Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6893912 | 'Pseudolymphoma'. A case associated with primary immunodeficiency disease and polyglandula | 1981 Jan | An atypical lymphoproliferative process occurred in the liver and spleen of a child with combined immunodeficiency disease and polyglandular failure syndrome. The initial pathologic interpretation was that of malignant lymphoma, although the child's subsequent clinical course was complicated by rheumatoid arthritis, thyroiditis, and chronic active hepatitis, with no clear evidence of lymphoid neoplasia. This case illustrates that unusual lymphoid proliferations in patients with immunodeficiencies may simulate malignant lymphoma. | |
| 1253487 | Giant synovial cyst of the calf and thigh in a patient with granulomatous synovitis. | 1976 Mar | A giant synovial cyst with granulomatous synovitis was removed from the thigh and calf in an 80-year-old woman. The lesion included necrotizing, epitheloid cell granulomata with Langhans' type giant cells. Chest X-ray, tuberculin testing, cultures for Acid Fast bacilli, as well as aerobic, anaerobic and fungal cultures were all negative. The treatment consisted of synovectomy and total knee arthroplasty with an uneventful recovery. A giant calf cyst, usually associated with rheumatoid arthritis, but in this situation, noted in granulomatous synovitis seems not to have been reported previously. | |
| 1198018 | Synovitis in polymyalgia rheumatica. | 1975 Nov | Synovitis was observed in 13 out of 88 consecutive patients with polymyalgia rheumatica. It is described in detail in five patients, on the basis of clinical radiological observations, joint aspiration, arthroscopy and biopsy. The synovitis of polymyalgia rheumatica cannot be distinguished histologically or at arthroscopy from the appearance seen in mild rheumatoid arthritis. Clinically, however, the synovitis of polymyalgia rheumatica is mild, transient and confined to one or two joints or tendon sheaths. It is not followed by joint deformity or by radiological erosive changes in the bone ends. It may occur at any stage of the disease but particularly at its onset, or when the dose of corticosteroid treatment is reduced. | |
| 1131632 | Screening for hypothyroidism in elderly inpatients. | 1975 Jun 14 | Routine biochemical screening for hypothyroidism in 2000 geriatric inpatients proved valuable and practicable and yielded 46 cases (2.3%). A non-specific clinical picture was particularly common, with less than a third of the cases showing "typical" signs and symptoms. Psychiatric manifestations, especially depression, were important and frequent and responded well to thyroxine. There was a preponderance of female cases of hypothyroidism and a strong association with other autoimmune diseases, notably pernicious anaemia and rheumatoid arthritis. | |
| 1129471 | Popliteal cysts: presentation as thrombophlebitis. | 1975 Jun | Synovial-lined cysts in the popliteal space associated with rheumatoid arthritis or meniscal tears may compress the popliteal vein and produce signs and symptoms suggestive of thrombophlebitis. Because of a presumptive diagnosis of thrombophlebitis, venography may be performed initially and demonstrate compression of the popliteal vein by an extrinsic mass. The correct diagnosis of a popliteal cyst can easily be made with B-mode ultrasonography, and, if desired, confirmed by arthrography. Four cases are presented which emphasize these features. | |
| 6176247 | Multiple interferons in the circulation of patients with systemic lupus erythematosus and | 1982 Apr | Recently, we found interferon in the sera of patients with systemic lupus erythematosus, rheumatoid arthritis, scleroderma, and Sjögren's syndrome. In this study, we surveyed a variety of other immunologically mediated diseases. We did not find interferon in the sera of patients with Wegener's granulomatosis, sarcoidosis, infectious mononucleosis, minimal change nephritis, kidney transplants, myasthenia gravis, or uveitis, but we did find this protein in the sera of patients with active systemic and cutaneous vasculitis. Attempts to characterize the interferon in the sera of patients with systemic lupus erythematosus and vasculitis revealed that antibody to alpha (leukocyte) interferon, but not to beta (fibroblast) interferon, partially or completely neutralized the antiviral activity. The failure of antibody to alpha interferon to completely neutralize the antiviral activity in certain specimens and the lability of the antiviral activity in some specimens to pH 2.0 treatment both suggest that more than one type of interferon was present. | |
| 6978407 | Immunoregulation by alpha 1 antitrypsin. | 1982 Feb | alpha 1 antitrypsin (alpha 1 AT) deficiency is a common genetic disorder seen in about 10% of the population. It predisposes to the development of a large number of inflammatory and immunologic disorders including rheumatoid arthritis, systemic lupus erythematosus, juvenile chronic arthritis, anterior uveitis, ankylosing spondylitis, fibrosing alveolitis and emphysema. We have investigated immunologic function in subjects with severe alpha 1 AT deficiency and demonstrated serum mediated enhancement of lymphocyte response to PHA and increased zymosan activation of mononuclear cells and neutrophils as measured by their chemiluminescence. These patients also have accelerated delayed hypersensitivity responses and increased levels of factor B, C3 and C5 but normal levels of immunoglobulin and other complement components. Such abnormalities in immunoregulation demonstrate a tendency to hyperreactivity that may contribute to disease predisposition. | |
| 24822776 | Reconstructive surgery of the thumb in rheumatoid arthritis. | 1980 Jun 1 | This article presents recommendations for reconstructive thumb surgery based on results obtained by team evaluation of 79 patients who had 186 thumb operations performed by the Arthritis Service at Rancho Los Amigos Hospital from January 1, 1962 through December 31, 1976. The operations included: 11 synovectomies and reconstructions, with synovitis recurring in two; 10 metacarpophalangeal silastic arthroplasties, with no infections or breakage; 11 carpometacarpal silastic arthroplasties, with dislocation in two and superficial infection in one; and 154 arthrodeses, with 139 fusions. If there is inadequate response to nonoperative treatment, and no significant joint changes or instability, we recommend soft tissue surgery. For the boutonniere deformity, we recommend an Inglis or Nalebuff procedure. For the flexible swan neck deformity we recommend a capsulodesis and/or percutaneous pinning. An adduction contracture can be treated with tenotomy and/or arthrodesis. If there is instability and/or roentgenographic changes, we recommend a silastic arthroplasty in the carpometacarpal joint and an arthrodesis in the interphalangeal joint. We also prefer an arthrodesis (15° flexion, 15° internal rotation) in the metacarpophalangeal joint unless there is no carpometacarpal motion, when we recommend a silastic arthroplasty. All involved thumb joints should be operated on at the same time. The Kirschner wires used in arthrodeses should be left buried for 10-12 weeks, as it can be difficult to determine fusion clinically and radiographically. | |
| 3861056 | Polymorphous exudates and atypical mononuclear cells in the cerebrospinal fluid of patient | 1985 Jul | Central nervous system (CNS) complications of Sjögren's syndrome are now well recognized. To determine if any of the pathologic changes in the CNS in patients with Sjögren's syndrome were reflected in the cellular composition of cerebrospinal fluid (CSF), we examined the CSF of 14 patients with Sjögren's syndrome and neurologic symptoms and compared the differential cell counts in those cases with those of 14 control patients with similar neurologic symptoms. Patients with Sjögren's syndrome had polymorphous (mixed) inflammatory exudates in CSF, composed predominantly of lymphocytes, but including variable numbers of plasma cells, neutrophils and erythrocytes. In addition, the CSF of all patients with Sjögren's syndrome contained large, atypical, morphologically distinct mononuclear cells. The mean percentage of these cells in the CSF of patients with Sjögren's syndrome (8.3 +/- 1.9) was significantly higher (p less than 0.001) than that observed in the control patients (0.7 +/- 0.2). These results suggest that involvement by Sjögren's syndrome may be suspected by noting a polymorphous exudate containing characteristic atypical mononuclear cells in CSF obtained by lumbar puncture. | |
| 6467680 | Effect of nandrolone decanoate on Sjögren's syndrome like disorders in NZB/NZW mice. | 1984 Sep | The effects of 2.5-40 mg/kg nandrolone decanoate (ND) on the development and growth of mononuclear cell infiltrations in the submandibular glands of NZB/W (B/W) mice have been studied using a quantitative histological method. Injections with ND for 9 months, once every 3 weeks, starting at 4 weeks of age, reduced the number and total area of infiltrations in submandibular glands of female and castrated male B/W mice. Since ND has relatively weak virilizing properties, this substance may be useful for the treatment of Sjögren's syndrome in humans. | |
| 6382904 | [Serum ferritin--its diagnostic relevance and clinical significance]. | 1984 | The introduction of a WHO Standard for serumferritin effected a standardisation of different methods, improving quality and security for clinical routine diagnostic purposes. Therefore the clinical evaluation of serumferritin gained even more importance. For Evaluation of iron stores of children, pregnant women, population studies, patients on hemodialysis or patients with rheumatoid arthritis low serumferritin values give safe results. In addition serumferritin is of clinical usefulness in monitoring therapy of both iron deficiency and iron overload. Evaluating a single serumferritin value one should consider the total clinical situation of the patient. As some tumors can produce and secrete serumferritin, e. g. acute myeloblastic leukemia, germ cell tumors, malignant melanoma, serumferritin might be helpful in monitoring the malignant disease. The ongoing characterization of tissue isoferritin, especially acidic isoferritin, may eventually lead to a clinically significant diagnostic marker of neoplasia. | |
| 6370367 | Spontaneous healing and relief of pain in a patient with intractable vasculitic ulceration | 1984 Apr | A case is reported of a patient with diabetes and rheumatoid arthritis who presented with vasculitic ulceration of the lower leg and foot. The ulceration was associated with severe pain and showed no sign of healing despite conservative treatment and skin grafting. At the time when amputation seemed inevitable an intravenous infusion of prostacyclin was given. There was a rapid and lasting relief of pain and the ulcerated area began to heal spontaneously. | |
| 6603830 | Hepatic changes in a patient with alpha 1-antitrypsin deficiency (MZ phenotype). Portal tr | 1983 Sep | A 57-year-old woman with rheumatoid arthritis and alpha 1-antitrypsin deficiency (PiMZ phenotype), recovering from intraabdominal sepsis in association with gastric ulcer perforation, had portal hypertension. An operative liver biopsy specimen showed a distinctive elastosis of the portal tracts without cirrhosis. | |
| 6830330 | Thymopoietin and levamisole in chronic granulomatous inflammation. | 1983 Feb | Two animal models were used to investigate the mode of action of levamisole and thymopoietin. Neither compound influenced the subcutaneous carrageenan air pouch. While thymopoietin inhibited the formation of cotton pellet granulomas, levamisole enhanced it. This supports the conclusions of clinical studies reported elsewhere that levamisole and thymopoietin do not act in the same way in rheumatoid arthritis. | |
| 7136087 | [Polymorphism of articular chondrocalcinosis]. | 1982 Jul 1 | The articular chondrocalcinosis--conditioned by the formation of crystals of calcium pyrophosphate dihydrate in the joint cartilage--increasingly gains clinical interest. The symptomatology is multivariant: mono-, oligo- and polyarticular with simultaneous localisation in the discs. Characteristic, but not proving, is the calcification demonstrated in the X-ray picture. Apart from the familial forms increasingly are observed spontaneous, solitary cases in persons older than 50 years (in 3% of all postmortem examinations). The chondrocalcinosis gains differential-diagnostic importance as to primary osteoarthroses, attacks of gout, rheumatoid arthritis and other diseases of bones and joints. It appears symptomatically in hyperparathyroidism and hemochromatosis. The present paper gives as survey on the modern state of knowledge concerning clinic, heredity, diagnostics and pathogenesis. | |
| 6451338 | Immune regulation in inflammatory bowel disease: absence of a serum inhibitor of suppresso | 1980 Nov | Suppressor cell function of normal peripheral blood mononuclear cells was unaltered by preincubation with sera from patients with severe inflammatory bowel disease (IBD). These results suggest that, in contrast to juvenile rheumatoid arthritis and systemic lupus erythematosus, the decreased suppressor cell activity in IBD is not mediated by anti-suppressor cell antibodies. | |
| 509811 | Predictive range of motion after total knee replacement. | 1979 Sep | Evaluation of 145 consecutive total knee arthroplasties pre- and postoperatively revealed that regardless of the preoperative deformity (varus, valgus, and flexion contracture), normal alignment of the knee with full extension was obtainable. The amount of flexion to be achieved postoperatively may be determined by the amount of flexion the patient had preoperatively, especially if the degree of flexion was less than 75 degrees. The prosthesis design, sex, age and diagnosis of rheumatoid arthritis were found not to correlate with postoperative motion and stability. In the osteoarthric knee, however, statistical analyses at 6 and 12 months generally showed less postoperative than preoperative range of motion. | |
| 1197181 | Ruptured popliteal cyst stimulating deep vein thrombosis with false positive radiofibrinog | 1975 Oct | A case is described in which deep vein thrombosis of the calf was initially diagnosed on the basis of the clinical signs and the radiofibrinogen uptake in a patient suffering from rheumatoid arthritis. The correct diagnosis of ruptured popliteal cyst was later established by arthrography and phlebography. Attention is drawn to the unreliability of the radiofibrinogen uptake test in the presence of ruptured popliteal cyst and alternative diagnostic methods are discussed. | |
| 6654725 | Defining and measuring exposure in epidemiologic studies of potential zoonoses. | 1983 Dec 15 | Articles suggesting the zoonotic potential of certain human diseases (eg, multiple sclerosis, rheumatoid arthritis, and leukemia) periodically appear in the literature and frequently receive considerable attention in the popular press. Although various epidemiologic study designs have been utilized to test these hypotheses, defining and accurately measuring animal exposure has been a problem common to most of these studies and in some instances has limited their usefulness. The relative strengths and limitations of the definitions and measurements used most commonly by investigators evaluating potential zoonoses are discussed. In addition, several recommendations for assessing animal exposure in future studies are made. | |
| 6221988 | Sarcoidosis: diagnosis and management. | 1983 Jun | Predominantly a disease of young adults, sarcoidosis may present in a variety of guises, masquerading as acute rheumatoid arthritis, lymphadenopathy, cor pulmonale, erythema nodosum, Crohn's disease, etc. Although the characteristic granulomatous lesions of sarcoidosis can affect almost any organ system, they will appear on chest films in at least 90% of patients. |