Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3630656 | Poor results of double osteotomy for the rheumatoid knee. | 1987 Jun | A series of 27 patients (30 knees) with rheumatoid arthritis was studied 3 to 8 years after double osteotomy of the knee. Long-term results were poor. Double osteotomy should be abandoned in the management of the rheumatoid knee. | |
| 2705077 | Acute upper airway obstruction in rheumatoid arthritis of the cricoarytenoid joints. | 1989 Apr | We have reported two cases of acute, life-threatening upper airway obstruction due to previously unrecognized rheumatoid arthritis of the cricoarytenoid joints with severe acute and chronic deformities of the larynx. Attempted endotracheal intubation with the rigid laryngoscope failed in each case, resulting in the need for emergency tracheostomy. We recommend the use of the fiberoptic bronchoscope for elective or emergency endotracheal intubations in patients with severe rheumatoid arthritis involving the cervical spine and the larynx. | |
| 3180537 | Class specific rheumatoid factors and their complement binding property in the sera of pat | 1988 Apr | In this prospective study of 44 patients suffering from recent-onset rheumatoid arthritis we followed the changes in serum levels of rheumatoid factors (RF) of the main immunoglobulin classes and their complement binding property (C3BP) and studied the correlations of these variables with clinical and laboratory parameters of disease activity. The study showed that RFs of all immunoglobulin classes and C3BP fluctuated longitudinally correlating significantly with each other and with laboratory variables of disease activity. IgG-RFs, however, appeared to predict the erosiveness and to correlate best with the articular activity of the disease. Chrysotherapy was shown to decrease serum levels of all RF isotypes irrespectively of whether the patients responded to the therapy or not. | |
| 2343346 | Therapeutic requirements in rheumatoid arthritis. | 1990 May 19 | Therapeutic requirements were determined for a group of 256 patients with rheumatoid arthritis (RA) attending the Rheumatic Diseases Unit in Cape Town. Two-thirds of the patients had received or were receiving physiotherapy and half occupational therapy. Antidepressants had been taken by 24.2%, and 31.3% had received tranquillisers. All the patients had received non-steroidal anti-inflammatory drugs and 84 (32.8%) oral corticosteroids. One hundred and eighty-two patients (71.1%) had received one or more intra-articular or intralesional corticosteroid injections. A remittive agent or immunomodulatory drug had been prescribed to 163 patients (63.7%). Half the patients had undergone one or more surgical procedures for their RA. The outcome of management was favourable in the majority of patients, 78.1% having little or no functional disability. The management of patients with RA requires a team effort involving many different health professionals, and patients often require multiple drugs for the control of their disease. | |
| 3199399 | Coping strategies in rheumatoid arthritis. | 1988 Sep | Our purpose was to investigate the importance of the coping process for patients with rheumatoid arthritis (RA). Eighty-four patients with classic or definite RA were examined. The relationship between coping strategies and psychological status, functional status, pain, and disease activity was analyzed. Coping was measured by an adapted version of the Ways of Coping Scale, and measures of psychological status, life stress, functional status, pain, and disease activity were also obtained. Canonical correlation revealed a significant relationship between the coping process and psychological status. Coping also was significantly related to functional status, but not to pain or disease activity. Patients who coped by restructuring life goals were found to have better psychological adjustment and functional status than patients who hoped for unrealistic solutions or engaged in self-blame. | |
| 2712618 | Azathioprine induced hepatic veno-occlusive disease in rheumatoid arthritis. | 1989 Apr | A patient with rheumatoid arthritis developed hepatic veno-occlusive disease following the use of azathioprine. Although azathioprine induced veno-occlusive disease is suspected to occur more frequently in patients with autoimmune dysfunction, it has not previously been reported as a complication of treatment in rheumatoid arthritis. The mechanism responsible for this condition remains unknown. | |
| 2917233 | A controlled evaluation of arthritis education. | 1989 Feb | The benefits of patient education for those with chronic arthritis are well documented. Informed patients should practice self care more often, and may show reduced disability from their disease. An important question relates to maintenance of the knowledge and skills acquired in educational programmes. This prospective study evaluated an education programme for people with rheumatoid arthritis (RA) and osteoarthritis (OA). The intervention group participated in a comprehensively planned six session behaviourally based programme. A questionnaire was given to 100 patients and 95 matched but non-random controls before the programme, 1 month later, and at 3 and 12 months. The intervention group demonstrated improvements in knowledge, self-reported health behaviour and disability scores at 12 months, compared to the controls. No differences were reported in symptoms, compliance with therapy, pain perception, and locus of control. | |
| 2241291 | Lymphoedema of the limbs as an extra-articular feature of rheumatoid arthritis. | 1990 Sep | Seven patients with lymphoedema of the hands and arms, an unusual extra-articular feature of rheumatoid arthritis, are described. In all cases the lymphoedema persisted throughout follow up--in one case for more than five years--and was resistant to treatment with slow acting drugs, steroids, or cytotoxic agents. There was no correlation with severity of disease. It is concluded that the lymphoedema in these patients may be associated with reduced numbers of lymphatic vessels; increased capillary permeability or abnormal fibrinolysis may also be contributory factors. Conservative management of such patients is recommended. | |
| 3047874 | Symmetrical erosive peripheral polyarthritis in the Late Archaic Period of Alabama. | 1988 Sep 16 | Rheumatoid arthritis was first described unambiguously in 1800, but its etiology and historical origins are still obscure. Definite rheumatoid arthritis has not been demonstrated in pre-19th century Old World skeletal remains. Six individuals who lived 3000 to 5000 years ago in northwestern Alabama and present erosive polyarthritis characteristic of rheumatoid arthritis are described. The diagnosis raises the possibility that rheumatoid arthritis can be associated with a New World pathogen or allergen. | |
| 3602949 | Radiological findings in the rheumatoid knee joint in a seventeen-year follow-up. | 1987 | In 1967 a population survey of rheumatoid arthritis (RA) was carried out in Stockholm. In a sample of 15,268 subjects, 239 were found to have RA. In 1983, i.e. 17 years later, all the 127 subjects still living could be traced, 109 of them were re-examined and 98 radiographed. Whole-leg weight-bearing radiographs of the 168 knee joints were available for determination of the HKA (Hip-knee-ankle) angle and of the articular space. In this sample, which represented the epidemiological spectrum of RA, disease activity could be associated with radiologic changes in the knee joint, e.g., erosions, cysts and sclerosis. These radiologic findings were predictable owing to the fact that New York criterion no. 3 or 4 for RA had been fulfilled 17 years earlier. In 52% of those with active RA at the follow-up, the articular space was seen to be narrowed. A certain varus angulation (2.2 degrees) was ascertained in the joints of subjects with inactive RA, while this angulation was less pronounced (0.7 degrees) in knee joints of subjects with an active disease. | |
| 1946061 | Flexion-extension MRI of the upper rheumatoid cervical spine. | 1991 Sep | Seven rheumatoid arthritis patients with involvement of the upper cervical spine were evaluated with a dynamic MRI study. Lateral T1 weighted images of the upper C-spine were obtained in the flexion, extension, and neutral positions. The indications for performing the dynamic MRI were radiographic instability of the upper C-spine, myelopathy, superior migration of the odontoid process, obliteration of bony landmarks on plain radiographs, and to determine the contribution of pannus on cord configuration. The dynamic MRI clearly delineated the relationship between the odontoid, foramen magnum, and cervical spinal cord as the neck was moved through a range of motion. This aided in the selection of operative candidates in four cases, and was instrumental in determining fusion levels. In three cases with suspected myelopathy secondary to cord impingement, MRI showed no significant cord compression, and aided in the decision to treat the patients conservatively. Lateral flexion-extension MRI is the diagnostic study of choice in dynamically evaluating the upper rheumatoid C-spine. | |
| 3652595 | The acromioclavicular joint in rheumatoid arthritis. | 1987 Oct | The acromioclavicular (AC) joint was clinically and roentgenographically examined in 49 rheumatic patients with painful shoulders. Clinically, the AC joint was tender and painful in about one-third of the shoulders. Roentgenographically, AC changes were encountered in 85% of the shoulders. The AC joint destruction was frequently associated with the glenohumeral joint disease. There was a time-dependent progression of subchondral bone erosion, tapering, and osteolysis of the acromial end of the clavicle corresponding to the duration and/or severity of the rheumatoid disease. | |
| 3608270 | Depression, anxiety and rheumatoid arthritis activity. | 1987 Apr | The temporal relationship of rheumatoid arthritis activity and mood has rarely been studied and the findings have been unclear. This study focuses on this problem in a prospective, multiple assessment design. Depression, anxiety, and rheumatoid arthritis (R.A.) variables were assessed weekly during hospitalization and monthly for six months after discharge in a sample of 39 patients. Evidence was found for a relationship between depression and increased R.A. activity occurring in association with clinically relevant R.A. related events such as flare-ups leading to hospitalization, improvement resulting from hospitalization, and adjustment after discharge. No evidence was found for relationships between depression, anxiety, and less dramatic changes in R.A. variables occurring during regular weekly in-hospital and monthly post-hospital assessments. The results demonstrate the inadequacy of assessments done at one point in time and also suggest that somatic complaints such as reduced energy, disturbed sleep or poor appetite may be associated as much with depression as R.A. activity. | |
| 14552308 | Auranofin improves outcome in early rheumatoid arthritis. Results from a 2-year, double bl | 1988 Dec | The effect of early initiation of auranofin (AF) therapy on outcome measures was studied in a controlled 24-month double blind trial in 138 patients with early rheumatoid arthritis (RA) using an intent to treat approach. Patients were randomized to AF or placebo but in case of insufficient effect or intolerable adverse events, they switched to open disease modifying antirheumatic drug therapy. Patients who started AF fared significantly better in improved joint swelling. Stanford Health Assessment Questionnaire index, Keitel functional test, and mental depression, and furthermore, radiologic progression was significantly retarded. Our results support a disease modifying beneficial effect of AF in early active RA.se | |
| 3395381 | Correlates of a clinical classification schema for the arthritis helplessness subscale. | 1988 Jul | We examined the categorization of the helplessness subscale of the Arthritis Helplessness Index (AHI) into clinical ranges analogous to laboratory values, and the predictive validity of these cutoff scores over a 2-year period. Data were obtained via questionnaires mailed every 6 months over 5 time periods to 368 patients who had been diagnosed as having rheumatoid arthritis. The results demonstrate that patients classified as low helpless were distinct from those classified as normal. In turn, those classified normal were distinct from high helpless patients on numerous measures of beliefs, affect, behavior, and symptom severity. Even after 2 years, the 5-item helplessness subscale identified distinct clinical courses for these 3 groups. | |
| 2369420 | Evaluation of the 1987 revised criteria for rheumatoid arthritis in a cohort of newly diag | 1990 Jul | The revised criteria for the diagnosis of rheumatoid arthritis (RA) were presented in 1987. We tested these criteria on 135 women from a population-based study of patients with newly diagnosed RA. None of the 19 women with probable RA and 100 of the 116 women with definite RA met the 1987 criteria. The 1987 criteria appear to be less sensitive or more specific than the criteria formulated in 1956. | |
| 2060195 | Ankle arthrodesis with vertical Steinmann's pins in rheumatoid arthritis. | 1991 Jul | Many techniques for ankle arthrodesis have been described but some of them are not applicable in patients with severe rheumatoid arthritis (RA) who have also developed osteopenia and decreased bone density. A technique utilizing two longitudinally placed Steinmann's pins to fixate and align the joint was used in five patients with severe RA and is described here. Results showed a 100% fusion rate and patient satisfaction over an average follow-up time of six years. This ankle arthrodesis technique was found to be applicable in arthritic patients with osteopenia and decreased bone density caused by RA. | |
| 1943548 | [Distant radiotherapy in rheumatoid arthritis]. | 1991 | During an open controlled study of 20 patients with rheumatoid arthritis (resistant forms) their lymph nodes were irradiated at a dose of 7.5 Gy. Clinical improvement, including reduced morning rigidity, the number of inflamed joints, and Riccis index, was noted shortly after therapy and 6 mos. after irradiation in 50% of the patients. Immunosuppression and moderate lymphopenia were noted in all of them. Of the side-effects there was nausea that disappeared without additional treatment. A conclusion has been made that irradiation of the lymph nodes at a total dose of 7.5 Gy is equally effective but less toxic than irradiation of 20 Gy. | |
| 3075078 | B lymphocytes, B cell clones and rheumatoid factor antibodies in rheumatoid inflammation. | 1988 | This report focuses on the B lymphocytes and plasma cells in rheumatoid inflammation, and discusses the major autoantibodies in the pathogenetic mechanisms, i.e. the rheumatoid factor (RF) antibodies. We describe ways of raising human hybridomas that produce RF antibodies in rheumatoid arthritis (RA) in order to elucidate how these antibodies differ from the RF antibodies that are part of the normal immune response in man and animals, and from those in diseases other than RA, e.g. in M-components seen in mixed cryoglobulinaemia and in Waldenström's macroglobulinaemia. The preliminary results of these studies are presented and discussed. | |
| 3215550 | Breath pentane excretion as a marker of disease activity in rheumatoid arthritis. | 1988 | Activated inflammatory cells are capable of stimulating lipid peroxidation. In 27 patients with rheumatoid arthritis, we measured the pulmonary excretion of pentane, a product released during lipid peroxidation. We found highly significant correlations between pentane excretion and both joint inflammation (r = 0.88, p less than 0.001) and the erythrocyte sedimentation rate (r = 0.80, p less than 0.001). Patients treated with gold compounds or D-penicillamine excreted diminished amounts of pentane. The data suggest that lipid peroxidation may be related in part to the mechanism of injury in rheumatoid arthritis. |