Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3172112 | The occurrence of rheumatoid factor isotypes in early definite rheumatoid arthritis--no re | 1988 Jul | Seventy-one patients with definite rheumatoid arthritis and disease duration less than 2 years were followed prospectively. At study entry 43 patients had IgG rheumatoid factor (RF), 59, IgA-RF and 64, IgM-RF as measured with an ELISA; 48 were Waaler-Rose positive. After 2 years, joint erosions were present in 51 patients and absent in 19. One patient has not been followed long enough. The calculated relative risks contributed by different RF to the presence of erosions were low. No significant correlations between markers of disease activity and RF levels initially were found. The clinical value of RF isotype determination seems limited. | |
| 1862236 | An animal model of food allergic arthritis. | 1991 May | Progress in understanding rheumatoid arthritis has been slow in large part because no widely accepted animal model exists that clearly reflects naturally occurring human disease, and because the clinical expression of rheumatoid arthritis may represent multiple etiologies with shared or subtly different immunopathogenic pathways. New insights about pathogenesis and causes are needed to understand this disease and ultimately to care for patients better. | |
| 3212748 | [Rheumatoid arthritis with systemic manifestations: its diagnosis and clinical aspects]. | 1988 | A total of 104 patients with rheumatoid arthritis (RA) with systemic manifestations were investigated on the basis of a joint program in the Institute of Rheumatology, AMS, USSR, and in the Polyclinic Medical Institute (Leipzig), GDR. RA systemic manifestations were described, their diagnostic signs presented. Modern instrumental methods for the detection of RA manifestations before the development of their clinical picture (echocardiography, computed tomography, electrophysiological methods for a study of the peripheral nervous system) were assessed. Analysis of correlations between various RA manifestations and laboratory findings permitted the detection of peculiarities of the onset and a course of disease in the study group. The results will contribute to the early detection of systemic RA manifestations. | |
| 11188584 | The Beck Depression Inventory, Center for Epidemiological Studies Depression Scale (CES-D) | 1991 Mar | Three widely used depression scales--the Beck Depression Inventory (BDI), Center for Epidemiological Studies Depression scale (CES-D), and General Well-Being Schedule depression subscale (GWB-D)--were studied in rheumatoid arthritis (RA). Twenty-three rheumatologists identified 19 of the 45 items on these three questionnaires as likely to differ in patients with RA and control subjects because of the presence of RA, regardless of psychological status. Responses to 13 of these 19 individual scale items, designated as "RA-related items," differed significantly in 41 RA patients versus 57 age-matched control subjects. Only three of the other 26 items differed significantly in the two groups. These data extend evidence that responses of people with RA on widely used depression scales might be affected by somatic disease regardless of psychological status. | |
| 3397981 | Rheumatoid arthritis and hereditary angioedema. | 1988 Apr | We describe a case in which rheumatoid arthritis (RA) developed in a patient with hereditary angioedema. Hereditary angioedema, one of the inherited complement deficiencies, has been reported in association with a number of autoimmune disorders, but there has been only 1 report of an association between RA and hereditary angioedema. | |
| 2949753 | Long-term followup of rheumatoid arthritis patients treated with total lymphoid irradiatio | 1987 Jan | Total lymphoid irradiation was administered to 32 patients with intractable rheumatoid arthritis. Twenty-four patients showed at least a 25% improvement in 3 of 4 disease activity parameters, which persisted during the followup period of up to 48 months. Eight of the 32 patients required adjunctive immunosuppressive drug therapy to maintain improvement. Four patients died after total lymphoid irradiation; the causes of death were acute myocardial infarction (1 patient), pulmonary embolism (1 patient), and rheumatoid lung disease complicated by respiratory infection (2 patients). After therapy, patients exhibited a prolonged reduction in the number and function of circulating T helper cells. | |
| 2621408 | The Wrightington classification of rheumatoid wrist X-rays: a guide to surgical management | 1989 Nov | We have reviewed the pre-operative radiological appearances, the type of operation performed and the results of surgery of 234 wrists in 179 patients with rheumatoid arthritis. Based on this, a classification of X-rays of the rheumatoid wrist is described. It is designed to provide practical guidance to the surgeon who is planning surgery in a patient with rheumatoid disease. The surgical choices at each stage of the disease are briefly discussed. | |
| 2170287 | Reduction of complement activation in rheumatoid arthritis by steroid treatment. | 1990 | Patients with severe active active rheumatoid arthritis (RA) have higher than normal plasma concentrations of the complement C3 split-product C3d, indicating increased complement activation. Treatment with steroids reduced plasma C3d levels in these patients. Ten patients with classic or definite RA and high disease activity were studied during six days of treatment with steroids. The C3d plasma concentrations declined in a dose-related manner with an increase in daily prednisolone dosage. However the statistical significance of this relationship did not seem to be high enough to validate the use of serial C3d estimations to monitor changes in disease activity in RA patients during short-term steroid treatment. | |
| 2322779 | It is said that elevated erythrocyte sedimentation rate and the elevation of C-reactive pr | 1990 Apr | It is said that elevated erythrocyte sedimentation rate and the elevation of C-reactive protein (CRP) may be indicators of continuing joint destruction in rheumatoid arthritis. What then is the explanation for joint destruction in some patients in whom there is no such apparent elevation of either the sedimentation rate or CRP? | |
| 3662651 | Evolution of benign rheumatoid nodules into rheumatoid arthritis after 50 years. | 1987 Aug | A patient with benign rheumatoid nodules who developed rheumatoid arthritis after 50 years is described. | |
| 3766311 | Rheumatoid inflammation and joint destruction: cause and effect or parallel phenomena? | 1986 Aug | Joint damage is a characteristic and important consequence of rheumatoid arthritis; it is usually considered to be a direct result of the inflammatory synovitis. This view implies that by treating actively the synovial inflammation subsequent joint damage will be reduced and the long-term outlook of patients with rheumatoid arthritis thus improved. However, there is relatively little clinical evidence that suppressing inflammation reduces rheumatoid joint damage. An alternative view is that the mechanisms causing inflammation and those leading to joint destruction are parallel processes related only indirectly. Considerable evidence supports such a concept. Clinical studies show radiological progression of the disease occurs despite improvements in measures of joint inflammation and a reduction in the levels of acute phase proteins. Damage can progress in either actively inflamed hot joints or cool swollen joints. Histopathologically the features of rheumatoid synovitis are non-specific, while the radiological pattern of joint damage is very characteristic. There is evidence that lymphocytic infiltration is not a poor prognostic finding, despite it being a typical feature of inflamed joints. Experimental studies also fail to show a close correlation between inflammation and cartilage damage: this is seen in experimental arthritis, coculture in vitro systems, and the air pouch model of cartilage damage. We suggest that attempts to improve the outcome of rheumatoid arthritis should not merely concentrate on controlling inflammation but should also seek to modify the associated connective tissue changes of the disease. | |
| 3257874 | Natural course of joint destruction and fluctuation of serum C1q levels in patients with r | 1988 Jan | Using the number of joints with erosion in a total of 68 joints throughout the body, we studied a population of patients with rheumatoid arthritis whose disease duration was 10-15 years. Three groups, each showing a Poisson distribution, were found: the subset with least erosive disease (LES), the subset with more erosive disease (MES), and the subset with mutilating disease (MUD). The mean number of joints with erosion was 10.9 in LES, 32.2 in MES, and 53.5 in MUD. In LES, erosive articular changes were primarily limited to the peripheral smaller joints. In MES, the larger axial joints were also involved. Almost all joints were extensively damaged in MUD. During the early period of disease, differences between the 3 groups were highly significant in the rapidity of carpal bone destruction, as assessed by the yearly reduction of carpal height ratio (P less than 0.001), and in the serum C1q level (P less than 0.001). | |
| 3305931 | The MACTAR Patient Preference Disability Questionnaire--an individualized functional prior | 1987 Jun | A new approach to assessing disability in arthritis that quantifies the functional priorities of the patient is described. Comparison against global improvement suggests that this instrument has the potential to detect small clinically important changes in function. | |
| 3680643 | The laboratory identification of serum rheumatoid factor in the dog. | 1987 Sep | A modified Rose-Waaler test with sheep red blood cells coated with canine IgG was found satisfactory for detecting rheumatoid (antiglobulin) factor (RF) in dog serum. Low titres of RF were found in some normal dogs. Most dogs with rheumatoid arthritis were positive for RF at titres of 1 in 40 or greater. A small proportion of dogs with diseases other than polyarthritis were also positive for RF. A commercial slide agglutination test used for detecting human RF was unsatisfactory for the dog, giving false positive and negative reactions. A latex tube agglutination test with latex particles coated with dog IgG was developed but non-specific agglutination was a constant technical problem. | |
| 3418641 | Depression in rheumatoid arthritis. | 1988 Jun | Operationalized diagnostic criteria for depression were used to assess 137 (76% male, 24% female) patients with rheumatoid arthritis (RA). Forty-two percent met criteria for some form of depression. Discriminant function analysis revealed a significant relationship between the presence or history of depression and higher levels of pain, but not between current depression and common indicators of RA activity or severity. These results suggest that depression is a frequent disorder among persons with RA. The importance of patient appraisal of disease and assessment of repeated depressive episodes is discussed. Attention to specific interventions for depression in conjunction with the treatment of the RA is suggested. | |
| 1754667 | The pattern of rheumatoid arthritis in West Africa and comparison with a cohort of British | 1991 Aug | Inadequate information is available on the care burden and severity of rheumatological diseases such as rheumatoid arthritis in West Africa. We therefore studied patients with rheumatoid arthritis presenting to a rheumatology unit in Nigeria and compared these with patients presenting to a British rheumatology unit. The West African patients were younger at onset of disease, less frequently had a family history, showed fewer extra-articular features and erosions and were less commonly rheumatoid factor positive. The overall mildness of the disease in the West Africans was striking. | |
| 3616389 | Multiple peripheral pulmonary nodules preceding rheumatoid arthritis. | 1987 | The case of a young woman is reported, presenting multiple peripheral lung nodules, preceding the onset of classical rheumatoid arthritis 3 months later. The nodules observed seemed to be of pleural origin because they all had contact with the pleura which was partly thickened as demonstrated by computer-assisted tomography. The histopathology of material obtained by an open-lung biopsy revealed rheumatoid necrobiotic nodules. Although very rare, rheumatoid arthritis should be considered as a differential diagnosis of pulmonary nodules of unknown origin. | |
| 3042069 | Historical aspects of the aetiology of rheumatoid arthritis. | 1988 | Since the first description of the disease in the early part of the nineteenth century, the aetiology of rheumatoid arthritis has been associated with the interacting concepts of diathesis or internal factors and environment or external factors. | |
| 1994480 | Prevalence of biochemical and immunological abnormalities in rheumatoid arthritis. | 1991 Feb 2 | The prevalence of biochemical and immunological abnormalities was studied in a group of 256 patients with rheumatoid arthritis (104 coloureds, 100 whites and 52 blacks). The most common biochemical abnormalities detected were a reduction in the serum creatinine value (43.4%), raised globulins (39.7%), raised serum alkaline phosphatase level (42.3%), reduction in serum albumin value (8.1%), a mild rise in serum creatinine value (6.6%), and a raised serum gamma-glutamyltranspeptidase (GGT) level (6.5%). The prevalence of a rise in the GGT was less frequent than reported in other published studies. The immunological abnormalities noted were a positive rheumatoid factor (78.9%), positive anti-nuclear factor (36%), raised serum IgG (43.3%) and IgA (10.5%) values, positive smooth-muscle antibody (12.5%) and elevated double-stranded anti-DNA antibody levels (2.3%). Inter-group comparisons showed that the serum IgG and IgA and total globulins were significantly higher in blacks and coloureds than whites; these findings may be related to a higher prevalence of malnutrition and infection in childhood in these communities. There were no significant inter-group differences that could be attributed to rheumatoid arthritis. | |
| 2049584 | High definition computed tomography in rheumatoid arthritis associated pulmonary disease. | 1991 Jun | Eighteen patients with rheumatoid arthritis (American Rheumatism Association definition) were selected consecutively from a rheumatology clinic. All patients were examined with plain chest radiographs, thin slice computed tomography, and pulmonary function tests. Four patients with normal chest radiographs, and normal pulmonary function tests were found to have normal CT scans. In ten patients, abnormalities consistent with rheumatoid associated lung disease were demonstrated, including changes of interstitial fibrosis in seven cases. This fibrosis had a predominantly peripheral pattern on CT scan. Computed tomography was found to be more sensitive than plain radiographs in detecting abnormalities; however, all the patients in this series with CT lung changes had abnormalities on pulmonary function testing. |