Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 938594 | Hypertrophic osteoarthropathy and rheumatoid arthritis: simultaneous occurrence in associa | 1976 May | A patient is described who was treated with high-dose prednisone in an attempt to halt progressive respiratory insufficiency associated with diffuse interstitial fibrosis. On cessation of steroid therapy the patient was noted to have radiologic manifestations of hypertrophic osteoarthropathy (HOA) as well as clinical and laboratory features of rheumatoid arthritis (RA). Subsequently a diffuse vasculitis developed with bowel perforation and sepsis leading to death. | |
| 3924059 | Reduced joint count indices in the evaluation of rheumatoid arthritis. | 1985 Jun | Two types of summary measures of joint disease were evaluated in 2 controlled clinical trials in rheumatoid arthritis patients. One measure was based solely on the clinical/biologic judgment approach; the other combined this methodology with statistical approaches using reliability and factor analyses. "Signal joint" indices, summarizing disease activity in 2-5 key joints, were found to be insensitive to deterioriation of nonsignal joints. Therefore, they are not recommended as replacements for the complete articular survey in rheumatoid arthritis. A reduced version of the complete articular survey was found to be desirable based on its validity, reliability, accuracy, precision, and sensitivity to active drugs. Its sensitivity can be slightly higher or lower than that of the full joint survey. | |
| 6878105 | Psoriatic spondylitis in a patient with classical rheumatoid arthritis. | 1983 May | A patient exhibiting typical features of classical rheumatoid arthritis and psoriatic spondylitis is described. The patient, a woman, presented at the age of 29 with an inflammatory arthritis. Twenty years later, she developed psoriasis, and after a further 3 years, she was first noted to have rheumatoid nodules and to be strongly seropositive. Now at the age of 60, she has a rigid spine with radiographic changes of spondylitis. Neither rheumatoid arthritis, nor psoriatic spondylitis can account for all the features of her disease and there is evidence to suggest that both conditions combined to damage her peripheral joints. | |
| 954367 | Bone-resorbing activity in the sera of patients with rheumatoid arthritis. | 1976 Aug | 1. Foetal rat hemi-calvaria were incubated in organ culture with sera from patients with active rheumatoid arthritis. 2. Increased 45Ca resorption was produced by sera from patients who were hypercalcaemic. 3. This bone-resorbing effect could be inhibited by calcitonin. | |
| 170764 | Isolation, purification and properties of a factor from rheumatoid synovial fluid activati | 1975 | 1. An activator catalysing specifically conversion of latent forms of human leucocyte collagenase and gelatin-specific protease into the active forms, has been isolated from rheumatoid synovial fluid and purified 55-fold with a yield of 16%. 2. Molecular weight of the activator is about 35 000. 3. The activator is thermolabile, and is irreversibly inactivated at pH below 5.5 or in the presence of low concentrations of trypsin or papain; it is resistant to the action of lysozyme, hyaluronidase, diisopropylfluorophosphate, soybean trypsin inhibitor, p-chloromercuribenzoate, iodoacetamide and dithiothreitol. 4. The activator did not show any activity towards collagen, gelatin, casein, haemoglobin, histones, elastin or p-phenylazobenzyloxycarbonyl-peptide. | |
| 6347307 | Clinical judgement analysis--practical application in rheumatoid arthritis. | 1983 Aug | Clinical judgment analysis has been used to investigate differences in assessing disease activity in rheumatoid arthritis. Rheumatologists as a group do not adopt a single underlying policy for the assessment of changes in disease activity; each has his or her own approach to such judgements. Some rheumatologists are inconsistent in applying their judgment policies, leading to disagreements even when underlying policies are similar. Having identified these problems of assessment, clinical judgement analysis may be employed to reduce clinical disagreement and to improve coordination and consistency between rheumatologists in different centres during clinical investigations. | |
| 5007840 | Pernicious anaemia and rheumatoid arthritis. | 1972 Jan 15 | In a study of 99 patients with pernicious anaemia the incidence of clinical rheumatoid arthritis was normal but rheumatoid factor was present significantly more often than in controls. This was not related to the presence of circulating antibody to intrinsic factor.Intrinsic factor antibody was not detected in any of 151 latex-fixation-positive rheumatoid sera. | |
| 2580092 | Significance of antikeratin antibodies in rheumatoid arthritis. | 1985 Feb | Antikeratin antibodies (AKA) were found in the sera of 59% (121/204) of patients with rheumatoid arthritis (RA). There was a significantly higher incidence of AKA (73%) in male patients compared with females (53%) and a correlation between AKA positivity and IgM rheumatoid factor was found. Antibody reactivity was positively associated with the presence of nodules, antinuclear antibody, C-reactive protein and disease severity. AKA would appear to have possible prognostic significance in patients with RA. | |
| 4037555 | Weekly pulse methotrexate in rheumatoid arthritis. Clinical and immunologic effects in a r | 1985 Oct | Twelve patients with refractory rheumatoid arthritis were treated with weekly pulse methotrexate in a double-blind, placebo-controlled, crossover study. After 13 weeks of therapy, patients receiving methotrexate showed greater improvement, judged by degree of joint swelling and tenderness, duration of morning stiffness, and subjective assessments of clinical condition, compared to those receiving placebo (p less than or equal to 0.002). This improvement was associated with a decrease in sedimentation rate and decreases in levels of IgG, IgM, and IgA; no changes were seen in serum rheumatoid factor titer or complement protein levels. Proportions of mononuclear cell subsets that were abnormal before treatment (decreased percentage of total T cells, increased percentage of monocytes) improved toward normal after therapy with methotrexate. However, no changes were seen in elevated pretreatment Leu-3/Leu-2 ratios, in in-vitro proliferative responses of lymphocytes to mitogens, or in immunoglobulin secretory responses to pokeweed mitogen. Weekly pulse methotrexate is effective in the short-term treatment of refractory rheumatoid arthritis. Little evidence for cellular immune suppression was associated with this clinical benefit. | |
| 6614844 | Stanmore total knee replacement in rheumatoid arthritis. | 1983 Apr | Stanmore Prosthesis was used to replace 115 knees in 83 patients suffering from rheumatoid arthritis. The operative technique is simple and the prosthesis is reliable in restoring stability to the most unstable knees, correcting deformity, restoring mobility and relieving pain. | |
| 7267942 | Patterns of hostility revealed in the fantasies and dreams of women with rheumatoid arthri | 1981 | Data relevant to the feelings of hostility harbored by 25 women with rheumatoid arthritis is reported. Noteworthy points include: (1) a high incidence of early loss by death, often by suicide, of one of the parents; (2) a high incidence of involvement in incestuous relationships; (3) the occurrence in the period of onset of illness of severe provocation by an ambivalently loved person whom the patient cannot relinquish; (4) the presence of conscious fantasies of revenge toward this person which tend not to be carried over into action; (5) the presence of vicious dreams, often containing frankly oral-sadistic motifs in many of which the patient herself is portrayed in the role of victim. | |
| 6156968 | Volz total wrist arthroplasty in rheumatoid arthritis: a preliminary report. | 1980 May | The results of 20 Volz design total wrist arthroplasties in 19 patients with stages III and IV rheumatoid arthritis are presented. Follow-up averaged 18 months. Using a 100-point evaluation form, there were 75% excellent or good results and 10% poor results. An effective extensor carpi radialis brevis tendon and the presence of volar and ulnar contractures were the most important factors influencing the results. This operation is recommended in patients with painful stage III or IV rheumatoid wrist disease, and in whom the extensor carpi radialis brevis is functioning where preservation of motion is desired. | |
| 1124951 | Rheumatoid synovitis and joint disease. Relationship between arthroscopic and histological | 1975 Feb | Arthroscopic and histological synovial features have been studied in forty-two patients with classical or definite rheumatoid arthritis. A total index of disease activity as judged arthroscopically correlates significantly with a total index of histological activity. In those patients who have dense, waxy looking villi, the intensity of the villus-proliferation is associated with lymphocytic infiltration of the synovium. No relationship between synovial lining cell proliferation and cartilage disease nor between sparsity of lymphocyte infiltration and cartilage disease could be established. | |
| 1262462 | Mixed lymphocyte cultures in rheumatoid arthritis. | 1976 May | Random one-way microtiter mixed lymphocyte cultures between 43 rheumatoid arthritis (RA) patients and 45 controls consisting of 26 normal subjects and 19 miscellaneous non-RA patients were performed and results were evaluated as relative responses. Low responses (consisting of relative response less than 38%) were found in 31 out of 43 RA patients in cultures against eight of the RA stimulators. The remaining 35 RA stimulators tested yielded only normal mixed lymphocyte culture reactions. The same RA patients used as responders never produced low responses when stimulated by non-RA lymphocytes. But six of the control subjects gave low responses to two RA stimulators. The low responses did not appear to correlate with intake of aspirin, prednisolone, or gold salts, nor could they be reproduced by addition of RA serum of 7S or 19S fractions thereof containing either polyclonal or monoclonal rheumatoid factors. Short-term culture and washing before mixing with the allogeneic cells did not change the low responses suggesting that in vivo bound autoantibodies against lymphocyte receptors were not involved. Study of the inheritance of HLA and mixed lymphocyte culture determinants in the family of patient A. C. who most frequently elicited low responses indicated she was homozygous for a lymphocyte-defined determinant which has been called R. The low responses to A. C. could be interpreted as typing responses based on sharing of the same or of a similar lymphocyte-defined determinant. This gene appears to be increased in patients with RA with respect to non-RA controls and may reflect an association of genes within the HLA chromosomal region leading to predisposition for the development of RA. | |
| 7047743 | The study of a lymphokine, polymorphonuclear leukocyte chemotactic factor from lymphocytes | 1982 Apr | The production of a lymphokine, polymorphonuclear leukocyte (PMN) chemotactic factor (CF) was studied in lymphocytes obtained from patients with rheumatoid-factor positive rheumatoid arthritis (RA). Control lymphocytes and PMN were obtained from normal individuals. The stimulation of the lymphocytes was by phytohemagglutinin (PHA) and by mixed leukocyte culture. CF was produced to the same degree by the cells from normals and from patients with RA by either type of stimulation. There is significantly less 3H-Thymidine uptake in cells from RA patients as measured by counts per minute although the stimulation index was the same. This can be accounted for by decreased proliferation of RA cells. | |
| 6600826 | Transcutaneous electrical nerve stimulation in rheumatoid arthritis. | 1983 Mar 9 | The therapeutic effect of once weekly transcutaneous electrical nerve stimulation in patients with rheumatoid arthritis was compared with placebo in a randomised, double-blind, non-crossover study lasting three weeks. Thirty-two patients with classic or definite rheumatoid arthritis and wrist involvement were evaluated. Transcutaneous electrical nerve stimulation was better than the placebo in relieving pain at rest and while gripping. In addition, grip strength, measured as power and work done, immediately improved following transcutaneous electrical nerve stimulation but returned almost to initial values between assessments. No significant improvement was shown for the placebo group. | |
| 6879095 | [Retrospective study of the effects of D-penicillamine and pyrithioxin in the treatment of | 1983 Apr | The authors made a comparative study of the effectiveness and tolerance of D-penicillamine (DP) and pyrithioxine (Pyr) and investigated possible prognostic factors for the tolerance and effectiveness of these two treatments. This retrospective study concerned 150 patients with rheumatoid arthritis (RA). 86 patients were treated with DP and 64 were treated with Pyr. The percentage effectiveness, evaluated in terms of morning stiffness and the articular index as well as the need for steroidal and non-steroidal anti-inflammatory agents, attained 67.4 p. cent with DP and 51.6 p. cent with Pyr. Suspension of treatment because of ineffectiveness, was more frequent with Pyr. The changes in the following laboratory parameters were also compared: ESR, rheumatoid serology, ANF, C3 and C4 complement levels, IgG, IgA and IgM levels. The treatment was stopped definitively because of intolerance in 37.2 p. cent of cases with DP and in 29.7 p. cent of cases with Pyr. Serious renal and haematological complications are essentially, but not exclusively, due to DP. | |
| 333539 | Salmonella typhimurium arthritis in rheumatoid disease. | 1977 Aug | Septic arthritis is a well recognized complication of rheumatoid arthritis (British Medical Journal, 1976; Mitchell et al., 1976), particularly after joint replacement (Freeman, 1976). We report here infection with an unusual organism--Salmonella typhimurium. | |
| 7352929 | Evidence for the presence of receptors for C3 and IgG Fc on human synovial cells. | 1980 Jan | The presence of receptors for IgG Fc and fragments of C3 on primary cultures and cryostat sections of normal and rheumatoid synovial tissues was assessed. Significant proportions of large rounded cells with asteroid projections found in such cultures had receptors for both IgG Fc and fragments of C3. Moreover, Gram negative bacteria that had fixed complement, but not EAC, bound in a linear fashion on the superficial layers of synovial cryostat sections. On the basis of morphologic and histochemical criteria, the cultured cells bearing these receptors were tentatively determined to represent a subset of synovial lining cells. The possible role of such receptors on synovial lining cells in the pathogenesis of rheumatoid arthritis is discussed. | |
| 7327926 | Results of the total-condylar knee prosthesis. | 1981 Apr | The Total-Condylar knee prosthesis is a non-hinged, semi-restricted prosthesis with partial intrinsic stability, incorporating a prosthetic surface covering the patella. The surgical technique involved includes release of the contracted soft tissues, so as to obtain symmetry and balance of the ligaments before the bone is cut. These bone cuts are made at a right angle to one another and are standardised. The cases presented comprise forty-eight knees (in forty-one patients), of whom thirty-eight were affected by arthrosis and ten by rheumatoid arthritis. The mean age of the patients was sixty-five years. They were examined not less than twenty-four months nor more than seventy months after operation. This was a prospective survey and the cases were consecutive. Excellent or good results were obtained in 89.5 per cent of cases. Only one case had to undergo re-operation, due to loosening of the tibial component, not to deep infection. The results were permanent over the review period, and the quality was as good as in prostheses of the hip. |