Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3977421 | Effect of intravenous iron dextran on rheumatoid synovitis. | 1985 Mar | Eleven patients with rheumatoid arthritis received a total dose infusion of iron dextran for anaemia. Two of them had anaphylactic reactions and the remaining nine an exacerbation of synovitis. Quantitative infrared thermal imaging was used to assess the extent and distribution of joint involvement resulting from this therapy. In all eight patients examined the 'thermographic index' increased in two or more joint areas, indicating an increase in inflammation. Small joints of the hands were maximally affected, though larger joints when previously inflamed also worsened. Uninflamed joints were rarely affected. The exacerbation of synovitis occurred 24-48 h after completion of the iron dextran infusion and corresponded with a saturating of the serum iron binding capacity. Levels of immune complexes were unaltered, implying normal reticuloendothelial function. In one further patient, reported to have synovial flares when challenged with oral ferrous sulphate, iron dextran was infused at a lower dosage. All previously inflamed joints in this patient worsened 12 h after the infusion was discontinued. Concomitant with this was an increase of lipid peroxidation products in synovial fluid and to a less extent serum. Iron dextran in vitro stimulated lipid peroxidation, but dextran alone had no effect. It is therefore suggested that iron dextran worsens synovial inflammation by promoting lipid peroxidation. | |
| 219812 | Immunological experimental arthritis in pigs. III. Inflammatory reactions in the brain of | 1978 | Histopathological brains and spinal cords of pigs were examined at different times of immunization with the virus of Aujeszky's disease (AD). Temporary inflammatory reaction was found to have the features of non-suppurative disseminated inflammation in the second week after the second virus dose had been given. Perivascular and subependymal lymphocytic infiltrations were observed and the focal multiplication of microglia. | |
| 241599 | The effect of alclofenac on clinical and laboratory measures of disease activity in rheuma | 1975 | The results are presented for the first 11 patients in an on-going 3-month study of 1 g. alclofenac t.d.s. or matching placebo added to the drug regime of patients with active rheumatoid arthritis uncontrolled by full doses of analgesic/anti-inflammatory medication. Two patients dropped out, 1 due to a rash on alclofenac and 1 for incidental reasons. The numbers at this stage are too small for meaningful statistical comparison, but show an apparent trend towards clinical improvement and increase in the free:bound plasma tryptophan ratio in the alclofenac-treated patients. Three acute phase proteins, C-reactive protein, alpha-acid glycoprotein and alpha-1 antitrypsin, were measured. They did not correlate with the E.S.R. and did not appear to be useful additional predictors of disease progression. It is hoped that the results from the rest of the participants in the trial will allow more meaningful discussion of the place of these tests in the assessment of rheumatoid arthritis. | |
| 3839465 | [Anti-triiodothyronine antibodies in patients with rheumatoid arthritis associated with Ha | 1985 Mar 20 | Anti-triiodothyronine antibody was found in a case of rheumatoid arthritis associated with Hashimoto's thyroiditis. The patient was a 40 year-old woman who had complained of polyarthralgia, joint-swelling and stiffness for seven years. She had a rheumatoid nodule and showed a positive RA test. Radiographic changes of hands and wrists showed osteoporosis, erosions and narrowing of joint space. Nonsteroidal anti-inflammatory drugs had been used for seven years. The diagnosis of Hashimoto's thyroiditis had been made by open biopsy of the thyroid gland seven years before. Serum T4, TSH, TBG, free T4, free T3 and r-T3 were all normal. On the other hand, serum T3 level was almost unmeasurable by radioimmunoassay. Binding of 125I-T3 to the patient's serum was studied by using polyethylene glycol (PEG) and column chromatography. By using the PEG method, the binding of 125I-T3 to the patient's serum was tenfold compared to control serum. Sephadex G-25 column chromatography (0.9 X 1.5 cm) of 125I-T3 with the patient's serum in the presence of 0.1% ANS showed an early radioactive peak, while control serum did not show an early peak. In the next experiments, the patient's serum was labelled with 125I-T3, mixed with human anti-IgG, IgM, IgA, lambda, kappa, incubated at 4 degrees C for 20 hours and centrifuged for 20 min. Strong binding to the anti-IgG and anti-lambda was detected. The presence of this abnormal T3-binding globulin in the patient's serum may have produced an undetectable T3 level. | |
| 7046652 | Rheumatoid knee synovitis successfully treated with intra-articular rifamycin SV. | 1982 Jun | Thirty rheumatoid patients with persistent knee effusion were treated intra-articularly with rifamycin SV, 500 mg weekly, or with saline solution, 10 ml, in a double-blind study. A complete disappearance of effusion and an impressive clinical improvement was observed in the patients on rifamycin. The synovial fluid and membrane underwent some changes. In 2 patients the rifamycin caused a painful local reaction. After a follow-up of 5 years only one patient has experienced effusion relapse, 5 months after the termination of rifamycin SV treatment. The patients on saline showed no significant change. On the basis of the results obtained from the monoarthritis experimental model and from clinical trials it is tempting to consider that rifamycin has an antimitotic effect, impeding the synthesis of RNA and DNA polymerases in immunocompetent cells. | |
| 6620262 | Reticuloendothelial system fc receptor function in rheumatoid arthritis. | 1983 Aug | Patients with systemic lupus erythematosus (SLE) have abnormal reticuloendothelial system (RES) IgG Fc receptor function which is correlated with disease activity and levels of immune complexes (IC). We studied RES function, IC levels, clinical and laboratory manifestations in 43 patients with RA. The articular index was abnormal in 42 patients (range of 6 to 153). Thirty were seropositive; 31 had an elevated erythrocyte sedimentation rate. Extraarticular manifestations included nodules (25), anemia (19), Sjögren's syndrome (6), vasculitis (4), and Felty's syndrome (2). Medication included corticosteroids (32), nonsteroidal antiinflammatory drugs (33), slow acting antirheumatic drugs (18), and cytotoxics (2). Thirty-three patients had IC (30 by the Clq binding assay, 21 by the Raji cell assay); 13 patients had normal RES function (t 1/2-24-60 min; upper 95% confidence limit in normals = 62 min). Thirty had prolonged clearance times (65-210 min, mean 106 min). In contrast to SLE, clearance times were not found to be correlated with IC levels, or clinical or laboratory measures of disease activity. Defective RES immune clearance may not be an important determinant in the pathogenesis of immunologic tissue damage in rheumatoid arthritis. | |
| 3919415 | Anti-rheumatic drugs and joint damage in rheumatoid arthritis. | 1985 Jan | The effect of second-line anti-rheumatic drugs such as gold on the course and progression of joint damage has been the subject of considerable controversy. We have evaluated the effects of second-line anti-rheumatic drugs in three studies of 46-84 patients with rheumatoid arthritis given a second-line drug continuously for 12 months. Using two different methods of radiographic assessment we found that there was significant progression over the 12-month period when the mean changes in the groups of patients were examined, and there was similar indications of continuing disease activity shown by mean values of acute phase proteins and ESR which were above the normal range at both six and 12 months. But there were subgroups of patients who showed a reduction in ESR and joint tenderness with a related slowing of the rate of radiographic progression in the second six months of treatment. There was no direct relationship between changes in the ESR and radiographic progression in individual patients. Although anti-rheumatic drugs are not ideal and therapy does not cause remission in many patients, some patients respond well. Rheumatoid arthritis may represent a heterogeneous collection of patients who respond individually to different drugs. | |
| 7302763 | The team approach to rheumatoid arthritis. Rehabilitation at the H. F. Verwoerd Hospital, | 1981 Nov 28 | Rheumatoid arthritis, being a progressive destructive disease, is best treated by using a team approach. Besides intensive medical and surgical treatment, a definite programme of physiotherapy and occupational therapy is given. This includes educational lectures, home visits, group exercise therapy and an analysis of situations which may strain the joints. Splints and aids are supplied accordingly. | |
| 7436583 | Radiological articular involvement in the dominant hand in rheumatoid arthritis. | 1980 Oct | Scoring the severity of joint involvement in the x-rays of hands of patients with rheumatoid arthritis showed significantly greater joint destruction in the dominant hand. The difference was seen in all the joints, and especially in the wrists, but with the exception of the metacarpophalangeal joint of the thumb. The grip strength was not, however, different in the 2 hands. | |
| 6802258 | Reduced amyloid-A-degrading activity in serum in amyloidosis associated with rheumatoid ar | 1982 Feb 27 | The ability to degrade amyloid A fibrils was studied in the serum of 31 patients with amyloidosis associated with rheumatoid arthritis, 33 patients with rheumatoid arthritis without amyloidosis, and 47 healthy controls. Fibrillar amyloid A protein and the radial diffusion method were used. The mean degrading activity in serum was significantly lower in patients with rheumatoid arthritis complicated by amyloidosis (58 +/- 19% SD of the activity in a pooled sample of sera from 100 healthy blood donors used as standard) than in patients with rheumatoid arthritis alone (78 +/- 14%; p less than 0.001) or controls (99 +/- 19%; p less than 0.001). Alpha 1-antitrypsin, concentrations of which were raised in both groups of patients, inhibited the degrading activity in serum even in low concentrations. A negative correlation between degrading activity and alpha 1-antitrypsin concentrations was observed. These findings suggest that reduced amyloid-A-degrading activity is due to inhibition rather than to deficiency of enzyme. | |
| 6819630 | Altered thiol status in patients with rheumatoid arthritis. | 1982 | The thiol status of patients with rheumatoid arthritis is significantly different from that of controls. Plasma thiol levels are lower, albumin thiol reactivity is altered and intracellular thiol levels measured after hemoglobin precipitation are increased. These variations correlate with other indices of disease severity and are one measure of a disturbance in the degree of oxidation of the blood. Penicillamine, in common with other effective therapeutic agents, produces an increase in serum thiol concentration. It causes a greater effect on serum thiol reactivity than other drugs and in particular it increases 'fast reacting' thiol levels without significantly altering the 'slow reacting' thiol level. | |
| 6455522 | Autologous and allogeneic MLC-reactivity in patients with rheumatoid arthritis. | 1981 Jul | In vitro interaction of autologous peripheral blood and synovial fluid lymphocytes was studied using isolated lymphocytes from 15 patients with rheumatoid arthritis. In the applied one way mixed lymphocyte cultures (MLC) a significant proliferative response was obtained when peripheral blood lymphocytes were cultured with mitomycin treated synovial fluid cells. In contrast, when the reverse situation was examined, only a marginal stimulation of synovial fluid lymphocytes by peripheral blood lymphocytes was recorded. Studies on the effect of macrophage depletion on the autologous MLC made in unlikely that the decreased proliferative response of SFL was due to the presence of a monocyte suppressor cell population in SFL. Likewise no evidence could be obtained that the decreased MLC response of SFL to autologous and allogeneic lymphocytes was caused by the predominance of short lived T-suppressor cells in the synovial fluid. | |
| 929119 | The intra-articular residual rate of 131I-fibrinogen and microautoradiographs of the synov | 1977 | In this study, 131I-labeled human plasma fibrinogen (200 muCi) was injected intravenously into 21 patients with rheumatoid arthritis and 10 control patients without rheumatic diseases. The residual rates of radioiodinated fibrinogen in the knee joints were calculated by measuring with a scintillation counter the microautoradiographs of the synovial tissue obtained by punch biopsy from the knee joints. The residual rates in the knee joints without as well as with objective symptoms of RA were higher than in control patients. Radio-iodinated fibrinogen was demonstrated on the synovial villous surface, on the area of inflammatory cellular infiltration and stromal necrosis, and on the perivascular region of the synovial tissue from the knee joints of patients with RA, not only with, but also without clinical objective symptoms and histopathologic findings of fibrinoid necrosis, vascular superficial fibrinoid coating and fibrinoid degeneration of vascular wall. It is suggested that fibrinogen plays a role even in the early synovial tissue lesions of knee joints affected by RA. | |
| 6756321 | Histopathology of the synovial membrane of peripheral joints in ankylosing spondylitis. | 1982 Dec | The histological features of the synovial membrane of peripheral joints in ankylosing spondylitis are similar to those seen in rheumatoid arthritis. There is intimal cell hyperplasia, a diffuse lymphocyte and plasma cell infiltrate, and formation of lymphoid follicles. Peroxidase-antiperoxidase staining shows the presence of IgG-, IgA-, and IgM-containing plasma cells in ankylosing spondylitis. The percentage of IgM-containing cells is significantly lower in ankylosing spondylitis than in rheumatoid arthritis. | |
| 6971545 | Predominance of T-lymphocytes with a high-affinity receptor for sheep red blood cells in t | 1981 Jan | Using different modifications of the spontaneous rosette-forming assay, T-lymphocytes were determined in the synovial fluid and the peripheral blood of patients with rheumatoid arthritis (RA). It was shown that a T-lymphocyte subpopulation, forming E-rosettes by a high affinity receptor for SRBC was enriched in the synovial fluid as compared to the peripheral blood. | |
| 299863 | Differential diagnosis of rheumatic disease in the elderly. | 1977 Feb | To illustrate the diagnostic problems of rheumatic disease in patients over 60 years of age, 4 cases are presented: 1) osteoarthritis, 2) late-onset rheumatoid arthritis, 3) polymyalgia rheumatica, and 4) pseudogout with crystalline synovitis. In each case the correct diagnosis should have been suspected from the history and physical examination alone, with the laboratory and x-ray findings providing supportive evidence. | |
| 1124958 | Terminal phalageal osteosclerosis. | 1975 Feb | Osteosclerosis of the terminal finger phalanges was assessed by means of a grading score in two age-matched groups of 96 females, each suffering from rheumatoid arthritis (RA) and osteoarthrosis (OA), respectively, and in a sample of 894 males and females, above the age of 44 years, from Dutch small town populations. Cortical thickness of the therminal phalanges decreases markedly with age. Whereas in the age group 45-54 years, terminal phalangeal osteosclerosis is more pronounced in females, at higher ages the difference between the sexes disappears. The diameter of the terminal cortex increases gradually from the second to the fifth finger. No differences were found between the RA and the OA groups, nor were these groups different from the population survey except for a lower incidence of terminal phalangeal osteosclerosis in female osteoarthrotics between 45 and 55 years of age, compared to females of the same age group from the population sample. | |
| 995766 | Effect of aggregated human gamma-globin on leukocyte migration-inhibitory test in patients | 1976 Jul | In 69 patients with rheumathoid arthritis (RA): 49 sero-positive and 20 sero-negative for rheumatoid factor and in a group of 20 healthy blood donors the leukocyte migration-inhibitory test was carried out. Heat-aggregated gamma-globulin was used in the culture medium as antigen. Both groups of patients exhibited a significant inhibition of migration, as compared with the group of healthy subjects. However, a significant difference in the mean value of the migration indices between the sero-positive and sero-negative individuals was observed. | |
| 629595 | Neutrophil chemotaxis in rheumatoid arthritis. Effect of D-penicillamine, gold salts, and | 1978 Feb | The effect of therapeutic concentrations of D-penicillamine, sodium aurothiomalate, and levamisole on in vitro neutrophil chemotaxis and random migration in normal subjects and patients with rheumatoid arthritis was studied. D-penicillamine produced no changes. Sodium aurothiomalate produced dose-related reductions in chemotaxis in normal subjects and in patients who had a good clinical response to gold therapy, while patients who had failed to respond to gold showed a minimal nondose dependent reduction. Levamisole produced dose-dependent stimulation of chemotaxis, a greater effect found with the patients cells. Neutrophil chemotaxis improved to normal values in most patients responding to several months of D-penicillamine treatment but showed an immediate and marked stimulation in patients treated with levamisole. | |
| 6378307 | Fenclofenac and diclofenac in the treatment of rheumatoid arthritis. | 1984 Aug | A six-month single-blind, randomized parallel group study comparing the effects of fenclofenac and diclofenac in 63 patients with rheumatoid arthritis is described. Both treatments produced improvements in clinical measurements, with a significant between-treatment effect in favour of fenclofenac for overall pain, night pain and duration of morning stiffness. Both treatments produced a decrease in IgM and the fenclofenac group produced decreases in plasma viscosity and ESR, the latter showing a significant between-treatment effect in favour of fenclofenac. No clinically significant changes in routine haematology and biochemistry were noted. Unwanted effects leading to withdrawal of therapy were reported by five patients in the fenclofenac group and three patients in the diclofenac group. Two patients in the fenclofenac group and one in the diclofenac group were withdrawn for reasons unrelated to therapy. In the diclofenac group two and four patients were withdrawn for clinical deterioration and inadequate effect respectively. |