Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3617157 | Corticosteroids-salicylate interaction in a case of juvenile rheumatoid arthritis. | 1987 Jun | In an 11-year-old child with juvenile rheumatoid arthritis (JRA), the addition of prednisone caused a significant decrease in salicylate serum concentrations. A pharmacokinetic assessment suggested that these changes were not the result of altered compliance or impaired absorption of salicylate but rather an increase in salicylate clearance induced by the corticosteroid. | |
| 2481872 | [Comparative evaluation of the effectiveness of intra-articular therapy with contrical and | 1989 Jul | The paper analyses the results of intravascular therapy by contrykal (10 patients) and hydrocortisone (10 patients) in juvenile rheumatoid arthritis. High efficacy of treatment by contrykal was noted. | |
| 3375358 | Facial deformity of juvenile rheumatoid arthritis. | 1988 Jun | Arthritis of the temporomandibular joint and resulting deficient mandibular growth are seen in as many as 25 percent of patients with juvenile rheumatoid arthritis. The magnitude of joint involvement and resulting growth deficiency varies significantly. These patients typically develop a "birdface" deformity with retruding mandible, alteration of the cervicofacial angle, and class II occlusion with limitation of the bite opening. A multidisciplinary approach, including the surgeon, a dentist, an orthodontist, and a rheumatologist, is necessary to ensure a safe and successful surgical outcome. The side effects of pharmacologic agents used to control the disease on coagulation, healing, and bone density should be considered seriously. | |
| 3425283 | Hematogenous infection after knee arthroplasty. | 1987 Oct | Twenty-five hematogenously infected knee arthroplasties in 20 patients (17 with rheumatoid arthritis and 3 with arthrosis) were followed for 3 years. Staphylococcus aureus was the major infecting organism. Three patients with four arthroplasties died of sepsis. Two patients had removal of the arthroplasty, one of which resulted in an above-the-knee amputation. Four out of five arthrodeses fused. Two knees healed after early debridement and two healed without surgery. Ten knees had successful revision arthroplasty. Rheumatoid arthritis and constrained prostheses increase the risk of hematogenous infection. Any infection and especially cutaneous lesions in a patient with a knee arthroplasty should be treated vigorously. | |
| 2871188 | Sulphasalazine in the treatment of juvenile rheumatoid arthritis: a preliminary open trial | 1986 Feb | Sulphasalazine was administered to 18 patients with juvenile rheumatoid arthritis (JRA). The mean duration of therapy was 7.8 +/- 2.6 months. There was significant improvement in all clinical variables and erythrocyte sedimentation rate. Five children developed minor and transient side effects. Medication was discontinued in 3 patients: one because of leukopenia, 2 for lack of effect. These results suggest that sulphasalazine is an effective and relatively safe drug which may prove to be a useful second line agent in the management of JRA. | |
| 3500319 | Comparison of antinuclear antibody and rheumatoid arthritis factor test results between tw | 1987 Oct | Antinuclear antibody and rheumatoid arthritis factor test results were compared between two nearby hospitals of approximately the same size but with different patient populations. There were dramatic differences in percentage of positive results, titers, and patterns (for antinuclear antibody tests) between the two institutions. | |
| 3793893 | Factors relating to hip joint arthritis following three childhood diseases--juvenile rheum | 1986 Nov | This article discusses factors that relate to the prognosis for development of hip joint arthritis following juvenile rheumatoid arthritis (JRA), Perthes disease, and postreduction avascular necrosis in congenital hip dislocation (CDH). In JRA, the integrity of the articular cartilage determines prognosis. In Perthes disease, prognosis is strictly related to the shape of the hip. In postreduction avascular necrosis in CDH, half the patients have a prognosis primarily related to hip joint shape, and half have a prognosis apparently more related to the integrity of the articular cartilage. | |
| 1978760 | [HLA-DR positive T cells and CD45R positive CD4 cells in primary Sjögren's syndrome]. | 1990 Jun | In 55 patients with primary Sjögren's syndrome (PSJS), we studied on peripheral HLA-DR positive T cells, suppressor inducer (CD4 + CD45R) cell and helper inducer (CD4 + CDw29) cells by 2-color analysis using flow cytometry system. As shown in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), progressive systemic sclerosis and myositis, the rate of pheripheral HLA-DR positive T cells in PSJS (5.9% +/- 3.9) was significantly higher than in normal (1.6% +/- 1.1). The rate of CD4 +/- CD45R + cells in PSJS (12.8% +/- 6.1) and SLE (12.8% +/- 8.2) were significantly lower than in normal (16.6% +/- 3.9). With respect to the disease pattern of PSJS, the increase of HLA-DR positive T cell and decrease of CD4 + CD45R cell were recognized in patients with leucopenia, high titer of anti-RNP antibody and/or abnormal findings of sialography, and the decrease of CD4 + CD45R + cell was not recognized in patients with kerato-conjunctivitis sicca alone. In either SLE or RA, there were no correlations between the rate of T cell subsets (HLA-DR positive T cells and CD4 + CD45R cells) and the degree of salivary gland damage. T cell subsets in PSJS were useful indicators of disease severity and it is also useful for classifying PSJS into several subtypes. To analyze T cell surface markers in PSJS is very important for investigation of functions of lymphocytes in this disease. | |
| 1812557 | [Campylobacter pylori gastroduodenitis in children with juvenile rheumatoid arthritis]. | 1991 Jul | Clinico-morphological study of the gastroduodenal system and also morphometric investigations of the degree of gastroduodenitis activity and the condition of the local immune system were made in 30 children aged from 4 to 15 years with juvenile rheumatoid arthritis (JRA). Microbiological, histological and electron microscopic methods for revealing Campylobacter pylori (CP) were used. Interrelationship between various clinical manifestations of JRA with the nature of gastroduodenal system affection and with the incidence of microbial colonization of SP was determined. All the patients with JRA had lesions in the gastric and duodenal mucosa, and some morphological features were revealed in them. SP was diagnosed in 86.7 per cent. There was a relation between the microbial clonization of SP and the degree of the rheumatoid process activity. It is suggested that SP does not play an etiological role in the development of gastroduodenitis in JRA but may serve as a pathogenetic factor in the development of an erosive-ulcerous lesion. | |
| 3277687 | Outcome in juvenile arthritis. | 1988 | Juvenile chronic arthritis has a number of subtypes with only seropositive juvenile rheumatoid arthritis and systemic juvenile chronic arthritis having equivalents in adult life. In 75% of patients the inflammatory disease has subsided by adulthood, leaving some with degenerative and mechanical problems. Systemic, polyarticular and pauciarticular subgroups, based on mode of presentation, have been related to prognosis. Seropositive polyarticular disease behaves as an aggressive form of adult rheumatoid arthritis. Standard methods of assessment are inappropriate in children. Active joint score is most useful. Radiographs are difficult to interpret because of growth and lack of early erosive disease. Growth and social outcome is important. Death occurs in 7% of cases and is due to infection and cardiac involvement during active systemic disease, and due to secondary amyloidosis later. Slow-acting drugs and surgical procedures may alter outcome. The aetiology of these diseases remains unknown and there is a need for diagnostic tests, particularly to identify those children who will do badly. | |
| 1946625 | Physical therapy management of patients with juvenile rheumatoid arthritis. | 1991 Dec | Juvenile rheumatoid arthritis (JRA) is the most common pediatric rheumatic disease and is a leading cause of childhood disability. Physical therapists play a crucial role in the treatment of these children and serve as essential members of the interdisciplinary treatment team. An understanding of the etiology and background of this disease is critical to appropriate evaluation, goal setting, and treatment planning. This review article will provide an overview of the epidemiology, immune system pathophysiology, and clinical characteristics of JRA. Physical therapy principles of care, evaluation procedures, and treatment techniques will be covered in depth. In addition, common orthopedic manifestations and their management, including surgical approaches, will be discussed. | |
| 2388211 | Hepatic fibrosis with the use of methotrexate for juvenile rheumatoid arthritis. | 1990 Jun | Methotrexate (MTX) is currently under study for use in juvenile rheumatoid arthritis. One complication of MTX is hepatotoxicity. Although liver function tests may be abnormal with its use, in this setting they do not correlate well with the development of hepatic fibrosis. Periodic liver biopsy is required to monitor for the hepatotoxic changes secondary to MTX. We describe and discuss the case of a 17-year-old woman who developed evidence of hepatic fibrosis after 3 years of MTX therapy. | |
| 1755205 | [Evaluation of heart disease in rheumatoid arthritis using echocardiography]. | 1991 Jul | The authors examined, using one- and two-dimensional echocardiography, 95 patients with rheumatoid arthritis and 11 patients with lupus erythematodes generalisatus. They revealed acute and chronic changes on the pericardium, impaired left ventricular function and valvular changes in percentages which are not negligible. Although the problem of the aetiopathogenesis of these pathological changes is frequently speculative, their detection is of considerable importance for further treatment and the life-style of these patients. Echocardiography is a suitable method for the comprehensive examination of patients with rheumatoid arthritis, in particular when the course is severe or when patients of advanced age groups are involved. | |
| 1845414 | Arthroscopic synovectomy in the treatment of patients with juvenile rheumatoid arthritis. | 1991 | Since January 1982, operative arthroscopy in the knee joint has been performed by us to 22 patients with juvenile rheumatoid arthritis, by whom synovectomy was considered to be indicated. The age of the patients varied from 5 to 16 years. In general anaesthesia, in the connection of arthroscopy, the abrasion of the hypertrophic synovial membrane was made by Stryker's chondrotome. The surgical debris was evacuated by suction. The mobilisation of the knee joint was started 2 days after the operation, and most of the patients walked on the fifth postoperative day. The arthroscopic synovectomy is considered to be a safe operation and, in our opinion, a good alternative method for synovectomy. Rehabilitation time is decisively shorter and, if necessary, operative arthroscopy can easily be repeated, without disturbing scars. | |
| 2566114 | An Eco RI polymorphic site in the human complement C4 gene distinguishes juvenile rheumato | 1989 Apr | Susceptibility to acquire Juvenile Rheumatoid Arthritis (JRA) is linked to HLA-DR5 and DRw8 antigens in Caucasoid populations. However, the frequency of HLA-DR5 is too high in the normal Spanish population and JRA cannot thus be found to be associated with this antigen. It has been found a 14.3 kb-C4-Eco RI restriction fragment length polymorphism which correlates significantly with JRA and may be used as a marker for this disorder in Spaniards. | |
| 3261669 | The clinical associations of antinuclear antibodies in juvenile rheumatoid arthritis. | 1988 Oct | To clarify further the clinical correlates of antinuclear antibodies (ANA) in children with juvenile rheumatoid arthritis (JRA) this study compared the features of 60 ANA positive and 25 ANA negative children with JRA. ANA was more likely to be present in those with pauciarticular JRA than polyarticular JRA particularly if the ANA was of high titer. ANA positive subjects were more likely to have extraarticular manifestations, especially iridocyclitis. No significant differences were observed in onset ages, sex distribution, season of disease onset, family histories, or prognosis. There was no correlation between ANA titer and disease activity. Thus, while certain clinical features do correlate with ANA positivity in JRA, most clinical manifestations do not occur with distinctively different frequencies in the ANA negative and ANA positive groups. | |
| 3768057 | Incidence of arthritis in urban Finnish children. A prospective study. | 1986 Oct | The incidence of various types of arthritis in children was estimated by a prospective 1-year study in the greater Helsinki area (population under 16 years of age: 148,362). Patients were sought from primary care physicians, and 71% of the patients studied were seen within 1 week of the onset of symptoms. All patients received followup care for at least 3 months; patients whose symptoms were prolonged received followup care for a minimum of 2 years. The incidence per 100,000 children under 16 years of age was as follows: 108.5 for all cases of arthritis, 6.7 for septic arthritis, 5.4 for enteropathic arthritis, 51.9 for transient synovitis of the hip, 18.9 for prolonged arthritis (duration greater than 3 months), and 25.8 for acute transient arthritis. The incidence of juvenile rheumatoid arthritis was 19.6. Oligoarticular disease was prevalent (76%) among the juvenile rheumatoid arthritis patients. | |
| 2131310 | Progressive pseudorheumatoid chondrodysplasia simulating juvenile rheumatoid arthritis. | 1990 Nov | Four patients from a Muslim family with an inherited skeletal dysplasia are presented. It is more crippling than usual form of spondylo-epiphysial dysplasia tarda and the onset is very early in the life i.e. at 4 years. The disorder is progressive, crippling and has striking clinical resemblance to juvenile rheumatoid arthritis. The striking X-ray appearance is of platyspondyly and irregularities of capital femoral epiphysis. There is absence of any synovitis. Two of these patients are females aged 8 years and 18 years. The third patient is their cousin brother aged 6 years and their uncle who is of 50 years old and crippled. | |
| 3565875 | Popliteal cysts in a pediatric patient. | 1987 May | A 12-year-old boy with recurrent complaints of knee pain and swelling for six months, but without diagnosed rheumatological disease, presented with calf swelling and knee pain of several days duration. Examination revealed findings consistent with juvenile rheumatoid arthritis and a ruptured Baker's cyst. This is the sixth reported case of ruptured Baker's cyst reported in a child less than 14 years old and should alert emergency physicians that calf pain and swelling secondary to a ruptured popliteal (Baker's) cyst may be an early manifestation of juvenile rheumatoid arthritis. | |
| 2670253 | Importance of intestinal mucosal immunity and luminal bacterial cell wall polymers in the | 1989 Aug | The distal intestine contains bacterial cell wall polymers capable of inducing acute and chronic polyarthritis if systemically distributed. Parenteral injection of peptidoglycan-polysaccharide (PG-PS) polymers from certain bacterial species produces spontaneously relapsing erosive synovitis in susceptible rat strains, and normally subarthropathic amounts of PG-PS and lipopolysaccharide (endotoxin) can reactivate arthritis initially induced by PG-PS. These experimental results illustrate the inflammatory potential of luminal bacterial products and the importance of genetically determined host susceptibility factors in the pathogenesis of arthritis. Normally, luminal complexing by secretory IgA and an intact epithelial barrier limits uptake of luminal antigen; however, intestinal inflammation enhances mucosal uptake and systemic distribution of potentially injurious macromolecules, including PG-PS and lipopolysaccharide. Occult intestinal inflammation, which may be related to non-steroidal anti-inflammatory drugs or may be disease-associated, occurs in approximately two thirds of patients with rheumatoid arthritis, idiopathic reactive arthritis and ankylosing spondylitis. Enhanced mucosal permeability to macromolecules occurs in rheumatoid arthritis, enteric infections and idiopathic inflammatory bowel disease. Intestinal inflammation is associated with increased mucosal IgG production and circulating immune complexes. Hyperactive IgA synthesis occurs in many types of inflammatory joint disease. Polyclonal IgA is increased in rheumatoid arthritis, Sjögren's syndrome, ankylosing spondylitis, Reiter's syndrome, and reactive arthritis following Yersinia infection. Anti-Klebsiella IgA cross-reacts with HLA-B27 antigen, and antibodies to enteric bacteria are able to lyse lymphocytes from HLA-B27 patients with ankylosing spondylitis. Anti-Yersinia IgA is produced at the mucosa in increased quantities in patients who develop arthritis following Yersinia enteritis, possibly as a consequence of defective cellular immunity. Serum concentrations of IgA correlate with activity of rheumatoid arthritis and ankylosing spondylitis, and serum IgA immune complexes are associated with rheumatoid vasculitis, suggesting that IgA contributes to the pathogenesis of arthritis. We speculate that intestinal injury may also induce or perpetuate arthritis by systemic distribution of inflammatory mediators produced by intestinal immune effector cells. |