Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2631664 | Hyperviscosity syndrome secondary to rheumatoid arthritis. | 1989 Dec | A women with longstanding seropositive rheumatoid arthritis presented with the insidious onset of a hyperviscosity syndrome. This responded to plasma exchange and corticosteroids. Plasma exchange was complicated by severe bleeding which was associated with disturbances of coagulation and of platelet function related to the marked increase in plasma immunoglobulins. | |
| 2939806 | Functional capacity and treatment data from a community based study of patients with rheum | 1986 Apr | A community based study of rheumatoid arthritis was undertaken to determine patient characteristics and the patterns of treatment. Three hundred and eighty subjects were visited in their homes throughout Tasmania (pop. 430 000) by a research team. The median age of the sample was 60 years (interquartile range (IR) 49-69), with a female predominance of 2.65 to 1. The average onset age was 41 years (IR 30-53). Prescribing data indicated that polypharmacy was not common in the community, and that the use of slow acting antirheumatic drugs (SAARDs) and oral corticosteroids was not widespread. At the time of the study 26% of subjects were assayed fully functional--class I of the American Rheumatism Association's (ARA) functional classifications. The functional capacity data provided evidence that the spectrum of rheumatoid arthritis found in the community differed from that found in specialist rheumatology clinics. | |
| 3259884 | Frequency of infection among patients with rheumatoid arthritis versus patients with osteo | 1988 May | We compared the frequencies and types of infections that occurred in 448 patients with rheumatoid arthritis (RA) versus those occurring in 185 control patients who had osteoarthritis or soft tissue rheumatism. At least 1 infection developed in 23% of the RA patients and in 27% of the control patients. Using a series of risk factors, we found no substantial difference in the risk of infection in RA patients compared with that in control patients. Some of these factors, such as being female, having poor functional capacity, and receiving glucocorticoid treatment, were associated with different levels of risk for infection, but the levels were similar in RA patients and control patients. | |
| 2060966 | [Osteocalcin in rheumatoid arthritis--a marker for accelerated bone turnover in late-onset | 1991 Feb | Increased levels of OC can be detected in late RA with high disease activity, whereas no major bone impairment is detectable in early and advanced stages of RA suggesting a more serious bone involvement in this form of the disease. OC appears to be a good marker to identify osteopenia in late onset active RA. | |
| 2810286 | Classical rheumatoid arthritis associated with relapsing polychondritis. | 1989 Sep | Relapsing polychondritis is rare in rheumatoid arthritis (RA). We report a case of classical RA with relapsing polychondritis. Nasal septal chondritis resulted in cartilage collapse and a characteristic saddle nose deformity. HLA typing of the patient showed the presence of HLA-DR4 antigen. | |
| 3764724 | [Place of hemocarboperfusion and hyperbaric oxygenation in the treatment of patients with | 1986 | Altogether 12 patients were treated by the hemocarboperfusion method and 20 patients with systemic symptoms by the hyperbaric oxygenation (HBO) method. Positive results were obtained and it made it possible to recommend the above methods for multimodality therapy of patients with rheumatoid arthritis with systemic symptoms. A severe, rapidly progressive course of rheumatoid arthritis with the development of various systemic symptoms, a high titer of the rheumatoid factor should serve as an indication for hemocarboperfusion. HBO is found appropriate in such systemic symptoms as ischemic polyneuropathy, digital arteritis, trophic ulcers and Raynaud's syndrome. | |
| 2290151 | Winning the battle, losing the war? Another editorial about rheumatoid arthritis. | 1990 Sep | Major advances in the therapy of RA will likely require future scientific breakthroughs in the understanding of pathophysiology. That is not to suggest that clinical investigations should be put on hold while the entire focus of research shifts to the laboratory bench. Clinical studies of very early RA, including early treatment interventions, would appear to be of major importance. However, better characterization of the early clinical course and identification of pathologic markers of progressive disease are needed before formal randomized treatment studies of early disease can be initiated. The entire role of aggressive management, particularly with combination chemotherapy, at any stage of RA is in desperate need of answers. In clinical practice it would appear that combination chemotherapy is widely used, often as a last resort in treatment resistant patients who have failed conventional therapies. The published clinical studies would seem to support, but certainly not prove, a valuable potential role for combination chemotherapy in this setting. Moreover, the studies seem to indicate some increased risk of drug toxicities, the limitations of which are not readily apparent for most combinations. Based on the successes observed in these patients that are very difficult to treat, the possibility of a more fundamental role of combination chemotherapy in treatment of the disease has been advocated. These questions need to be resolved by well designed, randomized controlled trials. There is an urgent need to do the trials soon before combination chemotherapy gains an even stronger foothold in therapy. | |
| 2758770 | Evening primrose oil and olive oil in treatment of rheumatoid arthritis. | 1989 Jun | The effects of 10 ml of evening primrose oil or olive oil, administered twice daily for 12 weeks, on clinical and laboratory signs and on plasma prostaglandins were studied in 18 patients with rheumatoid arthritis. The plasma concentration of PGE2 decreased and that of TxB2 increased in both treatment groups, but no significant improvement could be seen in either group. | |
| 3212404 | 17-year follow-up of symptoms and signs in the knee joint in rheumatoid arthritis. | 1988 | A population survey was carried out in Stockholm, Sweden, in 1967. In a sample of 15,268 individuals, 239 were found to have rheumatoid arthritis according to the New York diagnostic criteria. In 1983, i.e. 17 years later, 109 of the 127 individuals still living were reexamined. Among these, 79 complained of knee symptoms and 30 stated that the knee was the joint that presented the greatest hindrance to walking. Fifty-nine found difficulty in walking up or down stairs and 47 had to use a walking aid. These shortcomings were more often noted in the knees that had been swollen, or painful, 17 years previously. In addition, at follow-up, narrowing of the articular space was observed in the knees that were swollen and painful. Valgus deformity was associated with swelling, while varus deformity also involved, apart from the swelling, pain and restricted motility. In all, 108 operations were performed on 48 of the 109 subjects who were re-examined; 12 of these were knee operations. | |
| 2793577 | Rheumatoid arthritis subsequent to Borrelia burgdorferi infection in two dogs. | 1989 Oct 1 | Two dogs with clinical signs of polyarthritis developed rheumatoid arthritis subsequent to Borrelia burgdorferi infection. In both dogs, the diagnosis of B burgdorferi infection was based on clinical signs of disease and high serum B burgdorferi titer. After antibiotic administration, both dogs had decreased B burgdorferi titer, but clinical response was temporary or was lacking. The dogs subsequently were rheumatoid factor-positive (antinuclear antibody- and anti-globulin-negative) and responded to anti-inflammatory drug administration. Development of rheumatoid arthritis in both dogs after B burgdorferi infection implicates the Borrelia organism as an infective agent leading to the development of rheumatoid arthritis in dogs. Dogs with clinical signs suggestive of B burgdorferi infection should have antiglobulin, anti-nuclear antibody rheumatoid factor, and B burgdorferi tests performed to aid definitive diagnosis. | |
| 3196080 | Influence of diet with different lipid composition on neutrophil chemiluminescence and dis | 1988 Oct | Neutrophil chemiluminescence was determined in patients with active rheumatoid arthritis. Twelve patients were randomly assigned either to a diet high in polyunsaturated fatty acids supplemented with eicosapentaenoic and docosahexaenoic acids or to a diet high in saturated fatty acids. A correlation with clinical and laboratory parameters is also reported. No statistical difference was observed in neutrophil chemiluminescence and in clinical parameters in the group of patients treated with a diet high in saturated fatty acids. Fish oil ingestion resulted in subjective alleviation of active rheumatoid arthritis and reduction of neutrophil chemiluminescence. This study corroborates the hypothesis of an anti-inflammatory role for polyunsaturated fatty acids in patients with chronic inflammatory diseases. | |
| 3649791 | Coping with rheumatoid arthritis. | 1987 Sep | Rheumatoid arthritis, a chronic systemic connective tissue disorder that affects women three times more often than men, that is of unknown cause, and that involves inflammatory changes primarily in the small peripheral joints of the hands and feet, afflicts approximately 8 million people in the United States. In its mildest form, rheumatoid arthritis causes little interference with normal activity. However, in its severest form, it can render the afflicted person bound to a wheelchair, house, or even a bed. As a result of its crippling effects, simply accomplishing the tasks of daily living can be a feat for some people. Coping with the existence of pain, disabling effects, and/or deformities brought on by rheumatoid arthritis is not an easy task for the afflicted person. To cope with the physical aspects of the disease, the afflicted person is likely to use the coping mechanisms of information seeking, direct action, inhibition of action, intrapsychic processes, and social support. Which coping mechanisms are used, how the mechanisms are used, and how effective the mechanisms are, must be determined by the nurse so that appropriate psychosocial interventions can be planned and implemented. | |
| 2213777 | Reliability of pain scales in the assessment of literate and illiterate patients with rheu | 1990 Aug | The assessment of a measure of chronic pain, should be reliable, valid and sensitive to change. Our study evaluated the reliability of 3 pain scales, visual analogue scale (VAS), numerical rating scale (NRS) and verbal rating scale (VRS) in literate and illiterate patients with rheumatoid arthritis (RA). Patients with RA attending an outpatient rheumatology clinic were interviewed and asked to score their pain levels on the 3 pain scales. The scales were presented in random order, twice, before and just after a regular medical consultation. Ninety-one patients were studied (25 illiterate and 66 literate). The Pearson product moment correlation between first and second assessment was 0.937 for VAS, 0.963 for NRS and 0.901 for VRS in the literate patient group and 0.712 for VAS, 0.947 for NRS and 0.820 for VRS in the illiterate patient group. These results indicate that the NRS has the higher reliability in both groups of patients. | |
| 2751719 | Predicting individual differences in pain and functional impairment among patients with rh | 1989 Jul | Objective measures of disease activity (erythrocyte sedimentation rate and joint swelling), disease severity (radiographic ratings), and psychological variables (coping strategies and affective states) were used to predict the degree of pain and functional impairment that would be experienced by a group of 53 patients who had rheumatoid arthritis. The severity of disease demonstrated no significant relationship to measures of outcome. Multiple regression analyses revealed that psychological variables explained a substantial proportion of the variance in outcome scores, even after disease activity was taken into account. Our study highlights the discrepancies between biomedical measures of disease severity and activity and patient outcome in a rheumatoid arthritis population, and our observations suggest that some of these discrepancies may be explained by psychological variables. | |
| 3138414 | Exercise tolerance and disease related measures in patients with rheumatoid arthritis and | 1988 Jun | One hundred and twenty patients with symptomatic rheumatoid arthritis (RA) or osteoarthritis (OA) in weight bearing joints (RA = 40; OA = 80) performed subjective maximal graded exercise tests on a motor driven treadmill. Disease related measures were also assessed. Findings from this sample indicated that people with arthritis were significantly impaired in exercise tolerance, flexibility and biomechanical efficiency. Significant differences between diagnoses appeared on a number of disease related measures; however, there was little correlation between disease related measures and exercise tolerance. Women demonstrated a greater aerobic impairment than men; and women with RA had a greater aerobic deficit than women with OA. | |
| 3805621 | Combined radiocarpal arthrodesis and midcarpal (lunocapitate) arthroplasty for treatment o | 1987 Jan | Arthroplasties for the wrist with rheumatoid arthritis are usually revised for the articulation between radius and carpus. The midcarpal joint is disregarded although it remains structurally better preserved and is therefore better suited for the preservation of stable motion. When the midcarpal surfaces are satisfactory, a radio-scapho-lunate fusion, accompanied by a midcarpal synovectomy, is an excellent procedure. When the midcarpal surfaces, particularly the head of the capitate, are also destroyed, the tendency has been to either perform a pan-arthrodesis, or to insert a wrist endo-prosthesis. For these severely unstable and destroyed wrists, a stabilization of the radiocarpal joint by arthrodesis, combined with preservation of motion at the midcarpal level by resection of the damaged head of the capitate and its replacement with a small implant has been done. This procedure has allowed all patients to retain a functional range of motion and to experience satisfactory relief of pain. | |
| 3182571 | Coming to terms with chronic illness: the negotiation of autonomy in rheumatoid arthritis. | 1988 | This paper examines ways in which daily life is sustained in the face of chronic illness. Using data from interviews with people with rheumatoid arthritis, we try to capture the complexity of the interdependence between individuals with chronic illness and society. The main areas focused on cover the disordered body, disruption of relationships, and management of a deviant identity. What emerges is the relativities in everyday negotiations involved as people assimilate or come to terms with the circumstances of disablement. A great deal of research by rehabilitation specialists and advocates of independent living makes use of an abstract notion of the individual and a categorical definition of independence. We suggest that through the subtle relativities individuals in fact sustain considerably more self-determination than is suggested by prevalent notions of independence. This state of affairs is more appropriately referred to as autonomy. The implications of this perspective for health care professionals are discussed. | |
| 2533833 | [The liver and rheumatoid arthritis]. | 1989 | The present paper deals with the relation of rheumatoid arthritis to hepatic diseases. Rheumatoid arthritis is regarded as a general disease though the predominant articular symptoms are also accompanied by changes in other organs. Rheumatoid arthritis includes distinct dysproteinemia conditioning the positivity of the flocculation tests. This dysproteinemia is not identical with that found in hepatic diseases. The level of serum mucoproteids in case of liver damage is always lower and in rheumatoid arthritis higher. The elevated mucoprotein level makes the serum more resistant to flocculation, but his protective influence is only restricted and the flocculation cannot even be prevented by the considerably higher mucoproteid level of pronounced dysproteinemia. The specific nature of hepatic involvement could not be proved so far. | |
| 1703234 | Rheumatoid arthritis: the role of the kinder and gentler therapies. | 1990 Nov | Rehabilitative therapies, as adjuncts to pharmacological and surgical therapies in rheumatoid arthritis (RA), help minimize pain and inflammation, improve functional capabilities, and, above all, enhance quality of life. The effects of heat, cold, and electrical stimulation on neurohumoral, inflammatory, and immunological mechanisms has been noted, although knowledge about their mode of action is lacking. There is, however, much that these modalities, in addition to splints, bracing, exercise, activities-of-daily-living training, and psychological, social, and vocational counseling can offer to reduce suffering and disability in patients with RA. Far more, however, needs to be learned to provide precise prescriptions and more effective applications. | |
| 2338008 | Rheumatoid factor isotypes and circulating immune complexes in rheumatoid arthritis. | 1990 Mar | Solid phase enzyme immunoassays were here used to quantify rheumatoid factors (RF) of the IgM, IgG and IgA classes and the immune complexes (IK) by their ability to bind to C1q or conglutinin in both the serum and synovial fluid of patients with rheumatoid arthritis (RA). Elevated serum levels of any RF isotype could be found in all patients with seropositive RA (IgM: 63%, IgG: 87%, IgA: 90%). Seronegative patients with RA presented to a significantly lesser extent with elevated levels of all the RF isotypes tested (IgM: 0%, IgG: 40%, IgA: 32%). Synovial fluid RF levels were significantly higher in SPRA patients than in SNRA patients with the exception of IgG-RF. All of the RF classes in both RA groups, however, were elevated when compared to RF in the synovial fluid of patients with osteoarthrosis. Both C1q binding and conglutinin binding immune complexes were significantly higher in the synovial fluid than in the serum of RA patients. The erythrocyte sedimentation rate and plasma iron levels were correlated with the levels of C1q binding immune complexes (IC) in the synovial fluid; total iron binding capacity showed an inverse relationship to synovial fluid IgG-RF levels. A radiographic index was also correlated with IgG-RF levels in the synovial fluid. Extraarticular manifestations were significantly more frequent in patients with elevated serum levels of IgM-RF or conglutinin binding IC. These findings indicate that IgG-RF in the synovial fluid and the formation of IC determined by their ability to bind C1q seem to be closely related to clinical features of local disease.(ABSTRACT TRUNCATED AT 250 WORDS) |