell (PFC) response against T cell-dependent antigen. However, TEI-3096 had no effect either on normal PFC response or on antibody formation against T cell independent antigen. Although orally administered TEI-3096 had no obvious effect on anti-SRBC PFC response in normal mice, it normalized the colchicine-induced enhancement of antibody formation against TNP-HGG. TEI-3096 also enhanced the delayed type hypersensitivity in mice and rats. These results suggests that TEI-3096 restores the abnormal immune response. Therefore, it may be useful for the treatment of auto-immune disease such as rheumatoid arthritis. | |
| 17741201 | Erratum. | 1984 Apr 27 | On page 1426 of the report "Association of parvoviruses with rheumatoid arthritis of humans" by R. W. Simpson et al. (30 Mar., p. 1425), a portion of the text beginning on line 18 of the first full paragraph in column 3 was incorrectly printed. It should have read, "We were unable to detect 24-nm particles in brains of normal mice from our colony or mice intracerebrally inoculated with extracts of synovial cells from patients with noninflammatory degenerative joint disease (DJD). More conclusive evidence for the identity of RA-1 as a parvovirus comes from our recent success in demonstrating that CsCl gradient fractions containing the infectious 24-nm particles can be extracted for a single-stranded DNA which is approximately 4.5 kilobases in size." | |
| 1261268 | Some biological and physical chemical properties of Erysipelothrix rhusiopathiae. | 1976 Apr | Fourteen strains of Erysipelothrix rhusiopathiae, representing extremes of host-range and world distribution, were examined for: 1) protein composition as determined by electrophoresis and electrofocus patterns, 2) guanine-cytosine mole ratios of their respective deoxyribonucleic acids, and 3) carbohydrate fermentation patterns. No correlation is apparent between any particular physical-chemical property and virulence in mice. The role the bacterial fragments play in the pathogenesis of a rabbit model of rheumatoid arthritis is discussed. | |
| 6600809 | Copper salicylate as an anti-inflammatory and analgesic agent in arthritic rats. | 1983 Feb 28 | Recent research indicates that endogenous copper is involved in anti-inflammatory and tissue repair processes. Of interest also is the analgesic efficacy of Cu complexes, since rheumatoid arthritis and similar inflammatory conditions are extremely painful. In pilot experiments, arthritic rats failed to increase voluntarily their rate of drinking a 5 mg/ml solution of copper salicylate (Cu Sal). The data from the experiment reported here showed that a forced oral dose of Cu Sal calculated at 200 mg/kg body weight significantly reduced sensitivity to mechanical pressure in less than 30 minutes but more than 15 minutes. The analgesic effect of the Cu Sal was greater for arthritic than for non-arthritic rats, suggesting that two types of analgesia are involved. First, it produces a direct analgesic effect which works irrespective of the presence of inflammation. Second, it appears to have an indirect analgesic effect due to reduction of inflammatory hyperalgesia. It was also found that Cu Sal administered orally reduces inflammation in rats with adjuvant arthritis. In summary, the results from this experiment demonstrate that Cu Sal has specific and general analgesic properties and anti-inflammatory potential. | |
| 4064756 | Iododerma occurring during thyroid protection treatment. | 1985 Oct | A patient with rheumatoid arthritis developed nodules and ulcers shortly after treatment with supersaturated potassium iodide (SSKI) drops. The SSKI was administered for thyroid protection during an iodide fibrinogen uptake test to detect phlebothrombosis of the legs. Discontinuation of SSKI was accompanied by regression of all lesions. Previous case reports include other patients who experienced iododerma after receiving low doses of iodides. This should be borne in mind if ever a mass iodide prophylaxis program is undertaken following a nuclear event. | |
| 7316290 | [Collagenosis in childhood (author's transl)]. | 1981 Jul | A revision of the present concept of the named collagenosis in the pediatric age, supported of the experience of the Pediatrics Department at the Barcelona University is exposed. A casuist of 109 cases of the Schoenlein-Henoch syndrome, 55 observations of juvenile rheumatoid arthritis and 16 pediatric patients affected of classic collagenosis is included. A classification of the collagenosis in pediatrics, discriminating classic forms and other process and in both groups the entities of known etiology, and the unknown ones, that are majority, been considered as collagenosis in the strict sense is offered. | |
| 6974956 | Hand symptoms associated with diabetes mellitus. An investigation of 765 patients based on | 1981 | A number of 738 patients with diabetes mellitus (DM) and 371 matched controls answered a questionnaire constructed to detect rheumatic hand symptoms. The SM patients showed significantly more palmar thickening, indicating Dupuytren's contracture and flexor tenosynovitis, and a significantly lower frequency of neurological sensations. There was no statistically significant difference in the estimated frequency of rheumatoid arthritis between the total population and our DM population. | |
| 7430586 | Spontaneous recurrent ulnar dislocation of the long extensor tendons of the fingers. | 1980 Sep | Ulnar dislocation of the long extensor tendons of one or more fingers occurred in five elderly women. There was no history of trauma or any of the stigmata of rheumatoid arthritis. In all fingers there was loss of active extension in the metacarpophalangeal joints following flexion. It is postulated that this is a definite clinical entity occurring in the elderly associated with excessive joint laxity. | |
| 568887 | Bilateral necrotizing scleritis. | 1978 Nov | A 53-year-old woman whose history was noncontributory for rheumatoid arthritis and collagen disease had bilateral necrotizing inflammation of the sclera. The left eye had necrotizing nodular scleritis and the right eye, massive granuloma of the sclera. In the right eye the orbital adnexae were also involved by granulomatous infiltration and developed a mass of fibroadipose tissue simulating an orbital tumor within a week after enucleation. | |
| 6652391 | Elisa studies in ankylosing spondylitis. | 1983 Nov | Specific IgA antibodies were measured by ELISA against Klebsiella, E. coli and Candida antigens in five different groups: active ankylosing spondylitis (high ESR), inactive ankylosing spondylitis (normal ESR), healthy controls, psoriasis and rheumatoid arthritis. Elevated levels of IgA antibodies against Klebsiella were found only in active ankylosing spondylitis patients. |