Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3212405 | Scintigraphic findings in the rheumatoid knee joint. | 1988 | An increased uptake of 99m-technetium methylenediphosphonate was found in 42 knees of 24 patients afflicted with rheumatoid arthritis. All the 23 knees which were painful and the 21 knees which had synovitis showed an increased concentration of isotope. Articular space narrowing was observed in 26 joints, all but one of which were subjected to increased isotopic accumulation and synovitis. The degree of radiologic cartilage destruction correlated significantly with the isotopic uptake. In the early stages of rheumatoid arthritis, the isotopic uptake was found to be heterogeneous within the joint in one half of the cases. In the later stages, with a narrowed articular space and valgus angulation, the isotope was concentrated to the lateral side of the joint, while joints with varus angulation had a more symmetric distribution. The degree and distribution of uptake seemed to be governed by several factors, among others, inflammatory activity and mechanical load. | |
| 3387930 | Activated monocytes induce arthritis-associated changes in mitochondria of cultured synovi | 1988 | We have recently shown that synovial fibroblasts cultured from patients with reactive or rheumatoid arthritis exhibit increased autofluorescence when compared with controls. Morphological studies suggested that this increase was related to the anomalous structure of mitochondria in cells cultured from rheumatoid or non-rheumatoid inflammatory synovial tissue. The present study describes attempts to find an explanation for these observations. The effects of conditioned media of cultured mononuclear cells were tested on normal synovial fibroblasts. Conditioned media of monocytes stimulated with lipopolysaccharide or poly-IC induced an increase in the cellular autofluorescence and changes in the morphology of mitochondria in normal fibroblasts. These changes were indistinguishable from those seen in synovial fibroblasts cultured from various arthritides. Indomethacin or gold salts did not abolish the effects of monocyte-conditioned media. Abnormal mitochondria could not be induced in the presence of cycloheximide. This study describes a new aspect of monocyte-fibroblast interactions during rheumatoid and non-rheumatoid inflammation of synovial tissue. | |
| 3458433 | Occurrence of autoimmune diseases and autoantibodies in multicase rheumatoid arthritis fam | 1986 Apr | The presence of autoimmune diseases and autoantibodies has been studied in 237 individuals from 17 families with two or more members affected by rheumatoid arthritis (RA). Hyperthyroidism occurred significantly more frequently than in a local control population (p less than 0.05), but if the RA cases were excluded this significance was lost. Thyroid cytoplasmic and microsomal antibodies were significantly more common (p less than 0.001), and this remained true if RA sufferers were excluded (p less than 0.01). The prevalence of both clinical thyroid disease and circulating thyroid autoantibodies was similar in the families where RA was associated with HLA-DR4 and in those where no DR4 association was observed. RA and immune thyroid disease may, therefore, share a common inherited factor, but this is unlikely to be at the HLA-DR locus. Antinuclear factor (ANF) was found in association with RA and with HLA-DR3 within the RA group (p less than 0.02). Relatives of RA sufferers did not show any excess of ANF positivity. The prevalence of pernicious anaemia (PA) and gastric parietal cell antibody did not differ from the expected. | |
| 2487709 | Compliance measurement with arthritis regimen. | 1989 Sep | Rheumatoid arthritis affects nearly 6.5 million Americans, causing significant disability and suffering. Improvement of treatment efficacy is of considerable importance. Because adherence moderates treatment effects, efficacy studies need to account for the extent to which the patient complied. This paper reviews the methods of assessing adherence. These methods fall into four categories: (1) clinical measures (therapeutic outcome and clinician judgement); (2) self-report (interviews, questionnaires, and daily records); (3) direct measures (direct observation and biologic assays); and (4) indirect measures (pill counts, pharmacy refills, and electronic monitors). The most commonly used measure is some form of self-report. The clinical measures are problematic as compliance indicators and should not be used in this regard. Selections among the other categories should be made based upon the behavior being studied, the cost and resources available, the capabilities of the patient, the questions being asked, and the level of accuracy and detail desired. There are no perfect measures. | |
| 2722296 | Haemopericardium in rheumatoid arthritis. | 1989 May | We report two cases of haemopericardium presenting as tamponade in patients with rheumatoid arthritis. Pericardial aspiration produced a good clinical response with no reaccumulation. We suggest that, although rare, haemopericardium can be a feature of rheumatoid disease and may be associated with significant haemodynamic disturbance. | |
| 3123614 | The total cost of care and the use of pharmaceuticals in the management of rheumatoid arth | 1988 | Medicaid claims data were analyzed to investigate the prevalence and cost of rheumatoid arthritis (RA) in the Medi-Cal program. It was estimated that approximately 24,000 Medi-Cal recipients receive treatment for RA each year. The sample of Medi-Cal RAs studied averaged more than $2500 annually in total direct health care expenditures. The total cost of RA to Medi-Cal is projected to be $19.26 million (+/- $0.90 million) annually. Inclusion of possible gastrointestinal side effects of drug therapy increases the total cost to $20.49 million (+/- $0.91 million). While only 6.5% of the sample of RAs were hospitalized and 4.9% received nursing home care annually, these services are estimated to account for nearly 70% of RA-related expenditures. Less than 7% of Medi-Cal RAs receive disease modifying antirheumatic drugs (DMARDs). More than 75% of Medi-Cal RAs received aspirin or NSAIDs. These relieve pain and inflammation, but have not been demonstrated to halt the process of joint destruction. | |
| 2590801 | Evaluation of the Dutch Arthritis Impact Measurement Scales (DUTCH-AIMS) in patients with | 1989 Dec | The Arthritis Impact Measurement Scales (AIMS) have been used to measure health status in patients with rheumatic diseases in North America. In this study, a Dutch version of this self-assessment questionnaire named the DUTCH-AIMS was evaluated in 73 Dutch patients with rheumatoid arthritis. Significant correlations between scores from the DUTCH-AIMS on the one hand and ARA functional class, haemoglobin, erythrocyte sedimentation rate, self-assessments of functional impairment and perceived overall health on the other hand indicate that the scales are valid and provide good estimations of various components of the health status of the Dutch arthritic patient. | |
| 2848461 | Large granular lymphocytosis associated with rheumatoid arthritis. | 1988 Oct | A 74 year old woman with rheumatoid arthritis, hepatosplenomegaly, neutropenia, and peripheral blood lymphocytosis is described. The lymphocytes had a large granular morphology and expressed a CD3+ CD8+ Leu7+ surface antigen phenotype. They did not have natural killer cell function. Southern analysis of the lymphocyte DNA using two restriction enzymes showed a rearranged pattern for the T cell receptor beta chain gene, indicating a monoclonal lymphoproliferation. Large granular lymphocytosis is a rare and heterogeneous phenomenon, which has become more clearly characterised through the application of molecular biology techniques. Most cases appear to be forms of T cell leukaemia with a chronic benign course. The association between rheumatoid arthritis and large granular lymphocytosis is emphasised. | |
| 2742406 | Symptomatic manubriosternal joint involvement in rheumatoid arthritis. | 1989 Jun | The manubriosternal joint is commonly involved in rheumatoid arthritis but rarely gives rise to symptoms. A patient is reported with seropositive, erosive rheumatoid arthritis, who developed symptoms resembling pleuritic pain, arising from synovitis of the manubriosternal joint. Treatment with intra-articular steroid injection resolved these symptoms rapidly. | |
| 1883696 | The rheumatoid cervical spine. | 1991 Jun | The cervical spine contains 31 joints and moves about 600 times per hour. This makes it a site with a predilection for synovitis, ligamentous inflammation and mechanical stress in all types of chronic arthritis. Accordingly, eight different atlantoaxial or subaxial sublaxations and numerous other pathologic conditions occur in this area. The vital structures contained in this area impart particular significance to this involvement. Because there are practically no similarities between the structure and function of the lumbar spine and cervical spine, no parallels can be drawn between these two anatomically separate sites. Therefore, the anatomy, physiology, pathology, clinical syndromes, and treatment of the rheumatoid cervical spine have to be understood and dealt with on their own. This review article contains an update of topics of utmost importance in patient care, in light of the most recent basic and clinical science studies. Particular attention has been paid to new imaging and neurophysiologic techniques and their relevance to clinical design and treatment decisions, and modes of treatment in light of new advances in surgical technique and in our understanding of the long-term effects of active expectance and surgical intervention. | |
| 2786527 | [Differences in the clinical feature of Sjögren syndrome in the presence and absence of r | 1989 Feb | In our study, we investigated the clinical features of sicca syndrome in the presence and absence of rheumatoid arthritis. Twenty patients with sicca syndrome alone and 22 patients with sicca syndrome accompanied by rheumatoid arthritis were examined. The average onset age of the sicca syndrome alone is 12 years younger than the syndrome associated with rheumatoid arthritis. Moreover, rheumatoid arthritis tended to antecede the clinical onset of the sicca syndrome in the latter group. Relevant to the clinical investigative data, frequent lower values of CH 50 and positive reactions to the anti-nuclear antibody were noted in the sicca syndrome alone group. In this group, a lowering of cell-mediated immunity and a decrease in lysozyme density in lacrimal fluid were also noted. Relevant to the clinical manifestation, a high frequency of recurrence of parotitis, purpura and lymphadenopathy was also noted. Related to the joint findings, 45% of the patients with sicca syndrome alone disclosed clinical evidence for arthritis, however, no significant radiographic findings were observed. It is clear that there were distinct differences in clinical figures in both groups, while continuity of the clinical figures between them was also confirmed. When we take the known pathological and molecular genetic findings into consideration, it may be assumed that the differences in the clinical figures between these two entities could result from the difference of the causative mechanism of the conditions. Furthermore, we may safely say that the sicca syndrome alone may reflect the essential pathophysiologic figure of this particular syndrome. | |
| 2372020 | Rheumatoid arthritis and hypercoagulable state. | 1990 Jul | Rheumatoid arthritis is not considered to be associated with recurrent thrombosis. We report a patient, who while receiving anticoagulants had repeated life-threatening episodes of thrombosis. She later developed severe rheumatoid arthritis. After receiving successful antiarthritic therapy and withdrawal of anticoagulants, she had no further episodes of thrombosis. | |
| 2137159 | Hand handicap and rheumatoid arthritis in a fish-eating society (the Faroe Islands). | 1990 Jan | In the county of Klaksvik, the Faroes, a simple hand test was used for screening all inhabitants between the ages of 40 and 74 years. With its high sensitivity and specificity it revealed a diagnostic panorama entirely different from that seen in previous investigations in other nordic countries. In Klaksvik the prevalence of hand handicap was about 40%, which is due to the high incidence of osteoarthrosis. The prevalence of rheumatoid arthritis was 1.1%. The high functional capacity and the lower occurrence of rheumatic nodules and erosions found in the patients with rheumatoid arthritis as compared with previous studies suggest that the disease takes a milder course in Klaksvik. This should support the hypothesis that RA patients benefit from a diet rich in fish. | |
| 3204597 | The clinical value of the Stanford Health Assessment Questionnaire Functional Disability I | 1988 Oct | We administered the Stanford Health Assessment Questionnaire functional disability questionnaire to a cohort of 400 patients with rheumatoid arthritis (RA) every 6 months during a mean followup of 3.1 years. Simple classification into 3 groups based on Functional Disability Index (FDI) scores (0-1, 1.1-2, 2.1-3) identified patients with increasingly more severe scores for clinical, psychological, and demographic variables; and FDI scores at entry predicted increased inpatient and outpatient utilization of services, and mortality. The FDI provided important and clinically useful current and predictive information regarding RA status, utilization of services, and mortality that was not available through conventional testing. Our data suggest that such information can be easily and inexpensively obtained. | |
| 2672138 | Low-dose prednisone therapy. | 1989 Aug | Low doses of corticosteroids are beneficial in the management of certain patients with rheumatoid arthritis, and provide definitive symptomatic relief for patients with polymyalgia rheumatica. They are probably of similar value in the treatment of older adults with acute seronegative polyarthritis, a condition that may bear close resemblance to polymyalgia rheumatica. | |
| 1771399 | The effect of olive oil and fish consumption on rheumatoid arthritis--a case control study | 1991 | In an interview based, case control study of Rheumatoid Arthritis (RA) 168 cases and 137 controls were included. Patients and controls were interviewed with regard to a variety of socioeconomic, medical and dietary factors. During univariate analysis it was found that RA cases consumed significantly less olive oil and fish and adhered more rarely to the dietary restrictions traditional in Orthodox lent than controls. Applying multiple logistic analysis though (by which several variables were controlled for), only the association with olive oil consumption and lent adherence remained significant. More specifically; an increase in olive oil consumption by two times per week, resulted in a Relative Risk (RR) for development of RA of 0.49, whereas adherence to lent during the 27 weeks per year prescribed by the Orthodox Church, resulted in a RR of 0.33. We conclude that olive oil consumption and adherence to Orthodox lent may have a protective effect on the development and/or the severity of RA. This is a hypothesis generated by the present study that needs verification. | |
| 3772917 | The effect of tonsillectomy and appendectomy on the development of rheumatoid arthritis. | 1986 Aug | The possibility of an association between rheumatoid arthritis (RA) and prior tonsillectomy and appendectomy was investigated in a community based case-control study of 229 female cases of probable and definite RA and 458 appropriately matched controls. No association was found with logistic analysis even when controlling for a variety of factors such as socio-economic status, oral contraceptive use, and their interactions. | |
| 2837251 | Effects of fasting on disease activity, neutrophil function, fatty acid composition, and l | 1988 May | Fourteen patients with rheumatoid arthritis (RA) were studied before, during, and after a 1-week total fast. Disease activity decreased, as did the neutrophil release of lysozyme induced by the ionophore A23187. The ability of zymosan-activated RA patient serum to aggregate control neutrophils was reduced, together with serum concentrations of C3. The relative contents of arachidonic acid and eicosapentaenoic acid were increased in serum, platelets, and neutrophils, whereas levels of linoleic acid and linolenic acid were unchanged. Fasting also reduced the release of leukotriene B4 from neutrophils. We thus conclude that a reduced ability to generate cytotaxins, reduced release of enzyme, and reduced leukotriene formation from RA neutrophils, together with an altered fatty acid composition of membrane phospholipids, may be mechanisms for the decrease of inflammatory symptoms that results from fasting. | |
| 2504917 | Short term effects of low dose methotrexate on the acute phase reaction in patients with r | 1989 Jul | Sequential daily measurements of erythrocyte sedimentation rate (ESR) and serum C-reactive protein (CRP) were performed for one week after an I.V. injection of 7.5-13 mg methotrexate (MTX) in 18 patients with rheumatoid arthritis. Early decreases of ESR and CRP were observed. Serum CRP was more sensitive than ESR, displaying more pronounced falls from baseline to both the minimal and to the 7th day levels. Patients receiving their first dose of MTX (n = 9) exhibited a more prominent reduction of CRP levels in comparison to veteran MTX users (n = 9). The prompt response of acute phase reactants to MTX may correspond to the relatively rapid clinical effect of the drug in RA. It may also support an antiinflammatory mechanism of action of low dose MTX. | |
| 2003172 | [Rheumatoid arthritis: what do patients do with our prescriptions?]. | 1991 Feb 5 | This study encompassing a sample of 103 out-patients with chronic polyarthritis revealed that only 71.6% of the patients showed good compliance with the prescribed medication. A relatively large cohort (61%) used paramedical treatments. Factors influencing compliance-behavior, in particular attitude to paramedical methods are investigated. |