Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3361539 | Tarsal ankylosis in juvenile and adult onset rheumatoid arthritis. | 1988 Feb | It has been suggested that tarsal arthritis with ankylosis may be characteristic of late onset Still's disease. In our study 16 of 88 (18%) patients with juvenile rheumatoid arthritis (JRA) and 22 of 97 (23%) patients with adult RA had radiographic findings of tarsal joint ankylosis. In our patients, tarsal bony fusion was not related to type of disease onset, age of onset or sex; rather it was related to a longer duration of disease. Tarsal ankylosis should not be regarded as a special feature of Still's disease since it can also be seen in adult RA. | |
| 3689464 | A comparison of changes seen on radiographs of rheumatoid arthritis patients in Australia | 1987 Nov | To test the hypothesis that rheumatoid arthritis in patients in China is milder in severity than that in patients in a western country, a comparison was made of 2 series of consecutive outpatients with definite or classic rheumatoid arthritis who were attending referral centers in Melbourne, Australia and Shanghai, China. This paper reports the findings on radiographs of the wrists and hands. Making allowances for age and duration of disease, changes were more frequent and severe in the Australian patient series, particularly at the metacarpophalangeal joints. | |
| 2089446 | [Determining the optimal time for synovectomy in rheumatoid arthritis of the knee joint]. | 1990 | In 108 patients with rheumatoid arthritis in whom before 4 years synovectomy of the knee joint was performed the relationship between the clinical state and selected indices of inflammatory process was studied. The clinical state of patients was evaluated using modified Gschwend test. Using the Mahalanobis D2 test no relationships between the erythrocyte sedimentation rate, Waaler-Rose test results, and seromucoid level during pre-surgery period on one side and the actual clinical state of patients were stated. According to the authors opinion the decision concerning the surgical treatment should be based solely on clinical state of patients and not on indices of inflammatory process. | |
| 3760110 | Observational studies of cause-effect relationships: an analysis of methodologic problems | 1986 | We review the structure of the two most common observational study designs, cohort and case-control studies, and outline guidelines to help clinicians evaluate the validity of studies that employ these designs. To demonstrate the use of these guidelines we apply them to the important issue of whether oral contraceptive usage may reduce the risk of developing rheumatoid arthritis. A recent case-control study has contradicted provocative evidence from two previous studies suggesting the existence of such a protective effect. Our analysis leads to the conclusion that the case-control study suggesting no association of oral contraceptives with the subsequent development of rheumatoid arthritis provides the best estimate of the effect of oral contraceptives currently available, and furthermore, the analysis permits recommendations to be made for the design of future investigations on this topic. | |
| 3379618 | Familial vs sporadic rheumatoid arthritis: a comparison of the demographic and clinical ch | 1988 Mar | We studied the demographic, clinical, and disease severity characteristics of 96 patients with rheumatoid arthritis (RA) from multicase families (familial RA+) and 860 nonfamilial RA cases (familial RA-) seen consecutively in an outpatient rheumatic disease clinic between April, 1976 and August, 1986. Familial RA (+) and (-) cases were similar in essentially all demographic, clinical, and disease severity characteristics. Subgroups of 2nd generation patients with familial RA and sib-sib patients were similar, and neither group differed from the set of familial RA (-) individuals. The failure to find differential severity in these groups indicates that inferences from studies of families with RA may be extrapolated safely to patients with RA at large, but differences between rheumatoid factor positive (RF+) and RF (-) patients suggest that RA (+) and RF (-) patients should be analyzed separately. | |
| 1680256 | [Rheumatoid arthritis developing into systemic lupus erythematosus during long-term treatm | 1991 Jun | A female patient with IgM RF seropositive rheumatoid arthritis according to criteria of the American Rheumatism Association was treated for 133 months with Penicillamine and for 17 months also with Sulfasalazine. Both types of treatment were discontinued because the patient developed symptoms meeting diagnostic criteria of systemic lupus erythematosus, as defined by the same society. Early recognition of this diagnosis was made possible by regular follow up of clinical and laboratory data (ANA, anti DNP, anti dsDNA, C3, C4 and others). Marked improvement, incl. improvement of the nephropathy, was recorded after pulsed treatment with methylprednisolone. | |
| 3175451 | Progressive joint damage during penicillamine therapy for rheumatoid arthritis. | 1988 | Progressive joint damage characterises rheumatoid arthritis despite treatment with slow-acting drugs such as penicillamine. We examined a cohort of 145 RA patients, treated with 250 or 500 mg penicillamine daily for 18 months to study progressive joint damage measured using Larsen's standard radiographs. Overall damage increased significantly over 18 months at both doses of penicillamine. Radiological changes between 6-18 months were studied in detail in 55 cases. They were divided into rapidly progressive (increases in Larsen score of more than 5) or slowly progressive (increases in Larsen score of 5 or less). Overall clinical response, visual analogue pain score, ESR, haemoglobin and platelet count were significantly lower in the slowly progressive patients; articular index and duration of morning stiffness were slightly lower; latex titre, RAHA titre, joint size and white cell count showed no differences between groups. There is an indirect relationship between progressive joint damage and some clinical and laboratory measures. The reasons underlying our failure to control progression in some cases need further definition. | |
| 2718445 | [The fibrinogen-fibrin-fibrinolysis system in rheumatoid arthritis]. | 1989 Jan | The enzymatic, nonenzymatic and XIIa-dependent fibrinolysis was inhibited. In RA without systemic manifestations the main cause of appearance of soluble complexes of monomeric fibrins (SCMF) in the blood is a local activation of coagulation in the inflamed joint tissues. It is suggested that an increase of SCMF concentration in the blood in patients with RA is a reliable and dynamic index of the activity of the inflammatory process. | |
| 3827335 | Failure to find disease similarity in sibling pairs with rheumatoid arthritis. | 1987 Feb | Clinical and laboratory measures of disease expression were compared within and between 33 families with two or more affected siblings with rheumatoid arthritis (RA). None of the variables studied--age and calendar year of disease onset, pattern of joint involvement, the presence of rheumatoid nodules, Sjögren's syndrome, a positive latex or antinuclear antibody (ANA) titre--showed a greater concordance within the families than between them. The families were then divided into those in which the affected sibling pairs were and were not HLA identical. Such a division did not alter the conclusion, with the possible exception of a positive latex titre. These results suggest that genetic or unique environmental factors within families may have only a limited role in explaining disease heterogeneity in RA. Conversely, the absence of homogeneity within the families justifies their use in genetic linkage studies and the extrapolation of results obtained from affected siblings to the commoner sporadic disease. | |
| 3075070 | Cells and matrix expressing cartilage components in fibroblastic tissue in rheumatoid pann | 1988 | Our studies of the cartilage-pannus junction in rheumatoid joints have demonstrated the frequent presence of a transitional fibroblastic zone (TFZ) overlying articular cartilage. Using immunohistochemical techniques this zone has been shown to contain cells and matrix expressing specific cartilage components but not antigens present on cells in invasive vascular pannus. These findings support the concept that fibroblastic pannus is derived from the underlying articular cartilage rather than adjacent tissues. This type of reaction involving a metaplastic change in the chondrocyte is particularly common in large weight-bearing joints and may represent a different mechanism of cartilage degeneration to the classically described direct invasion of cartilage by hypertrophic synovial tissue. | |
| 3418642 | An analysis of the relationship between psychological morbidity and disease activity in rh | 1988 Jun | The hypothesis that the duration and activity of rheumatoid arthritis (RA) determine a patient's psychological state and adjustment was tested with a longitudinal research design using quantitative measures. A group of 30 patients with RA was examined on 2 occasions, 3 years apart. There were few significant relationships between duration of illness, disease severity and the psychological measures. A strong correlation occurred between disability and attitude to illness. Our data suggest that a patient's psychological state needs to be assessed as a variable, independent of physical impairment. | |
| 3369247 | [Incomplete Felty syndrome with manifestation of arthritis following a long-standing cours | 1988 Jan | A 62-year-old female patient with splenomegaly, severe granulocytopenia, recurrent infections and negative rheumatoid factor test initially had no clinical evidence of rheumatoid arthritis. Leucopenia responded to splenectomy and did not recur during 7 years follow-up. Symmetrical metacarpophalangeal joint-swelling developed 9 months after 7 years of radiographic destruction. This case emphasizes that arthritis may occasionally be a late and minor manifestation of Felty's syndrome. | |
| 2922353 | Halo-body jacket immobilization in rheumatoid arthritis patients with cervical myelopathy. | 1989 Mar | The rehabilitation nurse may care for patients with arthritis in a variety of settings. When the patient has advanced RA, the problem of cervical myelopathy may require surgical intervention and use of the halo-body jacket immobilization orthosis. Expert pre- and postoperative management requires a knowledge of surgical nursing as well as rehabilitation nursing, in the traditional sense, to prevent complications and promote optimum recovery. When dealing with people who have lived with RA for many years, the rehabilitation nurse must continue to assess the patient's knowledge of the disease and use of self-management strategies and community resources. | |
| 3735274 | Interference with total hemolytic complement assay in rheumatoid arthritis: correlation wi | 1986 Jun | A subgroup of patients with rheumatoid arthritis (RA) whose sera agglutinated sensitized sheep erythrocytes used for total hemolytic complement determination has been identified. These patients have higher titers of rheumatoid factor (RF) and more severe rheumatoid disease compared to controls. The agglutination of sensitized sheep erythrocytes by sera of some patients with RA may be related to qualitative or quantitative variations in their RF. | |
| 3179626 | A comparison of the ability of 28 articular indices to detect an induced flare of joint in | 1988 Oct | Comparison of the ability to detect a flare of joint inflammation provoked by withdrawal of non-steroidal anti-inflammatory drugs from 10 patients with rheumatoid arthritis was made between 28 computer generated articular indices. The results suggest that this method can be used to compare the sensitivity of articular indices. Identifying joint inflammation by the simultaneous presence of tenderness and swelling and weighting for joint size produced the most sensitive indices. Identifying inflamed joints by swelling alone, or swelling and/or tenderness, grading for the severity of the signs, or selecting a restricted range of joints provided no advantages. | |
| 2084237 | Radiologic progression during intramuscular methotrexate treatment of rheumatoid arthritis | 1990 Dec | The radiographic evolution of joint lesions in 41 patients with severe and longstanding rheumatoid arthritis (RA) (mean duration: 12.9 years) treated with methotrexate (MTX) for more than 24 months (mean 31.2 months) was studied in a double blind manner by 2 rheumatologists using Larsen's score. All the patients were clinically improved. The radiological study of hands and wrists was possible in only 37 of 41 patients for surgical reasons. We found a deterioration of joint lesions in 31 cases (83.8%), a stabilization in 6 cases (16.2%). MTX does not appear to be able to slow down the radiographic evolution of RA. Whether it could prevent the radiologic progression in early RA remains to be elucidated. | |
| 1807934 | Levels of the soluble receptor for interleukin-2 in serum of patients with rheumatoid arth | 1991 | The authors assessed, using the method of sandwich enzyme immunoassay (ELISA), the soluble receptor for interleukin-2 (s-r IL-2). In patients with rheumatoid arthritis mean values of 620.5 = 500.0 u./ml were recorded which was significantly higher than in patients with osteoarthritis (p less than 0.001) (313.3 +/- 155 n./ml) and in healthy controls (181.7 +/- 159.6 n./ml). In patients with rheumatoid arthritis a correlation was found between the activity of the disease expressed by means of Lansbury's index (r = 0.61, p less than 0.01). There was no correlation between s-r IL-2 and the sedimentation rate (r = 0.32, p = n.s.). The author reviews the literature and discusses the hypothesis that s-r IL-2 acts as a competitive inhibitor for interleukin-2. | |
| 2634523 | [Early results of rehabilitation after synovectomy in rheumatoid arthritis of the knee joi | 1989 | In 1976-1987 synovectomy was performed in 537 knee joints in 459 patients. Rehabilitation should be performed before and after operation. The used rehabilitation, with respect to early and late synovectomy, was evaluated. The obtained results of early rehabilitation are a stimulus for the use of the adopted method of treatment. | |
| 2088645 | Nutritional habits of patients suffering from seropositive rheumatoid arthritis: a screeni | 1990 Dec | Although the nutritional status of patients suffering from rheumatoid arthritis is considered to be poor and inversely related to disease activity, information on nutritional habits of these patients is scanty. Dietary habits of 93 patients suffering from active seropositive rheumatoid arthritis, functional class 2 or 3, confirmed by an interview with a dietician (dietary history method), revealed a significant gap between energy, carbohydrate, and fat intakes and recommended amounts, adjusted for age, sex, body weight and physical activity. | |
| 3073035 | Radiological changes in rheumatoid arthritis: measurement of area of juxta-articular bone | 1988 Dec | A high degree of intra - and inter - rater reproducibility was obtained in measurement of a standardized area of the head of the first right metacarpal using a precision digitizer. This instrument had an accuracy for every point digitized of 0.127 mm. Intra-rater difference between readings at approximately a month's interval showed no significant differences. The method is reasonably simple to perform and is applicable to small joints such as the proximal interphalangeal joints. The method may prove useful in following progression of joint damage in rheumatoid arthritis. |