Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
ID | PMID | Title | PublicationDate | abstract |
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2758704 | Plasma and synovial fluid lanthanides in rheumatoid arthritis: variations after intra-arti | 1989 May | Lanthanides (Ln), or rare earth elements, are detectable in trace amounts in organisms. Increased concentrations of Ln have been observed in rheumatoid arthritis (RA) in plasma (pl) and synovial fluid (Sf). We have evaluated pl and Sf concentrations of Ln (in particular La, Nd, Ce, Yb, Lu, Eu), in rheumatoid arthritis patients, before and after intra-articular steroid injection. Increased pl and Sf concentrations of Ln were confirmed in RA. No detectable synovial fluid concentrations of Ln were observed in healthy controls. A statistically significant Ln reduction (p less than 0.001) was observed in Sf 3 and 6 days after local steroid injection and in pl after 6 days. The decrease in Ln concentrations in Sf and pl, after antiphlogistic therapy, reflects the reduction of the inflammatory condition. | |
2360002 | Rheumatoid arthritis lesions of the wrist examined by rapid gradient-echo magnetic resonan | 1990 | Alterations of magnetic resonance imaging (MRI) relaxation time and intensity can be helpful in the diagnosis of rheumatoid arthritis (RA) lesions like synovial infiltration, local inflammation and exudation. Fast low angle shot magnetic resonance imaging (FLASH-MRI) is a rapid method showing anatomy and inflammatory pathology of the examined joint comparable to late spin echo T2 images. The following study presents our results of FLASH-MRI wrist examinations of 15 patients suffering from RA according the ARA criteria and 10 healthy volunteers compared to T1 and T2 weighted MR-images and conventional X-rays. | |
3050081 | Multicenter evaluation of synovectomy in the treatment of rheumatoid arthritis. Report of | 1988 | A controlled multicenter evaluation of open surgical synovectomy in the treatment of rheumatoid arthritis (RA) was carried out over a period of 5 years after the operation. There was evidence of benefit in some knees but none in finger joints. Synovectomy performed at a stage of minimal damage did not result in fewer recurrences of disease activity than when done after greater damage had occurred. The results showed little longterm value of surgical synovectomy in the general treatment of RA or in the prevention of recurrences of disease activity or progressive articular damage. These results emphasize the need for controls in trials of this type. | |
1929588 | Nocardia asteroides pneumonia complicating low dose methotrexate treatment of refractory r | 1991 Sep | Low dose methotrexate is used increasingly often in the treatment of rheumatoid arthritis. Severe complications due to toxicity of the lung or bone marrow occur infrequently. This report describes a 71 year old woman with longstanding rheumatoid arthritis who developed pleuritis, a pulmonary infiltrate, and pancytopenia during treatment with low dose methotrexate. Fatal respiratory insufficiency followed, and cultures from the lung after death showed Nocardia asteroides. | |
2031114 | [Rheumatoid arthritis in an Alpine region, incidence, social and occupational consequences | 1991 Apr 9 | Two hundred patients with rheumatoid arthritis were identified in our region. This number means a prevalence of around 0,1%, which is far less than usually described. Environmental factors could explain this. We studied the work capacity and the grade of invalidity of our patients. Women seem disadvantaged. | |
1822109 | Rheumatoid arthritis antirheumatic drug trials. II. Tables for calculating sample size for | 1991 Dec | The calculation of sample size requires knowledge of the standard deviation (SD) of index variables. Unfortunately, there are no published lists of SD and it is exceedingly difficult to locate variance estimates based on relevant populations. We used standardized procedures to determine in 60 patients with rheumatoid arthritis (RA) the SD of key outcome measures recommended in current Food and Drug Administration and European League Against Rheumatism guidelines for RA clinical trials. We anticipate that these tables will be useful to clinical researchers in selecting outcome measures as well as for calculating sample size requirements for future clinical studies in RA. | |
3259983 | Clinical significance of anti-Ro(SSA) antibody in rheumatoid arthritis. | 1988 Mar | A group of 12 patients with rheumatoid arthritis (RA) with anti-Ro antibody were compared to an age and sex matched group with RA. Both had similar articular manifestations but the anti-Ro positive patients had more severe extraarticular as well as serological abnormalities. Vasculitis, liver abnormalities, neutropenia and circulating immune complexes were prominent while sicca features were not. Treatment with remission inducing drugs failed frequently without increased toxicity. Two patients with classical RA with anti-Ro developed subacute cutaneous lupus erythematosus and anti-dsDNA. Our observations suggest that the presence of anti-Ro in RA sera may be a marker for a small but significant subset of rheumatoid disease. | |
2259838 | Early rheumatoid arthritis--onset, course, and outcome over 2 years. | 1990 | Eighty-nine patients, 33 men and 56 women, with early definite rheumatoid arthritis were followed for 2 years. Two-thirds were seropositive. About 1/3 were eventually treated with second line drugs. The disease mostly had an insidious onset initially involving the finger joints. Early remission occurred in 16%. Patient relevant measures such as pain, patient's overall assessment of disease activity and anxiety decreased significantly. Disability evaluated by the HAQ disability index remained at a low level. The joint damage score (JDS) in hands and feet increased steadily and only 18% were nonerosive after 2 years. One-third developed hand deformities which was associated with higher JDS. A joint function index (SOFI) correlated significantly with JDS. Twenty-eight percent had a slower rate of joint damage progression the second year. There was no significant correlation between JDS and disease duration. Six patients developed rapidly progressive damage in larger joints, five in the hip joints and one in the shoulder joint, all requiring joint replacement. The ability to predict outcomes with clinical and laboratory variable obtained at entry was of limited clinical usefulness. By applying discriminant analyses 67%-80% of the cases who fared worst regarding clinical, functional, and radiological features could be correctly classified. | |
1782749 | HLA-B40: a marker for susceptibility to lung disease in rheumatoid arthritis. | 1991 Mar | We have compared the frequency of HLA antigens in groups of patients with rheumatoid arthritis (RA) who had pulmonary manifestations, other extra-articular features or articular disease alone. There was a significantly increased frequency of the antigen HLA-B40 in patients with lung involvement compared to other forms of extra-articular RA (relative risk 40.54), and when compared to the total RA group (relative risk 4.94). In contrast there was little variation in the frequency of HLA-DR4, which was significantly increased in all patient groups. These data suggest that HLA-B40 is a marker of increased susceptibility to lung disease in patients with rheumatoid arthritis. | |
3075089 | Characterization of synovial macrophages by monoclonal antibodies in rheumatoid arthritis | 1988 | Inflamed synovium in rheumatoid arthritis (RA) and activated (inflammatory) osteoarthritis (aOA) sometimes demonstrates close similarities in routine histology. If the clinical findings are ambiguous, too, differentiation may become difficult, and the only diagnosis is "chronic unspecific synovitis". By immunohistologic staining with monoclonal antibodies of the Ki-M-series directed against cells of the monocyte/macrophage lineage semiquantitative evaluation of tissue samples is possible thus gaining helpful results for the differential diagnosis. There are significantly more macrophages in RA than in aOA especially in the synovial lining. Proliferating and activation markers also show slight but significant augmentation (OKT9) in RA. | |
3229023 | Magnetic resonance imaging for the study of cervical myelopathy in rheumatoid arthritis. | 1988 Oct | Cervical myelopathy is found fairly often with rheumatoid arthritis. It is one of the worst complications of the disease and can lead to tetraplegia or even to sudden death. However, when we consider the high incidence of involvement of the cervical spine in rheumatoid arthritis, the number of cases of cervical myelopathy, even of slight degree, is not very high. We have used magnetic resonance to identify the condition of the cervical structures, especially the nerve structures, in 15 patients with rheumatoid arthritis, with involvement of the cervical articulations but without neurological symptoms. We found anterior compression of the spinal cord caused by the odontoid process of the epistropheus in 13 cases. One case had lateral deviation of the spinal cord and another had compression of a vertebral artery. In another the lumen of the nasopharynx was decreased and one had posterior compression of the spinal cord by the posterior arch of the atlas. Magnetic resonance also makes it possible to detect a rheumatoid pannus on the affected articulations. We conclude that magnetic resonance is at present a useful instrument for evaluation of the presence of cervical myelopathy in rheumatoid arthritis patients, to prevent more serious complications. | |
3814200 | An open, controlled, randomized comparison of cyclosporine and azathioprine in the treatme | 1987 Jan | Cyclosporine (10 mg/kg/day) and azathioprine (2.5-3 mg/kg/day) were compared for 26 weeks in an open, controlled, randomized study of 24 patients with rheumatoid arthritis. Each treatment group consisted of 12 patients. Those patients who took cyclosporine improved significantly in the 50-foot walk time, circumferences of proximal interphalangeal joints, Ritchie articular index, global assessment by investigator, and grip strength, when compared with baseline findings. In the azathioprine group, there was improvement only in grip strength. | |
3172113 | Resorptive arthropathy in rheumatoid arthritis. | 1988 Jul | Our survey was undertaken to determine the prevalence of resorptive arthropathy in rheumatoid arthritis (RA). A group of 256 patients with classical or definite RA were studied and resorptive arthropathy was noted in 13 (5.1%). The age and sex ratio of the patients with resorptive arthropathy was similar to the remainder of the patients, but the duration of RA was significantly greater (p = 0.003). Patients with resorptive arthropathy had severe radiographic changes. There was no significant difference in the prevalence of nodules, a positive rheumatoid factor or antinuclear factor and functional classification (American Rheumatism Association) in patients with resorptive arthropathy when compared to the remainder of the patients. Our study shows that, in a hospital based study of patients with RA, resorptive arthropathy may be commoner than generally recognized, and its prevalence may be similar to the findings in psoriatic arthritis. | |
3816092 | Calculating radiological progression in rheumatoid arthritis. | 1986 Dec | We examined two methods of calculating radiological progression in rheumatoid arthritis using hand and wrist radiographs scored by Larsen's method. Progression over 12 months was calculated in two ways: absolute change in score; relative change in score. The two methods of scoring progression were investigated in two studies. In the first 173 patients with rheumatoid arthritis treated with a variety of non-steroidal and slow-acting anti-rheumatic drugs were evaluated. There were different results using absolute and relative changes in score. Relative changes gave more meaningful results. The second study looked at 80 rheumatoid patients treated with slow-acting drugs for 6 months; patients with a persistently high ESR had significantly more progression assessed by relative change but not by absolute change. Evaluating the progression of joint damage by methods employing a scoring system must be interpreted with caution. Relative change may provide a more valuable measure than absolute change. | |
3422013 | In vitro rheumatoid factor synthesis in patients taking second-line drugs for rheumatoid a | 1988 Sep | Rheumatoid arthritis (RA) patients whose unstimulated peripheral blood mononuclear cells produce high levels of IgM rheumatoid factor (IgM-RF) in vitro have more severe disease activity. RA patients being treated with second-line agents, including gold salts, penicillamine, or methotrexate, tend to be low producers or nonproducers of IgM-RF in vitro. The possibility that low production or nonproduction of IgM-RF in vitro may be explained by treatment with second-line agents alone, irrespective of disease activity, was analyzed in 133 RA patients whose disease status was assessed by multiple laboratory and clinical measures. The results indicate that treatment with second-line agents and in vitro IgM-RF synthesis are independently associated with disease activity. | |
3579387 | Lymphadenopathy in rheumatic patients. | 1987 Mar | Lymph node biopsy specimens from 22 patients with chronic inflammatory joint disease have been studied. The histology has been reviewed and immunoperoxidase staining carried out for the major immunoglobulin heavy and light chains, macrophage markers, and MT1, MB1 surface markers. Although two of these patients had been initially diagnosed and treated for malignant lymphoma, the clinical course has not substantiated the diagnosis, and on review malignancy could not be identified in any of the biopsy specimens. Careful attention to specific histological features, together with adequate clinical information, is therefore essential if the true nature of the lymph node enlargement is to be recognised. Clinical review of the 22 patients suggested that lymphadenopathy may, in some cases, be an early feature of inflammatory polyarthritis, and this was supported by the observation that 20% of patients with otherwise unexplained reactive lymphadenopathy developed an inflammatory polyarthropathy within one year of biopsy. | |
2066941 | Rheumatoid factor detection in the unaffected first degree relatives in families with mult | 1991 Apr | Rheumatoid factor (RF) was assayed in 354 unaffected first degree relatives from 59 families with multicase rheumatoid arthritis (RA), using both the latex test and ELISA for different RF isotypes. The association between HLA and presence of RF was also analyzed. In all, 39% of the relatives were positive for at least one class of RF compared to 7% positive for latex. There were no differences between the sexes in these rates. There were significant excess rates of HLA-DR4 in RF positive when compared to the RF negative relatives. The HLA-DR4 frequency in these RF positive RA negative individuals is similar to that observed in series of RA positive patients. Thus HLA status did not usefully discriminate between RA positive and RA negative but RF positive individuals in these families. | |
3500823 | An epidemiologically based follow-up study of recent arthritis. Incidence, outcome and cla | 1987 Sep | Incidence and outcome of inflammatory joint disease (IJD) were studied by an epidemiologically based follow-up study of unselected adult arthritis patients. The annual incidence of all IJD together was 2.18% in the population of 16 years and older; 5.67% in the HLA B27 positive and 1.62% in the B27 negative population. Almost half of all arthritides were of non-specific nature. Incidence of definite rheumatoid arthritis was 0.42% per year. The outcome after 8 years was worst in seropositive rheumatoid arthritis and best in seronegative oligoarthritis of unknown etiology. Outcome of seronegative polyarthritis was bimodal: majority of patients with a favourable and minority with a poor outcome. In Yersinia arthritis, patients with a mainly IgA-class antibody response had a more severe clinical picture than those with a mainly IgG-class response. Diagnosis of rheumatoid arthritis at the early stage of the disease should be based on specific features like rheumatoid factor, radiological signs, symmetric peripheral polyarthritis and morning stiffness with a long duration. Erosive rheumatoid arthritis is almost always seropositive, at least at some stage of the disease. | |
3332134 | Prolonged remission of severe refractory rheumatoid arthritis following allogeneic bone ma | 1986 Dec | Aplastic anaemia developed in a 33-year-old woman whose rheumatoid arthritis was refractory to the administration of many drugs, including penicillamine and gold. Allogeneic bone marrow transplantation reversed the haematological abnormality and simultaneously resulted in a 2-year period of relief from joint pain. Symptoms then reappeared and the serological tests for rheumatoid arthritis again became positive. The arthralgia has responded slowly to the administration of anti-inflammatory drugs and steroids. The protracted asymptomatic period may have been due to the intense immunosuppression required for marrow grafting and the subsequent administration of cyclosporin. Since she developed chronic graft-versus-host disease, the arthritis may be an unusual complication of this syndrome. | |
3723493 | A multicenter study of hospitalization in rheumatoid arthritis: effect of health care syst | 1986 Apr | During 1981, centers in Phoenix, Saskatoon, Stanford and Wichita monitored hospitalizations for 816 patients with rheumatoid arthritis. Admission rates varied 2-fold, and admissions for evaluation and treatment 10-fold across centers. Admissions were related primarily to disease severity, but in US centers, were reduced by a factor of 3 by prepaid health care. Length of stay was shortest in California (7.3 days), and longest in Saskatoon (16.3) where designated arthritis beds and government prepaid health care existed. Average charges for surgery were as high as $10,000 in Phoenix and as low as $4550 in Wichita. Charges and length of stay were unrelated to disease severity, but were responsive to health care delivery system, availability of facilities, and geographic and center variation. |