RABC

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Biomarkers name	Biomarker Type	Source database	Information	Details
HIF1A	gene	CTD	Gene Symbol=HIF1A; Gene ID=3091; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Dinoprostone\|Edaravone\|entinostat\|glyphosate\|Hydrocortisone\|Leflunomide\|Minocycline\|ochratoxin A\|Oxygen\|Ozone\|Plant Extracts\|Prednisone\|Reactive Oxygen Species\|Resveratrol\|Sulfasalazine\|Sulindac\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=53.16; Reference Count=97	details
TRIB3	gene	CTD	Gene Symbol=TRIB3; Gene ID=57761; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Azathioprine\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|entinostat\|Indomethacin\|Leflunomide\|Methotrexate\|ochratoxin A\|Oxygen\|Piroxicam\|Tacrolimus\|Thalidomide\|Tobacco Smoke Pollution\|Tretinoin\|valdecoxib; Inference Score=53.14; Reference Count=202	details
AIFM1	gene	CTD	Gene Symbol=AIFM1; Gene ID=9131; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Cyclosporine\|Dexamethasone\|Diclofenac\|entinostat\|glyphosate\|Gold\|Minocycline\|ochratoxin A\|Oxygen\|Ozone\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Sulfasalazine\|Sulindac\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|Vorinostat; Inference Score=52.97; Reference Count=80	details
ERN1	gene	CTD	Gene Symbol=ERN1; Gene ID=2081; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Arsenic Trioxide\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Edaravone\|glyphosate\|Gold\|GW 506033X\|Hydroxychloroquine\|Leflunomide\|Methotrexate\|Minocycline\|Plant Extracts\|Resveratrol\|Tacrolimus\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=52.85; Reference Count=180	details
CEBPB	gene	CTD	Gene Symbol=CEBPB; Gene ID=1051; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Arsenic Trioxide\|Aspirin\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|entinostat\|Hydrocortisone\|Indomethacin\|Leflunomide\|Methotrexate\|ochratoxin A\|Oxygen\|Ozone\|Piroxicam\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|tamibarotene\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=52.55; Reference Count=205	details
BCL3	gene	CTD	Gene Symbol=BCL3; Gene ID=602; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Antirheumatic Agents\|Arsenic Trioxide\|Curcumin\|Cyclosporine\|Dexamethasone\|Diclofenac\|Gold Compounds\|Leflunomide\|Methotrexate\|Oxygen\|Ozone\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Tacrolimus\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=52.4; Reference Count=152	details
CDH1	gene	CTD	Gene Symbol=CDH1; Gene ID=999; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Aspirin\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Diclofenac\|Dinoprostone\|entinostat\|Indomethacin\|Methotrexate\|ochratoxin A\|Oxygen\|Ozone\|Pesticides\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Sulfasalazine\|Tacrolimus\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=52.28; Reference Count=219	details
GCLC	gene	CTD	Gene Symbol=GCLC; Gene ID=2729; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Azathioprine\|Chlorambucil\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Diclofenac\|Hydrocortisone\|Indomethacin\|Ketoprofen\|Leflunomide\|Maneb\|Meloxicam\|Methotrexate\|Naproxen\|ochratoxin A\|Oxygen\|Ozone\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Sulindac\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|valdecoxib; Inference Score=52.2; Reference Count=195	details
BAD	gene	CTD	Gene Symbol=BAD; Gene ID=572; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Aspirin\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|entinostat\|Gold\|Indomethacin\|Maneb\|Methotrexate\|ochratoxin A\|Oxygen\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Sulindac\|Tacrolimus\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=52.06; Reference Count=187	details
TP53	gene	CTD	Gene Symbol=TP53; Gene ID=7157; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Aspirin\|Azathioprine\|Chlorambucil\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|entinostat\|Flurbiprofen\|glyphosate\|Gold\|GW 506033X\|Indomethacin\|Levamisole\|mancozeb\|Methotrexate\|Minocycline\|ochratoxin A\|Oxygen\|Penicillamine\|Piroxicam\|Plant Extracts\|Quinacrine\|Reactive Oxygen Species\|Resveratrol\|Sulindac\|Tacrolimus\|Thalidomide\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|Vorinostat; Inference Score=52.05; Reference Count=399	details
CYCS	gene	CTD	Gene Symbol=CYCS; Gene ID=54205; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Curcumin\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Edaravone\|Enalapril\|entinostat\|glyphosate\|Gold\|Hydrocortisone\|Indomethacin\|mancozeb\|Methotrexate\|Minocycline\|ochratoxin A\|Oxygen\|Plant Extracts\|Resveratrol\|Thalidomide\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=52.01; Reference Count=180	details
RELB	gene	CTD	Gene Symbol=RELB; Gene ID=5971; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Antirheumatic Agents\|Arsenic Trioxide\|Curcumin\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|glyphosate\|Gold Compounds\|Methotrexate\|Oxygen\|Ozone\|Plant Extracts\|Resveratrol\|Tacrolimus\|tamibarotene\|Thalidomide\|Tobacco Smoke Pollution\|tofacitinib; Inference Score=51.89; Reference Count=146	details
TLR4	gene	CTD	Gene Symbol=TLR4; Gene ID=7099; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Auranofin\|Azathioprine\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Enalapril\|Hydrocortisone\|Indomethacin\|Methotrexate\|Naproxen\|ochratoxin A\|Oxygen\|Ozone\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Sulfasalazine\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=51.88; Reference Count=220	details
CASP1	gene	CTD	Gene Symbol=CASP1; Gene ID=834; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Adjuvants, Immunologic\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Diclofenac\|Freund's Adjuvant\|glyphosate\|Gold\|Indomethacin\|Leflunomide\|Maneb\|Minocycline\|Oxygen\|Ozone\|Plant Extracts\|Resveratrol\|Sulfasalazine\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=51.58; Reference Count=112	details
HSPD1	gene	CTD	Gene Symbol=HSPD1; Gene ID=3329; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Gold\|Indomethacin\|Methotrexate\|Minocycline\|ochratoxin A\|Oxygen\|Ozone\|Pesticides\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|Vorinostat; Inference Score=51.48; Reference Count=196	details
SPP1	gene	CTD	Gene Symbol=SPP1; Gene ID=6696; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Aspirin\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Enalapril\|entinostat\|Freund's Adjuvant\|Hydrocortisone\|Naproxen\|ochratoxin A\|Oxygen\|Ozone\|Piroxicam\|Plant Extracts\|Resveratrol\|Sulfasalazine\|Tacrolimus\|tamibarotene\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=51.18; Reference Count=83	details
IKBKB	gene	CTD	Gene Symbol=IKBKB; Gene ID=3551; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Aspirin\|Chloroquine\|Curcumin\|Dexamethasone\|Diclofenac\|Freund's Adjuvant\|Gold Sodium Thiomalate\|Indomethacin\|Oxygen\|Ozone\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Sulfasalazine\|Sulindac\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|Vorinostat; Inference Score=51.11; Reference Count=123	details
NGFR	gene	CTD	Gene Symbol=NGFR; Gene ID=4804; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Aspirin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Fenoprofen\|Flurbiprofen\|Indomethacin\|Ketoprofen\|Methotrexate\|Naproxen\|Oxygen\|Ozone\|Pesticides\|Resveratrol\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=51.01; Reference Count=175	details
EFEMP1	gene	CTD	Gene Symbol=EFEMP1; Gene ID=2202; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Azathioprine\|Dexamethasone\|Gold Sodium Thiomalate\|Indomethacin\|Methotrexate\|Methylprednisolone\|ochratoxin A\|Oxygen\|Ozone\|Plant Extracts\|Prednisolone\|Resveratrol\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=50.95; Reference Count=184	details
FOXO1	gene	CTD	Gene Symbol=FOXO1; Gene ID=2308; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Antirheumatic Agents\|Arsenic Trioxide\|Azathioprine\|Curcumin\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|entinostat\|glyphosate\|Hydrocortisone\|Indomethacin\|Leflunomide\|Methotrexate\|Methylprednisolone\|Oxygen\|Plant Extracts\|Resveratrol\|Tretinoin\|Vorinostat; Inference Score=50.95; Reference Count=181	details