Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6871583 | Grip strength and torquometry in the assessment of hand function in patients with rheumato | 1983 Aug | Hand function was studied in 33 patients with rheumatoid arthritis. Grip strength and torquometry, two distinct quantitative indices of grip, each correlated well (p less than 0.001) with the score obtained in an occupational therapy assessment of hand function both in the presence of active synovitis and chronic joint deformity. Grip strength correlated better with certain hand skills and torquometry with others, the relative relationships often being predictable from the type of grip entailed. | |
| 694700 | Sudden quadriparesis in a patient with rheumatoid arthritis. A case report. | 1978 Jul 15 | A case of sudden quadriparesis in a patient with rheumatoid arthritis is described. The aetiology of motor weakness in the rheumatoid patient is outlined. The natural history of the subluxated rheumatoid cervical spine is once again emphasized. | |
| 6673984 | Perna canaliculus in the treatment of rheumatoid arthritis. | 1983 | Freeze-dried extracts of the New Zealand green lipped mussel, Perna canaliculus, have been promoted extensively as a treatment for rheumatoid arthritis for some years though there have been few published trials of its effectiveness. Our study was designed to test the ability of the mussel extract to relieve the symptoms of rheumatoid arthritis as both a supplement and an alternative to orthodox anti-inflammatory medication. | |
| 4032400 | Phospholipase A2 activity in sera and synovial fluids in rheumatoid arthritis and osteoart | 1985 Apr | Phospholipase A2 (PLA2) activity was found in the sera and synovial fluids (SF) in rheumatoid arthritis (RA) and osteoarthritis (OA). PLA2 activity in RA SF was 6158 +/- 549 (SEM) U/ml (n = 48) and in RA sera 554 +/- 175 U/ml (normal sera-115 +/- 12 U/ml). In OA SF PLA2 activity was 5069 +/- 542 U/ml (n = 28), and in OA sera 268 +/- 55 U/ml. There was no significant difference between SF PLA2 activity in RA and OA. PLA2 activity in SF did not correlate with muramidase (lysozyme), beta-glucuronidase, total protein or white cell count, which were all significantly higher in RA SF than OA. A positive correlation between PLA2 in SF and matched sera was found in both RA and OA. It may be concluded that significant elevation of extracellular PLA2 occurs in both RA and OA, especially in the SF. The fact that high PLA2 did not correlate with other enzymes such as lysozyme and beta-glucuronidase, which are usually high in RA and low in OA SF, may mean that the handling of PLA2 in the joint space is different from other enzymes. | |
| 2859902 | Serum amyloid A protein during the treatment of rheumatoid arthritis with second-line drug | 1985 May | Serum amyloid A protein (SAA), serum C-reactive protein (CRP) and the ESR were measured in 19 patients with rheumatoid arthritis before treatment and during therapy with gold, penicillamine or sulphasalazine for a mean period of 14.8 months (range 6-23 months). All three measurements decreased significantly; however, only 7% of SAA values fell to within the normal range (18-44 mg/l), compared to 38% measurements of serum CRP (less than 10 mg/l) and 32% of the ESR (less than 25 mm/h). In 8 (42%) of the 19 patients, SAA remained high (greater than 400 mg/l) for 3 months or more whilst serum CRP was depressed below 20 mg/l; this discrepancy was not related to particular drugs. We conclude that during treatment of rheumatoid arthritis with gold, penicillamine or sulphasalazine, SAA concentrations can be high when serum CRP and ESR are suppressed. SAA may be a more sensitive index of disease activity. | |
| 6821522 | Study of trace elements in patients with rheumatoid arthritis stage I-II, before and after | 1982 Oct | The study of the copper, zinc, iron and magnesium serum values in 35 patients with rheumatoid arthritis (RA) stage I-II, before and after therapy with indocin, gold salts and transfer factor showed a significant increase of copper to 129-340 gamma/100 ml, mean value 214.6 gamma/100 ml as compared with 65-145 gamma/100 ml, mean value 107.6 gamma/100 ml in the controls. The values of serum copper were found to evaluate with the severity of diseases returning to normal values in the patients with good response to therapy. In disagreement with some authors who found decreases of serum zinc in the course of rheumatoid arthritis, in our study the values obtained did not vary significantly as compared to normal (mean value 119 gamma/100 ml in RA as compared with 94.7 gamma/100 ml in the controls). The decrease of iron and magnesium serum concentration was also found nonsignificant in the patients with RA investigated. The results are discussed in terms of physiopathology. | |
| 6666392 | [Standardization of roentgenologic studies in chronic polyarthritis for therapeutic studie | 1983 Nov | For multicenter therapeutic studies of rheumatoid arthritis (chronic polyarthritis, RA), radiological criteria for RA have been set up by a working group of rheumatologists and radiologists: the result is a radiological index for RA. For the special therapeutic studies planned, only those patients with RA should be included who have manifestations of the disease in their hands and/or feet. Radiological control at yearly intervals will show the progression of the disease by increases in radiological index values. All X-rays should be taken in the standard position and by the standard procedure, on films without intensifying screens. For exposure and quality control a metacarpal bone embedded in paraffin should be interposed between the hands or feet during radiography. Reading and interpretation of radiographs should be controlled by a second observer uninformed as to the patient and stage of disease. | |
| 6146419 | Precipitating antibodies to nuclear antigens in systemic vasculitis. | 1984 Jun | We have examined sera from 61 patients with systemic vasculitis for precipitating antibodies to components of saline tissue extracts. Precipitins were rare in patients with polyarteritis nodosa (PAN) and their absence helped to distinguish PAN from vasculitis associated with other connective tissue diseases. Precipitins were detected in some patients with other vasculitides. Previously described precipitating antibodies (anti-Ro [SSA] and anti-La [SSB]) were restricted to a few patients with features of systemic lupus erythematosus (SLE). A different, as yet unidentified, precipitin which reacted with a component of rabbit thymus extract but not calf thymus or human spleen extracts was detected in many patients with rheumatoid disease. This precipitin was present in all patients with active rheumatoid vasculitis (RV) as well as 52% of patients with uncomplicated but active rheumatoid synovitis. Higher titres of precipitating antibody were present in patients with active RV than those with inactive RV or uncomplicated rheumatoid synovitis, and serial studies showed a good correlation between a fall in antibody titre and healing of vasculitis with treatment. These studies suggest that this unidentified precipitin may be an important marker of RV. | |
| 1190850 | Attempt to classify patients with arthritis of the hip suitable for prosthetic replacement | 1975 Aug | Using clinical, radiological, and morbid anatomical data about patients with arthritis of the hip and their femoral heads resected during total hip replacement, an attempt has been made first, to classify patients and femoral heads by a cluster analysis technique, and secondly and more realistically, to use existing clinical and radiological classification as a basis for seeking discriminating features in the data from the femoral head. Both types of analysis failed to give results, and led to a conclusion that arthritis of the hip is a spectrum of disease. This may not pose problems to the clinician, but it does to the investigator studying the pathogenesis of osteoarthrosis. This problem is briefly discussed. | |
| 394282 | Diclofenac sodium (Voltarol): a double-blind comparative study with ibuprofen in patients | 1979 | A double-blind comparative trial in 60 patients, using diclofenac (Voltarol) and ibuprofen (Brufen), showed a considerable improvement in morning stiffness amongst females in the diclofenac group. However, no significant differences was noted between these two drugs in relation to pain score, articular index or proximal interphalangeal joint size. Analysis of withdrawals and side-effects suggests that while ibuprofen may be slightly better tolerated, it is also associated with significantly more withdrawals due to lack of effect. No significant change in laboratory studies was noted, except for a slight decrease in mean haemoglobin levels. The trialist noted that all of the drop-outs and side-effects reported came from one hospital out of the four participating; this was possibly due to differences in pre-trial drug therapy and to the hospital being in an urban, rather a rural, situation. | |
| 1223123 | The interphalangeal joint of the great toe in rheumatoid arthritis. | 1975 Dec | The radiographic abnormalities of the interphalangeal joint of the great toe in 50 patients with rheumatoid arthritis were compared with those in 14 patients with psoriatic arthritis. Alterations were seen in 50% of the rheumatoid joints. Characteristic superficial erosions along the medial aspect of the proximal and distal phalanges, with little change in the joint space, differed from more widespread and extensive destruction of this joint in psoriasis. In addition, periosteal proliferation, bony ankylosis and tuft resorption, frequently noted in psoriatic arthritis, were unusual in rheumatoid disease. An anatomic investigation of the interphalangeal joint of the great toe explains the sites of marginal erosions in rheumatoid arthritis. Although selective involvement of this articulation occurs in psoriatic arthritis and Reiter's syndrome, it is the radiographic pattern of articular abnormality which allows their differentiation from rheumatoid arthritis. | |
| 6481941 | An autopsy case of rheumatoid arthritis with aortic steno-insufficiency, angina pectoris a | 1984 Sep | Although nonspecific pericarditis, myocarditis, valvulitis, and coronary arteritis are known as cardiac lesions that accompany rheumatoid arthritis (RA), there have been few reports of the occurrence of clinically severe valvular disease. We report here the case of 69-year-old man with a 25-year history of RA who died of acute left-sided heart failure complicating to aortic steno-insufficiency and angina pectoris. Autopsy findings revealed the coincidence of a congenital bicuspid aortic valve with chronic inflammation, fibrosis and calcification; eccentric hypertrophy and myocardial fibrosis of the left ventricle; 75% luminal narrowing of the proximal portion of the coronary artery due to atherosclerosis, and narrowing of the small arteries of the cardiac muscle due to angitis. It is deduced that the coronary artery lesions, aortic valve lesions and myocardial lesions were aggravated by the bicuspid aortic valve, changes with ageing and corticosteroid therapy. | |
| 6138117 | Sulphasalazine in rheumatoid arthritis: a double blind comparison of sulphasalazine with p | 1983 Oct 15 | Uncontrolled studies have suggested that sulphasalazine may be an effective second line agent in rheumatoid arthritis. Sulphasalazine was therefore compared with placebo and intramuscular sodium aurothiomalate in 90 patients with active rheumatoid arthritis. After six months' treatment both sulphasalazine and sodium aurothiomalate had produced significant clinical and laboratory benefit, whereas placebo had produced no significant change in any variable. Thirteen patients stopped taking the placebo because of lack of effect whereas only two patients stopped taking sulphasalazine and one sodium aurothiomalate for this reason. The major toxicity encountered in the group treated with sulphasalazine was nausea or vomiting, or both; this may be related to slow acetylator phenotype. Sulphasalazine appears to be an effective second line agent, and further pharmacokinetic studies might prove useful in diminishing gastrointestinal side effects. | |
| 6966395 | Laboratory diagnosis of rheumatoid diseases. | 1980 May | The diagnosis of most collagen diseases requires particular clinical findings. Rheumatoid factor assays are tests commonly used to detect seropositive rheumatoid arthritis. Latex tests are highly sensitive for rheumatoid factors but relatively nonspecific for rheumatoid arthritis, while sheep cell agglutination tests are moderately insensitive for rheumatoid factors but highly specific for rheumatoid arthritis. These tests are not helpful in following the course of the disease, however, since titers remain stable. Serial observations of elevated C-reactive protein levels or ESR may be more helpful in this regard. Specific antibodies have been identified for some collagen diseases, notably the mixed connective tissue disease syndrome, aiding in differential diagnosis. | |
| 6625786 | Sweet's syndrome associated with rheumatoid arthritis. | 1983 Oct | A case of Sweet's syndrome (acute febrile neutrophilic dermatosis) is reported in a patient with long-standing rheumatoid arthritis. Although Sweet's syndrome has been described in association with leukemias, other malignancies, and a variety of inflammatory disorders, it has not been associated with rheumatoid arthritis. Sweet's syndrome is reviewed with regard to pathogenesis and associated diseases. | |
| 710990 | The conservative treatment of the Swan-Neck deformity in the rheumatoid hand. | 1978 Feb | A technique is described to correct rheumatoid Swan-Neck deformity in those patients where there is limited proximal interphalangeal joint flexion in all positions. It involves the manipulation of these joints and their temporary immobilisation with Kirschner wires followed by mobilisation using an elastic band method. | |
| 6927511 | National Center for Health Care Technology assessment of therapeutic apheresis for rheumat | 1982 | The National Center for Health Care Technology coordinated the Public Health Service's assessment of therapeutic apheresis for rheumatoid arthritis in response to the Health Care Financing Administration's request for advice regarding Medicare coverage of this rapidly emerging technology. The information considered included reports available in the medical literature (as of early 1981), advice from the National Institutes of Health and Food and Drug Administration, advice from the appropriate medical societies, as well as information submitted by interested parties in response to a notice published in the Federal Register announcing the assessment. Synthesis of this information provided the basis for concluding that therapeutic apheresis for rheumatoid arthritis was considered experimental with the possible exception of treatment for life-threatening complications such as vasculitis, cryoglobulinemia, or hyperviscosity syndrome. | |
| 88067 | The extra-articular deposition of fibrinogen antigenic material in patients with rheumatoi | 1979 | Experimental suction blisters were elicited on extensor and flexor sites or forearm skin of patients both with rheumatoid arthritis and without rheumatoid diseases. The blister fluid obtained was investigated, together with rheumatoid bursa fluid and rheumatoid noduli material by crossed and quantitative immunoelectrophoresis for fibrinogen antigenic material, plasminogen and inhibitors of fibrinolysis. In rheumatoid noduli and rheumatoid bursa fluid, fibrinogen degradation products identical with those previously described in rheumatoid synovial fluid and in bullous dermatosis were found (3, 14). On the other hand, no fibrinogen antigenic material was found in the experimental suction blisters. These results indicate that the fibrinogen degradation products in rheumatoid inflammatory exudate are probably not specific for a rheumatoid process, but rather part of a general mechanism in inflammation. | |
| 925498 | Intra-articular steroid injection in acute rheumatoid arthritis of the larynx. | 1977 Oct | A case of stridor due to rheumatoid arthritis of the cricoarytenoid joints is presented, with special emphasis on a new line of treatment by local intra-articular steroid injection. | |
| 3882293 | Nicolas Andry Award, 1984. Deleterious interactions of immune complexes in cartilage of ex | 1985 Mar | Immune complexes were detected by plain and immunoelectron microscopy amongst electron-dense material that rapidly formed and extended over and into the cartilaginous surfaces of immune arthritic rabbits' knees. The sinuous extension of electron-dense material into the surface matrix was associated with fragmentation and detachment, resulting in erosions. The findings implicate the formation of immune complexes in the destructive process of the matrix. Since the eroded pannus-free matrix of rheumatoid cartilage surfaces contains extensive concentrations of immune complexes, the data of this immune arthritis model suggest a causative relation between immune complexes and matrix loss in rheumatoid arthritis. |