Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2012076 | Interleukin-6 positive follicular hyperplasia in the lymph node of a patient with rheumato | 1991 Apr | We examined interleukin-6 production in the hyperplastic lymph node of a 77-year-old male rheumatoid arthritis patient with lymphadenopathy. The interleukin-6 production of the lymph node was observed by both immunohistological staining and in vitro culture. The results suggest that interleukin-6 plays a significant pathogenic role in the etiology of the lymphadenopathy seen in many rheumatoid arthritis patients. | |
| 3599006 | Synovial fluid oxalate deposition complicating rheumatoid arthritis with amyloidosis and r | 1987 Apr | A patient with quiescent rheumatoid arthritis, amyloidosis and chronic renal failure developed an inflamed knee. Intracellular bipyramidal crystals characteristic of oxalate were found and are suggested as the cause of the acute arthritis. Since the patient had been treated with vitamin C, this precursor of oxalate is proposed as a possible factor in the crystal deposition. | |
| 2772754 | [Evaluation of disease activity by hand X-ray findings in rheumatoid arthritis]. | 1989 Apr | It would appear to us that the patients with rheumatoid arthritis (RA), in whom articular bone lesions were confined to the wrist and/or carpal joints in X-ray films, may follow a milder disease activity than do the patients with the hand and finger joint lesions. To clarify it, the present study was performed retrospectively. RA patients showing stage II or more lesions in the wrists and/or carpal joints but no lesions over stage II in any hand and finger joint (MCP, IP and PIP) radiologically after 5 years or more duration were regarded as the carpal type (C type). The clinical and laboratory data were compared between 44 patients of the C type RA and 44 patients of other type RA, matched in the sex, age and disease duration. Significant differences were observed in the following parameters between the 2 groups; the functional class, Lansbury's activity index, number of the affected joints, ESR, CRP and hemoglobin values, and ADL scores. That is, Hb values and ADL scores were higher, but the others were lower, in the C type RA group than in other type RA group. The positive percentage and titer of rheumatoid factor were not significantly different between the 2 groups. It was concluded that C type RA patients are milder in the activity and fewer in the number of affected joints than other type RA patients. Furthermore it was suggested that C type RA patients may have milder clinical course and better prognosis than other type RA patients. | |
| 3277681 | Setting the scene and posing the questions. | 1988 | Rheumatoid arthritis (RA) is a common disabling disease. We are only just developing the necessary skills to assess the outcome of RA in both the short and long term. We can measure outcome in terms of radiological change, functional capacity and death. Patterns of disease onset and process measures, such as ESR and CRP, help to predict outcome. Without satisfactory methods of documenting the natural history of RA we cannot hope to be able to identify effective therapies or to develop sensible policies for their use. | |
| 2218259 | [Roentgeno-morphological comparisons in rheumatoid arthritis based on data of a long-term | 1990 Apr | During a prospective observation lasting 6 years 68 patients with rheumatic arthritis (RA) were repeatedly examined (up to 8 times) roentgenologically with parallel puncture biopsy of the synovial fluid of the knee joint made with an atraumatic needle, and numerical evaluation of markedness of 25 morphological signs of synovitis. A comparative analysis of the markedness of morphological signs of synovitis in relation to the degree and dynamics of destructive changes in the knee joint was made on the basis of the findings of 254 puncture biopsies and the same amount of roentgenograms. There is a close relationship between the activity of synovitis and the progress of destructive arthritis except for the morphological signs characterizing the reaction of hypersensitivity of an immediate type that may serve the purpose of prognostication of further articular destruction and of the choice of an early adequate therapy. | |
| 2028029 | [Magnetic resonance of the rheumatoid hand]. | 1991 Apr | The purpose of this study was to evaluate MRI diagnostic accuracy in rheumatoid arthritis (RA), to compare MRI and radiological findings and to correlate these findings with the clinical and serological profile of the disease. The hands of 24 patients (20 females, 4 males) affected with typical RA (ARA criteria) were studied using a tomograph Magnetom 1.0 T Siemens. Two patients affected with RA refractory to conventional second-line drugs who received a bolus of methylprednisolone (1 g) were studied before and after such treatment. The hands of healthy volunteers were examined as controls. Besides MRI study all patients underwent: (1) radiological examination of the hands performed with a standard technique and (2) clinical and serological investigation aimed at characterizing diseases activity and extent. The radiographic and MRI findings were evaluated by two different observers who found 15 pathological elementary lesions and assigned a MRI and a radiological score to each patient. MRI exhibited significantly higher accuracy than radiography in evaluating rheumatoid soft-tissue changes and in detecting minimal skeletal lesions, while severe skeletal lesions were better detected by radiology. No correlation was found between pathological MRI findings, radiological results and clinical or serological data. A significant drop in soft-tissue effusion was observed after methylprednisolone pulse in two patients. This study confirms MRI potential in the study of rheumatoid joint lesions and in the early detection of minimal soft-tissue changes. Its use appears to be suitable for accurate monitoring of RA patients under specific therapy. | |
| 2306894 | Iodine-131 uptake in a patient with thyroid cancer and rheumatoid arthritis during acupunc | 1990 Jan | A patient with thyroid carcinoma had abnormal accumulation of I-131 in the areas of both feet and hands on whole body scan. The sites of abnormal accumulation of I-131 were similar to those on bone scintigraphy. The radiographic examination of the lesions showed characteristic findings of rheumatoid arthritis, and the presence of small gold needles for acupuncture treatment was demonstrated. There were no findings of bone metastases. Although the mechanism of accumulation of I-131 in this patient is unknown, interpreters of I-131 whole body scintigraphs should keep this case in mind when acupuncture treatment has been done. The authors can only speculate on a common blood flow mechanism for enhanced HMDP and I-131 uptake in this arthritic patient who had been treated by acupuncture. | |
| 2011713 | The association and predictive value of the complex immunoglobulin A-alpha 1-antitrypsin i | 1991 | Immunoglobulin A-alpha 1 antitrypsin complex (IgA-AT), its constituent components and nine other clinical or laboratory variables were measured in thirty-three patients with early, non-erosive rheumatoid arthritis (RA) in order to assess their value in predicting the subsequent development of erosions. After 12 months, eighteen patients had developed erosions. Comparison of variables measured at outset between the group of patients subsequently developing erosions and those not, showed only the complex IgA-AT level to be significantly different, the mean being higher in the erosive group. In the subgroup of patients with high IgA-AT levels (greater than 3.0 arbitary units) all developed erosions. The possible therapeutic implications of these findings are discussed. | |
| 2693704 | [Shoulder bursitis in rheumatoid polyarthritis]. | 1989 Nov | Shoulder bursitis seldom appears in rheumatoid arthritis. It is usually associated with an involvement of the omohumeral joint but it may be isolate and sometimes indicative. The production of foreign bodies is very rare (3 published cases). We report about one observation of subacromiodeltoid bursitis with rice bodies, associated with rheumatoid arthritis following a severe evolution. | |
| 2790919 | [Indicators of the advance and rate of progress of radiographic changes in patients with r | 1989 Jan 27 | In a double blind study with hydroxychloroquine sulphate used for treatment of rheumatoid arthritis the correlation of six X-ray criteria of progression of RA, based on calculation of the narrowing of the articular spaces and erosions (Sharp and Amos) and 23 clinical and laboratory criteria was assessed. Before treatment a satisfactory correlation of the majority of clinical and laboratory criteria with X-ray criteria was found. As after one-year treatment the majority of clinical criteria improved significantly and X-ray criteria did not differ significantly before and after treatment, the authors found very few correlations between changes of clinical and X-ray criteria, in particular after a dose of 20 mg/day. The X-ray criteria recommended by Sharp and Amos are not sensitive enough to be used for the evaluation of changes of the X-ray picture after one-year treatment with anti-rheumatic drugs which modify the course of RA. This applies in particular to more advanced cases. | |
| 2742402 | Reduced bone formation in non-steroid treated patients with rheumatoid arthritis. | 1989 Jun | The cellular basis of trabecular bone loss in rheumatoid arthritis was investigated in 45 non-steroid treated patients. Mean wall thickness, an indicator of the amount of bone formed per remodelling unit, mean interstitial bone thickness, which is related to resorption depth, and the extent of trabecular surface covered by osteoid, which reflects the number of remodelling units, were assessed in iliac crest biopsy specimens. The mean wall thickness was significantly reduced in the patient group when compared with controls matched for age and sex (mean (SD) 39.8 (5.4) v 51.6 (9.7) microns). There was no significant difference between patients and controls in the mean interstitial bone thickness (51.0 (26.4) v 61.4 (31.9) microns) or osteoid surface (16.7 (11.4) v 21.0 (10.5)%). These results show that reduced bone formation at the remodelling unit level is the predominant mechanism of bone loss in rheumatoid arthritis. | |
| 2625057 | [Interposition of the fascia and capsule in treatment of hip joint dysfunction in rheumato | 1989 | A surgical method of recovery of functional activity and painlessness of the hip deprived of the cartilage in the loaded part has been presented. The operation consisted of interposition with the fascia or a joint capsule flap. The results obtained in 12 patients after 1-12 years of follow-up have been given. Recovery of functional activity was obtained in 8 patients and improvement in 4 patients. In comparison with a group of 32 similar cases of interposition on the background of another etiology; interposition in rheumatoid arthritis gives more good and fair results. | |
| 3956116 | A double-blind study on the effect of discontinuation of gold therapy in patients with rhe | 1986 Jan | To assess the benefit of further gold treatment of rheumatoid arthritis (RA) patients who had already received more than 6 g of this metal, 24 such patients were included in a double-blind trial. Besides this "gold group" comprising 11 patients who received gold (Auromyose) in the same dosage schedule as before the study, the trial included a "placebo group" comprising 13 patients who received gold in a suspension diluted 1/100. In either group clinical, laboratory, and radiological data did not differ after 6 and 24 months in relation to the results at entry except for the serum gold concentrations, which were lower in the placebo group. We conclude that discontinuation of the treatment in RA patients who have received more than 6 g gold is not harmful to the patients for at least two years after withdrawal. | |
| 1920304 | Relationship of progression of radiographic changes in hands and wrists, clinical features | 1991 Jul | One hundred and twelve hospital based outpatients with rheumatoid arthritis (mean duration +/- standard error, 10.7 +/- 0.9 years) were studied for radiological progression of the hands and wrists over a mean period of 26.5 +/- 0.5 months. The majority were taking slow acting antirheumatic drugs (SAARD). The rate of radiographic progression was positively and independently associated with the female sex (p less than 0.01), erythrocyte sedimentation rate (ESR, p less than 0.05) and HLA-DR1 (p less than 0.05). There was a negative association with HLA-DR4 (p less than 0.05) but this was no longer significant after adjusting for ESR. There was no relationship between the rate of radiological progression and the presence of rheumatoid factor, rheumatoid nodules and duration of treatment with SAARD. | |
| 2914380 | Automated enhanced latex agglutination assay for rheumatoid factors in serum. | 1989 Feb | This improved assay of rheumatoid factors in serum, described here for use with the Baker "Encore" centrifugal analyzer, is efficient, with 250-sample throughput per hour; reproducible, with between-batch CV = 5% and within-batch CV = 2% (mid-assay range); and results correlate well (r = 0.9) with those by other methods. The method is fully quantitative and automated, involves no predilution steps, and can be adapted for use in a wide range of systems. It has a sensitivity of 96% and specificity of 80% in diagnosing rheumatoid arthritis. | |
| 2204216 | [New classification criteria of chronic polyarthritis]. | 1990 Jun 30 | The criteria for the classification of the rheumatoid arthritis were defined more precisely, reduced and simplified in 1987 by the American Rheumatism Association. The more detailed specification was achieved at the cost of sensitivity. We find the revision positive as the classification criteria are supposed to mainly serve the purpose of systematic organisation and as a base for multicentered studies. Only then they can give a little help in diagnostic orientation. Never the criteria can take the place of the individual differential diagnosis and the observation of the development of the disease. | |
| 2637461 | [The surgical treatment of the elbow joint in rheumatoid arthritis patients]. | 1989 Oct | Preliminary assessment of early and late synovectomies of the elbow joint in rheumatoid arthritis (RA) was made on the basis of combined examination of 48 patients with RA (23 patients from the USSR and 25 patients from Finland). All the patients were subjected to synovectomy of the elbow joint, early surgical interventions being conducted in the Finnish group and the late ones in the Soviet group. Every patient was examined one year after the operation, pain disappeared in about 7/10 of the patients. Late synovectomy proved effective in 3/5 of the cases. Surgical treatment of late classes of elbow joint arthritis made a favourable effect on the function of the hand as a whole and its capacity for self-service. A more lengthy observation is required to make a comparative assessment of early and late synovectomies of the elbow joint. | |
| 3247662 | [The potentials of a peroral gold preparation (Ridaura) in treating rheumatoid arthritis b | 1988 | Ridaura was given to 72 patients with true rheumatoid arthritis (RA) in the period of 6 mos to 2 yrs. Patients with I-II degree of activity and II-III x-ray stage of RA prevailed. Extraarticular RA manifestations were detected in 79% of the patients. The efficacy of Ridaura was assessed by its effect on the indices of activity (clinical manifestations of the articular syndrome, ESR, morphological signs of rheumatoid synovitis) and progression (the rates of erosive arthritis development in the hand and foot joints, the time course of the level of the serum rheumatoid factor and RA systemic manifestations). The drug efficacy was assessed with relation to the preceding variant of a RA course by the onset of treatment and after 3, 6, 12 and 18 mos. The results obtained indicated a high clinical efficacy of the drug and the presence of its basal activity which manifested itself in a good clinical effect by a decrease in the rates of x-ray progression, a serum RF level, the expression of morphological signs of synovitis and extraarticular RA manifestations, in particular myocarditis, diffuse interstitial pulmonary fibrosis, fever, and Aschoff's nodules. The therapeutic effect of the drug was on an increase in the period over 1 year. The highest efficacy of the drug was noted in RA with persistent activity of I-II degree or with activation up to II degree. Side-effects were revealed in 19% of the patients. Good tolerance of the drug was observed in 63% of the patients with a previous history of intolerance to parenteral gold drugs. | |
| 2781482 | [Some features of the effect of voltaren on the coronary blood flow in patients with rheum | 1989 | Electrocardiography and tetrapolar rheoplethysmography of the finger have demonstrated that voltaren and 5-NK activity produce an adverse action on the coronary blood flow in patients with rheumatoid arthritis. It has been found possible to correct the induced disorders by cordarone. | |
| 3355261 | Rheumatoid disease presenting as a nephrotic syndrome. | 1988 Mar | A 62 year old man with no relevant previous history presented with a nephrotic syndrome. Renal biopsy showed a membranous glomerulopathy and coincident investigation showed high serum titres of rheumatoid factors. It was not until some months later that he developed articular and extra-articular manifestations of rheumatoid arthritis. |