Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 921821 | Lymphocyte activation in rheumatoid synovial effusion. | 1977 Nov | A rapid method based upon increase in intranuclear birefringence occurring in early stages of lymphocyte activation was used to examine whether there is any difference in lymphocyte activation between lymphocytes from synovial fluid and those from peripheral blood in patients with rheumatoid arthritis and other joint diseases. Increased activation of synovial fluid lymphocytes compared with peripheral blood lymphocytes was seen only in synovial effusions obtained from patients with rheumatoid arthritis. | |
| 6237413 | Inhibition of immune precipitation in rheumatic disease. A clinical and laboratory study. | 1984 | Antigen-antibody complexes formed in the presence of serum do not precipitate. This complement-dependent function is impaired in approximately half of all patients with seropositive rheumatoid arthritis (RA) but not in patients with other chronic inflammatory arthropathies. As patients with seropositive RA have normal or elevated serum complement levels, this findings suggests that an inhibitor is present in the serum of these patients. Although degree of impairment of solubilization is correlated with rheumatoid factor (RF) titre, decreases in RF titre in patients receiving gold therapy were not always accompanied by improvement of the solubilization process. Thus we can conclude that impaired solubilization is related to, but may be distinct form, RF. Impaired solubilization was associated with the presence of subcutaneous nodules, but not with other systemic features of RA. Thus this phenomenon may be of pathogenetic importance. | |
| 6188207 | Immunoreactive alpha 2-macroglobulin in rheumatoid synovial membrane. | 1982 | alpha 2-Macroglobulin was demonstrated immunohistochemically in macrophage-like cells of rheumatoid arthritic synovial tissue. It is concluded that these intracellular deposits probably represent phagocytosed protease-alpha 2-macroglobulin complexes. A contributing local production of alpha 2-macroglobulin is, however, not excluded by the present findings. | |
| 6849766 | Dose-response study with ibuprofen in rheumatoid arthritis: clinical and pharmacokinetic f | 1983 Mar | Clinical response and plasma pharmacokinetics were studied in 20 rheumatoid patients receiving three dosages of ibuprofen. There was a significant response to 1600 mg daily of ibuprofen by all three clinical measurements but increasing the daily dosage to 2400 mg produced no overall increase in response. The AUC increased with increasing daily drug dosages from 800 to 2400 mg daily and the dose normalised AUC fell by 15% over the same dosage range. The fraction of ibuprofen not bound to plasma proteins increased with increasing dosage and may contribute to the fall in the dose normalised AUC. There was a considerably inter-individual variation in the AUC. There was no significant correlation between AUC and clinical response as measured by articular index and there was a weakly significant correlation between AUC and clinical response as measured by a visual analogue pain index. Pharmacokinetic variables probably account for only a small part of the inter-individual variation in response of rheumatoid patients treated with increasing dosages of the non-steroidal, anti-inflammatory drug ibuprofen. | |
| 535261 | Reconstruction of the knee with endoprosthesis in rheumatoid arthritis: a report of 112 co | 1979 Nov | In a consecutive series of patients with advanced, seropositive rheumatoid arthritis, 112 severely damaged knees were reconstructed with a stabilizing, total resurfacing prosthesis in 80%, a hemiprosthesis in 13% (3% biocompartmental) and a hinge prosthesis in 7%. Eighty per cent of patients receiving the resurfacing prosthesis were satisfied and, in addition, 8% improved at prospective follow-up examinations one to 5 years postoperatively. The subjective results showed good correspondance with the clinical and roentgenologic assessments. The joints reconstructed with the total resurfacing prosthesis were free from effusion or any inflammatory activity in 96%, stable in 88%, and showed full correction of deformity in 84% while 16% showed a fixed flexion of 10 degrees up to 20 degrees. Walking ability with regard to the need for walking aids was considerably improved. So far, 2% of the knees have had the prosthesis removed and a fusion performed; one per cent because of primary deep infection and the other one per cent because of late deep infection. Four per cent of the cases have shown loosening of the tibial component, necessitating reoperation. | |
| 6587852 | DR antigens and gold toxicity in white rheumatoid arthritis patients. | 1984 Jun | An increase in the frequency of DR3 in rheumatoid arthritis (RA) patients exhibiting toxic reactions to chrysotherapy has been reported in several studies of white patients. This study was designed to compare DR antigen frequencies in local white RA patients undergoing chrysotherapy with their response to treatment. The results from our sample of RA patients (n = 148) confirm the fact that there is increased frequency of DR3 in patients who develop toxic reactions to gold therapy, as reported in other studies of white patients. The DR3 increase was attributable to those gold-treated patients who developed proteinuria, and was not observed in patients who developed skin toxicity. Interestingly, the associations were not as strong as those found in other reports. Only 21.1% of the patients with DR3 manifested toxic reactions overall, with only one-third of the patients with proteinuria being DR3 positive. There was also an association of toxicity, albeit not significant, with a decreased frequency of DR2, which is consistent with the suggestion that this phenotype may protect against adverse reactions to gold treatment. These results suggest that while DR3 is significantly associated with adverse response to gold treatment, the relationship is not as strong as that previously reported. Explanation of these differences remains to be elucidated. | |
| 886551 | Antirheumatic drugs, the ESR, and the hypohistidinemia of rheumatoid arthritis. | 1977 Spring | The longterm administration of prednisone and gold to patients with rheumatoid arthritis (RA), in doses that decreased the sedimentation rate (p less than 0.05), did not alter the serum histidine concentration (p greater than 0.5). In patients with RA receiving various combinations of aspirin, prednisone, and gold, the regression lines relating the serum histidine concentrations to the sedimentation rates had similar slopes but different elevations compared to patients receiving no anti-inflammatory drugs. In the patients receiving anti-inflammatory drugs, the regression lines were displaced so that in patients with similar serum histidine concentrations, the stronger the antirheumatic therapy, the less abnormal the sedimentation rate. These observations are consistent with the hypothesis that hypohistidinemia contributes to the pathogenesis of RA. | |
| 7406929 | A controlled study of plasma exchange in the treatment of severe rheumatoid arthritis. | 1980 Jul | To learn whether the removal of immune complexes from the circulation by plasma exchange could effect an improvement in disease activity in rheumatoid arthritis (RA) patients, we performed a controlled study of 20 patients, we performed a controlled study of 20 patients with severe progressive disease which had not responded to previous therapy. Ten patients (Group 1) were hospitalized, continued on their regular anti-inflammatory medication, and given a graded course of physiotherapy. A further 10 patients (Group 2) received the same treatment as the first group with the addition of a concurrent course of plasmapheresis. Clinical measurement of disease activity after treatment revealed little difference between the two groups with a statistically significant improvement in four measures in Group 1 and in five in Group 2. Laboratory studies suggested that the intensity of plasma exchange was sufficient to remove circulating immune complexes in these patients. Our results confirm that hospitalization in itself is of benefit in the treatment of acute exacerbations of rheumatoid arthritis. The marginal improvement achieved by the addition of plasma exchange in the management of these patients (despite the removal of circulating immune complexes) makes its short-term use of questionable value in the treatment of severe rheumatoid arthritis. | |
| 844411 | [The effect of treatment on circulating immune complexes in rheumatoid arthritis (author's | 1977 Mar 25 | Immune complexes were demonstrated by leucocyte phagocytosis assay in 37 of 55 patients with rheumatoid arthritis. After treatment with gold salts, penicillamine, alpha-mercaptopropionylglycine, immunosuppressive agents or levamisole a substantial fall or elimination of demonstrable circulating immune complexes occurred. In-vitro studies revealed that gold salts in therapeutic concentrations inhibited the phagocytosis of immune complexes, while other drugs - penicillamine, levamisole and all anti-inflammatory agents including corticosteroids - lack this effect. The reduction in circulating immune complexes under basic therapy may be due to a beneficial effect of these agents on the disease process itself. This test may, therefore, be of value in assessing the efficacy of drug treatment. | |
| 573377 | Cerebral amyloid angiopathy: possible relationship to rheumatoid vasculitis. | 1979 Oct | In three cases of cerebral amyloid angiopathy there was also a chronic cerebral vasculitis characterized by segmental fibrinoid necrosis, chronic adventitial inflammatory infiltrates, obliterative "endarteritis" and hyaline arteriolar change, resembling rheumatoid vasculitis. Two of these cases had rheumatoid arthritis, and one had unspecified "arthritis" at the onset of dementia. Both vasculitis and amyloidosis involved the leptomeningeal and cerebral cortical vessels. In the two autopsy-verified cases, the vascular disease was limited to the brain. In the third case, only a brain biopsy was available. Amyloid-containing neuritic plaques were present in the cerebral cortex in all three cases, but they were abundant only in one, which also showed numerous Alzheimer tangles. | |
| 7132810 | A hypothesis on the pathogenesis of rheumatoid and other non-specific synovitides based on | 1982 Jul | In early synovitides the tissue inflammatory cell reaction is often weak and sometimes absent, many alterations being consistent with nonvasculitic exudation (I). Increased permeability to protein may require little, if any, endothelial damage. In rheumatoid arthritis (RA) increased transfer of fluid and protein from vessels is not restricted to joints, suggesting that exudation is more liable to induce inflammation in joints than in other tissues of ambulant individuals (II). At least 17 vascular, rheological and other "primary" mechanisms may contribute to the formation of exudates; combinations of only a few of these may be required to produce joint effusions. Some mechanisms may explain why inflammation in RA favours joints (III). Joint effusions increase intra-articular hydrostatic pressure, contributing to synovial hypoxia, glycolysis and acidosis, which may be important "secondary" mechanisms in synovial inflammation (IV). Only a few of the "primary" mechanisms are strictly local ones, and RA may predominantly be a systemic disease dependent on combinations of minor aberrations in metabolic, endocrine and other functions (V). The combination of contributing mechanisms is not necessarily the same in two patients fulfilling the criteria for RA, and patients with clinically different types of synovitis may share pathogenetic mechanisms (VI). | |
| 6683802 | Seizures due to central nervous system rheumatoid meningovasculitis. | 1983 Aug | A patient with rheumatoid arthritis and seizures had rheumatoid meningovasculitis on brain biopsy. Infection was excluded as a cause of the seizures and cerebrospinal fluid abnormalities, which resolved with corticosteroids and azathioprine therapy. | |
| 6651368 | Clinical judgment in rheumatoid arthritis. I. Rheumatologists' opinions and the developmen | 1983 Dec | Opinions about the importance of various measures of disease activity in rheumatoid arthritis gathered from a survey of 20% of British rheumatologists showed a wide diversity for all clinical variables. 'Paper patients' have been developed as a method of investigating actual clinical decisions rather than expressed opinions. Assessments based on 'paper patients' correlate highly (r = +0.901) with those made on the equivalent real patients when seen in person. | |
| 6440982 | Radiographic evaluation of erosion in rheumatoid arthritis: double blind study of auranofi | 1984 Dec | PA radiographs of hands and wrists from a randomized 6 month study of auranofin (AF) vs placebo followed by 6 months of open AF were scored for progression of erosive disease by 2 independent readers. The readers were blinded both to treatment and sequence (month 0 vs month 12) of the films. The results of our study demonstrate a reduction in the advancement of erosive disease during AF therapy compared to placebo. | |
| 7378276 | Pathophysiological classification of Raynaud's phenomenon. | 1980 Jan | The main types of underlying mechanism in Raynaud's phenomenon were tested separately in thirty-six patients. Within each of three groups of patients who were clinically classified according to strict definitions as having primary Raynaud's disease, systemic sclerosis or rheumatoid arthritis, there was pathophysiological heterogeneity. It is therefore suggested that in studies of treatment, at least when it is aimed primarily at one pathophysiological mechanism, the patients whould be selected according to the mechanism rather than what is commonly done now, according to the associated disorder. | |
| 705268 | Posterior atlanto-axial subluxation in rheumatoid arthritis. | 1978 | A case of posterior atlanto-axial subluxation is presented, together with a survey of previously reported cases. The patient's history suggested affection of the vertebral artery, and involvement of the medulla, but there were no physical signs of such. The patient was treated with posterior atlanto-axial fixation with good results. | |
| 879867 | Relationship of radiological change to clinical outcome in rheumatoid arthritis. | 1977 Jun | Ninety-four patients with rheumatoid arthritis, seen within the first year after onset, have been followed prospectively with annual radiographs for a mean 63-1 months. An erosive arthropathy occurred in 72. The severity of the erosive changes showed a significant correlation with eventual clinical outcome. It is possible to predict a favourable outcome in those patients whose erosive changes become static at an early stage in the disease. | |
| 103180 | Gold treatment at an early stage of rheumatoid arthritis. | 1978 | The progression of erosive X-ray changes over a period of 5--6 years was evaluated in 39 patients exposed to a mean dose of 2030 mg aurothiomalate during the maintenance period. The cause for the low dose was the initial high incidence of side-effects. The progression of erosions was highest in patients with the low dose of gold in the initial stages of the disease. The best result in preventing development of erosions was achieved in patients with the high dose of gold in the early phase of the disease. It appears that gold treatment prevents the progression of the erosoins. The earlier the inception of treatment, the better the result. | |
| 1191345 | Studies on the infectious etiology of human rheumatoid arthritis. II. Search for humoral a | 1975 Sep | A total of 29 rheumatoid patients and 19 nonrheumatoid patients were tested for evidence of present or past infection by M pneumoniae, M hominis, M fermentans, M arthritidis, M pulmonis, and M hyorhinis. The techniques of lymphocye transformation, metabolic-inhibiting antibody test, and mycoplasmcidal antibody test indicated no significant difference in the response of rheumatoid as opposed to nonrheumatoid patients. | |
| 6586147 | A comparison of low dose levamisole and penicillamine in rheumatoid arthritis. | 1983 Dec | Levamisole (150 mg once weekly) was compared with penicillamine (250 mg daily) in a single blind independent observer study in 28 patients with rheumatoid arthritis over twelve months. Fifty percent (8/16) of patients stopped levamisole, five within three months of starting, while only two of twelve stopped penicillamine. In those patients able to tolerate treatment for twelve months, both regimens produced a significant and comparable reduction in disease activity, with the onset of action of penicillamine occurring at three months compared with six to nine months for levamisole. Radiological progression of disease occurred in both groups. Levamisole in low dose may improve parameters of disease activity in rheumatoid arthritis but poor patient tolerance, slow onset of action and failure to prevent radiological progression limit its usefulness. |