Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3125023 | Bone demineralization in rheumatoid arthritis. | 1987 | In a group of 210 patients with various stages of rheumatoid arthritis divided according to mobility in 3 groups the highest clavicular cortico-diaphyseal indices were found in the group of exercising patients and the lowest results were in the immobilized group. Double measurements repeated after two years allowed us to establish the annlay loss of cortical bone in each group: -2.19% in the exercising group, -6% in the non-exercising group and -8.94% in the immobilized group. Studying the effect of corticosteroids used in the treatment of rheumatoid arthritis in another group of 153 patients we found lower results of cortical thickness only in dependence on daily dose of this drug and not on the whole used dose. The computed annual loss of cortical bone thickness was 7% in patients on doses 5-10 mg of prednisolone, while in patients on doses 12.5-20 mg of prednisolone the annual loss exceeded 10%. | |
| 2084235 | Clinical course and predictors of length of stay in hospitalized patients with rheumatoid | 1990 Dec | Patients admitted for therapy of active rheumatoid arthritis were prospectively followed throughout their hospital stay. Average length of stay was 17.1 days. Serial global assessments, whether determined by rheumatologist, physiotherapist or patient appeared to improve linearly until at least hospital day 21. From admission to discharge, mean global assessment scores improved by about one third. Poor global assessment, high disability index, and the presence of comorbid disease and anemia on admission, as well as admission late in the week, were predictive of prolonged hospital stay. | |
| 3496456 | Classical rheumatoid arthritis associated with nondeforming relapsing polychondritis. | 1987 Apr | Two patients with classical rheumatoid arthritis and a mild nondeforming relapsing polychondritis are presented. DR4 antigen and depressed C4 levels were found and possible autoimmune mechanisms are discussed. The need for specific questioning to detect this rare association is proposed. | |
| 3671713 | Rheumatoid and seronegative arthropathies of the foot. | 1987 Nov | The foot is often involved in rheumatoid arthritis and its seronegative variants. This article presents an overview of the subject and highlights the various distinguishing features of these arthritic disorders in the foot. | |
| 1865409 | Relation between patients' own health assessment and clinical and laboratory findings in r | 1991 May | Health status encompasses not only physical aspects, but also psychological and social aspects. A multidimensional health status questionnaire was used in 69 Dutch patients with rheumatoid arthritis to assess their physical, psychological and social well being. The same day clinical and laboratory data were recorded. The health status questionnaire provided additional information to clinical and laboratory findings. The various clinical and laboratory measures of disease activity reflect aspects other than the self-reported measure of physical well being. As such they are not interchangeable. Furthermore clinical and laboratory measures of physical well being appeared to be unrelated with psychological and social measures. In contrast, the patients' self-report of physical well being was related only with depressive mood and to some extent with anxiety. | |
| 2380592 | [Roentgenological and histopathological studies of the hip joint in rheumatoid arthritis]. | 1990 May | In order to study the disease process of the hip joint in rheumatoid arthritis, roentgenological analysis was carried out along with histological studies on the resected femoral heads. For the roentgenological study, hip roentgenograms of seven patients with known natural course and sixty preoperative patients were used. For the histological study, sixteen resected femoral heads affected by various disease types were used. The histological findings were compared with the roentgenological findings. As specific roentgenological findings, there were osteoporosis, burrowing and inward protrusion of the acetabulum, and collapse and flattening of the femoral head. A sequential process of the femoral head destruction was demonstrated, starting from collapse, through flattening, and finally ending in disappearance. The collapse was divided into sclerotic collapse and porotic collapse, and their roentgenological and histological differences were discussed. In addition to the common destruction process, the presence of the following three uncommon types was suggested for a better understanding of clinical manifestations: stiff type (4.5%), synovial proliferation type (6.0%) and aseptic necrosis type (3.0%). | |
| 1834844 | Disease and psychosocial factors related to physical functioning in rheumatoid arthritis. | 1991 Aug | One hundred and fifty-five patients with rheumatoid arthritis (RA) were randomly selected from a tertiary care outpatient rheumatology clinic. Disease, treatment, psychosocial and demographic data were collected to test a biopsychosocial model of Physical Functioning as determined by the Arthritis Impact Measurement Scales (AIMS). Cross-sectional and longitudinal hierarchical and stepwise regression analysis were performed to identify variables associated with Physical Functioning. The results of the hierarchical regression revealed that only the disease and psychosocial sets of variables were significant. Stepwise regression revealed that Disease Severity (disease set) and Arthritis Helplessness (psychosocial set) accounted for 37% (longitudinal) to 60% (cross-sectional 12 months---greater than 12 months) of Physical Functioning variance. Our results suggest a role for the inclusion of psychosocial factors in studies of the development of physical disability in patients with RA. | |
| 1920306 | Auranofin treatment in early rheumatoid arthritis may postpone early retirement. Results f | 1991 Jul | The effect of early vs delayed initiation of slow acting antirheumatic drug (SAARD) therapy on the ability to maintain regular work, was evaluated in 83 patients with early rheumatoid arthritis (RA) in a placebo controlled, double blind 24-month study. The estimated probability to maintain working ability was higher in the early treatment group, especially during the second study year. Predicting factors were age, type of work, degree of disability and number of swollen joints. Despite the difficulties in interpreting the results due to the complexity of the underlying socioeconomical and labor market situation, the study supports early treatment in RA with regard to the maintenance of normal life. | |
| 3791871 | The influence of prednisone on the muscle morphology and muscle enzymes in patients with r | 1986 Dec | Thirty-five female patients, mean age 63 years, suffering from rheumatoid arthritis participated the study. Twenty patients had been on long-term low-dose corticosteroid treatment. Fifteen patients had never received corticosteroids. A control group of 15 age- and sex-matched healthy subjects was also studied. Examination of muscle biopsies from the (right) vastus lateralis and measurements of isokinetic and isometric knee-extension muscle strength were performed in all subjects. Rheumatoid arthritis patients treated with corticosteroid showed a low percentage of type I fibres, mean 35.7 (range 17-66) % compared with patients who did not receive corticosteroid (P less than 0.005). The latter group did not differ from the controls. The muscle fibre areas also were affected in the corticosteroid treated rheumatoid patients. Type I and type II mean fibre areas were reduced by 32% and 50%, respectively, when compared with non-prednisone treated patients. The latter group did not differ from the controls in this respect. A correlation was found between the isokinetic muscle strength of the knee extensors and the mean areas of type I and type II in patients treated with prednisone (r = 0.48, P less than 0.05 and r = 0.58, P less than 0.02 respectively). No such correlation was found when using isometric measurements of the knee extensors. A positive correlation was found in both groups of rheumatoid arthritis patients between the areas of the type I and type II fibres (r = 0.66 - 0.68, P less than 0.05 - 0.02).(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 2845505 | The cystic form of rheumatoid arthritis. | 1988 Oct | A non-erosive form of rheumatoid arthritis (R.A.) was found in 62 patients out of 660 patients with R.A. These 62 patients exhibit slowly progressive cystic changes in about the same joints in which usually erosions develop in classic R.A. The E.S.R. is often low, half of the patients remained seronegative and there are 35 males and 27 females in the group. A smaller group of 15 out of these patients could be followed from a stage wherein the radiographs were normal to a stage of extensive cystic changes, over a period of at least 6 years. An attempt is made to delineate this group within the Rheumatoid arthritis disease entity. | |
| 2784182 | Quantitative computerized joint scanning in rheumatoid arthritis: an accurate reproducible | 1989 Jan | Clinical trials in rheumatoid arthritis have been hampered by the highly subjective nature of disease assessment measures and lack of a consistently reliable laboratory test to follow. The authors devised a method of quantitating synovitis by computerized joint scanning and compared it with six conventional parameters in 18 patients entered into two treatment protocols and a control group. The results indicate that quantitative joint scanning probably is at least as reliable as the conventional measures and has the advantage of having no placebo or subjective component. | |
| 3180548 | Are 'homeopathic' doses of oral corticosteroids effective in rheumatoid arthritis? | 1988 Jul | When patients with rheumatoid arthritis whose clinical disease activity was stable had their oral prednisolone of less than 5 mg per day (mean 3.5 mg) replaced by placebo, there was an almost immediate flare in their arthritis. This confirms that such low dose prednisolone therapy is effective in controlling joint inflammation. | |
| 3572138 | Approach to evaluation of impairment in rheumatoid arthritis--a study by multiple regressi | 1987 Jan | We investigated the weight of various factors involved in the activity of rheumatoid arthritis (RA) and joint deformity in an attempt to establish a more objective method of evaluation of the impairment in RA using these factors as parameters. The subjects were 100 patients with RA. Multiple regression analysis was undertaken using Lansbury parameters and Stage as predictor variables and the classification of functional capacity (Class) as a criterion variable. The results of analysis showed that the weight was greatest, 32% for the time of appearance of fatigue, followed by 29% for the Stage, 16% for joint index, 10% for grasping power, 7% for ESR, 5% for morning stiffness and 0% for the dose of aspirin used. On the basis of these results, an original method of evaluation of impairment in RA was proposed. There was a close correlation (R = 0.82) between the Class and the total score obtained by this method. | |
| 2772485 | Thoracic and lower cervical spine involvement in a case of rheumatoid arthritis. | 1989 | The authors report a case of spine involvement in a severe case of rheumatoid arthritis treated with corticosteroids. First, the patient developed acute back pain, related to costovertebral joints arthritis at levels T9-T10. Then, neck pain and cord involvement yielded to diagnosis of cervical interapophyseal joints arthritis; there was a C5-C6 subluxation which necessitated surgical treatment. The conjunction of these two rheumatoid localizations is an uncommon feature. Study by the CT scan is valuable when rheumatoid arthritis of the spine is suspected. Lower cervical spine subluxation, even severe, may be well tolerated. Surgery is necessary when there is medullary involvement. | |
| 1787485 | Prediction of team care effects in outpatients with rheumatoid arthritis. | 1991 Nov | Predictive factors for the outcome of 1-year rheuma-team care were studied in 68 female rheumatoid arthritis (RA) outpatients (mean age 56 years, mean RA duration 15 years). Seventy-three background variables were analyzed in a 4-step statistical model including partial and multivariate correlations in order to disclose the best predictors of change scores of the outcome measures chosen. These concerned disease activity (C-reactive protein, Lansbury articular index), physical joint function (Keitel index), mood (Mood Adjective Check List, MACL), and overall health (Sickness Impact Profile). Between 14 and 47% of the variance of the 1-year outcome change scores was explained by combinations of 2 or 3 predictors out of 12 strong background variables. The lowest value of explained variance was noted for MACL, and the highest for C-reactive protein. Both clinical, social, and self-assessed health data were among the predictors. Our results can provide a guide in the selection of patients with RA for multidisciplinary team care, in the formulation of treatment goals, and the creation of cost-effectiveness schedules. | |
| 3397966 | Intraarticular progesterone: effects of a local treatment for rheumatoid arthritis. | 1988 Apr | The antiinflammatory effect of a single intraarticular injection of progesterone was investigated in 12 patients with rheumatoid arthritis. A local, but no systemic decline of inflammation was observed in 10 of them for at least one month. The average local scores of inflammation at Days 7, 14, 21 and 30 after injection were significantly lower than pretreatment scores (p less than 0.000003 for each comparison). In some patients the effect continued for up to 2 months. No important side effects were observed during the following 2 months. However, a more prolonged followup of treated patients is necessary to rule out the late onset of side effects. | |
| 2926412 | Nonconstrained total shoulder arthroplasty in patients with polyarticular rheumatoid arthr | 1989 | A retrospective review of 114 patients with polyarticular rheumatoid arthritis who had 140 total shoulder arthroplasties revealed that 93% of the patients had excellent pain relief; however, improvement in active forward elevation averaged 34 degrees. Nearly one-half of the patients had significant rotator cuff pathology. Three-fourths of the patients had a press-fit type of humeral component, and 5% of these have had variable amounts of subsidence. None have been sufficiently painful to require a revision. Eighty-two percent of the glenoid components developed radiolucent lines during the follow-up period. One percent of these were definitely loose and 9% were probably loose. To date, none have been revised. Complications occurred in 7% of the shoulders, but no deep or superficial wound infections were noted. | |
| 3135392 | Interferon gamma in rheumatoid arthritis--a double blind study comparing human recombinant | 1988 Apr | A double blind trial comparing recominant interferon gamma (IFN gamma) with placebo in rheumatoid arthritis is presented. Twenty-six patients entered the study and 22 completed the 6-month period. IFN gamma was administered subcutaneously as was placebo; the 1st week, patients treated with the active compound received a daily subcutaneous injection of 100 micrograms of IFN gamma and for the following 23 weeks the schedule was decreased to 2 injections of 100 micrograms every week. No serious side effects were observed. After Week 24 the group treated with the active compound showed a significant decrease of the joint tenderness score and the placebo group showed a significant increase of the number of subcutaneous nodules. All other variables shifted in favour of the active compound but not significantly. More double blind trials with a larger number of patients and using other treatment schedules or other routes of administration are required. | |
| 1827158 | D-penicillamine toxicity in Greek patients with rheumatoid arthritis: anti-Ro(SSA) antibod | 1991 Jan | Sixty-two consecutive patients, with rheumatoid arthritis (RA) who received D-penicillamine were studied retrospectively to identify predictive risk factors for D-penicillamine toxicity. Thirty-two developed side effects, while 30 did not. The clinical picture in both groups was similar, but the group with D-penicillamine toxicity was characterized by a high incidence of anti-Ro(SSA) antibodies (p less than 0.01) or circulating cryoglobulins (p less than 0.001). The presence of anti-Ro(SSA) antibodies was not correlated with the presence of circulating cryoglobulins (p greater than 0.5), while the coefficient of contingency (C) between anti-Ro(SSA) and cryoglobulins was 0.131. Men were predisposed to express more renal pathology (p less than 0.025), while anti-Ro(SSA) positive patients with RA more often expressed rashes (p less than 0.0001) and acute febrile reactions (p less than 0.05) than anti-Ro(SSA) negative patients. These observations should be considered when making therapeutic decisions at least for Greek patients with RA. | |
| 3789820 | Vertebral and peripheral bone mineral content and fracture incidence in postmenopausal pat | 1986 Oct | Peripheral and axial bone mass and fracture incidence were studied in a group of 104 postmenopausal patients with rheumatoid arthritis (RA). Patients were divided into non-corticosteroid and low dose corticosteroid treated groups after elimination of patients with concomitant disease or therapy which might affect bone mass. Results were compared with those obtained in controls matched for age and sex. Bone mass at the distal radius was significantly reduced compared with that of controls in both patient groups. Axial bone mass, however, was normal in both treatment groups, non-corticosteroid treated patients having even a significantly higher bone mass than controls (p less than 0.05) and corticosteroid treated patients (p less than 0.05). Fracture incidence (vertebral and femoral neck) was significantly (p less than 0.01) higher in corticosteroid treated patients than in the non-corticosteroid treated group. The mean lumbar bone mineral content and the body weight of the fracture group were significantly lower than in the controls. There were no significant differences in biochemical markers of bone turnover between the RA groups. |