Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2186885 | Immune abnormalities in the pathogenesis of juvenile rheumatoid arthritis. | 1990 Mar | This article reviews the immune abnormalities involved in the pathogenesis of juvenile rheumatoid arthritis (JRA). We review both the humoral and cellular immune systems of children with JRA with emphasis on the possible role of these immune abnormalities in the pathogenesis of JRA. | |
| 2796883 | [Selective deficit of IgA and infantile rheumatoid arthritis. Case reports]. | 1989 May | Three children with selective deficiency of serum IgA associated with oligoarticular juvenile rheumatoid arthritis (JRA) are presented. Before the appearance of JRA, all 3 children had shown frequently some respiratory infections. Indeed IgA deficiency may be asymptomatic or may cause a higher frequency of respiratory, gastrointestinal, allergic or autoimmune diseases, among which, JRA is one of the most important conditions. | |
| 1990111 | Chronic pain and the child with juvenile rheumatoid arthritis. | 1991 Jan | This article presents a summary of nursing issues concerning the assessment and management of pain in children with juvenile rheumatoid arthritis (JRA). Following a brief description of the difference between acute and chronic pain and a description of JRA, the developmental issues relating to pain assessment in this population are discussed. Three pain assessment tool alternatives are presented. Finally, current strategies for pain relief and treatment of children with JRA are presented. | |
| 2885990 | [Therapy of juvenile chronic arthritis with sulfasalazine]. | 1987 Mar | Sulfasalazine was used as second line agent in 15 children with different forms of rheumatoid arthritis. In 9 cases amelioration could be achieved with respect to clinical symptoms as well as laboratory parameters. Thus, sulfasalazine can be recommended as basic medication also in juvenile rheumatoid arthritis. | |
| 3486077 | Juvenile rheumatoid arthritis in Turner's syndrome. | 1986 Jan | An increased risk for autoimmune diseases has been recognized in Turner's syndrome (T.S.). However autoimmune rheumatic or connective tissue disorders have not been described. We report here on a 8-8/12 year old caucasian girl with T.S. and Juvenile Rheumatoid Arthritis (JRA). The hypothesis that the association is more than casual is discussed. | |
| 3281608 | Autoantibody profile in juvenile chronic arthritis. | 1988 Mar | Patients with juvenile chronic arthritis (JCA) may be subdivided into a minority, who carry IgM rheumatoid factor and have erosive polyarthritis resembling adult rheumatoid arthritis, and the majority (90%), who are seronegative by conventional means. Between 30 and 60% of patients with JCA have positive antinuclear antibodies (ANAs) according to the choice of substrate for indirect immunofluorescence. The importance of ANAs is the frequent development of associated asymptomatic chronic iridocyclitis, which may impair vision causing worse handicap than the arthritis, which remains predominantly pauciarticular in two thirds of these young children. ANA positive patients rarely possess antibodies to deoxyribonucleic acid (DNA) or extractable nuclear antigens (ENA), and current studies suggest that several different nuclear antigens, including histones, may be involved. | |
| 2795398 | Family variables and disease management in juvenile rheumatoid arthritis. | 1989 Sep | Examined the relationship between family functioning and regimen knowledge, medication compliance, and disease activity for children with juvenile rheumatoid arthritis. A strong relationship was found across several measures of family functioning and a self-monitoring index of medication compliance. Family functioning was not related to regimen knowledge or disease activity. The implications of these findings for the continued study of chronically ill children are discussed. | |
| 3234429 | Juvenile rheumatoid arthritis in two siblings with congenital leucocyte adhesion deficienc | 1988 Nov | A sister and brother with congenital leucocyte adhesion deficiency developed systemic-onset juvenile rheumatoid arthritis (JRA). They showed polyarthritis, spiking fever, reddish eruptions, anaemia, hepatosplenomegaly, increased erythrocyte sedimentation rate, and positive rheumatoid factor. Occurrence of JRA in our patients was thought to be mainly due to a combination of recurrent bacterial infections and abnormal lymphocyte function as a consequence of membrane adhesion-protein deficiency. In view of the familial occurrence, hereditary factors may have played a role in the development of JRA in our patients. | |
| 2403404 | Magnetic resonance imaging of articular destruction in juvenile rheumatoid arthritis. | 1990 Sep | We describe herein magnetic resonance imaging of the right knee of a patient affected by a severe form of juvenile rheumatoid arthritis. Magnetic resonance imaging findings of articular damage of the knee during the disease course and after arthroscopic synovectomy are described. | |
| 2261713 | Prevalence of IgM, IgA and IgG rheumatoid factors in juvenile rheumatoid arthritis. | 1990 Sep | Using an enzyme immunoassay, sera from 50 children with juvenile rheumatoid arthritis (JRA) and 39 controls were tested for IgM, IgA and IgG rheumatoid factors (RF). RF of the IgM and IgA isotypes were present in 11 (22%) patients, but in only one control (p = 0.008). IgG RF was present in the sera of 2 (4%) patients and in none of the controls (p = 0.21). Of the 22 patients with IgM RF or IgA RF, only 3 sera (14%) contained RF of both isotypes. IgM RF was more common in patients with polyarticular disease, while IgA RF was more common in patients with pauciarticular disease. These results indicate that IgM and IgA RF are present in a significant minority of JRA patients and suggest that there is independent expression of the respective RF isotypes. | |
| 2213760 | Prevalence and concentration of IgM rheumatoid factor in polyarticular onset disease as co | 1990 Jul | The prevalence and concentration of IgM rheumatoid factor (RF) in children with juvenile rheumatoid arthritis (JRA) and its major disease onset groups remains uncertain. In our study enzyme linked immunoabsorbent assay (ELISA) of 68 children with active JRA showed IgM RF in the area of 67% (16/24) of those with polyarticular onset disease, 26% (7/27) of those with systemic onset disease, and 6% (1/17) of those with pauciarticular onset disease. The median IgM RF concentration was 50-fold higher in polyarticular disease compared to systemic disease. The prevalence of IgM RF in polyarticular disease was greater in those with severe disease (functional classes and 3 and 4), with 90% (9/10) seropositive. By agglutination assay, the prevalence of IgM RF in JRA was significantly less than by ELISA, with 33% of the polyarticular group positive for IgM RF, and none of the systemic group positive, Relatively low concentration IgM RF similar to that seen in systemic JRA was also found in high prevalence in the area of children with non-JRA, systemic rheumatic disease (n = 8). In summary, our study shows by ELISA that high concentrations of IgM RF are found essentially only in the sera of children with polyarticular onset JRA and especially in those with severe disease. | |
| 3718567 | The relationship between ocular and articular disease activity in children with juvenile r | 1986 Jun | The onset patterns and disease courses of children with juvenile rheumatoid arthritis and uveitis were reviewed to establish correlations. Results indicated that although the disease activity of arthritis and uveitis may at times run a parallel course, it is more common for the activities to be independent. | |
| 3731573 | Insufficiency-type stress fractures in rheumatoid arthritis: report of an interesting case | 1986 Apr | A case of multiple insufficiency-type stress fractures (32 fractures), in the absence of any trauma, in a 51-year-old white woman with rheumatoid arthritis is described. The fractures healed satisfactorily with rest, treatment of osteoporosis, and discontinuation of her steroid therapy, following which a proximal humeral and total knee arthroplasties were successfully performed. The factors contributory to the development of stress fractures in rheumatoid arthritis are discussed, the literature is reviewed, and the salient features of our case are highlighted. | |
| 2619529 | Spondyloepiphyseal dysplasia associated with progressive arthropathy. An unusual disorder | 1989 | A family is presented with three affected siblings suffering from a rare form of spondyloepiphyseal dysplasia with progressive arthropathy affecting most joints of the body except for the craniofacial skeleton. This syndrome, probably of autosomal recessive inheritance, clinically presents diffuse and chronic joint involvement and should be differentiated from juvenile rheumatoid arthritis and other rheumatic disorders. | |
| 3628761 | Juvenile rheumatoid arthritis: assessment with MR imaging. | 1987 Oct | Thirty-three joints of the appendicular skeleton in 15 children with juvenile rheumatoid arthritis were examined with magnetic resonance (MR) imaging to determine if it could demonstrate synovial hypertrophy and status of the articular cartilage. Presumed synovial hypertrophy was seen in 13 joints as masses of varying sizes of low to intermediate signal intensity on T1- and T2-weighted images; sometimes foci of increased signal intensity, most likely due to fluid or inflammation, were seen on T2-weighted images. Probable abnormal articular cartilage was detected in ten joints, and MR imaging also demonstrated epiphyseal overgrowth, bone erosions, joint effusions, and joint space narrowing. Because MR imaging appears to provide an objective method of evaluating both synovial hypertrophy and status of articular cartilage, it may prove to be useful in monitoring progression of juvenile rheumatoid arthritis and response to therapy. | |
| 3485433 | A study of classification criteria for a diagnosis of juvenile rheumatoid arthritis. | 1986 Feb | Criteria for the classification of juvenile rheumatoid arthritis were analyzed in a detailed database of 250 children in order to assess the accuracy of diagnosis and validity of onset types and course subtypes. A number of conclusions have been derived from this study: All definitions of the 1973 criteria for classification of juvenile rheumatoid arthritis should be retained. The addition of onset types to the 1976 revision of the criteria has been validated. The course of the disease after the onset period of 6 months is as important to the outcome of a group of children as is the onset type. The current classification should be broadened to include the course subtypes. | |
| 2208878 | Total hip and knee arthroplasty in juvenile rheumatoid arthritis. | 1990 Oct | Total hip or knee arthroplasty is indicated in patients with juvenile rheumatoid arthritis when there is marked functional impairment and/or severe disabling pain from advanced structural hip or knee joint involvement. Relief of pain and dramatic improvement in function can be achieved in most patients. When both the hip and knee are involved, hip arthroplasty should probably be done first. Regional anesthesia is preferable. Careful preoperative planning is essential because custom prostheses are often required. Small bone size, osteoporosis, and soft-tissue contractures make the surgery technically demanding. Skeletal immaturity is not an absolute contraindication to surgery. Component loosening is the most frequent late complication in hip arthroplasty. It is less common in condylar metal-to-plastic knee arthroplasty in which patellar complications predominate. Cementless arthroplasty has an evolving role in the patient with juvenile rheumatoid arthritis and, to date, is more often used in the hip than in the knee. | |
| 27657417 | Gastric ulcers and rheumatoid arthritis. | 1990 Sep 19 | Reduced production of epidermal growth factor in saliva might contribute to a susceptibility to gastric ulceration in patients with rheumatoid arthritis (RA) and patients with the sicca syndrome might be a particularly at risk sub-group. | |
| 20144113 | Muramidase (lysozyme) in joint fluid and serum of rheumatic patients. | 1987 | The muramidase activity of serum was studied in 27 cases of rheumatoid arthritis. The enzyme activity in rheumatoid serum (mean 11.0 mug./ml.) did not differ significantly from that in the 30 healthy controls (mean 9.4 mug./ml.). The muramidase activity in the synovial fluid of 36 rheumatoid arthritis patients was markedly elevated (mean 20.2 mug./ml.). In osteoarthritic synovial fluid (8 cases) the muramidase activity was low (mean 8.0 mug./ml.). No correlation was found between the total white blood count and the muramidase activity in rheumatoid synovial fluid. A positive relationship was observed between the enzyme activity and the total protein concentration. The elevated concentration of muramidase in synovial fluid of rheumatoid arthritis patients is interpreted as evidence of increased release of hydrolytic lysosomal enzymes. It remains to be shown which type of synovial fluid leukocytes produces the enzyme in question. | |
| 1870588 | [TMJ in subjects with juvenile rheumatoid arthritis: functional and cephalometric analysis | 1991 May | The Authors studied 21 patients affected by Juvenilis Rheumatoid Arthritis. The TMJ compromission was evaluated by un objective, clinical and radiographic examination. A teleradiographic with cephalometric analysis was also performed to all subjects. The results show a greater TMJ compromission in earlier arisen disease subjects. |