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Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes

PMID	Title	PublicationDate	abstract
6400519	Polymyalgia rheumatica and rheumatoid arthritis: a prodromal or overlap syndrome?	1984	Seven patients seen over an eight-year period and drawn from a population of approximately one million are described, who presented with unequivocal polymyalgia rheumatica (PMR) and developed sero-positive, erosive rheumatoid arthritis (RA) within a year. Two of the patients were confirmed as having temporal arteritis (TA). The association of PMR and RA is discussed.
931550	HLA antigens and rheumatoid arthritis.	1977	One hundred twenty-five patients with rheumatoid arthritis were typed for 21 HLA antigens from A and B loci. The antigen frequencies found in patients were compared with the frequencies in a control population of 300 healthy individuals. No statistically significant differences were observed between patients and the control group.
7235790	Spontaneous hepatic rupture in rheumatoid arthritis.	1981 May	A fatal hepatic rupture developed, in a patient with rheumatoid arthritis, as a result of hepatic arteritis. The patient had hypotension, falling hematocrit level, hepatomegaly, and evidence of progressive hepatocellular dysfunction. Hepatic dysfunction is not uncommon in rheumatoid arthritis, but is usually asymptomatic. Hepatic arteritis is a rare manifestation of rheumatoid arthritis; however, recognition of this complication is important, since early intervention may be important in successful management.
3981499	Plasma and synovial fluid gentisate in patients receiving salicylate therapy.	1985 Feb	Our study was undertaken to assay gentisate, an oxidation metabolite of salicylate, in plasma and synovial fluid (SF) samples from patients taking antiinflammatory doses of aspirin. A close correlation between plasma and SF concentrations was found for (1) salicylate, (2) salicylurate, and (3) gentisate, in 20 patients studied. Our data suggest ready equilibration of these compounds between the plasma and synovial spaces. In vitro experiments confirmed that in the presence of an oxy radical flux, salicylate is oxidized to gentisate. However, no evidence was obtained to implicate peripheral conversion of salicylate to gentisate in inflamed joints where oxy radicals may be produced.
666872	Electron microscopic morphology of immunoglobulin aggregates and their interactions in rhe	1978 Jun	Immunoelectron microscopy for IgG and IgA was combined with plain electron microscopy and light microscopy to study a variety of articular collagenous tissues from 14 cases of classic rheumatoid arthritis. Numerous extensive aggregates of IgG and IgA positive material were found widely spread in locations that coincided with immunofluorescent staining for these immunoglobulins and B1c. This Ig positive material is thought to represent deposits of immune complexes. As great and greater amounts were seen in fibrocartilage menisci as in hyaline cartilage. A single specimen of disease tendon was also positive. Severe pathologic changes of the matrix characterized by loss of normal morphology, alterations in collagen, and overall reduced density were observed in regions of aggregate deposition with a consistent replacement and disappearance of collagen in the locale of the aggregates themselves. Polymorphonuclear cells in regions of degraded hyaline and tendon matrix were seen to have phagocytosed aggregates. These data give some credence to a direct role of immune aggregates in rheumatoid arthritis articular collagenous tissues in disease pathogenesis.
7000266	Increased incidence of faecal Klebsiella pneumoniae in patients with HLA B7 CREG antigen a	1980 Aug 30	In a study of the carriage of faecal Klebsiella pneumoniae in 106 patients with rheumatoid arthritis the incidence of carriage was higher in men (28%) than women (14%) (p < 0.001) and klebsiellae were isolated on two or more occasions from a higher proportion of men than women (p < 0.002). The incidence of carriage was increased among patients with rheumatoid arthritis who had B7 cross-reacting (B7 CREG) antigens (32% v 13%--p < 0.001). Carriage of klebsiellae was not associated with clinical disease activity, raised erythrocyte sedimentation rate, drug treatment, or the presence of HLA Dw4 or DRw4 or both. Thus the carriage and prevalence of faecal Klebsiella pneumoniae appear to be partly determined by the sex and HLA state of the host.
6234897	Suppressor T cell function in patients with rheumatoid arthritis complicated by vasculitis	1984 Jul	Concanavalin A (Con A)-induced suppressor T cell activity was determined in 10 rheumatoid arthritis (RA) patients with vasculitis, 34 RA patients without vasculitis, and 10 healthy individuals. The percent Con A-induced suppression in RA patients with vasculitis was 24.6. In contrast, it was 68.4% in those RA patients without vascular lesions. Further, the proportion of T cells reactive with OKT8 monoclonal antibody was also decreased in RA patients with vasculitis. Accordingly, the reduced Con A-induced suppressor T cell activity in these RA patients resulted, in part, from the reduction in the number of cells of the suppressor T cell subset. Those patients with vascular lesions also had a higher percentage of positive antilymphocytotoxic antibodies than RA patients without vasculitis. Since the differences in Con A-induced suppressor T cell activity and frequency of positive antilymphocytotoxic antibodies were so great, we believe RA patients with vasculitis could be recognized as a disease group distinct from RA patients without vasculitis.
6419597	Roentgenographic findings during auranofin treatment.	1983 Dec 30	Roentgenograms of hands and wrists from rheumatoid arthritis patients treated with auranofin for 12 and 24 months were scored for severity of erosive disease. Scores were analyzed by a method in which a calculated mean annual rate of erosion prior to treatment was compared with the annualized rate during therapy. The original films from a previous Myochrysine versus placebo study were reanalyzed in order to compare the results of different scoring methods and to provide an auranofin versus placebo comparison. Two readers found the rate of erosion during oral gold therapy to be less than that predicted by the analytical model. Interobserver differences in scoring were demonstrated. A breakdown of patient scores by duration of disease showed the greatest difference between scores observed during treatment with those predicted by the model in patients with early disease.
1130432	Still's disease in an adult: A link between juvenile and adult rheumatoid arthritis.	1975 Jan	A 52-year-old man developed rheumatoid factor negative, chronic, symmetrical polyarthritis associated with high intermittent fever and morbilliform evanescent rash at the onset. A detailed investigation and follow-up for two years failed to reveal any secondary cause. The onset and course resemble Still's disease in children. The synovial membrane histology and electron microscopy were consistent with early rheumatoid arthritis. Adult onset Still's disease reported in the literature is reviewed and compared with Still's disease in children.
4072616	[Technics and indications for surgical treatment in surgical neurologic complications of r	1985 Nov	A critical study of 11 cases of rheumatoid arthritis with neurological complications due to involvement of the cervical region of the spinal column induces the authors to reconsider their therapeutic strategy. After reviewing the various neurological complications and mechanisms involved, they propose wider use of surgical treatment within limits defined on the basis of neurological and radiological criteria and the risks of the respective methods.
8833	Distribution of benorylate in plasma, synovial fluid and tissue in rheumatoid arthritis.	1975	Six patients, not previously treated, with classical seropositive rheumatoid arthritis and highly active synovitis of one or both knee joints were treated with 4 g of 40% benorylate suspension twice daily for a period of 9--14 days prior to synovectomy. Blood samples were taken at scheduled times during administration of the drug. At operation, synovial fluid and tissue samples were taken and their salicylate, paracetamol and benorylate content measured. Plasma levels of salicylate and paracetamol were, in general, significantly higher than the concentration of these metabolites in the synovial fluid. Benorylate was found in the synovial tissues concentrated especially in the highly inflamed synovial villi. It is probable that benorylate and its metabolites penetrate the synovia but further studies are needed to determine if the metabolites are concentrated in the different synovial cell layers in the same way as benorylate itself. It is possible that part of the clinical effect of benorylate is due to its presence in the synovial tissue and that it has a direct effect in vivo on the synovial membrane. It is also possible that the pharmacokinetic properties of benorylate permit it to enter cell layers inaccessible to its metabolites.
6670515	Seven-year follow-up of total hip replacement with the Brunswik prosthesis.	1983 Dec	One hundred and sixty-one non-infected total hip arthroplasties were reviewed on average 4 years post-operatively and 113 of these were reviewed again on average 7 years post-operatively. Non-infectious stem loosening was observed in 38% and required exchange operation in 20%. At review, 12 sockets (7%) were found to be loose. However, the mean hip scores were good, which could partly be explained by cases excluded because of revision.
4032403	Abnormal bowel permeability in ankylosing spondylitis and rheumatoid arthritis.	1985 Apr	Intestinal permeability was measured using a low molecular weight polyethylene glycol as a permeability marker in patients with osteoarthritis, ankylosing spondylitis (AS) and rheumatoid arthritis (RA). Patients with AS showed a significant increase in bowel permeability when compared to controls. Intestinal permeability was also increased in patients with active RA but was less than the control group in RA patients who did not have active joint disease.
975760	Infection in rheumatoid arthritis.	1976 Oct	Sepsis is an unusually common cause of illness and death in RA. All sorts of infections occur, but pyarthrosis produces exceptional problems. Clinically, pyarthrosis, empyema, and purulent pericarditis mimic bland rheumatoid effusions. Aspiration of the attendant effusions is the only reliable diagnostic procedure. Subcutaneous nodules on the sacrum and back are easily overlooked. Necrosis and ulceration of these nodules may provoke septicemia. Those with Felty's syndrome do not uniformly have problems with recurrent infection. Splenectomy may not benefit such patients. The belief that corticosteroids cause increased infections in rheumatoid patients is not totally justifiable at present. Steroids can, however, disguise underlying sepsis and hamper proper diagnosis.
6100567	Expression of HLA-DR and HLA-DQ antigens on cells within the cartilage-pannus junction in	1984	The cartilage-pannus junction in joints from patients with active rheumatoid arthritis was studied by means of immunohistochemical analysis of frozen sections, using monoclonal antibodies directed against HLA-DR, HLA-DQ class II transplantation antigens, against the transferrin receptor and against T-lymphocyte subpopulations. Expression of HLA-DR antigens was seen on a large number of synovial cells in immediate contact with the cartilage, whereas the expression of HLA-DQ antigens was only seen on a subfraction of the HLA-DR-positive cells. Most of the cells in close contact with the cartilage expressed the transferrin receptor, indicating a proliferative state of these cells. It is suggested that class II antigen-expressing synovial cells in immediate contact with the cartilage in rheumatoid joints might, in addition to their potential role in the destructive process, also serve functions in the elicitation of immune reactions against molecules released from the cartilage.
7184044	[The sigma sedimentation rate in rheumatoid arthritis: comparative study of the erythrocyt	1982 Sep	The authors studied 54 patients suffering from rheumatoid arthritis by sigma SR method. The sigma SR, unlike the ESR, often reveals inflammatory activity in patients suffering from possible or probable rheumatoid arthritis and is very useful to diagnose the disease. The sigma SR constantly increases when the disease is in active period, unlike the ESR, in patients affected by classic or definite rheumatoid arthritis. The authors conclude the sigma SR determination is useful in every case of rheumatoid arthritis, especially when the disease is at beginning and is difficult to be diagnosed, i.e. cases of possible and probable rheumatoid arthritis, and when clinical and biohumoral picture disagree.
6226915	Efficacy of EMG biofeedback, pseudotherapy, and conventional medical treatment for chronic	1983 Sep	Twenty-four patients suffering from chronic rheumatic back pain were treated with EMG biofeedback, a credible pseudotherapy, or conventional medical treatment alone during a 4 week inpatient stay at a Rheumatology Clinic. At the end of the treatment phase and at the 4 month followup the patients in the biofeedback group showed significant improvements in the duration, intensity, and quality of their back pain as well as their EMG levels, negative self-statements, and utilization of the health care system. In contrast, the pseudotherapy group showed minimal, but non-significant improvements, and the medically treated group remained unchanged.
3966937	Reproducibility of multiple-observer scoring of radiologic abnormalities in the hands and	1985 Jan	Forty-one coded radiographic films from 16 patients with rheumatoid arthritis were read by 13 observers, using 4 different methods for scoring abnormalities. Although absolute scores differed widely among individual observers, correlation coefficients were greater than 0.850 for approximately 2 of 3 comparisons. When films were ranked, using the median rank of all readers, 72% of individual ranks were within 10% of the median ranks. Among serial films on individual patients, 92% of comparisons between early and late films were interpreted as demonstrating progression of abnormalities when mean standardized scores showed an increase in scores of 15 units or greater. Films with lesser changes were interpreted inconsistently. This study shows good general agreement among readers in scoring radiologic abnormalities of hands and wrists, when applied to a film set showing a broad spectrum of severity, and defines the sensitivity of radiologic detection of disease progression.
7455635	Serum sulfhydryl levels in rheumatoid patients treated with haloperidol.	1980	Six months of haloperidol treatment significantly increased the serum sulfhydryl (SH) levels in all 12 rheumatoid arthritis (RA) patients studied and significantly decreased the PIP joints technetium index (Tc-index), erythrocyte sedimentation rate (ESR) and joint count. These findings suggest a specific antirheumatic activity of haloperidol in the RA patients.
6434023	Red cell ferritin content: a re-evaluation of indices for iron deficiency in the anaemia o	1984 Sep 15	In iron deficiency anaemia basic red cell content of ferritin is appreciably reduced. This variable was determined in 62 patients with rheumatoid arthritis to evaluate conventional laboratory indices for iron deficiency in the anaemia of rheumatoid arthritis. For 23 patients with rheumatoid arthritis and normocytic anaemia irrespective of plasma ferritin concentration, red cell ferritin content did not differ significantly from that for non-anaemic patients with rheumatoid arthritis. For 27 patients with rheumatoid arthritis and microcytic anaemia, the mean red cell ferritin content for patients with a plasma ferritin concentration in the 13-110 micrograms/l range was appreciably reduced. It was indistinguishable from that for patients with rheumatoid arthritis and classical iron deficiency anaemia, indicated by plasma ferritin concentrations of less than 12 micrograms/l. In contrast, the mean red cell ferritin content for patients with rheumatoid arthritis, microcytic anaemia, and plasma ferritin concentrations above 110 micrograms/l did not differ from that for patients with rheumatoid arthritis and normocytic anaemia. Oral treatment with iron in patients with rheumatoid arthritis, microcytic anaemia, and appreciably reduced red cell ferritin concentrations was accompanied by significant increases in haemoglobin concentration (p less than 0.01), mean corpuscular volume (p less than 0.01), and red cell ferritin contents (p less than 0.05). This treatment, however, did not produce any appreciable change in haemoglobin concentration in patients with rheumatoid arthritis, normocytic anaemia, and normal red cell ferritin contents. These findings suggest that the indices for iron deficiency in patients with rheumatoid arthritis and anaemia should include peripheral blood microcytosis together with a plasma ferritin concentration of less than 110 micrograms/l.