Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1094038 | Results of a one-year trial of tolmetin in patients with rheumatoid arthritis. | 1975 May | The safety and effectiveness of tolmetin was assessed in ten patients with active rheumatoid arthritis for 12 months. All patients met the requirements of the American Rheumatism Association's diagnostic criteria for definite rheumatoid arthritis. None of the patients had received gold, antimalarials, or glucocorticoids. All had been stabilized, more or less, with aspirin. Monthly measurements were made of grip strength, duration of morning stiffness, time to the onset of fatigue, Westergren sedimentation rates, the number of swollen joints, number of hot joints, the time to walk 50 feet, and the circumference of proximal interphalangeal (PIP) joints (measured in millimeters with a plastic-loop arthrocircameter). The initial dosage of tolmetin in all patients was 600 mg a day, given orally in three divided doses. Upon completion of the study, the average daily oral dosage was 1400 mg tolmetin. No other antiinflammatory drugs were allowed. The results indicate that tolmetin affords symptomatic relief of rheumatoid arthritis; its use results in global improvement in 80 per cent of the patients, and a net improvement in one or more of the parameters used to assess disease activity in 100 per cent of the patients; it seems to be sufficiently safe to administer to patients over a long period of time; there was no evidence of severe toxicity of any kind; gastrointestinal side effects were uncommon, and epigastric distress, in particular, was not observed. | |
| 1117726 | Thoracic surgical problems associated with rheumatoid arthritis. | 1975 Mar | Nine cases are presented that represent nearly all of the pleural, lung, and pericardial manifestations of rheumatoid arthritis. Three of the 9 had lung biopsies for various reasons to confirm the presence of the rheumatoid change. Six patients had complications of the disorder that required thoracic surgical intervention. The operations included emergency exploration of an empyema cavity for hemorrhage, decortication of the heart and lung, permanent open empyema drainage, and tube thoracostomy. The fact that all of the patients withstood the major complications and major surgery proves that patients with severe rheumatoid disease can withstand major thoracic surgery whenever there occurs a problem that will further increase their disability or threaten their lives. | |
| 4001888 | Spontaneous fracture of atlas of cervical spine affected by rheumatoid arthritis. | 1985 | A case of spontaneous fracture of the atlas in a 67-year-old woman who had suffered from rheumatoid arthritis for more than 20 years is described. This fracture is unique and can present diagnostic problems. Lying in the coronar plane makes the atlas difficult to visualize radiographically. Computer-guided tomography is a helpful diagnostic technique. The brittleness of the cervical spine in long-term rheumatoid patients should also be kept in mind when performing endotracheal intubation. | |
| 7291957 | Capillary microscopy of the nailfold in psoriatic and rheumatoid arthritis. | 1981 | The nailfold capillaries of 35 patients with psoriatic arthritis and 30 with rheumatoid arthritis were studied by capillary microscopy and the findings compared. Seventy healthy subjects served as controls. The pronounced subpapillary plexus visibility, greater number of vessels and their elongation are indicative of rheumatoid arthritis, while shorter, fewer capillaries and especially characteristic psoriatic capillaries, when present, suggest psoriatic arthritis. Sluggish blood flow, higher number of hemorrhages and higher subpappillary plexus visibility are common to both patient groups as opposed to the controls. | |
| 935739 | Incidence of joint involvement in early rheumatoid arthritis. | 1976 May | The frequency of joint involvement is described in 102 patients seen within one year of onset of rheumatoid arthritis. The joints most commonly affected were metacarpophalangeal, proximal interphalangeal and wrists, followed by metatarsophalangeal and shoulders. The least commonly affected were the hips and spine. Temporomandibular and cervical spine involvement often occurred even in these early stages. Where there was unilateral involvement of corresponding joints there was a marked tendency for one side of the body to be more often affected. The arthritis was predominantly peripheral. There was a marked gradation of frequency in the small joints of the hands. The patients were followed prospectively for a mean 4.5 years and outcome assessed. An eventually more severe disease was associated with early writst and metatarsophalangeal joint involvement. | |
| 4063626 | Clinically significant vitamin C deficiency in rheumatoid arthritis. | 1985 Nov | Three elderly rheumatoid patients are described with significant cutaneous haemorrhages. All patients were ascorbic-acid deficient, and treatment with vitamin C supplements led to resolution of these lesions. | |
| 1014622 | [Value of the lymphocyte transformation test with phytohemagglutinin in rhematoid arthriti | 1976 Dec | The aim of the present study was to determine the significance of the lymphocyte transformation test with phyto-hemagglutinin in connection with the degree of inflammatory activity and serological changes. Lymphocyte transformation test with phytohemagglutinin was performed on 46 of the patients with rheumatoid arthritis active stage, diagnosed according to the New York criteria. In patients with low and moderate inflammatory activity the lymphocyte transformation test has values close to those of the controls. In patients with high inflammatory activity either low values or considerably higher were established as compared with the control group. The values of the test were proved, through the statistical analysis, to be heterogenous quantities in seropositive and seronegative patients. | |
| 6646415 | Neuroradiologic picture of cerebral vasculitis in rheumatoid arthritis. | 1983 | The central nervous system is rarely involved in rheumatoid arthritis. In this paper the authors report a case of a 50-year-old woman who had rheumatoid arthritis for about 6 years. A month before admission she presented a symptomatology resembling an expansive intracranial process. Angiography revealed cerebral arteritis and CT showed areas of hypodensity with marked contrast enhancement. | |
| 3917673 | Characterization of T cells bearing HLA-DR antigens in rheumatoid arthritis. | 1985 Jan | It has been demonstrated that T cells bearing HLA-DR antigens on their surface are actively involved in an immune response. In diseases of disordered immunoregulation, including rheumatoid arthritis (RA), there are elevated numbers of circulating HLA-DR+ T cells. In this study, we examined the cellular physiology of these T cells in RA patients. Using tritiated thymidine incorporation, we found that, in most patients, HLA-DR+ cells do not account for a significant amount of spontaneous proliferation found in peripheral blood T cells. RNA hybridization studies, using a cloned HLA-DR alpha chain gene probe, indicate that the T cells actively synthesize HLA-DR antigens rather than passively adsorbing them. The cell surface phenotype of the HLA-DR+ T cells was analyzed using double immunofluorescence and a variety of monoclonal antibodies. The expression of T cell differentiation antigens T4, T6, T8, and T10 varied markedly from patient to patient. In some patients, a significant number of cells expressed both T4 and T8 antigens. Most HLA-DR+ cells also express antigens defined by the following antibodies: anti-Tac (the interleukin-2 receptor), J2 (a glycoprotein found on T cell blasts), and ILR-1 (a class II major histocompatibility complex antigen). Activated T cells bearing HLA-DR antigens may play a role in the development of RA. Our data demonstrate that although these cells are not lymphoblasts, they possess a distinct cell surface phenotype. | |
| 1183034 | The influence of drugs and disease activity on biochemical and haematological data in rheu | 1975 Oct 15 | Biochemical and haematological data from 218 patients with rheumatoid arthritis were analysed and compared with data from a reference hospital population. The comparison demonstrated significant differences in several biochemical and haematological tests and that the patterns of change are different between males and females. The data were also analysed by conventional statistical methods and discriminant analysis using a computer to establish which tests were most influenced by the activity of the disease and drug therapy. The results obtained demonstrate marked difference between groups of patients with different disease activity or receiving different drugs. The discriminant analysis also identified those tests which differentiate these groups most effectively. | |
| 846509 | Sjögren's syndrome association with HLA-Dw3. | 1977 Apr 21 | Sjögren's syndrome is associated with a serologically defined histocompatibility antigen of the HLA-B locus, HLA-B8. Another closely linked locus, HLA-D, determines lymphocyte-defined cell-surface antigens. In laboratory animals such antigens are closely linked to immune response genes. To determine whether Sjögren's syndrome is primarily associated with an HLA-D antigent or with HLA-A and HLA-B antigens as well as HLA-Dw3, which is known to be in linkage disequilibrium with HLA-B8. We found the primary association of association of Sjögren's syndrome to be with HLA-Dw3, which we observed in 84 percent of patients with Sjögren's syndrome in the absence of rheumatoid arthritis as compared to 24 percent in controls (P less than 0.00001). The frequency of HLA-B8 and HLA-Dw3 in patients with both Sjögren's syndrome and rheumatoid arthritis did not differ from that in controls. Patients with Sjögren's syndrome and rheumatoid arthritis comprise genetically distinct groups. | |
| 7387218 | Relationship between pressure and digital vasculitis in rheumatoid disease. | 1980 Apr | The sites of 92 rheumatoid nailfold lesions were compared with sites of pressure as indicated by tissue blanching during gripping. A close correspondence between sites of blanching and sites of vasculitis was found, and this is discussed in relation to the possible role of vascular compression and blood stasis in the development of rheumatoid vasculitis. | |
| 4824989 | Arthritis, deformities, and runting in C5-deficient mice injected with human rheumatoid ar | 1974 Feb | The pathogenesis of rheumatoid arthritis might be more easily understood and the efficacy of therapeutic measures might be more accurately assessed if a convenient animal replica of this disease were available for laboratory study. Intraperitoneal injection of homogenates of inflamed synovium taken at operation from patients with rheumatoid arthritis produces inflammatory swelling and deformity in the tail and extremities of a proportion of injected mice from a complement (C5)-deficient inbred strain. Swelling of the paws leads to limping of the affected mice. The lesions are transmissible from generation to generation. The results support the theory of a transmissible agent in the inflamed synovium of rheumatoid arthritis patients. | |
| 779795 | Predominance of T cells in the lymphocytic infiltrates of synovial tissues in rheumatoid a | 1976 May | Synovial tissues from 5 patients with rheumatoid arthritis (RA) were examined with immunofluorescence microscopy for the presence of lymphocytes with either bone marrow-derived (B) or thymus-derived (T) surface markers. Five synovial tissues with severe to mild lymphocytic infiltrations by bright field microscopy were examined in parallel with immunofluorescence. B cells were identified with a pepsin-digested fluoresceinated anti-F (ab')2 antiserum and T cells were detected with a specific rabbit anti-T lymphocyte antiserum. By these techniques 75-90% of the lymphocytes in these frozen sections were identified as T cells. Cell suspensions were also prepared by collagenase digestion of two of the five synovial tissues. The lymphocytes in these cell suspensions were predominantly T lymphocytes (78-85%) as shown by their ability to form spontaneous rosettes with sheep erythrocytes (E rosettes). | |
| 6522597 | [Osseous sequelae to tenosynovitis in the fingers and toes in chronic polyarthritis]. | 1984 Dec | In rheumatoid arthritis, concomitant tenosynovitis causes erosions and different forms of demineralisation close to the margins of the phalangeal diaphyses. | |
| 6497461 | Clinical judgment in rheumatoid arthritis. III. British rheumatologists' judgments of 'cha | 1984 Oct | A realistic analysis of the criteria used by rheumatologists in evaluating the progress of patients suffering from rheumatoid arthritis must be based on actual clinical judgments rather than on expressed opinions. A randomly selected 15% sample of British rheumatologists (48) recorded judgements on the progress of 50 'paper' patients, based on data taken from actual patients participating in clinical trials. The rheumatologists differed markedly in their assessments of the progress of disease, with serious disagreements even when only 'clinically important' changes were considered. Some clinicians showed little consistency in their judgments of duplicate cases. Multiple regression analysis of the patient data in relation to the disease assessments provided a model of each clinician's judgment policy. These judgment policy models showed that the differences in clinical assessment were greater than could be explained by the inconsistent application of similar assessment policies, and were a consequence also of differences in the underlying judgment policies themselves. Judgments related more closely to changes in ESR and other process measures than to changes in functional ability. | |
| 6604304 | Sjögren's syndrome in systemic lupus erythematosus and rheumatoid arthritis: immune effec | 1983 | A simultaneously capturing azo dye method for acid alpha-naphthyl acetate esterase was used to characterize the cellular infiltrate in labial salivary glands in 25 patients with Sjögren's syndrome (SS). There was no significant difference in the T-pattern lymphocyte percentage in situ between the untreated group with SS and the group treated with 10 +/- 2 mg prednisone/day. There was a significant correlation (P less than 0.05) between the T-pattern lymphocyte percentage in situ and the focus-score value. In secondary (2 degrees) SS in cases of systemic lupus erythematosus (SLE) and rheumatoid arthritis, respectively, 55% +/- 4% (range 41-69) and 43% +/- 7% (range 15-80) of all inflammatory cells in the periductal lymphocyte-rich infiltrates were T-pattern lymphocytes. In other SS patients the corresponding value was 28% +/- 7% (range 4-50). The T-pattern lymphocyte percentage in situ was dependent on the disorder associated with SS (P = 0.07). The present results indicate the dominance of T-lymphocytes in situ in 2 degrees SS with SLE and suggest that there are differences in cell-mediated immunity in different clinical subgroups of SS. | |
| 6813469 | The influence of cigarette smoking on blood gold distribution during chrysotherapy. | 1982 Jul | Plasma and erythrocyte gold concentrations were measured in 35 patients taking gold sodium thiomalate (GSTM) for rheumatoid arthritis. In 6 patients with adverse effects attributable to gold therapy at the time of sampling, gold concentrations in plasma and erythrocyte fractions were no different from those without adverse effects. A significant difference was seen in the distribution of gold in the blood of cigarette smokers compared to non-smokers, with smokers having higher erythrocyte and lower plasma gold concentrations. A prospective study on 15 patients commencing treatment with GSTM showed that the higher concentrations of erythrocyte gold seen in smokers were achieved within the first 2 weeks of treatment. | |
| 3875716 | Rheumatoid factors and HLA-DR4 in RA. | 1985 Apr | The levels of serum rheumatoid factors (RF) and the in vitro production of immunoglobulin were studied in 21 patients with rheumatoid arthritis (RA) and compared to the in vitro responses of 20 controls. In RA patients the levels of serum IgM RF and IgG RF were not significantly increased in patients possessing HLA-DR4 or any other DR antigen. Lymphocytes from seropositive RA patients released measurable quantities of IgM RF spontaneously, greatest in those possessing HLA-DR4. When lymphocytes were treated with either pokeweed mitogen or the T cell mitogen derived from Mycoplasma arthritidis the increased production of IgM RF was not related to HLA-DR4 status, either for RA patients or controls. Seronegative RA lymphocytes, while having similar IgM RF responses to controls, differed in having IgG RF in their serum. | |
| 6426052 | Gold resistance in cultured human cells possible role of metallothionein. | 1983 | Insufficient therapeutic effect of auranofin (AF), used in the treatment of rheumatoid arthritis, is found in about 8% of the patients included in clinical trials until now. The mechanisms of resistance to gold-containing drugs are not known, but one reason might be acquired drug resistance. We have studied the relationship between the effects of gold and concentration of the cytoplasmic metal-binding protein metallothionein (MT), in order to evaluate MT as a possible contributing factor to resistance against AF. Different strains of cultured human epithelial cells derived from normal skin, treated with AF, were used as models. The experiments indicate two possible mechanisms for resistance against AF in cells: 1) binding of gold to pre-existent cadmium-induced MT or to de novo AF-induced MT, and 2) the cells' ability to keep the intracellular gold concentration at a low level. AF apparently causes a rapid and pronounced increase of MT-content in these cells. Preliminary results also indicated that AF causes increase of MT-content in human rheumatoid synovial cells, grown as primary cultures. These findings may have two clinical implications: 1) AF-induced MT may decrease therapeutic response, and 2) decrease the toxicity of AF. |