Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3764732 | [Evolution of seronegative arthritis]. | 1986 | The paper is concerned with the results of a follow up of 67 patients with seronegative arthritis. The average duration of observation was 7.6 yrs. Diagnoses in 4 patients were established on a repeated clinicolaboratory and x-ray study: ankylosing spondylitis, Reiter's syndrome, Yersinia arthritis and gonorrheal arthritis. A picture of seropositive rheumatoid arthritis was noted in 16 patients (24%). In 47 patients arthritis remained seronegative. Of them in 30 patients a course of disease did not differ from that of seropositive rheumatoid arthritis. Considerable progression of disease was noted at the acute onset of disease with multiple involvement of the joints and a high inflammatory and immunological activity of a process. A morphological investigation of the synovial bioptates in 20 patients did not reveal a classical picture of rheumatoid synovitis even in a prolonged course of seronegative rheumatoid arthritis. The authors defined two variants of morphological changes in the synovial tissue in this group corresponding to a benign and progressive course of seronegative RA. | |
| 3501470 | Antiperinuclear factor: indicator of more severe disease in seronegative rheumatoid arthri | 1987 Oct | The specificity of antiperinuclear factor (APF) for patients with rheumatoid arthritis (RA) is well documented. It is unknown whether detection of these antibodies adds information to the detection of rheumatoid factor (RF). In a group of 132 patients with RA, 94 were RF positive. Of the 38 patients persistently negative for RF, 14 (37%) were positive for APF. These 14 proved to have a disease course similar to that of RF positive patients. This similarity was shown most impressively by radiological progression of the disease, and to a lesser extent, by the medication needed to control the disease and the number of extraarticular manifestations. No significant correlation was shown between APF and antinuclear antibodies. Among the RF positive patients with their generally poorer prognosis, APF identified the worst affected. Our study suggests that APF in serum of patients with RA is associated with a poor disease outcome, especially in RF negative patients. | |
| 2211753 | Simultaneous or staged bilateral total knee replacements in rheumatoid arthritis. A prospe | 1990 Sep | In a prospective study of 100 knee arthroplasties in patients with rheumatoid arthritis, simultaneous bilateral surgery was compared with staged bilateral replacements. All patients had improved function following their operations but those who had staged surgery only achieved maximum benefit after the second knee had been replaced. The complication rate was no greater for simultaneous surgery and we therefore advocate the method for those patients who require bilateral replacements. | |
| 3258972 | [Monoclonal antibody assessment of lymphocyte subpopulations in rheumatoid arthritis in ad | 1988 Mar | Twenty patients with various stages of RA were examined. They included: 1) 7 cases in Steinbroker stage 1 (onset); 2) 13 cases in Steinbroker stage 2-3 (chronic). The group was divided into 16 treated and 4 untreated cases. Monoclonal antibodies were used to assay T3, T4, T8 and T4/T8 ratio and the results were compared with those in a control group. The results showed a T8 deficit and a consequent change in the T4/T8 ratio in untreated subjects with "onset" RA. The immune situation of the chronic and treated cases was very similar to that in the control group probably as a result of treatment. | |
| 3719205 | Current management of rheumatoid arthritis. | 1986 Jun | Although rheumatoid arthritis is usually a chronic polyarthritis, it progresses in a wide variety of ways often with organ involvement. It is characterized by periods of exacerbation and remission. Successful management, which must be tailored to individual patients' requirements, involves a multidisciplinary approach coordinated by the physician. Counselling, physiotherapy, occupational therapy, adequate drug therapy and surgery all play a part. | |
| 3418621 | Granulomatous cutaneous rheumatoid vasculitis. | 1988 Jun | Rheumatoid vasculitis is a term that includes many vascular reactions from capillaritis to severe systemic necrotizing vasculitis occurring in a patient with rheumatoid arthritis (RA), but generally has been used to describe an immune complex reaction. The presence of vasculitis in the patient with RA has often been associated with a poorer prognosis; however, the prognosis is dependent on the presence of systemic disease. We report a patient with RA in whom multiple purpuric, cutaneous nodules, diffuse interstitial fibrosis, and high levels of circulating immune complexes developed. The cutaneous disease was characterized by a granuloma formation secondary to leukocytoclastic vasculitis. | |
| 2333619 | [Emotional-volitional training in the combined treatment of patients with rheumatoid arthr | 1990 | The development of placebo effect was found to be related to the psychological status and neurophysiological features of the body. This made it possible to elaborate the disadaptation hypothesis of the disease development and a total systems approach to its treatment, characterized by the necessity of conducting both conventional (aimed at suppression of the autoimmune process and inflammation) and activation therapy. The method of emotional volitional training (EVT) designed by the authors is advanced as one of the components of the activation therapy lying in the use of music therapy, auto- and heteropsychic actions together with application of an optimal variety of group physical training. Application of the EVT to the treatment of 86 patients with rheumatoid arthritis enabled the drug dosage to be reduced by as many as 50%, to improve the patients' mental status and to enhance work fitness, promoting the decrease of the hospital treatment by 4-5 days and prolongation of the remission from 6 months to 1.5 years. | |
| 1941834 | Rheumatoid-like arthritis in a lion tailed macaque. | 1991 Aug | Very few satisfactory models of rheumatoid arthritis (RA) exist in nonhuman species. It is particularly striking that nonhuman primates have only rarely been described to have disease processes resembling classic RA seen in humans. We describe the case of a lion tailed macaque (Macaca silenus), housed at the National Zoological Park in Washington DC, that had a polyarticular inflammatory arthropathy resembling RA. Gross and histopathologic examination of necropsy tissues and radiographic findings strongly suggest a rheumatoid-like disease, never before described in this species. | |
| 1974926 | A one-year, open, prospective study of sulfasalazine in the treatment of rheumatoid arthri | 1990 Jun | Response to sulfasalazine was studied for 1 year in 45 patients with rheumatoid arthritis. Twenty-two patients achieved a satisfactory clinical response. Adverse reactions developed in 15. Hemoglobin rose, and platelet count, erythrocyte sedimentation rate, rheumatoid factor titer, immunoglobulins, and C3 component of complement fell in relation to degree of response. At 1 year, 18 patients elected to continue the treatment. No relationship between clinical response, adverse reactions, or laboratory changes and drug disposition was observed. | |
| 1757927 | Clinical and health status measures over time: prognosis and outcome assessment in rheumat | 1991 Sep | We studied clinical and health status measures in 561 patients with rheumatoid arthritis (RA). Two hundred sixty-four patients were seen within 2 years of disease onset and followed for an additional 2 years. Four other groups were each followed for 5 years, and had disease durations of 2-7, 7-12, 12-17, and 17-22 years, respectively, at the first clinic visit. Functional disability developed very early in the course of RA and continued to worsen at about an equal rate over 22 years. Anxiety, pain scores, and self-assessed severity also increased with time, but erythrocyte sedimentation rate (ESR), morning stiffness, and joint counts were unchanged. Treatment resulted in reduction in joint counts and in nonsignificant improvements in ESR, stiffness, and psychological scores. But functional loss increased in each time period in spite of treatment. Variables most effective in controlled clinical trials are not effective as longterm measures of RA outcome. | |
| 3137901 | Induction of antinuclear antibodies in patients with rheumatoid arthritis receiving treatm | 1988 Aug | Of six patients with rheumatoid arthritis (RA) treated with human recombinant interferon gamma for two to eight months, three developed antinuclear antibodies (ANAs). This was accompanied by a simultaneous clinical exacerbation of the disease activity. In this study both anti-inflammatory and immunostimulatory effects of human recombinant interferon gamma in patients with RA were observed. | |
| 2248565 | Polyarthritis. A diagnostic approach. | 1990 Oct | The authors discuss the general classification of rheumatic disorders and the likely diagnosis of polyarthritis based on the mode of presentation, the patient's clinical situation and appropriate investigations. There is no simple formula that will lead to the correct diagnosis and specific therapy for every patient. | |
| 2346005 | [The effect of dietotherapy on the clinico-immunological indices of rheumatoid arthritis p | 1990 Jan | The main requirements for the dietotherapy of rheumatoid arthritis (RA) patients have been formulated, and for the first time a pathogenetically balanced diet has been developed that produces antiinflammatory and immunocorrective effects. The effectiveness of the dietotherapy included into the combined treatment was studied in 41 patients with classic and proved RA. The authors have studied the influence of the dietotherapy on the clinical signs characterizing the activity of inflammation in the joints, and laboratory immunological parameters (IgG, IgM, IgA, IgD, the complement components: C1-inhibitor, C3, C4, C5, C9; haptoglobin, orrhozomucoid, transferrin, ceruloplasmin, alpha 1-antitrypsin, alpha 2-macroglobulin, prealbumin). The results of the study have shown that the dietotherapy is not only conducive to the improvement of the clinical picture of the disease, that permits diminishing the amount of nonsteroid antiinflammatory drugs used, but also produces a favourable effect on the RA patients' immunological state. It has been concluded that inclusion of the dietotherapy into the combined treatment of RA patients is advisable. | |
| 2677691 | [Pancreatitis in rheumatoid arthritis found in autopsy material]. | 1989 Jul | Authors have studied in autopsy samples of 80 patients having suffered from rheumatoid arthritis the incidence and types of pancreatitis. There were 6 acute, 4 chronic-recurrent and 11 chronic severe or moderately severe pancreatitis observed. In the ethiology of pancreatites the ductal origin, cholelithiasis and uraemia were not found to be of exclusively significance. In 3 cases a pancreatitis was found accompanied by vasculitis and a typical histological pattern characterized by the vasculitis-thrombovasculitis of arterioles and small arteries with simultaneously occurring necrotic foci. In one case a pancreatitis due to severe amyloidosis could be verified. Authors draw attention to the frequent occurrence of pancreatitis in patients suffering from rheumatoid arthritis and the difficulties of a clinical diagnosis. | |
| 2324448 | A critical analysis of Swanson ulnar head replacement arthroplasty: rheumatoid versus nonr | 1990 Mar | Clinical and radiographic assessment of the results of 40 Swanson silicone ulnar head prosthesis implants in three different patient groups is presented. Twenty-eight were done for treatment of rheumatoid arthritis, eight for ulnoradial impingement after the Darrach procedure, and four for ulnocarpal impingement resulting from malunited Colles' fractures. Patients were reviewed 12 to 48 months after operation (mean, 29 months). Seventy-eight percent of patients reported relief of pain and improved function. Radiologic examination showed that all patients exhibited resorption of the distal ulna (mean 4.4 mm) and that resorption was worst in the group with rheumatoid arthritis. Bone resorption about the implant predisposed the cap to both side-to-side tilt and pistoning of the prosthesis on supination and pronation. There was a 10% revision rate because of silicone synovitis. Although clinical results remain satisfactory for patients with rheumatoid arthritis and ulnocarpal impingement, the radiologic results suggest that Swanson ulnar head replacement should be restricted to elderly patients with rheumatoid arthritis. | |
| 1712419 | [High-dose immunoglobulins for the treatment of rheumatoid arthritis: pilot study of 7 cas | 1990 Oct | High intravenous doses (400 mg/kg) of gammaglobulin (IVIG) were administered monthly for six months to 7 patients with severe rheumatoid arthritis (RA). In all cases, previous treatment with NSAIDs and corticosteroids and in 3 of them with gold and/or methotrexate had been ineffective. A 50 per cent improvement of Ritchie index was obtained in 6/7 patients, morning stiffness was reduced from greater than 2 hours to less than 30 minutes in 6/7 patients. Swollen joints and Lee index improved in all patients. ESR did not show any change but RCP improved in 6/7 patients. The study of lymphocyte subpopulation showed no substantial changes in CD20+, CD3+, CD4 and CD8 cells as well as in CD4/CD8 ratio and a significant increase in 2H4+T cells without changes in 4B4+ subpopulation. IVIG improved the clinical and laboratory features of patients with severe RA. The major problem raised by IVIG therapy is its high cost suggesting that this therapy should only be applied in well selected patients with RA. | |
| 3942846 | Lymphocytapheresis--a feasible treatment for rheumatoid arthritis. | 1986 Feb | A short three-treatment out-patient course of lymphocytapheresis (LA) was compared with a standard six-treatment regimen in a group of rheumatoid arthritis patients pre-selected for poor cell-mediated immunity, which has been shown to be associated with a good response to LA. Significant clinical improvements were seen with both treatments. There did not appear to be any clear difference between three and six treatments. A short course of LA may represent a possible treatment for selected rheumatoid arthritis patients. | |
| 2359067 | Serial levels of soluble interleukin 2 receptor in the peripheral blood of patients with r | 1990 May | We serially assayed soluble interleukin 2 receptor (sIL-2R) levels in the peripheral blood (PB) of 22 patients with rheumatoid arthritis (RA) followed for a period of 12 months, and correlated these levels with disease activity. We examined the relationship between the direction in which each of the disease measures changed between assessments and the direction of change in sequential sIL-2R levels. In 22 of the 25 (88%) instances where there was a 30% change in the active joint count between sequential assessments, the direction of change of the PB sIL-2R level was found to be in parallel (chi 2 = 11.7, p less than 0.008). Our results suggest that serial sIL-2R levels are a useful means of confirming clinically significant changes in disease activity in patients with RA, irrespective of therapy. | |
| 3553590 | Evaluation of the American Rheumatism Association preliminary criteria for remission in rh | 1987 Feb | This study evaluates the American Rheumatism Association criteria for remission in rheumatoid arthritis (RA) using data gathered prospectively in 2 distinct patient groups: Americans (n = 181) and Peruvians (n = 44). The criteria were found to be highly specific in both patient groups but the sensitivity of the criteria was low in the American patients. The criteria most frequently not satisfied in the American patients with RA were subjective. Several explanations are offered: differences in disease severity, problems in using a translated questionnaire, differences in practice level among rheumatologists, but none of them fully explain the lower sensitivity of the criteria among the American patients. | |
| 3172092 | Dexamethasone modulated protein synthesis in polymorphonuclear leukocytes: response in rhe | 1988 | Nine polypeptides whose rate of synthesis is modulated in polymorphonuclear leukocytes (PMNL) by dexamethasone were studied by 2-dimensional polyacrylamide gel electrophoresis. In each case, there was a time lag between addition of dexamethasone and the appearance of any change in rate of synthesis. In PMNL from a group of patients with rheumatoid arthritis, dexamethasone modulated the synthesis of the same polypeptides as in PMNL from a group of healthy volunteers, but the degree of response of their polypeptides to dexamethasone was significantly reduced as measured by assaying the level of synthesis of a polypeptide of molecular weight 16,000. Reduced responses of PMNL polypeptide synthesis to glucocorticoid may allow the development of rheumatoid inflammation despite apparently adequate levels of endogenous corticosteroids. |