Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6432005 | [Possible mechanism of action of drugs in the basic therapy of rheumatoid arthritis: effec | 1984 May 30 | As it is known that platelets play an important role in arising and maintaining the inflammation, the authors have studied "in vitro", the effect on platelet aggregation of three drugs (Sodium Aurothiomalate, Auranofin and Penicillamine) used in basic therapy of Rheumatoid Arthritis (RA). The drugs are used in different concentrations and at different times of preincubation. The study was based on the principle of Born and using the Coagg-Salus aggregometer. The platelet aggregation was induced by ADP 2.5 microM. The authors have demonstrated that the above-named drugs inhibit the platelet aggregation induced by ADP in different percentile, according to the concentrations adopted and the time of preincubation with platelets rich plasma. This study seems particularly interesting because it can offer a possible interpretation on the mechanism of action of basic therapy in RA. | |
| 319117 | Treatment of rheumatoid arthritis with flurbiprofen or ibuprofen. | 1977 Jan | Flurbiprofen and ibuprofen were compared in a six-week double-blind randomized study in 208 patients with rheumatoid arthritis. Daily dosages were 120 mg flurbiprofen and 2400 mg ibuprofen for six weeks. Both drugs were effective in providing partial control of RA symptoms. Either or both drugs produced statistically significant improvement in mean values of time of onset of fatigue, grip strength and tender and swollen joint counts. All other standard endpoints of efficacy (except ESR) were improved but not at a statistically significant level. Slightly more than half of the patients improved during the trial. There was no statistically significant difference in the efficacy of the drugs. The incidence of side effects was low with both drugs. Most side effects were related to gastrointestinal tract irritation. | |
| 6349646 | Double-blind multicenter studies with meclofenamate sodium in the treatment of rheumatoid | 1983 | The therapeutic efficacy of N-(2,6-dichloro-m-tolyl)anthranilic acid, sodium salt (meclofenamate sodium, Meclomen) in the management of rheumatoid arthritis was clearly established in four large, double-blind, controlled multicenter studies in 757 patients. In one study, 200 mg/day of meclofenamate sodium was compared with 300 mg/day and placebo for six weeks. Another compared meclofenamate sodium, 300 mg/day, with acetylsalicylic acid (ASA), 3.6 g/day, for eight weeks. Two other long-term studies compared meclofenamate sodium and ASA, 300 mg/day and 3.6 g/day, respectively, for six months; in one, the patients were allowed to receive concomitant gold salts or steroids, while in the other, they were not. Both objective and subjective measures showed that meclofenamate sodium was as effective as ASA and superior to placebo. Gastrointestinal reactions, most commonly diarrhea, were seen more often with meclofenamate sodium than with ASA or placebo, but withdrawal for adverse reactions did not differ significantly between treatment groups. ASA-associated side effects such as tinnitus and deafness were not experienced by the patients receiving meclofenamate sodium. Meclofenamate sodium is a safe, effective agent for the treatment of rheumatoid arthritis. | |
| 7146264 | Life events before the onset of rheumatoid arthritis. | 1982 | All female patients seen at a rheumatological clinic within 1 year of the onset of rheumatoid arthritis were referred for psychiatric assessment. There was 1 refusal and 22 patients were seen by the author, a psychiatrist working in the Department of Rheumatology. Psychiatric assessment, combined with a brief survey of important life events in the year before the onset of symptoms, was compared with a similar assessment made on randomly selected age-matched well women, among whom there was also 1 refusal. 12 of the patients and 5 controls (p = 0.03) reported a bad relationship in childhood with their mothers. 15 patients reported life events in the year before the onset of the arthritis, compared to 8 controls in the matching year (p = 0.03). In 12 of these 15 patients and 3 of the controls the events were assessed as carrying moderate or considerable long-term emotional threat (p = 0.005). In 11 of these 12 patients the interval between the event and the onset was less than 3 months. | |
| 542915 | Frequency dependence of dynamic compliance in patients with rheumatoid arthritis. | 1979 Dec | An investigation of lung function was carried out in 99 randomly selected patients with calssic or definite rheumatoid arthritis and in 60 control subjects matched for age, sex, and smoking habits. Mean FEV1 and mean VC were both significantly lower in the rheumatoid patients due to significant differences for women but mean FEV/VC ratio was 73.0% in the rheumatoid group and 72.1% in the control. Steady-state transfer factor was significantly greater in the normal men than in the comparable rheumatoid group, but there was no difference for women. After excluding patients with FEV1 less than 80% predicted normal and patients with low compliance, 72 rheumatoid patients and 45 controls provided series of tracings that could be assessed for a fall in Cdyn of 20% between 20 cycles and 60 cycles a minute. Dynamic compliance was not significantly different in any group at any rate of respiration. Fourteen of 72 rheumatoid patients and three of 45 controls showed frequency dependence (FDC). After the age of 50 the prevalence in the rheumatoid groupwas 11/38 and in the control group 2/27. This difference was significant (P less than 0.05). FDC was not consistently related to other abnormalities of lung function or to the duration, severity, or treatment of the rheumatoid arthritis. In various categories of smoking habits, dust exposure, or allergic tendency, the prevalence was always greater in the rheumatoid group. This provides evidence of patchy involvement of small airways, or alveoli and connective tissue, by the rheumatoid process. | |
| 389264 | The aspirin-ibuprofen interaction in rheumatoid arthritis. | 1979 Nov | 1 This was a double-blind crossover trial of ibuprofen and soluble aspirin against each drug alone and against placebo in patients with rheumatoid arthritis. Two dosage regimes were tested. 2 A weak clinical additive effect was demonstrated between soluble aspirin and ibuprofen in patients with rheumatoid arthritis using moderate (1600 mg ibuprofen and 3.6 g aspirin daily) but not low (800 mg ibuprofen and 2.4 g aspirin daily) dosages of both drugs. 3 A significant correlation between clinical efficacy and serum ibuprofen but not salicylate level was found in the single drug periods of the trial. 4 No consistent effect of ibuprofen administration on serum salicylate levels was found. 5 Concurrent salicylate administration produced significant lowering of serum ibuprofen levels without affecting elimination half-lives of the drug. | |
| 6676624 | Case report: massive osteolysis in a case of rheumatoid arthritis: clinical, histologic an | 1983 | A 54-year-old male with a 10-year history of seropositive rheumatoid arthritis subsequently developed generalized osteoporosis, multiple cervical spine subluxation, vertebral collapses, and massive osteolysis of the humeral and femoral heads and carpal bones. These lesions were accompanied by neurologic manifestations in both the upper and lower extremities. Bone matrix collagen and noncollagenous proteins in this rare syndrome were analyzed. The pathogenesis of this rare phenomenon is discussed. | |
| 219814 | Immunological experimental arthritis in pigs. V. Reaction of the synovial membrane in the | 1978 | Immunized animals were given intraarticular complexes formed in vitro from the autologous serum and virus AD. 7 days after complex administration with excess of the virus, weak inflammatory reactions of the immunological type were noted. After neutral complex administration virulent immunological inflammation of the synovial membrane took place. The histological picture resembled rheumatoid arthritis in the man and the changes obtained after the virus administration to the joints with a high level of antibodies. Administration of complexes and homological serum alone to the joints of the nonimmunized animals caused the occurrence of superficial focuses of fibrinoid necrosis, but there was a lack of cellular reactions. | |
| 6360179 | Interaction of polymorphonuclear leukocytes with immune complexes trapped in rheumatoid ar | 1983 Dec | When rheumatoid articular cartilage samples were incubated with normal polymorphonuclear leukocytes (PMN) in vitro, large numbers of PMN were seen attached to the articular surface. As observed by electron microscopy, significant numbers of these cells invaded the cartilage tissue and phagocytosed amorphous material which presumably contained immune complexes. In control cartilage from osteoarthritic, pyogenic, and normal subjects, only a few PMN were attached to the articular surface after incubation with PMN. These results demonstrate that immune complexes trapped in the superficial region of the rheumatoid articular cartilage may play an important role in the destruction of cartilage by the release of lysosomal enzymes from PMN. | |
| 1235940 | The Gm and Inv factors in rheumatoid arthritis. | 1975 | The Gm(1), Gm(2), Gm(4), Gm(12), and Inv (1) factors were studied in the sera of 56 patients suffering from rheumatiod arthritis and 26 from various rheumatic diseases, by the hemagglutination inhibition test, using optimally reacting mixtures of Ragg and Nagg sera. The distribution of these factors was found to agree with that of healthy Greeks. No correlation was found between hypergammaglobulinemia and the discovery of the Gm(1) and Inv (1) factors. The presence of the rheumatoid factor was independent of the Gm and Inv phenotypes. | |
| 6894843 | Arthrographic study of the rheumatoid knee. Part 2. Articular cartilage and menisci. | 1981 Aug | The changes of the articular cartilage and of the menisci in 129 knee joints with classical rheumatoid arthritis have been investigated by an improved arthrographic technique. The changes of the intra-articular components on the arthrograms coincided well with direct views at arthroscopy and surgery. The changes of the articular cartilage on the arthrograms were graded as normal, deposit and pooling, thinning, filling defect, destruction, and disappearance, and those of the menisci as normal, degeneration, tear, and disappearance. The results showed that: (1) The radiographs did not always reflect the changes of those intra-articular components in the early stages; especially in stage 2 they showed various conditions from intact to destruction. (2) The changes of the menisci were less advanced than those of the articular cartilage in the early stages. (3) The changes in those components progressed almost symmetrically in both compartments. It is necessary to appreciate not only the pathological condition of the bones of the knee joints but also that of the intra-articular components to devise more careful programmes of treatment for rheumatoid knees. | |
| 6699830 | Spontaneous synthesis of IgM rheumatoid factor by blood mononuclear cells from patients wi | 1984 Feb | Spontaneous IgM rheumatoid factor (sIgM RF) synthesis in vitro by blood mononuclear cells (BMC) from rheumatoid arthritis (RA) patients has been previously shown to correlate with disease activity. Ten active RA patients were studied prior to and after the start of therapy with gold salts or penicillamine. sIgM RF decreased steadily over the period of study and was strongly correlated with mean joint count (r =0.94, p less than 0.001), erythrocyte sedimentation rate (r = 0.90, p = 0.014), and duration of morning stiffness (r = 0.78, p = 0.068). In 9 patients with significant decreases, mean sIgM RF was 8% of the initial value after 9 weeks of treatment. The decrease in sIgM RF was relatively specific since the ratio of sIgM RF to total spontaneous IgM synthesis (sIgM) declined during the treatment period. The results indicate that changes in sIgM RF constitute a sensitive indicator of disease activity and response to therapy in RA. | |
| 7401069 | Evaluation of a province-wide physiotherapy monitoring service in an arthritis control pro | 1980 May | We evaluated our rheumatoid arthritis patient follow-up service in British Columbia in a 1 yr prospective study. The follow-up by 45 specially trained Arthritis Society physiotherapists involved contact of 1,701 patients; 1,081 were assessed and 440 were judged to need therapy or physician services; 279 required further physiotherapy, 191 had functional problems needing occupational therapy and 108 had medical problems requiring return to the family doctor. Within 2 months 72% of patients requiring physiotherapy and 84% of patients requiring occupational therapy had received their therapy. The study underlines the value of physiotherapy follow-up monitoring of rheumatoid patients. | |
| 316588 | Effects of oral administration of D-penicillamine on T- and B-lymphocytes in peripheral bl | 1979 Nov | The effects of D-penicillamine on T-lymphocytes (rosette forming cells) and B-lymphocytes (surface IgG- and surface IgM-bearing cells) in peripheral blood of 13 patients with classical or definite rheumatoid arthritis were investigated at 4 weeks, 12 weeks and 24 weeks of treatment. At the same time, the determination of the concentrations of serum immunoglobulins and RA tests were carried out, and the rheumatoid activity index was calculated. The administration of D-pencillamine caused a gradual increase in the percentage of T-lymphocytes and a concomitant decrease in the percentage of B-lymphocytes with time. It was found that the tendency toward reduction of the percentage of surface IgM-bearing lymphocytes was more remarkable and accelerated than that of surface IgG-bearing lymphocytes. A decrease in the concentrations of serum IgM and IgG was observed in association with these findings. The agglutination in RA-test became significantly weaker in about half of the cases. Also the rheumatoid activity index became gradually smaller after treatment. The marked decrease in the percentage of B-lymphocytes and in the concentration of serum immunoglobulins may be related to the inhibition of the production of abnormal immunoglobulins. | |
| 901031 | The painful heel. Comparative study in rheumatoid arthritis, ankylosing spondylitis, Reite | 1977 Aug | This study presents the frequency of severe and mild talalgias in unselected, consecutive patients with rheumatoid arthritis, ankylosing spondylitis, Reiter's syndrome, and generalized osteoarthosis. Achilles tendinitis and plantar fasciitis caused a severe talalgia and they were observed mainly in males with Reiter's syndrome or ankylosing spondylitis. On the other hand, sub-Achilles bursitis more frequently affected women with rheumatoid arthritis and rarely gave rise to severe talalgias. The simple calcaneal spur was associated with generalized osteoarthrosis and its frequency increased with age. This condition was not related to talalgias. Finally, clinical and radiological involvement of the subtalar and midtarsal joints were observed mainly in rheumatoid arthritis and occasionally caused apes valgoplanus. | |
| 496604 | Serial nerve conduction studies in carpal tunnel syndrome secondary to rheumatoid arthriti | 1979 Sep | Twenty patients with definite rheumatoid arthritis fulfilling the criteria of the American Rheumatism Association were examined for clinical and electrodiagnostic evidence of carpal tunnel syndrome. Of the 40 wrists studied, 8 (20%) had evidence of carpal tunnel syndrome. All wrists were followed up with serial electrodiagnostic, clinical, and laboratory studies at intervals of 4 months over a period of a year. All patients were seen by a rheumatologist and were put on effective anti-inflammatory drug therapy. At each visit serum drug level and sedimentation rate were estimated. Two of the wrists were splinted. In the 4 affected patients (8 wrists) the drugs were used were aspirin in 3 and gold in 1. All 8 wrists showed a decrease in the abnormally prolonged median sensory latencies. This finding paralleled clinical improvement of rheumatoid disease as shown by symptomatic relief of paresthesia, reduced swelling of joints (including wrists), absence of Tinel sign at the median nerve, and fall of sedimentation rate. The study strongly suggests that serial electrodiagnostic studies should be used as 1 parameter in the follow-up of carpal tunnel syndrome secondary to rheumatoid arthritis. The study also indicates that good anti-inflammatory therapy and splinting can control carpal tunnel syndrome in rheumatoid arthritis. None of the wrists involved needed surgery during the period of study. | |
| 6467862 | Prevalence of decreased bone mass in rheumatoid arthritis. Relation to anti-inflammatory t | 1984 Jun | The bone mineral content (BMC) in both forearms (highly correlated to total body calcium) was measured by photon absorptiometry in a representative sample of rheumatoid arthritis outpatients comprising 129 patients treated with either gold salts (n = 29), penicillamine (n = 61), prednisone (n = 24), or other anti-RA drugs (n = 15). The mean BMC value was 84% of normal (p less than 0.001) with the lowest mean value in the group treated with prednisone (73% of normal). The patients as a group had hypocalcaemia (p less than 0.001), raised serum alkaline phosphatase (p less than 0.001), and normal urinary excretion rates of calcium and hydroxyproline. These results indicate that RA patients have disturbances in their calcium and bone metabolism. | |
| 214511 | In vitro effects of Epstein-Barr virus on peripheral blood mononuclear cells from patients | 1978 Nov 1 | Peripheral blood mononuclear cells from 10 patients with rheumatoid arthritis and 9 control subjects were cultured in vitro for 30 days with and without infection by Epstein-Barr virus. All cultures showed polyclonal stimulation of B cells as indicated by rising levels of IgM in the culture supernates, reaching maximal at 18-24 days, and with no quantitative or kinetic difference between the RA and control cells. IgM anti-IgG was also produced in both groups and maximally at 18-24 days, but in greater quantity by the RA lymphocytes. The anti-IgG made by the RA lymphocytes was more easily absorbed by solid phase IgG than was the anti-IgG made by the normal lymphocytes and thus was judged to be of higher affinity. RA lymphocytes uninfected with EBV had higher transformation scores than did the normal controls and developed spontaneously into permanent cell lines in six instances. | |
| 3909379 | Selenium treatment in rheumatoid arthritis. | 1985 | A low selenium level has been reported in rheumatoid arthritis and juvenile chronic arthritis. Selenium is an essential part of the enzyme glutathione peroxidase, which catabolizes peroxides, compounds which are suggested to be of pathogenetic importance in rheumatic diseases. To assess a possible antirheumatic effect of selenium, 40 patients with active RA were included in a 6-month double-blind clinical study of selenium versus placebo. The patients in the selenium group were given daily supplements of 256 micrograms selenium in selenium-enriched yeast. Although concentrations of selenium in serum and erythrocytes increased considerably, no significant antirheumatic effect of selenium could be demonstrated. | |
| 3875589 | Steroids reduce complement activation in rheumatoid arthritis. | 1985 | Patients with seropositive, classical rheumatoid arthritis (RA) with severe active disease have raised plasma concentrations of the complement C3 split product C3d. These values display little diurnal or circadian variation in the individual patient. During a 3-month period the variation was within 10 mU/l in 45 patients (ref. range 20-52 mU/l, RA patients up to 120 mU/l.) Six RA patients were treated with steroids on clinical indication, and the plasma C3d, Ritchie index and pain score before and during the treatment (30 mg prednisolone per day) were measured. The variables showed a steady decrease during the next 14 days. Plasma C3d fell 2/3 of the total fall within the first 48 hours, while the serum total haemolytic complement activity, complement C3 and C4 did not change significantly. This shows that the anti-inflammatory effect of steroids is accompanied by a reduction of complement activation. |