Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 287931 | Current trends in the treatment of rheumatoid arthritis in general practice. | 1979 Mar 14 | Questionnaires were sent to 180 randomly selected general medical practitioners in the Auckland area, to determine the source of prescribing information and current drug prescribing pattern in general practice, for the treatment of rheumatoid arthritis. Medical journals were the main current source but postgraduate seminars and lectures were the preferred source of prescribing information. Aspirin remains the drug of first choice in the treatment of rheumatoid arthritis and along with indomethacin, phenylbutazone and prednisone (10 mg daily), considered to be more effective than the newer propionic acid derivatives. Enteric coated aspirin was preferred in the patient with an active peptic ulcer. Almost all of the replying doctors, endeavoured to give their patients an explanation as to the underlying nature of their disease and treatment, but had little confidence that they would comply with the therapeutic instructions. | |
| 7273511 | Total elbow arthroplasty: a clinical review of 30 cases employing the Mayo and AHSC prosth | 1981 Jul | Chronic synovitis of the elbow in rheumatoid arthritics that has not responded to four to six months of optimal nonoperative management should be treated by synovectomy even in the absence of significant intra-articular X-ray changes. When intra-articular damage is significant, an arthroplasty will not only relieve the pain, but may also provide a satisfactory range of motion. It is necessary to consider all the possible complications and the fact that technically, total elbow arthroplasty is a difficult operation to perform. Because of the potential for loosening, one might consider using an unconstrained device in the patient with adequate bone structure, reserving the semiconstrained devices for elbows with disintegrated bone tissues. The constrained prostheses should be used only for the most severely disorganized and unstable elbows. | |
| 6093716 | The presence of abnormal lysosomes in lymphocytes and neutrophils during chloroquine thera | 1984 Oct | Lysosomal ultrastructure in circulating lymphocytes and neutrophils from the blood of 22 patients with rheumatoid arthritis or systemic lupus erythematosus undergoing chloroquine therapy has been examined and compared with that of rheumatoid cases receiving alternative forms of treatment and non-rheumatoid controls. The lymphocytes of all 22 patients receiving chloroquine showed a highly significant number of lamellar inclusion bodies (mean 9.3%) compared with only occasional inclusions in six of the 14 rheumatoid and four of the 12 non-rheumatoid controls (means 0.86% and 0.83% respectively). Neutrophils from eight chloroquine-treated patients also showed abnormal granules which were absent from both control groups. These findings confirm our earlier in vitro work which indicated that lymphocytes, compared with neutrophils, had a greater susceptibility to chloroquine action with respect to alterations in lysosomal structure. | |
| 6990881 | Rheumatoid arthritis: effects of a new agent (ICI 55 897) on serum acute phase proteins an | 1980 Feb | Thirty-four patients with rheumatoid arthritis (RA) were treated with a new agent (ICI 55 897) in addition to basic therapy with nonsteroid anti-inflammatory drugs. Five patients had the drug for less than 28 days; the remaining 29 were observed for periods up to a year. At 140 days, when all but 2 patients were in the study, there had been statistically significant improvement in clinical score, serum C-reactive protein, erythrocyte sedimentation rate, and plasma fibrinogen. Thereafter results continued to improve but were biased because some patients had stopped taking the drug. The final conclusion was that 17 patients had improved with 1 late relapse, and 15 had not responded. Adverse effects were trivial except in 2 instances: one patient had a transient unexplained rise in blood urea, another had a haematemesis. Neither effect could be attributed with certainty to the drug. ICI 55 897 has no intrinsic analgesic or anti-inflammatory properties. We suggest the findings of this study indicate that this agent, with low toxicity and the ability to lower acute-phase protein levels, may be an alternative to gold or penicillamine in the treatment of RA. | |
| 6315067 | The effect of D-penicillamine on human myeloperoxidase, a mechanism for the efficacy of th | 1983 Nov 28 | We investigated the effect of D-penicillamine on the ability of myeloperoxidase, purified from human leukocytes, to catalyse the oxidation of chloride ions to hypochlorite (HOCl) in the presence of H2O2. It is shown that, due to the interaction of D-penicillamine with both myeloperoxidase itself and HOCl, the chlorinating activity of myeloperoxidase in the presence of H2O2 and chloride ions is prevented. A concentration of 100 microM D-penicillamine inhibits the chlorinating activity of myeloperoxidase completely, which Is due to the stabilization of Compound II, an inactive form of the enzyme. In addition, HOCl reacts directly with D-penicillamine. Analysis of the reaction products of D-penicillamine and HOCl showed that D-penicillamine was oxidized to penicillamine disulphide and penicillamine sulphinic acid, and eventually deaminated (indicated by the release of ammonia). Lower concentrations of D-penicillamine (10 microM) inhibited myeloperoxidase less, but still acted as effective scavengers of HOCl. In very low concentrations (1 microM), D-penicillamine did not scavenge HOCl effectively, but rather stimulated the chlorinating activity of myeloperoxidase. However, when instead of D-penicillamine a comparable amount of ascorbate was added, a similar but even larger stimulation was observed. Since the concentration of free D-penicillamine in serum from rheumatoid patients treated with this drug is about 20 microM (Saetre, R. and Rabenstein, D.L. (1978) Anal. Chem. 50, 276-280), the therapeutic effect of D-penicillamine may be due to the protection of tissues against the reactive HOCl released by activated granulocytes at inflammation sites. | |
| 2413723 | Serum and urinary ferritin levels in patients with rheumatoid arthritis. | 1985 Aug | The serum and urinary ferritin levels in 52 RA patients were measured by the 2-site immunoradiometric assay method. Serum ferritin levels in RA patients correlated with C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) but not with serum iron levels and hemoglobin concentrations, although they were within the normal range. High serum ferritin levels were associated with sera with hyper gamma-globulin and rheumatoid factors. In sequential studies, serum ferritin changed in parallel with ESR, CRP and disease activity in a majority of the patients. The urinary ferritin levels and u/s ratios in some RA patients were higher than control values. Higher values were found particularly in the group of patients under gold therapy but not in groups under other treatments. | |
| 475875 | The rarity of Felty's syndrome in blacks. | 1979 Sep | Evidence is presented that Felty's syndrome (FS) is rare among black patients with rheumatoid arthritis (RA). All of 12 patients with FS seen at Parkland Memorial Hospital, Dallas, Texas betwen 1964 and 1978 were white. During this period 52% of patients admitted to the Parkland medical service were black and 31% of patients dischargd with a diagnosis of RA were black. The number of expected black cases of FS on the basis of the racial distribution of hospitalized patients with RA was 3.7 (P is less than 0.02 when the zero incidence in blacks was compared with the expected incidence). All 7 cases of FS observed at Charity Hospital, New Orleans, Louisiana between 1968 and 1978 were also white. During this period, 65% of patients discharged with a diagnosis of RA were black, and the number of expected black cases of FS was 4.5 (P is less than 0.001). These findings suggest a genetic basis for the development of leukopenia and splenomegaly in RA patients. | |
| 7048794 | [Inflammatory rheumatic diseases in old age]. | 1982 Mar | Although in higher age degenerative diseases of the spine and joints preponderate, the portion of inflammatory rheumatic diseases is relatively high, and may raise difficult diagnostic problems. Prevalence of rheumatic fever, ankylosing spondylitis, gout and some connective tissue diseases starting in higher age is low and their course is more benign and milder than in earlier age groups. Chondrocalcinosis (pseudogout) and polymyalgia rheumatica are typical rheumatic diseases of higher age. Rheumatoid arthritis with first onset in higher age is also not rare. This disease may start explosively and may run a progressive course. Very hig blood sedimentation rate, early arthritis of shoulder joints and symptoms of a severe general disease often are the leading symptoms. Diagnostic similitarities with other diseases like malignant tumors or with paraneoplastic arthritis may mislead in diagnosis of senile rheumatoid arthritis. | |
| 1207313 | [Priniciples of reconstructive surgery of the rheumatic hand (author's transl)]. | 1975 Nov | Rheumatic diseases such as rheumatoid arthritis, psoriatic arthropathy, and ankylosing spondylitis very often cause deformities of the hand. Especially during the early stages of these diseases, synovectomy of joints and tendons is indicated; destructive and degenerative lesions can be limited in this way. If they are already present, in most cases only reconstructive operations such as arthrodesis, resection, interposition arthroplasty, articial joint replacement, tendon transfer etc. can improve the impaired function. | |
| 6974779 | Synovial fluid total hemolytic complement activity in rheumatic diseases - a reappraisal. | 1981 May | The varied and contradictory claims made of the clinical value of measuring total hemolytic complement activity in rheumatic diseases prompted a reappraisal of its role, and a review of the literature, taking into account the anomalies of assay and the semi-quantitative nature of the procedure. We found that measurements of synovial fluid (SF) total hemolytic complement activity were of limited value in determining the diagnosis or prognosis of joint diseases. Also there was no significant relationship between SF total hemolytic complement activity and either clinical activity or other laboratory findings. We believe that measurements of SF complement activity will prove of little use as a guide to the effectiveness of drug therapy. | |
| 1130199 | Studies on the pathogenicity for rat of a mycoplasma isolated from rheumatoid arthritis. | 1975 Feb | The pathogenicity for rat of M. arthritidis strain Jasmin and strain 20-P from rheumatoid synovial tissue were studied. Only strain Jasmin produced signs of illness in four of the 12 rats infected. A mycoplasma was isolated from three tissue specimens. Ten of the 48 rats investigated showed mycoplasma antibodies. Five rats showed minor inflammatory changes in the distal joints of the limbs. The failure to induce arthritic symptoms in rats inoculated with strain 20-P from rheumatoid arthritis may be due to its 10-year long storage outside the animal host. | |
| 6235084 | Sthenia, ambition and educational level in patients suffering from ankylosing spondylitis: | 1982 Dec | As compared to control-groups of rheumatoid arthritis and chronic non-inflammatory low back pain, over a hundred polyclinical patients suffering from ankylosing spondylitis were assessed with respect to several personality characteristics by psychological testing and proved to be relatively sthenic and educated. In trying to explain these personality features some disease-related factors seem to be relevant in ankylosing spondylitis: a relatively mild course of disease, the relief of complaints by exercise and a long pre-diagnostic period. | |
| 1249197 | The effects of adrenal corticosteroids on regional adipocyte size in man. | 1976 Jan | In order to determine the effects of adrenal corticosteroids on regional adipose tissue cellularity groups of age-matched women subjected to long-term treatment with adrenal corticosteroids due to bronchial asthma or rheumatoids due to bronchial asthma or rheumatoid arthritis were compared with control of women. A small group of women suffering from Cushing's syndrome was also examined. Body composition, adipose cellularity in four major subcutaneous regions and metabolic variables were determined. The Cushing's syndrome patients weighed more than the other groups and seemed to have more fat cells while the patients with rheumatoid arthritis showed decreases in body cell mass, body fat and average fat cell size. These differences necessitated a body fat matching between patients and controls before analysis of regional depot fat differences. Body fat, average fat cell size and total fat cell number were similar in patients and controls. The Cushing's syndrome group was too small to allow this matching. All three groups exposed to increased levels of adrenal corticosteroids showed smaller fat cells in the gluteal region in comparison with controls, but no differences in fat cell size in the femoral, epigastrial or hypogastrial regions. This change also corresponded to a diminution of the thickness of subcutaneous plus skin layer in the gluteal region, measured with an ultrasonic technique. All the groups of patients had elevated fasting plasma insulin. The possibility was considered that the observed regional redistribution of fat is characteristic for adrenal corticosteroids. | |
| 46621 | Elevated salivary and synovial fluid beta2-microglobulin in Sjogren's syndrome and rheumat | 1975 Mar 28 | Beta2-Microglobulin is normally present in low concentrations in serum and other bodily fluids. By use of a radioimmunoassay, elevated concentrations of beta2--microglobulin were found in saliva and synovial fluid from patients with Sjogren's syndrome and rheumatoid arthritis, autoimmune inflammatory diseases that attack and destroy the salivary glands and articular tissues, respectively. Elevated beta2-microglobulin concentrations decreased in the saliva of two patients who simultaneously showed a clinical response to systemic treatment. Measurement of beta2-microglobulin in inflammatory fluids may offer a simple method of quantifying local activity in autoimmune states. | |
| 912977 | Flexor tendon ruptures in the rheumatoid hand: bilateral flexor pollicis longus rupture. | 1977 | In a 42-year-old male with a 15-year history of rheumatoid arthritis, bilateral rupture of the flexor pollicis longus was associated with subluxation with radial deviation of the carpus and increased angulation of the tendon in relation to the navicular. Flexor tenosynovitis in the rheumatoid hand may present as carpal tunnel syndrome or ruptured flexor tendons. The condition is associated with invasive rheumatoid granulation tissue, vasculitis, ischemic necrosis due to compartment compression, and attrition rupture due to navicular bony protuberance. | |
| 4093924 | Should acute gold overdose be invariably treated? | 1985 Dec | Acute gold overload is rare and its clinical and pathophysiological consequences are not well delineated. Consequently the therapeutic approach has not been formulated. We describe 2 patients with rheumatoid arthritis in whom an acute gold overload was inadvertently administered. Their subsequent course, without specific treatment, was benign and uneventful. We suggest that with similar cases a conservative approach of watchful expectancy be adopted. | |
| 6497462 | Clinical judgment in rheumatoid arthritis. IV. Rheumatologists' assessments of disease rem | 1984 Oct | Seven rheumatologists made judgments about the improvement or deterioration of identical sets of 50 'paper' patients on two occasions one year apart. The stability of their judgments over one year (rs = 0.70) compared favourably with the reliability of duplicate judgments on each occasion (rs = 0.76). Multiple regression analysis of the patient data in relation to the disease assessments provided a model of each clinician's underlying judgment policy. The stability of judgments predicted by these policy models was even higher (rs = 0.83). | |
| 7259335 | Coexistent rheumatoid arthritis and tophaceous gout: a case report. | 1981 Aug | Rheumatoid arthritis and gout are both common rheumatic diseases, but their coincidence is rare. We report the case of a 67-year-old Caucasian woman with rheumatoid arthritis who later developed tophaceous gout. The tophi disappeared with remarkable rapidity on treatment with allopurinol. | |
| 6882039 | Menstrual cyclicity of finger joint size and grip strength in patients with rheumatoid art | 1983 Aug | Daily measurements of finger joint size, grip strength, and body weight have been made throughout 2 complete menstrual cycles in 7 female patients with rheumatoid arthritis and 6 healthy female controls. Sine wave analysis showed significant individual cyclical rhythms (p less than 0.05) for finger joint size (5 patients, 4 controls), nude weight (5 patients, 3 controls), and grip strength (4 patients, 3 controls). In addition analysis of group data, on the assumption of a 28-day cycle, showed a significant cycle for grip strength in the rheumatoid patients, with a nadir at 28 days. In the normal subjects much of the cyclical variation in finger joint size could be explained by changes in weight (median 49.5%), but this was not so in patients with rheumatoid arthritis (median 2.8%). These findings suggest the existence of a cyclical variation in disease activity in rheumatoid arthritis. | |
| 7363551 | The supinator notch sign in rheumatoid arthritis. | 1980 Mar | Erosion of the ulna, giving a notch-like appearance in the region of the supinator groove, is reported in 18% of 110 unselected outpatients attending a rheumatoid clinic. The characteristic radiological, arthrographic and scintigraphic findings are presented. The mechanism, significance and differential diagnosis is discussed. |