Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 897188 | Intervertebral disk calcification associated with spine fusion. | 1977 Oct | Intervertebral disk calcification and spine fusion were observed in patients with Klippel-Feil syndrome, myositis ossificans progressive, juvenile rheumatoid arthritis, ankylosing spondylitis, and surgical spine fusion. The fusion appears to come first, leading to calcification. This suggests that fusion prevents the normal mechanical stresses within the disk, leading to premature degenerative changes and calcification of the nucleus pulposus. | |
| 59239 | Neutrophil dysfunction in Crohn's disease. | 1976 Jul 31 | The migration of neutrophils into skin windows has been examined in patients with Crohn's disease and rheumatoid arthritis and compared with normal. Leucocyte migration was significantly lower in patients with Crohn's disease than in others. This abnormality of neutrophil function in Crohn's disease appears to be secondary to a defective acute inflammatory response as the neutrophils themselves were found to behave normally on in-vitro testing. A weak acute inflammatory response to particulate or antigenic material in the bowel wall could result in the chronic inflammation observed in this condition. | |
| 4026410 | Calcinosis of joints and periarticular tissues associated with vitamin D intoxication. | 1985 Jul | We describe a patient with rheumatoid arthritis and widespread joint and periarticular calcinosis related to self-medication with vitamin D, which was aggravated by oral phosphate therapy prescribed for her hypercalcaemia. Hydroxyapatite was shown in the synovial fluid from affected joints. The role played by tissue injury in the pathogenesis of soft tissue calcification is discussed. | |
| 3158288 | Penicillamine-induced pemphigus foliaceus-like dermatosis. A case with unusual features, s | 1985 May | A case of a severe, widespread bullous dermatosis clinically resembling pemphigus foliaceus occurred during treatment with penicillamine hydrochloride in a patient with rheumatoid arthritis. Histologically, the disease showed changes compatible with pemphigus vulgaris as well as with a bullous drug eruption. Treatment by plasmapheresis proved to be effective in controlling the disease. | |
| 6722411 | Fracture through a geode in the proximal ulna. | 1984 May | Chronic joint pain in rheumatoid arthritis may mask that from other causes. Stress fractures, particularly in osteoporotic lower limb bones of such patients, are well described but can still cause diagnostic difficulty. These difficulties were highlighted by a case in which an unusual fracture occurred through a geode in the proximal ulna mimicking an exacerbation of synovitis in the elbow joint. | |
| 556266 | [Psoriatic arthritis: analysis of 69 cases and review of the literature]. | 1979 Jun 23 | In a retrospective study 69 cases of psoriatic arthritis evaluated at the Centre hospitalier de l'université Laval (CHUL) between 1968 and 1977 were studied. Certain clinical and laboratory features (age, sex, nail involvement, date of onset of the cutaneous psoriasis, date of onset of the arthritis, and the presence or absence of rheumatoid factor and the HLA-B27 antigen) and the radiologic data were compared with findings previously described in the literature. With three exceptions the findings compared well: at CHUL (a) the frequency of the HLA-B27 antigen in patients with axial psoriatic arthritis was very low, (b) patients with synchronous psoriasis and arthritis were not more severely affected, and (c) certain radiologic signs that seem to be rare and have probably been overemphasized in the literature were not found. | |
| 6517405 | Design of a total wrist prosthesis. | 1984 | Diseased wrist joints, in such cases as rheumatoid arthritis, are often required to be replaced by a prosthesis to relieve pain and to recover the wrist function. In designing this replacement, it is essential to understand the behavior of a normal wrist joint in its kinematic and kinetic aspects. An experimental and analytical study was conducted to obtain various parameters regarding the normal wrist joint. The significance of these parameters were discussed and are to be used for the design criteria. Based on normal wrist joint study, a universal, constrained, total replacement was designed and compared with the existing prosthesis in a laboratory experiment. | |
| 6108712 | Polyarteritis overlap syndrome with extensive bowel infarction. | 1980 Aug | An elderly female with laboratory evidence of rheumatoid arthritis presented with malnutrition, elevated erythrocyte sedimentation rate, peripheral eosinophilia with eosinophilic infiltration of the pleura, uterus, skin and muscle without granuloma formation. She developed a necrotizing vasculitis of the mesenteric vessels without granuloma and died. This case illustrates that polyarteritis nodosa, even of the overlap type, may produce severe widespread mesenteric vasculitis. | |
| 498647 | Arthrodesis of the first metatarsophalangeal joint for severe bunions and hallux rigidus. | 1979 Jul | Compression arthrodesis of the first metararsophalangeal joint using a modification of the technique of McKeever is described. This operation consistently produces the best results for hallux valgus and hallux rigidus of the great toe. The operation has been found to be applicable where there have been previous attempts at surgical correction. It also produces good results in patients having rheumatoid arthritis when there is minimal involvement of the interphalangeal joint. | |
| 727908 | Loosening of the femoral component in surface replacement of the knee. | 1978 Aug 11 | The incidence of loosening of the femoral component of the ICLH knee has been found to be lower than that of the tibial component. This is thought to be due to the fact that the compressive strength of the distal femur has been found to be greater than that of the proximal tibia. It has further been shown that the strength of even the femur can be so reduced by the osteoporosis accompanying Rheumatoid Arthritis that it becomes insufficient for adequate prosthetic fixation. | |
| 912981 | Morton's metatarsalgia. | 1977 | In a series of 25 patients (predominantly women) with Morton's metatarsalgia, the most likely site for a neuroma is the third cleft of the left foot. If a swelling is present or if radiographic examination shows toe divergence then the diagnosis in unlikely to be a simple digital neuroma. A review of the literature suggests that there are other causes of pain in the forefoot. Usually the pain is diffuse by when it is localized, Morton's metatarsalgia is diagnosed. However, causes other than a digital neuroma, e.g. traumatic bursitis and rheumatoid arthritis, epithelial cyst, and foreign body should be borne in mind. | |
| 6412468 | [Immunocoagulopathies as a possible cause of acquired hemorrhagic diathesis]. | 1983 May 15 | Spontaneous factor VIII inhibitors may be responsible for severe life-threatening haemorrhages. It is reported on two patients with inhibitors directed against factor VIII: C. In one female patient a rheumatoid arthritis could be made evident as basic disease. Diagnostics, therapy and course are reported and discussed. | |
| 7282114 | [Cervico-cephalic syndrome]. | 1981 May | The cervico-cephalic syndrome (CCS) plays an important part in the various diseases of the upper cervical spine. For a better understanding of the symptoms, the specific anatomical structures and the relationship to the possible manifestations are discussed. With the case histories of four patients the various causes of the CCS are presented. In cases that are resistent to treatment the possibility of an intracranial ailment must be differentially evaluated. The inflammatory alterations, especially those seen in rheumatoid arthritis, as well as the anomalies are described. | |
| 6791148 | Gold colitis, therapy and confirmation of mucosal recovery by measurement of rectal potent | 1980 Dec | A 38-year-old man with rheumatoid arthritis developed colitis after a course of 320 mg sodium aurothiomalate. Recovery comparable with that reported with corticosteroids or chelating agents was achieved by fluid replacement alone. Mucosal recovery was confirmed by measurement of rectal potential differences. | |
| 856646 | [Normolipemic xanthomatoses. a case of xanthoma disseminatum (author's transl)]. | 1977 | A short summary of normolipemic xanthomatoses is exposed. A case of xanthoma disseminatum is reported. The typical clinical picture is described and numerous investigations are recorded. No association with any systemic disorder neither diabetes insipidus nor rheumatoid arthritis could be found. Histologically the granulomas consist of many multinuclear giant cells embedded in an infiltration of histiocytic cells and lymphocytes. Fat staining demonstrates lipid accumulation as a secondary phenomenon. Systemic corticosteroid therapy was effective in preventing the regrowth of the granulomas after their surgical removal. | |
| 783165 | Cutis arthroplasty of the elbow joint. | 1976 Sep | Five patients with an average age of thirty-five years had satisfactory restoration of elbow motion by a cutis arthroplasty technique with minimum medial-lateral instability. In three patients marked stiffness or ankylosis had followed severe fractures or dislocations. The fourth patient had rheumatoid arthritis, and the fifth had sustained a birth injury to the brachial plexus. An average follow-up of three and one-half years confirmed the durability of the results. | |
| 1052100 | Initiation of a quality assurance program for social work practice in a teaching hospital. | 1976 | This first-stage paper describes the steps taken in implementing a quality assurance program. The rationale for writing social work protocols based on medical diagnosis or tasks rather than on psychosocial diagnosis is explained in detail. Protocols for adult rheumatoid arthritis, pediatric cancer, adult discharge planning, and adult nursing home placement are included to demonstrate the result of the medical diagnosis/task approach. | |
| 24822952 | Bilateral simultaneous rupture of the infrapatellar tendon: a case report and literature r | 1983 Nov 1 | Bilateral simultaneous patellar tendon rupture is a rare entity. Most case studies in the literature have been reported in patients with an underlying systemic condition, i.e. systemic lupus erythematosus, rheumatoid arthritis, or associated with a history of steroid injections about the infrapatellar tendon. A recent case report treated at Dwight David Eisenhower Army Medical Center without a predisposing underlying systemic condition or history of injection is presented. Our patient is the youngest to be reported in the literature. The literature is reviewed on this subject, and the mechanism of injury presented. | |
| 27518937 | Urinary erythropoietin levels in normal, anaemic, polycythaemic, and uraemic subjects. | 1975 Dec | The erythropoietin content of 24 hour urine collections has been assayed in a number of clinical conditions and in five normal subjects Low erythropoietin levels were found in polycythaemia vera, anaemia associated with uraemia and rheumatoid arthritis. High levels were found in association with hypoxic polycythaemia and anaemia due to iron deficiency, blood loss and marrow hypoplasia. In addition significant quantities of erythropoietin were found in renal cyst fluid and in the isotonic extract of a uterine leiomyoma removed from patients with polycythaemia. | |
| 2931845 | [Clinical effectiveness of the method of extracorporeal heparin precipitation of plasma pr | 1985 | The authors analyse the efficacy of extracorporeal heparin precipitation of plasma proteins (selective plasmapheresis) in patients with immune complex pathology. The method lies in extracorporeal precipitation at +4 degrees C of fibronectin, cryofibrinogen and other macromolecular complexes with the aid of heparin, followed by plasma return to the patient. The method was applied to 39 patients. Hemorrhagic microthrombovasculitis was diagnosed in 7, vasculitis paralleled by hepatosplenomegaly of unclear genesis in 1, generalized vasculitis with marked systemic manifestations in 1, immune complex vasculitis complicated by recurrent polychondritis in 1, chronic active hepatitis associated with immune complex vasculitis in 1, rheumatoid arthritis in 8, systemic lupus erythematosus in 4, spleen lymphoma and Sjögren's syndrome in 1, idiopathic amyloidosis in 2, multiple sclerosis in 10 patients. Altogether 309 sessions of selective plasmaphapheresis were carried out. The time course of the clinical and laboratory criteria of the disease activity were studied before and after each plasmapheresis session. It was ascertained that the method is highly effective in the treatment of hemorrhagic vasculitis. It is mostly used if conventional therapy with heparin, cryoplasm, and deaggregating agents appears abortive. Apparently, it is the only method that may rapidly arrest the abdominal syndrome associated with hemorrhagic vasculitis. The possibility and advisability of the use of chronic plasmapheresis are discussed. Application of the method to the treatment of rheumatoid arthritis permits reducing the dose of steroid hormones, thereby not stimulating the disease activity. The method is the therapy of choice in different diseases associated with polyvalent allergy. In amyloidosis and multiple sclerosis, the method efficacy is questionable.(ABSTRACT TRUNCATED AT 250 WORDS) |