Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2685847 | Rehabilitation of the patient with rheumatoid hand involvement. | 1989 Dec | The therapist working with patients with rheumatoid arthritis should consider that they are working with a person with a systemic, chronic disease who may require periodic, long-term treatment. A baseline evaluation helps to establish goals for individual treatment. Reassessment of the patient at various intervals allows the therapist to alter treatment as necessary. In this article, the therapist's role in evaluation and treatment at the various stages of the disease is discussed. | |
| 1838812 | The effects of cognitive distortion and depression on disability in rheumatoid arthritis. | 1991 Dec | The question explored in this study was: What is the effect of cognitive distortion and depression on disability in arthritis patients when stage of disease is controlled? Patients (N = 165) completed the Sickness Impact Profile, two Cognitive Error Questionnaires, and the Symptom Questionnaire, and were staged for severity of disease. Findings indicated a significant effect of distortion on disability in rheumatoid arthritis patients; however, this effect varied by stage. Distortion and depression best explained total disability in Stage II (R2 = .60 using general distortion; R2 = .58 using arthritis distortion). Future nursing interventions designed to decrease or prevent distortion might reduce disability as well as depression. | |
| 3779324 | Intensive immunosuppression in intractable rheumatoid arthritis. | 1986 Nov | Twelve patients with intractable rheumatoid arthritis were treated with antilymphocyte globulin (ALG), prednisolone and a cytotoxic agent, usually azathioprine, and were followed for 1 year. There was a significant (p less than 0.05) improvement in the mean score for early-morning stiffness, grip strength and the severity of nodules and vasculitis at 6 weeks and 3 months when compared to the initial visit. However, in most patients, this benefit was not sustained despite continued cytotoxic and steroid therapy. A rise in the haemoglobin and fall in ESR was maintained throughout the study period. | |
| 3179624 | Psychiatric disorder and illness behaviour in rheumatoid arthritis. | 1988 Oct | A detailed physical and psychiatric assessment of 80 patients with definite or classical rheumatoid arthritis was performed using diagnostic criteria for psychiatric disorder appropriate for those with physical illness. Seventeen (21%) patients had depression or anxiety severe enough to warrant treatment. The presence of pychiatric disorders was not related to the duration of the arthritis nor to 11 other indicators of its severity with the exception of grip strength (p less than 0.002) and Fries Functional grade (p less than 0.005). It was significantly related to the presence of social stress (p less than 0.05) and lack of social support (p less than 0.005). Those with psychiatric symptoms scored higher on an illness behaviour scale, indicating that they perceived their illness as very severe. These also worried excessively about it and failed to be reassured by the doctor. Such illness behaviour was displayed by some patients who had severe arthritis but lacked social support. In others the complaints were unfounded because their arthritis was mild. They also experienced much social stress and lacked social support. We conclude that psychiatric illness occurs in rheumatoid arthritis with similar frequency to that of other general medical patients. It is principally related to social stress and lack of support rather than severity of arthritis, and may lead to abnormal illness behaviour. Since lack of social support appears of prime importance in determining disability, its assessment is essential for the rehabilitation of the disabled patient with RA. | |
| 2341096 | Ankle arthrodesis in the rheumatoid patient. | 1990 Apr | We studied 11 patients with severe rheumatoid arthritis of the ankle joint who underwent arthrodesis employing the Charnley technique. Results of the procedure were assessed using the Fries score and the ankle evaluation grading system of Mazur et al. Four patients (36%) suffered pin-track sepsis. Three patients also showed delayed union, but sound bony fusion was eventually achieved in all patients. | |
| 3265423 | Stress factors, emotional stress and rheumatoid arthritis disease activity. | 1988 Jul | The purpose of this study was to determine the relationship between stress factors, emotional stress and rheumatoid arthritis (RA) disease activity. Subjects (n = 101) confirmed to have RA completed the Daily Hassles Scale (DHS) to identify daily stress factors and the State/Trait Anxiety Inventory (STAI) as well as a visual analogue (VA) to measure emotional stress levels. The investigator evaluated RA disease activity (RADA) and erythrocyte sedimentation rate (ESR). Pearson product-moment correlation was used for statistical evaluation. A statistically significant, positive correlation was found between RADA and both measures of emotional stress; STAI r2 = 0.16, VA r2 = 0.25, P less than 0.01. Utilizing a psychophysiological feedback loop model, it was hypothesized that emotional stress levels and RA disease activity each served as a driving force and a consequence, i.e. as emotional stress levels increased, RA symptoms intensified and, likewise, as RA symptoms intensified, emotional stress levels increased. Nursing interventions were identified which possibly would reduce emotional stress levels, and thus, perhaps, decrease the incidence and/or severity of RA disease activity. | |
| 2068543 | A randomized controlled trial to evaluate the effectiveness of homeopathy in rheumatoid ar | 1991 | Forty-four patients with active Rheumatoid Arthritis were entered into a 6-month double-blind trial comparing homeopathy and placebo. The treatments were generally equally effective in most assessments. Statistically significant improvements were produced, however, in 3 of 5 and 2 of 5 results respectively assessed in homeopathic and placebo treated groups. There was no statistically significant difference between groups. Adverse effects were scarcely and comparably reported in both groups and did not require a change in therapy. | |
| 3690987 | The natural history of rheumatoid arthritis over 20 years. Clinical symptoms, radiological | 1987 Sep | A 20 year follow up is reported on 100 patients with definite or classical rheumatoid arthritis when they were all initially seen within one year of the onset of arthritis. Forty-six patients have died and in 17 death was due to or related to RA. Mortality was greater in men than in women and in patients who had classical rather than definite RA at one year. Thirty of the surviving 54 patients have either no or only moderate restriction of physical activity. Those who had definite RA at one year are now better as regards functional capacity and joint score than those who had classical RA. In general the titre of the Rose test has tended to fall and those who have become seronegative have done better than those remaining seropositive. | |
| 2930262 | Handedness and deformities, radiographic changes, and function of the hand in rheumatoid a | 1989 Feb | The correlation of handedness with deformities, radiographic changes, and function of the hand was studied in a large group of patients with rheumatoid arthritis and a dominant right hand. There was no significant difference in the proportion of patients who had swan neck deformity, boutonnière deformity, uncorrectable ulnar deviation, and flexor tenosynovitis in the dominant and non-dominant hands. There were significantly greater radiological changes in the dominant hand, however, and the middle and index fingers were most severely affected. The severe involvement of these fingers may be related to their greater use in daily activities. There was also more severe functional impairment in the dominant hand. | |
| 2222531 | Diminished incidence of severe rheumatoid arthritis associated with oral contraceptive use | 1990 Oct | It has been suggested that the negative association between rheumatoid arthritis (RA) and oral contraceptive (OC) use might be limited to the more severe forms of RA. To investigate this further, we studied 121 consecutive female patients with definite RA, 52 female patients with probable RA, and 378 female controls. All patients had RA symptoms of recent onset. After a mean followup period of 6 years, patients with definite RA were classified as having either a severe disease course (n = 76) or a mild disease course (n = 45). The negative association between OC use prior to the onset of RA symptoms and the development of RA was limited to those patients with definite RA who had a severe disease course. We therefore conclude that OC use prior to the onset of RA symptoms is only associated with a reduction in the incidence of severe RA. This may explain the divergent results of previous studies. | |
| 2188345 | [Does rheumatoid polyarthritis come from the New World?]. | 1990 Apr 10 | While rheumatoid arthritis apparently did not exist in the Old World prior to the eighteenth century, a symmetrical erosive arthritis, indistinguishable from contemporary rheumatoid arthritis is clearly documented in the 1,000 year before present Fort Ancient-Anderson Village site. As lesions compatible with a diagnosis of rheumatoid arthritis have not been noted in the Old World prior to 1785, observation of 35 pre-Columbian cases of compatible lesions, suggests the likelihood that rheumatoid arthritis is a New World disease that subsequently spread to the Old World. Study of the geographical patterns and timing of distribution of rheumatoid arthritis and of New World organic items may provide an opportunity to identify the responsible pathogens or allergens. | |
| 1947899 | Intensive dynamic training in water for rheumatoid arthritis functional class II--a long-t | 1991 | The aim of the study was to assess the effects of once-weekly, intensive dynamic training in water of patients with Rheumatoid Arthritis (RA). Thirty patients with RA, functional class II, in a training group (TG) and 30 in a comparison group (CG) were assessed with respect to clinical, radiological and functional disease manifestations and psychosocial consequences before and after a four-year training period. After the training period the TG patients had significantly better grip strength and higher activity level, the latter maintained at two-year follow-up. There were significantly more CG patient admittances for acute hospital care during the training period. No other differences between the groups were found. Dynamic training at an intensive tempo does not seem, even in a long perspective, to lead to any undesirable consequences. | |
| 2183172 | Revised criteria for the classification of rheumatoid arthritis. | 1990 Mar | The Bulletin on the Rheumatic Diseases has published all of the classification criteria for the rheumatic diseases to date. These new revised classification criteria for rheumatoid arthritis are very important as they should provide understanding of the possibly changing face of rheumatoid arthritis. | |
| 1877853 | Two methods of assessment of methotrexate hepatotoxicity in patients with rheumatoid arthr | 1991 Jul | Serial liver biopsy specimens from 18 patients with rheumatoid arthritis receiving a weekly dose of methotrexate 7.5-20 mg for a minimum of 12 months were assessed semiquantitatively and by a microcomputer image analysis system. The semiquantitative histological method showed a significant increase in pericellular collagen and in overall disease while morphometry showed a significant increase in pericellular, perivenular, and portal tract collagen. There was a significant correlation between the two methods, but morphometry had the advantage of objectivity and efficiency. There was no correlation between the increase in collagen and the accumulated dose of methotrexate, which suggests that other factors in addition to methotrexate may contribute to liver injury. | |
| 2645007 | Autoimmune thyroid disease and thyroid autoantibodies in rheumatoid arthritis patients and | 1989 Feb | All 504 available members from 58 multicase rheumatoid arthritis (RA) families were interviewed and examined for the presence or history of autoimmune thyroid disease and were tested serologically for thyroid autoantibodies. The serological data were compared with those from a major population survey which used the same assay methods. Overall, 6% had thyroid disease with a fivefold female excess. Thyroglobulin antibodies were present in 5% of males and 11% of females and thyroid microsomal antibodies in 5% of males and 15% of females. These rates were all significantly greater than published rates for the general population. The differences persisted after analysing separately by age group. The results confirm the suggestions by others that there may be a common genetic link between RA and autoimmune thyroid disease. | |
| 2241263 | Smoking, lung function, and rheumatoid factors. | 1990 Oct | Positive rheumatoid factor (RF) reactions commonly precede the onset of clinically manifest rheumatoid arthritis (RA). Thus if items associated with RF reactions were traced at the community level this might provide clues to the cause of RA. The relations between smoking and lung functions and the occurrence of RA and RFs in a population sample representative of the adult Finnish population were studied. Rheumatoid factor testing was performed for 7124 subjects (89% of the sample) by the sensitised sheep cell agglutination test. Forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) were measured with spirometry. 'False positive' RF reactions occurred twice as often in current smokers and ex-smokers than in those who had never smoked. The prevalence of high titres was fourfold greater among current smokers than among those who had never smoked. These associations were statistically significant and independent of age, FVC, and FEV1 in both sexes. The women with airflow limitation (FEV1/FVC less than 70%) had a significantly increased occurrence of RFs which was independent of their smoking history, but no such relationship was found in men. The results suggest an impact of smoking on RF production; a follow up study may show whether the raised RF titers in smokers will be reflected as an increased incidence of RA. | |
| 3278696 | Effect of dietary restrictions on disease activity in rheumatoid arthritis. | 1988 Jan | Additions in five steps were made, as a possible therapeutic measure, to the diet of 27 patients with rheumatoid arthritis (RA) after a period of two weeks of a basal isocaloric diet free from pulses, cereals, milk, and non-vegetarian protein foods. Fourteen patients finally took part in the trial, 10 (71%) of whom showed significant clinical improvement. Only three patients (11%) adhered to the diet for a period of 10 months. The others discontinued the diet and were then treated with conventional disease modifying drugs. The study indicates that dietary factors may influence inflammatory response in RA. | |
| 3051234 | Pulmonary function of nonsmoking patients with rheumatoid arthritis in the presence and ab | 1988 | One hundred nonsmoking patients with rheumatoid arthritis, including 63 with rheumatoid arthritis alone (RA group) and 37 who also had secondary Sjögren's syndrome (sSS group), underwent a detailed evaluation of their pulmonary function. The results were compared with those of 110 age-matched nonsmoking controls. Normal function was significantly less common in both patient groups than in the controls. A significant percentage of patients had small airways disease (SAD) which was observed with similar frequency in the control group. If this were excluded, then isolated impairment of carbon monoxide diffusing lung capacity (DLCO) was the most commonly detected significant abnormality in both patient groups. Restrictive disease was following in frequency in the RA group, but was absent in the sSS group. Obstructive disease was very uncommon in all of the patients. In general, there were no significant differences in the frequency of the various respiratory function abnormalities between patients with RA only and those with concomitant sSS, whereas between patients and controls, the only statistically significant differences were the higher frequencies of isolated DLCO impairment and restrictive disease in the RA group. | |
| 2816311 | Atlantoaxial laxity in rheumatoid arthritis. | 1989 Aug | We found that 14 of 162 rheumatoid arthritis patients with chronic occipitocervical pain had anterior atlantoaxial instability in the absence of any corresponding radiographic changes in the joint cartilage or subchondral bone. Our findings suggest that ligamentous instability is a prerequisite for this type of change. At the time of the detection of the instability, the median duration of disease was 12 (6-28) years. Rheumatoid occipitocervical pain may be initially caused by facet-joint arthritis or inflammation in the ligaments, and at a later stage also by irritation of the C2 nerve roots. | |
| 2303301 | Severe pulmonary hypertension in rheumatoid arthritis. | 1990 Feb | We report a patient with seropositive rheumatoid arthritis who had clinical and haemodynamic findings of severe pulmonary arterial hypertension. Histopathology proved this to be plexogenic rather than thromboembolic. We report the case to highlight this rare association. |