Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 366141 | Experience and recommendations for treatment schedule of levamisole in rheumatoid arthriti | 1978 | A review is presented of the different treatment regimens of levamisole used in rheumatoid arthritis (RA). A large double-blind EULAR multicentre trial has shown that the beneficial effects obtained with continuous (150 mg per day) and with intermittent (3 days per week, 150 mg) treatment are comparable in RA. Unfortunately with both regimens a high frequency of agranulocytosis was observed. Recent data of another double-blind trial have shown that a treatment schedule of 150 mg one day per week gives equally good results as both previous regimens. Furthermore regular control of white blood cell counts 10 hours after intake of the drug can detect early high risk patients for agranulocytosis. Results of longterm use of levamisole in RA are also presented and the different kinds of responses are discussed. Finally the authors propose a treatment scheme. This consists of one single weekly dose of 150 mg; if no response is obtained after 6 or at most 9 months, a final trial can be performed with two intakes of 150 mg each week. | |
| 6334741 | D-Penicillamine induced toxicity in rheumatoid arthritis: the role of sulphoxidation statu | 1984 Oct | Sulphoxidation of carbocysteine, a drug structurally similar to D-penicillamine, displays a skewed distribution within a population. In 66 patients with rheumatoid arthritis (RA) a significant association between impaired sulphoxidation and toxicity (p less than 0.001) was found; HLA-DR3, although associated with toxicity (p less than 0.05), appeared to be an independent risk factor of most importance in the group with extensive sulphoxidation. The relative risk of toxicity in a patient possessing either DR3 or impaired sulphoxidation was 25. The prevalence of poor sulphoxidizers within this group of RA patients was increased compared to that in a previous population study and requires further investigation. Our findings explain a number of the toxic phenomena associated with D-penicillamine administration in RA. | |
| 6723124 | Effects of D-penicillamine on inflammatory and immune reactions. | 1984 | The effects of D-penicillamine (D-Pen) in rheumatoid arthritis suggest that the drug may be anti-inflammatory and immunosuppressive. Paradoxically D-Pen therapy may also induce antibody formation, and autoimmune disease. D-Pen is not consistently effective in animal models of immune disease. It is weakly suppressive in cellular responses to mitogens, but has a more pronounced effect on macrophage-dependent mixed leukocyte responses. The drug has an inconsistent effect on various components of the inflammatory reaction but under certain circumstances inhibits oxygen radical generation by monocyte/macrophages. | |
| 125289 | Immune complexes in sera and synovial fluids of patients with rheumatoid arthritis. Radioi | 1975 Aug | Evidence for the presence of immune complexes in blood, synovial fluid, and tisues of patients with rheumatoid arthritis (RA) includes low complement levels in blood and effusions, deposition of immunoreactants in tissues and vessel walls, precipitate formation after addition of monoclonal rheumatoid factor (mRF) to serum or synovial fluid. To quantitate immune complex-like material in RA patients, we developed a radioimmunoassay based on inhibition by test samples of the interaction of (125I)aggregated IgG (agg IgG) and mRF coupled to cellulose. This method could measure immune complexes of human antibody with hemocyanine prepared in vitro. The assay was not influenced by presence of polyclonal RF in test samples, nor by freezing and thawing. Normal levels of immune complex-like material in serum were less than 25 mug agg IgG EQ/ML. 12 of 51 RA sera examined (26%) contained more than 25 mug/ml. The presence of this material in RA sera was found to correlate with severity of disease, as measured by anatomical stage and functional class. There was an inverse correlation of the material with serum C4 level. Rheumatoid synovial fluids generally contained higher levels than serum, and five of 23 contained very much higher levels. The frequency of elevated levels of immune complex-like material in sera of patients with systemic lupus erythematosus (2 of 29) and with miscellaneous vasculitides (2 of 21 was much lower than in RA, suggesting that mRF exhibits a specificity for only certain kinds of immune complexes. The reason for this apparent specificity may explain such distinctive features of RA as the high frequency of polyclonal RF, the lack of immune complex nephritis, and the generally normal levels of serum complement. | |
| 6141777 | Intestinal infarction in rheumatoid arthritis. Three cases due to unusual obliterative vas | 1984 Feb | During a ten-year period, we observed three patients with complicated rheumatoid arthritis (RA) and bowel infarction in which the distal mesenteric vessels were occluded by proliferative endarteritis characterized by intimal proliferation, without vessel wall necrosis or inflammation. Proliferative endarteritis was originally described in patients with RA and digital infarcts and has only rarely been noted in patients with visceral infarcts. Our three patients' pathologic features suggested that these vascular lesions were progressive and rendered patients vulnerable to bowel infarction during periods of decreased cardiac output. Two of the three patients had intestinal infarction without clinical or pathologic evidence of systemic vasculitis. Proliferative endarteritis of visceral arteries rarely causes morbidity and mortality in patients with RA. | |
| 6824507 | Anemia associated with rheumatoid disease. Inverse correlation between erythropoiesis and | 1983 Jan | Cell culture techniques were used to evaluate the number of erythroid colonies formed by circulating progenitor cells from 24 patients with rheumatoid disease and controls. A highly significant inverse correlation was demonstrated between erythroid colony counts and serum IgM and rheumatoid factor concentrations in the rheumatoid patients. The potential role of these factors in the pathogenesis of the anemia of rheumatoid disease is discussed. | |
| 6678697 | Joint fluid leukocytosis of patients with rheumatoid arthritis evidence for neutrophil and | 1983 Sep | The cell picture of the synovial fluid of fourteen patients with rheumatoid arthritis was studied in smears contrasted with the May-Grünwald-Giemsa stain. The cytology was dominated by neutrophils, many with signs of necrobiosis. The mononuclear cells displayed signs of proliferation and differentiation. Comparison with the immobile erythrocyte provided evidence that the accumulation of leukocytes in the synovial fluid of patients with rheumatoid arthritis was due to active leukocyte migration, presumably stimulated random movement and chemotaxis. | |
| 7079867 | Severe airway obstruction associated with rheumatoid arthritis and Sjögren's syndrome. A | 1982 May 1 | Numerous pulmonary complications associated with rheumatoid arthritis (RA) and Sjögren's syndrome (SS) have been described. Mild airway obstruction has recently been recognized in these disorders, severe obstruction occurring in only a few patients with RA. We report a patient with RA and SS who developed severe irreversible airway obstruction, an association not hitherto described. The airway disease failed to respond to bronchodilators, steroids or immunosuppressive agents. | |
| 525065 | Synovial nature of pathologic periarticular structures, including subcutaneous nodules. de | 1979 Sep | In the embryo the periarticular fibroblasts were the producers of the greater part of the joint they surround in later life, as well as of the tendon sheaths and bursae. It is postulated that adult fibroblasts have retained atavistic arthrogenic properties, and may react to traumatizing, inflammatory and oncogenic stimuli by forming periarticular joint-like structures: "arthromas" such as ganglia, meniscal cysts, synovial cysts, synovial sarcoma and subcutaneous nodules. The arthroid nature of these growths manifests itself by the presence of a central cavity, which can be identified as a synovial cavity by histologic, histochemical and electron-microscopic methods. In case of affection of the joint all of these adnexa may be involved. A resemblance of these structures to embryonic joint tissues has been noted for years. The nature of the subcutaneous nodule is discussed at some length. It may contain one or more synovial clefts; synovial elements may be found in its centre by histochemistry and electron-microscopy. Recent and personal findings shed a new light on palisading cells, which may be fibroblasts, having taken up again their embryonic task as synovioblasts. From periarticular fibroblasts thus three kinds of tumors may arise; benign (ganglia, cysts, subcutaneous nodules), malignant (synovial sarcoma) and "semi-malignant" (pannus in rheumatoid arthritis). | |
| 1085148 | Serum antibody in rheumatoid arthritis reactive with a cell-associated antigen. Demonstrat | 1976 Jul | A cell-free extract of human diploid B lymphocytes (Wil2) in continuous culture was used as the source of antigen in immunodiffusion to detect a precipitating antibody referred to as rheumatoid arthritis precipitin (RAP) in sera of patients with rheumatoid arthritis (RA). The prevalence of RAP was determined in various arthritides and other connective tissue diseases. It was found in 67% of patients with seropositive RA and in 62% of patients with Sjögren's syndrome associated with RA. But its frequency was lower in many other connective tissue diseases, including seronegative RA and Sjögren's syndrome without associated RA. Matching sera and synovial fluids from patients with seropositive RA were also studied. Differences in serum and synovial fluid RAP titers were demonstrated, but generally when RAP was present in serum, it was also present in synovial fluid and vice versa. Indirect immunofluorescence (IF) with Wil2 cells as substrate was used to demonstrate RAP and to determine morphologically the nature of the reactive cellular antigen. When cells were treated with commonly used fixatives, little or no staining with RAP positive sera was observed. This outcome was shown to be the result of the extreme solubility of the cellular antigen reactive with RAP. The antigen was retained best in a reactive form in Wil2 cells after fixation of cells with dry heat at 37 degrees C for 30 minutes, and it was demonstrated by IF staining as small round granules distributed in the nucleus and cytoplasm. IF was also employed to demonstrate that RAP is immunoglobulin belonging to IgG and IgM classes and not to IgA or IgD. | |
| 1058293 | Surgical correction of temporomandibular joint arthritis. | 1975 Oct | Restoration of the contour of the articular eminence with a prosthesis has been successful when chronic sublaxation has resulted from flattening of the eminence. Use of a prosthesis is helpful in the treatment of patients with arthritic disease of the temporomandibular joint. A careful differential diagnosis is necessary to eliminate other possible causes of the patient's symptoms. | |
| 6859961 | Evidence for an association between rheumatoid arthritis and autoimmune endocrine disease. | 1983 Jun | Evidence is presented for the first time of a significantly increased prevalence of type 1 (insulin-dependent) diabetes in the close relatives of patients with rheumatoid arthritis. Thirty-nine (13%) of 295 patients with classical or definite rheumatoid arthritis had a first or second degree relative with type 1 diabetes and 38 (13%) had a close relative with autoimmune thyroid disease. These findings could be compatible with a possible common genetically determined mechanism of susceptibility to both diseases. | |
| 6670495 | Synovectomy with resection of the distal ulna in rheumatoid arthritis of the wrist. | 1983 Oct | Wrist synovectomy with resection of the distal ulna was performed in 47 cases, where rheumatoid affection in the wrist joint caused visible capsular swelling, pain and reduced range of motion. At follow-up after a mean observation time of 33 months, 31 cases had complete pain relief, eight cases had moderate pain relief. In eight cases pain during wrist motion was unchanged at follow-up and in five of these, recurrence of capsular swelling was noted. The range of motion (both supination/pronation and vola- and dorsiflection) was significantly improved, as was the subjective assessment of function. The radiographic findings showed progression in 41 cases. Deviation in the wrist was unchanged. In three cases reoperations were performed and one case had spontaneous rupture of the 4th and 5th extensor tendons 1 month postoperatively. In 15 cases dislocation of the extensor carpi ulnaris tendon in volar direction by rotational movement was noted. Stability was good in all cases and no serious postoperative complications occurred. Wrist synovectomy with resection of the distal ulna is recommended in cases where regular medical treatment has been attempted for a minimum of 6 months without successful results. | |
| 664948 | [Synovectomy of the cubital joint in rheumatoid arthritis (author's transl)]. | 1978 | 46 patients underwent synovectomy of the cubital joint for rheumatoid arthritis during the last seven years (1970 to 1977). 38 patients were followed up. The articular function improved in 71%, pain had been eliminated in 55%, no effusion was any longer present in 71%. In advanced stages of the disease resection of the head of the radius generally is performed because it facilitates surgery and improves the articular function later on. Synovectomy is recommended at an early stage. | |
| 7125712 | High-dose intravenous methylprednisolone in rheumatoid arthritis. | 1982 Oct | Fourteen patients with severe rheumatoid arthritis (RA) were given 27 courses of methylprednisolone intravenously, each of 3 infusions of 1 g on alternate days. After 7 days there was marked improvement in clinical state and most laboratory tests; levels of ESR and 4 serum acute-phase proteins, C3, C, IgG, and IgA, fell significantly. Serum IgM and rheumatoid factor titre were unchanged. 125I C1q binding fell in all instances where it was initially raised. Clinical remission lasted a mean of 10 weeks. Serum C-reactive protein (CRP) fell to less than 30 mg/l after all courses except one within 7 days and rose above this figure after a mean of 7 weeks. The ESR fell below 30 mm/h within seven days in 17 courses and remained below this value for a mean of 7 weeks. Three patients had clinical remissions, with serum CRP less than 30 mg/l and ESR less than 30 mm/h, lasting more than 42 weeks. | |
| 6696520 | Free thiomalate in plasma and urine of patients receiving sodium aurothiomalate. | 1984 Feb | Free thiomalate is measureable in the plasma and urine of patients with rheumatoid arthritis receiving sodium aurothiomalate (Myocrisin). Plasma concentrations and urinary excretion of free thiomalate were measured in 8 patients by high-performance liquid chromatography and electrochemical detection. After an initial intramuscular dose of 20 mg sodium aurothiomalate, free thiomalate was detected in plasma within 15 min, peak levels of up to 600 nmol/l occurring at 30 min. Plasma levels declined rapidly thereafter. During the first 24 h between 2 and 16% of the injected dose of aurothiomalate was recovered in the urine as free thiomalate, maximum excretion occurring during the first hour. | |
| 1014623 | [Serum complement level (C'H5O) during treatment of rheumatoid arthritis patients]. | 1976 Dec | Decreased total complement serum level (C'H50) was established in 72 per cent of the 78 patients examined, associated most likely with the developing processes of antigen-antibody reaction and the severe course of the illness. The applied treatment with different antirheumatic remedies, according to their mechanism of action, determined the respective changes in the complement level. Indomethacinum and chinoline derivatives induce complement values elevation, whereas the corticosteroids, salicylate and pyrazolone preparations lead to the complement values normalization. | |
| 109054 | Whole body elemental composition during drug treatment of rheumatoid arthritis: a prelimin | 1979 Apr | Thirty-two female patients with rheumatoid arthritis were divided into 3 groups and treated for 6 months with prednisolone, depot tetracosactrin, or indomethacin. Their whole body content of calcium, phosphorus, and nitrogen was measured before and after 3 and 6 months' treatment by in-vivo neutron activation analysis. No significant changes in these body elements were observed as a result of the treatments. The average amounts of calcium, phosphorus, and nitrogen were lower than normal in these patients, a finding consistent with the frequent observation of osteoporosis and muscle wasting in rheumatoid arthritis. | |
| 2865931 | Raised serum alkaline phosphatase and aspartate transaminase levels in two rheumatoid pati | 1985 Nov | Hepatotoxicity is a rare complication of sulphasalazine therapy in ulcerative colitis. This report describes two rheumatoid patients in whom raised serum levels of liver enzymes occurred soon after starting sulphasalazine treatment for their arthritis. In both cases the serum enzyme levels returned to normal after stopping the drug. Drug-induced hepatotoxicity should be considered in patients with rheumatoid arthritis (RA) who develop raised serum levels of liver enzymes while taking sulphasalazine. | |
| 6146296 | Circadian variation in biochemical assessments used to monitor rheumatoid arthritis. | 1984 Jun | Circadian variation has been demonstrated in several clinical parameters used to assess disease activity in rheumatoid arthritis, but circadian variation in modern laboratory assessments has not been studied in depth. We therefore made 2-hourly measurements of plasma viscosity, C-reactive protein, total serum sulphydryl, and serum histidine on samples obtained over a 24-hour period from 6 patients with classical or definite rheumatoid arthritis. Hourly control samples were also taken from 6 normal volunteers, 3 of whom starved from 2200 h the previous night and 3 of whom ate normally. There was no significant variation in any of these laboratory measurements between 0900 and 1800 h either in patients or controls. These findings enable us to eliminate circadian variation as a source of error when using these laboratory tests in clinical trials of slow-acting anti-rheumatoid drugs. |