RABC

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Biomarkers name	Biomarker Type	Source database	Information	Details
MAPK14	gene	CTD	Gene Symbol=MAPK14; Gene ID=1432; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Arsenic Trioxide\|Aspirin\|Curcumin\|Cyclophosphamide\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Dinoprostone\|Flurbiprofen\|Methotrexate\|ochratoxin A\|Oxygen\|Pesticides\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|tamibarotene\|Thalidomide\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|Vorinostat; Inference Score=47.41; Reference Count=163	details
SLC3A2	gene	CTD	Gene Symbol=SLC3A2; Gene ID=6520; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Azathioprine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|entinostat\|Indomethacin\|Leflunomide\|Methotrexate\|Oxygen\|Ozone\|Piroxicam\|Plant Extracts\|Sulfasalazine\|Sulindac\|Tobacco Smoke Pollution\|valdecoxib; Inference Score=47.34; Reference Count=191	details
HSP90AB1	gene	CTD	Gene Symbol=HSP90AB1; Gene ID=3326; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Arsenic Trioxide\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Gold\|Indomethacin\|Leflunomide\|mancozeb\|ochratoxin A\|Ozone\|Resveratrol\|Sulfasalazine\|tamibarotene\|Tobacco Smoke Pollution\|Tretinoin\|valdecoxib\|Vorinostat; Inference Score=47.25; Reference Count=90	details
HSPA1B	gene	CTD	Gene Symbol=HSPA1B; Gene ID=3304; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Chloroquine\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Diclofenac\|glyphosate\|Gold\|Leflunomide\|Maneb\|Methotrexate\|Oxygen\|Ozone\|Piroxicam\|Resveratrol\|Sulfasalazine\|Tobacco Smoke Pollution\|triptolide; Inference Score=47.25; Reference Count=206	details
AKR1C1	gene	CTD	Gene Symbol=AKR1C1; Gene ID=1645; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Arsenic Trioxide\|Aspirin\|Azathioprine\|Cyclosporine\|Dexamethasone\|entinostat\|Flurbiprofen\|Hydrocortisone\|Indomethacin\|Leflunomide\|Mefenamic Acid\|Naproxen\|ochratoxin A\|Plant Extracts\|Reactive Oxygen Species\|Sulindac\|Tobacco Smoke Pollution\|tofacitinib\|valdecoxib\|Vorinostat; Inference Score=47.24; Reference Count=86	details
AKR1C3	gene	CTD	Gene Symbol=AKR1C3; Gene ID=8644; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Aspirin\|Cyclosporine\|Dexamethasone\|Flurbiprofen\|Gold\|Hydrocortisone\|Indomethacin\|Mefenamic Acid\|Naproxen\|ochratoxin A\|Oxygen\|Ozone\|Resveratrol\|Sulindac\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=47.24; Reference Count=81	details
GSR	gene	CTD	Gene Symbol=GSR; Gene ID=2936; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Arsenic Trioxide\|Aspartame\|Azathioprine\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Freund's Adjuvant\|glyphosate\|Indomethacin\|Leflunomide\|Maneb\|Methotrexate\|ochratoxin A\|Oxygen\|Ozone\|Pesticides\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Sulfasalazine\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin\|valdecoxib; Inference Score=47.18; Reference Count=224	details
OCLN	gene	CTD	Gene Symbol=OCLN; Gene ID=100506658; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Arsenic Trioxide\|Chloroquine\|Cyclophosphamide\|deoxynivalenol\|Dexamethasone\|Diclofenac\|glyphosate\|Hydrocortisone\|Hydroxychloroquine\|Indomethacin\|Methotrexate\|ochratoxin A\|Oxygen\|Plant Extracts\|Resveratrol\|tamibarotene\|Thalidomide\|Tobacco Smoke Pollution\|Tretinoin\|triptolide; Inference Score=47.16; Reference Count=186	details
HLA-C	gene	CTD	Gene Symbol=HLA-C; Gene ID=3107; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Cyclosporine\|Dexamethasone\|entinostat\|ochratoxin A\|Ozone\|Piroxicam\|tamibarotene\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=47.11; Reference Count=25	details
PARP1	gene	CTD	Gene Symbol=PARP1; Gene ID=142; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Aspirin\|Auranofin\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Dinoprostone\|Edaravone\|glyphosate\|Gold\|Indomethacin\|Methotrexate\|ochratoxin A\|Organogold Compounds\|Oxygen\|Ozone\|Penicillamine\|Plant Extracts\|Quinacrine\|Reactive Oxygen Species\|Resveratrol\|Sulindac\|Thalidomide\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|valdecoxib\|Vorinostat; Inference Score=47.1; Reference Count=381	details
MAOA	gene	CTD	Gene Symbol=MAOA; Gene ID=4128; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Diclofenac\|entinostat\|glyphosate\|Hydrocortisone\|Methotrexate\|ochratoxin A\|Oxygen\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Sulindac\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=47.09; Reference Count=150	details
STAT6	gene	CTD	Gene Symbol=STAT6; Gene ID=6778; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Aspirin\|Diclofenac\|entinostat\|Leflunomide\|Methotrexate\|Methylprednisolone\|Ozone\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|thymoquinone\|Tobacco Smoke Pollution\|tofacitinib\|Tretinoin\|Vorinostat; Inference Score=47.05; Reference Count=174	details
CLDN1	gene	CTD	Gene Symbol=CLDN1; Gene ID=9076; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Chloroquine\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|entinostat\|glyphosate\|Hydroxychloroquine\|Leflunomide\|Levamisole\|Methotrexate\|ochratoxin A\|Resveratrol\|Tacrolimus\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=47; Reference Count=180	details
MET	gene	CTD	Gene Symbol=MET; Gene ID=4233; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Arsenic Trioxide\|Azathioprine\|Cyclosporine\|deoxynivalenol\|Diclofenac\|Gold Sodium Thiomalate\|Leflunomide\|Methotrexate\|Methylprednisolone\|ochratoxin A\|Oxygen\|Pesticides\|Piroxicam\|Plant Extracts\|Prednisolone\|Resveratrol\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=46.99; Reference Count=186	details
SLCO2A1	gene	CTD	Gene Symbol=SLCO2A1; Gene ID=6578; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Antirheumatic Agents\|Cyclosporine\|Dexamethasone\|Diclofenac\|Dinoprostone\|Indomethacin\|Ketoprofen\|Methotrexate\|Naproxen\|Ozone\|Resveratrol\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|valdecoxib; Inference Score=46.95; Reference Count=163	details
TNFRSF10A	gene	CTD	Gene Symbol=TNFRSF10A; Gene ID=8797; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Arsenic Trioxide\|Chlorambucil\|Chloroquine\|Curcumin\|Cyclosporine\|entinostat\|Gold\|Methotrexate\|Oxygen\|Ozone\|Plant Extracts\|Resveratrol\|Thalidomide\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|Vorinostat; Inference Score=46.94; Reference Count=169	details
IER3	gene	CTD	Gene Symbol=IER3; Gene ID=8870; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Azathioprine\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Diclofenac\|Indomethacin\|Leflunomide\|ochratoxin A\|Oxygen\|Ozone\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|tamibarotene\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=46.91; Reference Count=77	details
COL3A1	gene	CTD	Gene Symbol=COL3A1; Gene ID=1281; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Angiotensin-Converting Enzyme Inhibitors\|Aspirin\|Curcumin\|Cyclosporine\|Dexamethasone\|Diclofenac\|Enalapril\|Glucocorticoids\|Gold\|Indomethacin\|Methotrexate\|ochratoxin A\|Oxygen\|Ozone\|Plant Extracts\|Resveratrol\|Tacrolimus\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=46.86; Reference Count=187	details
PDGFA	gene	CTD	Gene Symbol=PDGFA; Gene ID=5154; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Arsenic Trioxide\|Azathioprine\|Cyclosporine\|Dexamethasone\|Dinoprostone\|entinostat\|glyphosate\|Indomethacin\|Leflunomide\|Methotrexate\|Naproxen\|Oxygen\|Ozone\|Reactive Oxygen Species\|Sulindac\|tamibarotene\|Tretinoin\|Vorinostat; Inference Score=46.81; Reference Count=173	details
ITGA2	gene	CTD	Gene Symbol=ITGA2; Gene ID=3673; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=NA; Inference Network=Acetaminophen\|Antirheumatic Agents\|Arsenic Trioxide\|Aspirin\|Cyclosporine\|Diclofenac\|Dinoprostone\|Enalapril\|glyphosate\|Leflunomide\|Ozone\|Pesticides\|Resveratrol\|Sulindac\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=46.79; Reference Count=60	details