Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3675383 | Juvenile rheumatoid arthritis in Auckland: a long term follow-up study with particular ref | 1987 Jun | Although features of juvenile rheumatoid arthritis (JRA) have been well described in British, American, and to a lesser extent Australian communities we can find no previous study of the clinical characteristics of this disease in a New Zealand population or indeed in any population containing Polynesians. In a follow-up study of 55 Auckland residents with juvenile rheumatoid arthritis, current information was obtained for 78% of the study group with a mean interval from disease onset to follow up of 9.3 years. The outcome for the group as a whole was excellent although patients with a polyarticular course, regardless of onset subtype, had a poorer outcome with respect to both ongoing disease activity and functional disability. Polynesian patients were represented in all onset subtypes in proportion to their frequency in the general community and there was no recognisable influence of race on the course of the disease. Despite careful ophthalmological examination only one case of mild uveitis was detected, a much lower incidence than in British and American reports. | |
| 1949090 | [Craniofacial characteristics of children affected with juvenile rheumatoid arthritis]. | 1991 Nov | The aim of this investigation was to determine the craniofacial characteristics of children affected with juvenile rheumatoid arthritis. The analysis concerned the profile cephalometric roentgenograms of 11 children of both sexes aged between five and ten years. Statistically significant differences between affected and healthy children were found for saddle angle, articular angle, Björk's sum of posterior angles and maxillo-mandibular angle. | |
| 1845406 | Serum lipid concentrations in juvenile rheumatoid arthritis. | 1991 | Plasma lipid parameters were measured in 99 children with Juvenile Rheumatoid Arthritis and compared with a large age-matched healthy control group. All measurements were made in the same laboratory. Changes in cholesterol levels were found, some levels increased, some decreased. The triglyceride levels were significantly higher. Most marked changes in triglyceride level were observed in patients with changes in the kidneys and amyloidosis. | |
| 1764842 | Correlation of antiperinuclear factor with antibodies to streptococcal cell-wall peptidogl | 1991 Nov | Antiperinuclear factor (APF) has been noted in most seropositive rheumatoid arthritis (RA) and juvenile rheumatoid arthritis (JRA) patients. The nature of the antigen is unknown; however, there are some suggestions that it might be a glycoprotein or proteoglycan. We studied the correlation of APF with antiproteoglycan antibodies and the reactivity of IgM-rheumatoid factor (RF) with the perinuclear antigen. Ten serum samples were separated to IgG, IgM, and IgM-RF enriched fractions. In seven samples, APF was found in the IgG fraction. Only 4 had APF in their IgM rheumatoid factor (RF)-containing fraction. In two of these, APF activity was present solely in the IgM RF fraction and was inhibited by pre-incubation with IgG. Fifty-five JRA patients' sera were also tested for the presence of antibodies to Streptococcal cell wall peptidoglycan-polysaccharide polymers (PG-PSP). 76% of the APF-positive sera were anti-PG-PSP positive and 59% of the APF-negative sera were also anti-PG-PSP negative. Furthermore, 75% of the APF-positive sera lost their APF activity following adsorption to Streptococcal cell wall PG-PSP. Our results show that in JRA sera APF are polyclonal antibodies of both the IgG and IgM classes. Although the presence of APF correlates with RF positivity, and they sometimes may cross-react, many IgM RF-containing fractions do not show APF activity. However, the presence of APF does correlate with anti-PG-PSP positivity and the data suggest cross-reactivity between these two antibodies. This implies antigenic similarity between Streptococcal cell wall PG-PSP and the perinuclear antigen. | |
| 3257872 | Characteristics of responders and nonresponders to slow-acting antirheumatic drugs in juve | 1988 Jan | A 12-month double-blind, parallel, randomized, placebo-controlled multicenter trial of D-penicillamine and hydroxychloroquine was conducted in 162 children with juvenile rheumatoid arthritis in the United States and in the Union of Soviet Socialist Republics. No statistically significant intergroup differences were detected in primary outcome variables. We investigated the possible existence of select subgroups of patients who have a higher likelihood of response to active drugs than to placebo. Using previously published criteria, each patient was classified as a responder or nonresponder, and their demographic and disease characteristics at baseline were compared. We were unable to identify a subgroup of individuals who were more likely to respond to D-penicillamine or hydroxychloroquine than to placebo. | |
| 3562339 | Anti-immunoglobulin antibody detection in adjuvant arthritis by an ELISA technique. | 1986 Dec | Sprague-Dawley rats, injected in the hind paw with heat-killed mycobacteria dispersed in oil, develop a severe polyarthritis. In this paper, we detected and quantified by a micro-ELISA technique autoantibodies against immunoglobulins in rats with adjuvant arthritis. Increased total anti-immunoglobulin antibodies levels were found from 3 days after induction and remained elevated until day 42. IgG anti-immunoglobulin antibodies in arthritic animals were significantly elevated during days 35-42. These results show that alterations in the humoral immune response (synthesis of anti-immunoglobulin antibodies) are present in adjuvant arthritis as they are in human rheumatoid arthritis. | |
| 2485752 | [The liver in juvenile rheumatoid arthritis]. | 1989 Sep | Hepatic involvement in juvenile rheumatoid arthritis of the systemic type (JRA) is a diagnostic challenge because of the varied clinical picture it presents. We describe a 21-year-old woman in whom JRA had started at the age of 4 years as an illness resembling familial Mediterranean fever. This long-standing illness was complicated by liver damage and needle biopsy showed massive hepatic deposition of amyloid. It is possible that this patient may have developed JRA as a complication of familial Mediterranean fever. | |
| 3820206 | Stridor due to cricoarytenoid arthritis in pauciarticular onset juvenile rheumatoid arthri | 1986 Oct | A 2-year-old girl developed severe inspiratory and expiratory stridor 2 months after onset of pauciarticular juvenile rheumatoid arthritis (JRA). Direct laryngoscopy demonstrated that both vocal cords were immobile and approximated to each other in the midline secondary to arthritis of the cricoarytenoid joints. High dose corticosteroid therapy resulted in clinical and laryngoscopic improvement and tracheostomy was avoided. Cricoarytenoid arthritis can be a life threatening complication in JRA. Early institution of corticosteroids appears to be the treatment of choice. | |
| 2077471 | Juvenile rheumatoid arthritis (JRA). | 1990 Sep | A case of Juvenile Rheumatoid Arthritis in a 12-year-old girl is reported; the patient had been suffering since she was 2.5 years old. The diagnosis was made based on history, clinical symptoms, radiology and laboratory findings. The patient showed abnormalities of the eyes, namely left papillar atrophy and right papillar edema. Osteoporosis was found in the proximal area of the right and left ulna and radius as well as in the lateral epicondylus. Laboratory findings such as rheumatoid factor, LE cells and ANA were negative; the C3 was low; ASTO was within normal ranges and the serum creatinine was 2.3 mg%. When this paper was made the patient was still under outpatient treatment; complaints of arthralgia disappeared after she had been treated with aspirin. | |
| 2698069 | [Measurement and comparison of the rheumatoid factors class IgG, IgM and IgA in chronic ju | 1989 Dec | The rheumatoid factor (RF) was studied in 35 sera from 23 children with juvenile rheumatoid arthritis (JRA). The immunoglobulin class of RF was investigated and also its reactivity to both human and rabbit IgG. The RF of IgG class (IgG-RF) was more frequently positive than the IgM-RF and the IgA-RF. Nevertheless, against human IgG we found IgM-RF in the 51% of sera and IgA-RF in 48%, and against rabbit IgG in 65 and 37% respectively. All classes of RF were more frequent in rheumatoid patients than in normal controls (p less than 0.0005) although the IgA-RF increase was not significant in some groups. The specificity of the 5 RF types was always very high (92-100%). The sensibility ranged between 71% (IgG-RF against rabbit IgG) and the 37% (IgA-RF against rabbit IgG). Most sera simultaneously contained more than one class of RF. Against human IgG, the 37% had 2 classes. When we used rabbit IgG, the 31% had 3 classes and the 62% had 2 classes. The correlation of every RF class each other generally was very high (p less than 0.001). A correlation was also present in the seronegative and the systemic group, when we separately studied every clinic form. The ELISA allows detect positive IgG-RF and IgA-RF in seronegative cases by agglutination tests, therefore the seronegative concept must be reconsidered. The correlation among different RF classes are, frequently, very closed. | |
| 3331324 | Seronegative arthropathies in the foot. | 1987 Aug | It has been seen that involvement of the foot in the seronegative arthropathies forms a regular and varied part of the clinical picture. This is often quite different from that seen in rheumatoid arthritis; its components, whether in joints, periarticular structures, or as surface manifestations, may be characteristic enough to raise the diagnosis of 'spondarthritis'. The features described, though characteristic of the spondarthritides, are, however, not pathognomonic. Thus, the osteolysis in psoriatic arthritis also occurs in neuropathic arthritis (e.g. syringomyelia, leprosy), psoriatic periosteal changes may mimic osteosarcomatous proliferations, and the calcaneal enthesitis so typical of spondylitis, Reiter's disease and psoriatic arthritis, may also be seen in metabolic arthropathies. It should also be mentioned here that the severe erosive osteolytic changes leading to psoriatic arthritis mutilans may also be seen, albeit rarely, in rheumatoid arthritis. Ankylosis, too, is not totally confined to the spondarthritides, having also been reported in occasional patients with rheumatoid arthritis. Calcaneal erosions, sometimes envisaged as a spondarthritic feature, also occur in rheumatoid patients. Within the spondarthritis matrix, a striking overlap is seen in the pattern of arthritis. Thus, involvement of the feet in psoriatic arthritis and in Reiter's disease shows many similarities, particularly the tendency to involve IP joints in asymmetrical oligoarticular fashion. In the hindfoot, too, parallels can be drawn between the tendency to Achilles and plantar insertion enthesitis in ankylosing spondylitis and Reiter's disease. On the other hand, the arthropathies of the chronic inflammatory bowel diseases, ulcerative colitis, Crohn's disease, and Whipple's disease, share with Behçet's syndrome an asymmetrical involvement of knees and ankles, but relative freedom from foot involvement. Regarding the surface features in the foot of spondarthritides, there is overlap here, too. For example, the nail dystrophy of psoriasis can be indistinguishable from that of Reiter's disease, and pustular psoriasis in its severe form cannot be differentiated from keratoderma blenorrhagica, even at the histological level. Other surface manifestations affecting the lower limb in general distribution may spread to the feet and thus fall within the ambit of this discussion. Such features include the lesions of erythema nodosum, patches of pyoderma gangrenosum, and the tender cords of thrombophlebitis, all of which have a higher prevalence in seronegative arthritis than in seropositive disease.(ABSTRACT TRUNCATED AT 400 WORDS) | |
| 3709082 | Chronic salicylism in a patient with juvenile rheumatoid arthritis. | 1986 Apr | A patient who developed chronic salicylism associated with salicylate therapy for treatment of juvenile rheumatoid arthritis is described, and the clinical presentation and treatment of chronic salicylism are reviewed. A 5 1/2-year-old boy was receiving aspirin 150/mg/kg/day for treatment of juvenile rheumatoid arthritis. While on salicylate therapy, the patient developed tachypnea and became increasingly hyperthermic, lethargic, and disoriented. The patient developed a maculopapular rash, weakness, and a decreased level of consciousness during the 11 days before admission to the hospital. Physical examination and laboratory determinations revealed that the patient had hypoprothrombinemia, hypoglycemia, and severe hepatic encephalopathy secondary to long-term salicylate toxicity. The patient was treated for hypoglycemia, electrolyte imbalances, thrombocytopenia, and anemia and was discharged after 24 days. Diagnosing chronic salicylism with hepatic dysfunction was difficult because the symptoms are similar to those of stage I to stage II Reye's syndrome. Liver enzymes, including aspartate aminotransferase (also called SGOT), alanine aminotransferase (also called SGPT), alkaline phosphatase, and lactate dehydrogenase, may be elevated in juvenile arthritis patients with hepatic dysfunction. Liver dysfunction usually improves when salicylate therapy is discontinued. Supportive therapy should always be used in symptomatic patients. Children on long-term, high-dose salicylate therapy should be monitored closely, and baseline liver function tests should be performed. The clinical effectiveness of administering sodium bicarbonate in attempts to alkalinize urine and increase salicylate elimination is controversial. In patients with juvenile rheumatoid arthritis who develop chronic salicylism, careful analysis of the patient's medication history, laboratory values, and clinical presentation are necessary to rule out Reye's syndrome. | |
| 3560106 | Discoid meniscus presenting as juvenile rheumatoid arthritis. | 1986 Dec | Discoid meniscus is a mechanical lesion described as having little inflammatory reaction. We describe a child with lateral discoid meniscus misdiagnosed as juvenile rheumatoid arthritis (JRA). Synovitis responded to aspirin, but function gradually deteriorated with increasing flexion deformity until arthrotomy and meniscectomy. Histology showed intense inflammatory changes compatible with JRA. Clinical and laboratory clues to early diagnosis were the localized nature of the inflammation on physical examination, radiographs and bone scan. | |
| 1784038 | The radiology of juvenile rheumatoid arthritis. A review of the English language literatur | 1991 Dec | The radiologic abnormalities seen in patients with juvenile rheumatoid arthritis (JRA) include disturbances of growth, various types of joint destruction, abnormalities of bone density, periostitis, and soft tissue abnormalities. We review the English language literature, which deals with the radiologic abnormalities in general, and at specific sites. We also review briefly radiologic abnormalities seen in other organ systems. The role of the other imaging modalities in the assessment of JRA is discussed. | |
| 2520840 | [Myelogram in systemic juvenile rheumatoid arthritis]. | 1989 Nov | A retrospective study was done to evaluate bone marrow smears in seven children with systemic onset juvenile rheumatoid arthritis (JRA). Eosinophilia and monocytosis were found in all the patients and in five there also were increased proportions of mononuclear basophils. Anemia is common in this disease and erythroid hypoplasia was present in six cases. Four patients had increased numbers of plasma cells and three had histiocytes with hemophagocytic activity. We did not find hemophagocytosis, as reported before, in bone marrow smears of JRA patients. | |
| 3258919 | Antibody to ribonucleoprotein in pauciarticular juvenile rheumatoid arthritis. | 1988 Feb | Sera from 8 children with pauciarticular juvenile rheumatoid arthritis (JRA) were studied to determine the nuclear antigen to which antinuclear antibody (ANA) is directed. No patient had antibody to native DNA, nuclear histones, or saline soluble nuclear antigens. Trypsin treatment of the nuclear substrate abrogated ANA staining for all sera tested, while RNase treatment abrogated ANA activity for 6 of 8 sera. These results indicate that ANA in most patients with pauciarticular JRA is directed to a ribonucleoprotein that requires both RNA and protein moieties for antigenic integrity. | |
| 2776306 | [C-reactive protein in inflammatory articular diseases: comparison of concentrations in bl | 1989 Aug | We evaluated the diagnostic value of measuring C-Reactive Protein (CRP) in blood and in synovial fluid for the detection of inflammatory articular diseases in 154 patients. High concentrations of CRP in blood were found in microcrystalin arthritis, polymyalgia rheumatica and Horton's disease. Our results show a good correlation between CRP and erythrocyte sedimentation rate for ankylosing spondylitis (p less than 0.01), systemic lupus erythematosus (p less than 0.01), rheumatoid arthritis (p less than 0.05), polymyalgia rheumatica and Horton's disease (p less than 0.05). The CRP measurement in blood did not separate seropositive versus seronegative rheumatoid arthritis, systemic lupus erythematosus versus rheumatoid arthritis and treated versus non-treated rheumatoid arthritis. There was a good correlation between CRP concentration in blood and in synovial fluid but the concentration was lower in synovial fluid than in blood (p less than 0.01). Then, the CRP measurement in synovial fluid does not have a higher diagnostic value than in blood. | |
| 1993360 | Detection of human and murine common idiotypes of DNA antibodies in tissues and sera of pa | 1991 Feb | The expression in tissue and serum of a panel of murine and human common DNA antibody idiotypes (Ids) (BEG 2, PR 4, F-423, I-402, II-28, IV-228, V-88) has been investigated. The murine V-88 Id was detected in eight out of 10 and the human BEG 2 Id in five out of 10 labial biopsies from patients with Sjögren's syndrome. The murine F-423, I-402 and IV-228 Ids were identified in one out of 10 biopsies. In each case the pattern of staining was similar with staining of the acinar basement membrane and a cell population. Using double-labelling immunohistochemistry this cell population were identified as plasma cells. No staining was seen in four normal labial biopsies. The V-88 Id was detected on the epithelial aspect of the thickened basement membrane in three out of nine renal biopsies from patients with systemic lupus erythematosus (SLE). None of the other Ids (BEG 2, PR4, IV-228, F-423 or I-402) could be detected in renal tissue. None of the Ids were found in skin biopsies from SLE patients. Id V-88 may, like the 16/6 Id to which it is phenotypically related, play a role in the pathogenesis of renal lesions in SLE. The BEG 2 Id could be detected in the serum of patients with rheumatoid arthritis (RA) and active untreated tuberculosis. Ids II-28, V-88 and I-402 were elevated in serum from patients with Sjögren's syndrome and II-28 Id in serum from patients with myositis and RA. None of the Ids were elevated in serum from patients with SLE. Apart from the BEG 2 Id, none of the Ids were elevated in serum from patients with tuberculosis or Gram-negative infections. The presence of murine Ids in human tissue and serum suggests that they are cross-species idiotypes and have been conserved through evolution. | |
| 1754480 | [Psoriatic arthritis and celiac disease in childhood. A case report]. | 1991 Jul | A case of a girl followed up for 18 years is reported. At the age of two, the patient presented psoriasis and coeliac disease confirmed by biopsy and by laboratory data. She followed a coeliac diet and at the age of twelve she manifested a rheumatoid arthritis of the left knee without pain, confirmed by laboratory data (RA test, ANA test). In this period, the patient underwent another gastrointestinal biopsy after suspension of the diet; the structural alterations of the gastrointestinal tract being always present, she continued the diet associated with non steroidal antiphlogistic drug therapy for rheumatoid arthritis. The Authors remark the association of diseases, making a comparison with literature data and confirming the current hypotheses. It is interesting to observe that when the patient presented articular symptoms, there was the reappearance of the gastrointestinal symptomatology. Very interesting is the presence of psoriasis: in fact there is the problem whether this case is a psoriatic arthritis with coeliac disease or a juvenile rheumatoid arthritis with coeliac disease and psoriasis. At last, the Authors report the good results obtained by coeliac diet and non steroidal antiphlogistic drugs; a complete remission of articular symptoms and a good puberal and intellectual growth have been observed. | |
| 2767143 | The orthodontist in the team-treatment for children with rheumatoid arthritis. | 1989 May | In 160 children with rheumatoid arthritis (RA) functional and morphological disorders of the stomatognathic system were found in 65 per cent of the group. The functional TMJ examination revealed the early involvement of these joints. The age of children, the insidious and irreversible damage of the TMJ development and its consequences, indicate the need for functional treatment of these joints and associated malocclusions. Thus the orthodontist's participation in the team-treatment of children with RA, from the early periods of the stomatognathic system development is necessary. |