RABC

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Biomarkers name	Biomarker Type	Source database	Information	Details
TRP53	gene	CTD	Gene Symbol=TRP53; Gene ID=22059; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Arsenic Trioxide\|Aspartame\|Aspirin\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Freund's Adjuvant\|glyphosate\|Gold\|mancozeb\|Maneb\|Methotrexate\|ochratoxin A\|Oxygen\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Sulindac\|Tacrolimus\|Tretinoin\|triptolide\|Vorinostat; Inference Score=55.32; Reference Count=203	details
TIMP3	gene	CTD	Gene Symbol=TIMP3; Gene ID=7078; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Antirheumatic Agents\|Arsenic Trioxide\|Curcumin\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|entinostat\|glyphosate\|Indomethacin\|Leflunomide\|Methotrexate\|Naproxen\|ochratoxin A\|Oxygen\|Plant Extracts\|Resveratrol\|Sulfasalazine\|Sulindac\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=55.26; Reference Count=186	details
ISG20	gene	CTD	Gene Symbol=ISG20; Gene ID=3669; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Antirheumatic Agents\|Azathioprine\|chloroquine diphosphate\|Cyclosporine\|Dexamethasone\|Diclofenac\|entinostat\|Gold Sodium Thiomalate\|Methotrexate\|Methylprednisolone\|Oxygen\|Ozone\|Piroxicam\|Prednisolone\|Resveratrol\|tamibarotene\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=55.09; Reference Count=182	details
S100A9	gene	CTD	Gene Symbol=S100A9; Gene ID=6280; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Azathioprine\|Curcumin\|Cyclosporine\|Dexamethasone\|Diclofenac\|Freund's Adjuvant\|glyphosate\|mancozeb\|Maneb\|Methotrexate\|Ozone\|Penicillamine\|Plant Extracts\|Resveratrol\|tamibarotene\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=54.95; Reference Count=326	details
C3	gene	CTD	Gene Symbol=C3; Gene ID=718; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|entinostat\|Freund's Adjuvant\|glyphosate\|Gold\|Methotrexate\|Oxygen\|Ozone\|Penicillamine\|Reactive Oxygen Species\|Resveratrol\|Tacrolimus\|Thalidomide\|Tobacco Smoke Pollution\|triptolide; Inference Score=54.76; Reference Count=321	details
MCL1	gene	CTD	Gene Symbol=MCL1; Gene ID=4170; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Antirheumatic Agents\|Arsenic Trioxide\|Aspirin\|Auranofin\|Chloroquine\|Curcumin\|Cyclosporine\|Dexamethasone\|entinostat\|glyphosate\|Gold Compounds\|Leflunomide\|Maneb\|Methotrexate\|ochratoxin A\|Ozone\|Penicillamine\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Thalidomide\|Tretinoin\|triptolide\|Vorinostat; Inference Score=54.76; Reference Count=358	details
HMOX1	gene	CTD	Gene Symbol=HMOX1; Gene ID=3162; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Aspirin\|Auranofin\|bucillamine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Dinoprostone\|Edaravone\|Enalapril\|entinostat\|glyphosate\|Gold\|Gold Compounds\|GW 506033X\|Indomethacin\|Maneb\|Methotrexate\|Methylprednisolone\|Nitrites\|ochratoxin A\|Oxygen\|Ozone\|Penicillamine\|Pesticides\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Sulfasalazine\|Sulindac\|Tacrolimus\|thymoquinone\|Tiopronin\|Tobacco Smoke Pollution\|Tretinoin\|triptolide; Inference Score=54.66; Reference Count=390	details
MMP3	gene	CTD	Gene Symbol=MMP3; Gene ID=4314; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Aspirin\|Azathioprine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Dinoprostone\|Enalapril\|Gold\|Indomethacin\|Methotrexate\|Minocycline\|Oxygen\|Ozone\|Plant Extracts\|Resveratrol\|Sulfasalazine\|Tobacco Smoke Pollution\|tofacitinib\|Tretinoin; Inference Score=54.59; Reference Count=220	details
EEF1A1	gene	CTD	Gene Symbol=EEF1A1; Gene ID=1915; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Aspirin\|Cyclosporine\|Dexamethasone\|entinostat\|glyphosate\|Indomethacin\|Maneb\|Methotrexate\|ochratoxin A\|Oxygen\|Ozone\|Plant Extracts\|Resveratrol\|tamibarotene\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=54.44; Reference Count=163	details
MAPK1	gene	CTD	Gene Symbol=MAPK1; Gene ID=5594; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antigens\|Antirheumatic Agents\|Arsenic Trioxide\|Aspartame\|Aspirin\|Azathioprine\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Dinoprostone\|Famotidine\|Flurbiprofen\|Freund's Adjuvant\|glyphosate\|GW 506033X\|Hydrocortisone\|Indomethacin\|Leflunomide\|LY 117018\|mancozeb\|Maneb\|Methotrexate\|Methylprednisolone\|ochratoxin A\|Oxygen\|Ozone\|Plant Extracts\|Quinacrine\|Reactive Oxygen Species\|Resveratrol\|Sulindac\|tamibarotene\|Thalidomide\|thymoquinone\|Tobacco Smoke Pollution\|tofacitinib\|Tretinoin\|triptolide\|Vorinostat; Inference Score=54.39; Reference Count=245	details
THBS1	gene	CTD	Gene Symbol=THBS1; Gene ID=7057; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Aspartame\|Aspirin\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|glyphosate\|Gold Sodium Thiomalate\|Indomethacin\|Leflunomide\|Methotrexate\|Methylprednisolone\|Ozone\|Pesticides\|Plant Extracts\|Prednisolone\|Resveratrol\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=54.16; Reference Count=200	details
CCNA2	gene	CTD	Gene Symbol=CCNA2; Gene ID=890; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Arsenic Trioxide\|Aspirin\|Azathioprine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|entinostat\|glyphosate\|Indomethacin\|Leflunomide\|Methotrexate\|ochratoxin A\|Oxygen\|Ozone\|Piroxicam\|Plant Extracts\|Resveratrol\|Sulindac\|Tacrolimus\|Thalidomide\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|Vorinostat; Inference Score=54.02; Reference Count=195	details
CXCL3	gene	CTD	Gene Symbol=CXCL3; Gene ID=2921; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Edaravone\|Gold Sodium Thiomalate\|Indomethacin\|Leflunomide\|Methotrexate\|Methylprednisolone\|Oxygen\|Ozone\|Piroxicam\|Prednisolone\|Resveratrol\|Tobacco Smoke Pollution; Inference Score=53.91; Reference Count=186	details
TIMP2	gene	CTD	Gene Symbol=TIMP2; Gene ID=7077; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Aspirin\|Chloroquine\|Curcumin\|Cyclosporine\|Dexamethasone\|Freund's Adjuvant\|Indomethacin\|Naproxen\|ochratoxin A\|Oxygen\|Ozone\|Pesticides\|Plant Extracts\|Resveratrol\|Sulfasalazine\|Thalidomide\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=53.89; Reference Count=109	details
VIM	gene	CTD	Gene Symbol=VIM; Gene ID=7431; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|entinostat\|glyphosate\|Gold\|Indomethacin\|Leflunomide\|Methotrexate\|ochratoxin A\|Oxygen\|Ozone\|Plant Extracts\|Resveratrol\|Sulfasalazine\|Tacrolimus\|tamibarotene\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=53.76; Reference Count=208	details
TJP1	gene	CTD	Gene Symbol=TJP1; Gene ID=7082; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Antirheumatic Agents\|Arsenic Trioxide\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Diclofenac\|glyphosate\|Hydrocortisone\|Indomethacin\|Levamisole\|Methotrexate\|ochratoxin A\|Oxygen\|Plant Extracts\|Resveratrol\|Thalidomide\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|Vorinostat; Inference Score=53.69; Reference Count=169	details
ASNS	gene	CTD	Gene Symbol=ASNS; Gene ID=440; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Azathioprine\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|entinostat\|Freund's Adjuvant\|Indomethacin\|Leflunomide\|Methotrexate\|Methylprednisolone\|ochratoxin A\|Oxygen\|Piroxicam\|Prednisolone\|Resveratrol\|Sulindac\|triptolide\|Vorinostat; Inference Score=53.64; Reference Count=196	details
SERPINE1	gene	CTD	Gene Symbol=SERPINE1; Gene ID=5054; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Azathioprine\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Diclofenac\|Enalapril\|entinostat\|Famotidine\|Gold\|Hydroxychloroquine\|Indomethacin\|Leflunomide\|Maneb\|Methotrexate\|ochratoxin A\|Oxygen\|Ozone\|Pesticides\|Plant Extracts\|Resveratrol\|Tacrolimus\|Thalidomide\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=53.41; Reference Count=224	details
VCAM1	gene	CTD	Gene Symbol=VCAM1; Gene ID=7412; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Aspirin\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Diclofenac\|Edaravone\|Enalapril\|entinostat\|Glucocorticoids\|glyphosate\|Hydrocortisone\|Indomethacin\|Methotrexate\|Naproxen\|Oxygen\|Plant Extracts\|Resveratrol\|Sulfasalazine\|Sulindac\|Tacrolimus\|Thalidomide\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=53.31; Reference Count=206	details
CYP3A4	gene	CTD	Gene Symbol=CYP3A4; Gene ID=1576; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Enalapril\|Etoricoxib\|Glucocorticoids\|Hydrocortisone\|Indomethacin\|Leflunomide\|mancozeb\|Mefenamic Acid\|Methotrexate\|Methylprednisolone\|ochratoxin A\|Oxygen\|Pesticides\|Phenylbutazone\|Plant Extracts\|Prednisolone\|Quinacrine\|Reactive Oxygen Species\|Resveratrol\|Tacrolimus\|Thalidomide\|Tobacco Smoke Pollution\|tofacitinib\|Tretinoin\|triptolide; Inference Score=53.27; Reference Count=225	details