Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7235896 | Sexual problems of women with rheumatoid arthritis. | 1981 Mar | A questionnaire concerning sexual problems was given to 112 female rheumatoid arthritic (RA) patients. Replies were collected from 91 (81%). The results indicated that 1) recently married patients were concerned about pregnancy; 2) the sexual desire of most patients diminished, and intercourse became less frequent and less satisfying; 3) affected hip and knee joints made it difficult to assume sexual intercourse positions; and 4) patients who had unsatisfying sexual relationship reported a decreased demand for intercourse by their spouses and diminished frequency of their own orgasms. To lead a fulfilling married life, patients with RA should be counselled to adopt a positive attitude toward sexual relationship with their husbands. | |
| 6488711 | Postoperative wound infection in rheumatoid arthritis surgery. | 1984 Sep | The purpose of this study was to determine whether any of a number of factors studied correlated with the incidence of postoperative infection in rheumatoid patients, which is regarded as high. Data relating to all early postoperative infections between 1975 and 1978, 136 cases in all, were analysed together with data relating to two control series, one matched for sex, age and operation type, the other randomly chosen. The infection rate overall was 1.7%. The type of antirheumatic medication used did not influence the incidence of infection. Unrelated post-operative infections in the past correlated with risk of infection. Highly significant differences in the incidence of infection between the various types of operation were demonstrated. | |
| 734379 | Rheumatoid arthritis contributing to lumbar spinal stenosis. Neurogenic intermittent claud | 1978 | Two patients with rheumatoid arthritis affecting the lumbar spine showed the clinical, roentgenological, and operative characteristics of lumbar spinal stenosis, which is a neurological complication of rheumatoid arthritis that can be treated by surgery. The clinical history is a prerequisite for suspicion of the syndrome, and lumbar myelography including roentgenograms of the extended lumbar spine may verify the diagnosis. | |
| 7213432 | The impact of chronic disease: a sociomedical profile of rheumatoid arthritis. | 1981 Mar | A large number of individuals with rheumatoid arthritis have been studied in order to better delineate the sociomedical problems experienced by patients with this chronic disease. Two hundred forty-five respondents were surveyed by use of a detailed questionnaire and interview, and the results indicate that major losses in the areas of work, finances, and family structure are extremely common. The majority of workers were totally disabled as a result of their disease. On the average, subjects in the group were earning only 50% of the income predicted for them had they not had arthritis. Sixty-three percent experienced a major change in their psychosocial status as a result of their disease. Work disability appears to be the most important sociomedical impact of rheumatoid arthritis since it is associated with significantly greater income and psychosocial losses. This evidence of numerous and serious sociomedical problems in persons with rheumatoid arthritis raises questions of emphasis and approach for physicians involved in the clinical care of chronic rheumatic disease patients. | |
| 365205 | Salicylates and homoeopathy in rheumatoid arthritis: preliminary observations. | 1978 Nov | This paper reports the results of a pilot study in which 41 patients with rheumatoid arthritis were treated with high doses of salicylate, 3.9 g per day, and the results compared with a further 54 similar patients treated with homoeopathy. Both groups were compared with 100 patients who received placebo. 2 The patients who received homoeopathy did better than those who received salicylate. The design of the trial was such, however, that it was not possible to distinguish between the effects due to the physicians and the effects due to the drugs and a further trial is planned to elucidate this point. 3 Patients on homoeopathic treatment did not experience toxic effects. | |
| 6678200 | Chloroquine in long-term treatment of rheumatoid arthritis. | 1983 Dec | The effect of long-term (18-70 months) chloroquine treatment 250 mg daily, in rheumatoid arthritis (RA) was studied in 20 patients. Sedimentation rates were significantly reduced, as compared to a reference group of 10 RA patients on no treatment of disease modifying anti-rheumatic drugs. Radiographical progression of the disease was low in the majority of chloroquine-treated patients but not significantly different from the finding in the patients of the reference group. Rapid radiographical progression during 2-3 years was, however, observed in 5 patients despite chloroquine treatment. | |
| 3883916 | Radiological progression of rheumatoid arthritis in renal transplant recipients. | 1985 Mar | Radiological progression of rheumatoid arthritis (RA) was evaluated retrospectively in eight patients with amyloidosis secondary to classical or definite RA and successful renal transplantation. Wrist joints, metacarpophalangeal, proximal interphalangeal, and metatarsophalangeal joints were graded on a scale from 0 to 5. The annual progression rate was calculated separately for the time before and after transplantation. A slight acceleration of the progression was observed after transplantation and is assumed to be due to activation of the rheumatoid disease when the azotaemia was corrected. | |
| 6488708 | Measurement of disability in Dutch rheumatoid arthritis patients. | 1984 Sep | A self-administered health-assessment questionnaire (HAQ) was completed by 38 Dutch rheumatoid arthritis (RA) patients and the results compared to those obtained objectively when the same subjects were interviewed and asked to perform standardised tasks included in the HAQ. The results of the interview and the questionnaire showed a high degree of overall correlation and inter-component correlation. The correlation was comparable in outpatients with milder disease and in patients with more severe disease and was not influenced by age. The questionnaire offers a valid approach to the assessment of the functional disability of RA patients. | |
| 160748 | Rheumatoid arthritis, immune complex disease, and hypereosinophilic syndrome. Report on a | 1979 | A patient with typical rheumatoid arthritis is presented. After a short period of the disease a hyperosinophilic syndrome (HES) developed with vasculitis, pulmonary fibrosis, and thrombosis, and the disease took a malignant course. The patient died within a year after the diagnosis of HES. High titres of rheumatoid factor were manifested and total complement (CH50) was very low, indicating an active immune disease. As HES has been suggested to have an autoimmune aetiology, these findings are interesting, as positive rheumatoid serology has very rarely been reported in patients with this syndrome. | |
| 7444048 | Cranial settling in rheumatoid arthritis. | 1980 Dec | Cranial settling occurs in about 5-8% of patients with rheumatoid arthritis, sometimes resulting in severe neurological problems or even death. It is caused by collapse of the supporting structures at the craniovertebral junction, mainly the lateral masses of C1. Twelve cases are presented; 2 patients with severe neurological problems were treated surgically. | |
| 6411919 | A clinical study of older age rheumatoid arthritis with comparison to a younger onset grou | 1983 Jun | The clinical features, therapy and course of disease in a group of 34 patients with older age onset rheumatoid arthritis (ORA) defined as disease onset after age 60 are compared with a group of 34 rheumatoid patients whose disease onset began at a younger age (YRA). Onset of rheumatoid arthritis (RA) beyond age 60 is not uncommon as ORA represented 33% of all RA patients seen in our rheumatic disease unit. The ORA patients had a shorter mean disease duration (p less than 0.001) and a tendency to less rheumatoid factor seropositivity (p = 0.06) despite random selection for active disease of less than 10 years' duration. Suppressive therapy was employed less frequently in ORA (p less than 0.01) than in YRA but the use of other therapeutic modalities and the last recorded functional class were similar in the 2 groups. ORA patients did have greater functional incapacity at some point in their disease course (p less than 0.01) as well as a greater frequency of weight loss (p less than 0.001) and other acute systemic features at onset than YRA patients. Seronegative ORA appeared to have a favourable disease course in comparison with seropositive ORA. | |
| 3975335 | Life stress and rheumatoid arthritis. A 15-year follow-up study. | 1985 | A 15-year follow-up study of 74 female patients with definite or classic rheumatoid arthritis (RA) was performed with special focus on the association between life stress and clinical course of the illness. Two categories of RA could be classified: a disease form less connected with genetic factors and more influenced by major psychodynamic conflict situations ('major conflict group' MCG) and a second form more associated with hereditary predisposition and less influenced by environmental psychosocial changes ('non-conflict group', NCG). | |
| 654900 | High tibial osteotomy for rheumatoid arthritis of the knee. A one to six year follow-up st | 1978 Feb | Although high tibial osteotomy for osteoarthrosis of the knee joint is well recognized, its place in the management of rheumatoid arthritis of the knee is much less well established. Thirty-six rheumatoid knees were reviewed 1 to 6 years following tibial osteotomy. The results were 42 per cent good, 19 per cent satisfactory and 39 per cent poor. No patient remained free of pain for more than 3 years, and recurrence of pain was not always associated with recurrence of deformity. Varus knees did considerably better than valgus knees despite some technical errors. Maintenance of a normal femoro-tibial angle range of 164 degrees to 177 degrees at follow-up was important but not as vital as in osteoarthrosis of the knee. The beneficial effect of tibial osteotomy in rheumatoid arthritis of the knee seldom lasted more than 3 years after which time an increasing number of bad results were seen. It was concluded that high tibial osteotomy was a satisfactory procedure for rheumatoid arthritis of the knee but its efficacy was not comparable to that seen in osteoarthrosis nor was its effect long-lasting. | |
| 7306232 | Preliminary criteria for clinical remission in rheumatoid arthritis. | 1981 Oct | A study was conducted to develop criteria for clinical remission in rheumatoid arthritis (RA). Data were provided by 35 rheumatologists on 175 RA patients considered to be in complete remission (with or without antirheumatic therapy) and 169 RA patients in partial remission or with active disease. Six criteria yielded optimal discrimination: morning stiffness absent or not exceeding 15 minutes, no fatigue, no joint pain by history, no joint tenderness, no joint or tendon sheath swelling, and no elevation of erythrocyte sedimentation rate. In this study sample, the presence of five or more of these criteria in an individual patient yielded 72% sensitivity for clinical remission and 100% specificity in discriminating RA patients with active disease. In a population sample, it is estimated that the overall accuracy of these criteria would be more than 90% in RA patients. | |
| 914085 | Swan neck deformity in rheumatoid arthritis of the hand. | 1977 Jun | Swan neck deformity is not a single entity. Significantly different types of swan neck deformity are found, each demanding careful clinical evaluation and specialised treatment. This paper discusses the pathomechanics of swan neck deformity and presents a classification upon which rational treatment can be based. The surgical treatment of each variant is briefly outlined. | |
| 1242641 | The pattern of meniscus damage in the rheumatoid arthritis. | 1975 Oct 27 | Forty-seven knees with rheumatoid arthritis were synovectomized. The changes at the cartilage surface were always more grave when seen at the operation as was expected from the conventional X-rays. On the other hand degenerative changes of the menisci were more advanced than those in the cartilages. An important destructive factor was the almost constant pannus-filled erosion found at the upper corner of the tibia under the menisci. Thus, it is indicated to remove the menisci if they show a slightest degree of destruction. | |
| 7387017 | Immune complexes and other laboratory features of pleural effusions: a comparison of rheum | 1980 Jun | We have evaluated the clinical usefulness of certain diagnostic tests in consecutive patients with pleural effusions, including 12 who had rheumatoid arthritis, nine who had systemic lupus erythematosus, and 39 who had other diseases. Effusions from patients with rheumatoid arthritis and systemic lupus erythematosus differed with respect to glucose level, lactic dehydrogenase activity, and pH. Complement levels differentiated rheumatoid from control effusions but did not segregate rheumatoid from systemic lupus erythematosus. Immune complexes were detected in all the rheumatoid pleural fluids by radioassays using monoclonal rheumatoid factor, C1q, and Raji cells. In most of the fluids, these complexes were reactive in all three assay systems and their levels higher than those found in paired serum samples. In effusions from patients with systemic lupus erythematosus, however, immune complexes were detected mainly by the Raji cell radioimmunoassay, and levels by all three assays were similar to those of paired serum samples. | |
| 7125719 | In-vitro studies of ineffective erythropoiesis in rheumatoid arthritis. | 1982 Oct | Ineffective erythropoiesis was assessed in a series of 32 patients with rheumatoid arthritis by means of a new in-vitro method which measures the release of haem from a labelled cohort of erythroblasts in culture. Haem release was significantly increased in patients with the anaemia of chronic disorders but was normal in those who were not anaemic or who had an iron-deficiency anaemia. In 2 patients with anaemia of chronic disorders haem release returned to normal after successful antirheumatic therapy. The increased ineffective erythropoiesis in patients with rheumatoid arthritis and anaemia of chronic disorders appeared to be unrelated to functional iron deficiency and was not attributable to a serum factor. | |
| 7059277 | Splinting in rheumatoid arthritis: I. Factors affecting patient compliance. | 1982 Feb | Fifty-four patients with rheumatoid arthritis were fitted with either unilateral or bilateral hand and wrist splints. Of 36 patients available for evaluation, 29 (greater than 80%) reported wearing their splints more frequently for activities requiring greater strength than dexterity. Patients also reported pain relief from wearing their splints, but did not report donning them for this purpose. We feel that a vigorous educational effort should be promoted to encourage patients to wear splints for diminution of inflammation and relief of pain as well as for support during heavier activities. | |
| 539842 | Studies on the frequency and pathogenesis of liver involvement in rheumatoid arthritis. | 1979 Dec | A systematic prospective survey of 100 outpatients with rheumatoid arthritis revealed that 45 had biochemical evidence of liver disease. In most cases this was due to increases in total serum alkaline phosphatase (ALP) and/or gammaglutamyl transpeptidase (GGT). Examination of serum ALP isoenzyme profiles in 50 of the patients showed that the liver isoenzyme was the sole or major component in 44 patients, including many with normal total ALP levels. 18% had raised serum liver ALP together with raised GGT, suggestive of an underlying hepatobiliary lesion. No correlation could be detected between raised serum levels of liver enzymes and the age or sex of the patient, duration or severity of arthritis, and drug or alcohol history. However, there was a significant correlation between raised serum ALP and lacrimal or salivary gland dysfunction. It is suggested that immunological mechanisms may be involved in the development of hepatic abnormalities in rheumatoid arthritis. |