Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6887175 | Pseudo-rheumatoid deformity in elderly osteoarthritic hands. | 1983 Jun | Three patients with severe ulnar deviation and metacarpophalangeal joint subluxation are described. They were all elderly women with interphalangeal joint osteoarthritis but no other rheumatic disease. The clinical appearance of the hands led to an incorrect diagnosis of rheumatoid arthritis in each case. Two were taking corticosteroids, predisposing to septic arthritis in one. Rheumatoid-like deformities may be common in the elderly. | |
| 3883868 | Efficacy of total lymphoid irradiation in intractable rheumatoid arthritis. A double-blind | 1985 Apr | Twenty-six patients participated in a randomized, double-blind study of the efficacy of total lymphoid irradiation in the treatment of intractable rheumatoid arthritis. All 26 patients, for whom therapy with gold compounds and penicillamine had failed, would ordinarily have been considered candidates for cytotoxic or antimetabolite drug therapy. Thirteen patients randomly assigned to receive full-dose total lymphoid irradiation (2000 rad) and 11 patients assigned to receive control low-dose total lymphoid irradiation (200 rad) completed radiotherapy. Alleviation of joint disease activity was significantly greater in the high-dose group as judged by morning stiffness, joint tenderness, and functional assessment (global composite score) at 3 and 6 months after radiotherapy. The high-dose group had a marked reduction in both T-lymphocyte function and numbers, but this finding was not observed in the low-dose group. Complications seen in the high-dose but not low-dose group included transient neutropenia, thrombocytopenia, pericarditis, and pleurisy. | |
| 7122355 | Synovial cyst presenting as forearm mass. | 1982 Oct | A 43-year-old man with rheumatoid arthritis that involved primarily the hands and feet was seen at Veterans Administration Wadsworth Medical Center, Los Angeles, for a painless mass on the left forearm. An antecubital synovial cyst was diagnosed on the basis of results of ultrasonography and arthrography. Arthrocentesis of the elbow joint yielded 5 ml of serous fluid. Intraarticular injection of a corticosteroid resulted in complete resolution of the mass within three days, thus surgery was avoided. | |
| 7288764 | In vitro lymphocyte response in early rheumatoid arthritis. | 1981 May | Streptokinase-streptodornase (SK-SD) skin tests and peripheral blood mononuclear stimulation to purified SK-SD delayed skin reactor (DSR) and phytohemagglutinin (PHA) was assessed in 41 patients with rheumatoid arthritis (RA) and 17 controls. Lymphocyte response to DSR correlated directly with the diameter of SK-SD-induced erythema, and PHA stimulation decreased with age. RA patients did not show significant depression by either test or did hyporesponsiveness predict rheumatoid disease activity or prognosis. Six patients without medication demonstrated increased PHA responsiveness and a direct rather than inverse correlation with age. | |
| 6837996 | Acquired laryngeal deviation associated with cervical spine disease in erosive polyarticul | 1983 May | Cervical spine disease in patients with erosive polyarticular arthritis often presents difficulties in endotracheal intubation at the time of surgery. After extensive experience with the use of the fiberoptic bronchoscope in such situations, the authors have identified a previously unrecognized and unanticipated tri-plane deviation in which the larynx is displaced caudally, deviated to the left, rotated to the right, and anteriorly angulated. A review of 710 consecutive fiberoptic intubations identified 15 arthritis patients with laryngeal deviation. Documentation was available in seven patients showing that the larynx was initially in a normal position, but was progressively displaced as the cervical spine disease worsened. Vertical penetration of the dens was the most significant underlying pattern of cervical spine disease. Computerized tomography with multiplanar reconstruction elucidated two patterns of deformity but was not necessary to detect the laryngeal deviation. One cause of the deviation was a scoliotic deformity of the trachea and larynx secondary to shortening of the neck resulting from the vertical penetration. The second mechanism was a rotational deformity of the cervical spine occurring from asymmetric bony erosions. Knowledge of this deformity permits it to be easily predicted preoperatively so that appropriate management can be planned. | |
| 6826249 | Clinical significance of circulating immune complexes in patients with metastatic breast c | 1983 Feb 15 | Serum circulating immune complexes (CIC) were repeatedly measured by means of the CIq binding assay (Cba) and the Raji cell assay (Rca) in 158 patients with metastatic breast cancer (mbc). Frequency of occurrence and levels of CIC were only slightly increased in mbc when compared to age-matched healthy women. They were identical to those of patients with localized breast cancer prior to mastectomy and to those of post mastectomy patients without evidence of recurrent disease. In mbc the results of the Cba and the Rca showed a poor correlation, whereas in a control group of patients with rheumatoid arthritis both tests showed significantly elevated levels of CIC. Patients with mbc were followed up clinically and biochemically by serially measuring CIC for an average of 10 months. Patients with positive CIC did not prove to be an unfavorable group regarding progression of disease and response to chemotherapy. When CEA and CIC levels were compared, CIC, unlike CEA, was a poor tumor marker. In conclusion, CIC as measured by CIq binding assay and Raji cell assay are not clinically significant tumor markers or prognostic indicators in patients with metastatic breast cancer. | |
| 1219992 | Assessment of surgery of the rheumatoid wrist. | 1975 | A series of 314 wrist operations performed on 227 patients with rheumatoid arthritis is presented. In 266 hands various wrist operations were undertaken with the object of synovial debridement and in 48 hands the wrist was also arthrodesed. The mean age at the time of surgical treatment was 51 years and the mean period of observation 4.2 years. This study shows that the main benefits of synovectomy are related to a constant and marked pain relief and prevention of tendon ruptures. The hope that synovectomy might arrest or prevent skeletal destruction was not realized and progression of X-ray changes was found in 74%. The very low recurrence rate in the present series as judged by clinical signs is probably not very significant and it is concluded that the X-ray findings are the most reliable criteria reflecting the real activity in a rheumatoid joint. In several wrists where prophylactic ulnar head resection had been performed through a small ulnar incision, an active dorsal tenosynovitis with tendon invasion developed later. These and other findings at the operation indicate that the erosive effect of the distal end of the ulna is certainly not the sole cause of tendon rupture in this area and that a complete exposure and decompression of the tendons should regularly be performed. Finally, arthrodesis of the wrist was so successful that it can be highly recommended. | |
| 849361 | D-penicillamine in the treatment of rheumatoid arthritis. | 1977 Mar | Forty-four patients with definite or classic rheumatoid arthritis and failure to tolerate or respond to gold therapy were treated with D-penicillamine on a so-called go-slow, go-low regime. Seventeen patients tolerated the drug and had a 3-13 month follow-up assessment; 8 were markedly improved, 6 moderately or slightly improved, and 3 unimproved. Penicillamine had to be discontinued in 9 patients because of toxic side effects. | |
| 7232779 | [Xeroradiographic study of rheumatoid arthritis hand (author's transl)]. | 1980 Dec | The hands of 50 rheumatoid arthritis patients and 32 non-arthritis controls were studied with conventional x-ray and xeroradiography. The xeroradiograph and radiograph of each patient were compared, assessing the degree of subperiosteal erosion, loss of joint space, soft tissue thickening and joint deformity. Each metacarpophalangeal and proximal interphalangeal joint alterations were scored on a 0-3 scale. Comparison between xeroradiographic and radiographic techniques showed that osteoporosis was better documented on conventional x-ray while loss of joint space and synovial thickening on xeroradiographs. In conclusion, conventional x-ray study of rheumatoid arthritis hand is comparable with xeroradiographic one, even if not substitutable. | |
| 287192 | Penicillamine in rheumatoid arthritis: clinical pharmacology and biochemical properties. | 1979 | The current status of the clinical pharmacology of penicillamine was reviewed. Its indications in the therapy of RA were defined, and current principles of dosage were presented. The autoimmune side effects were discussed in the light of their possible implication with regard to a locus of action of the drug on the immunological system. A comparison was presented of the biochemical properties of penicillamine and 5-thiopyridoxine, another mercaptan compound which appears to demonstrate a penicillamine-like action in patients with RA. It was found that 5-thiopyridoxine did not possess copper chelating properties, it failed to form a mixed disulfide with cystine, it did not induce dermolathyrism in the weanling rat, and it was not a vitamin B6 antagonist. If both of these compounds do work by a common mechanism in RA, then the aforementioned biochemical properties of penicillamine must be presumed to be not relevant to its fundamental action in this disease. | |
| 807714 | Inhibition of the primary lesion of adjuvant. induced polyarthritis in rats (18-hour arthr | 1975 Jun | Adjuvant-induced polyarthritis can be induced in rats 14 to 21 days after subplantar injection of 0.1 ml of a 0.5% suspension of Mycobacterium tuberculosis in heavy mineral oil into a hind paw. However, edema volume of the injected pay (primary lesion) developed rapidly and reached a peak in 18 hours after injection and persisted at this level for up to 90 hours. A single oral dose of 25 clinically effective or experimental antiarthritic agents given 1 hour prior to M. tuberculosis injection and tested 18 hours later significantly inhibited edema formation in a dose-related fashion. Only D-penicillamine and azathioprine which are clinically effected, gave false-negative responses in this test. However, cyclophosphamide, another immunosuppressive like azathioprine, was effective. The ED50 values for most drugs in this test were at least 2-fold greater than in the carrageenan edema test. On the other hand, of the 17 drugs considered as false-positives in the carrageenan test only the antihistaminic agent, chlorpheniramine maleate, was effective in the 18-hour arthritis test, whereas several other agents with this activity but different chemical structure proved ineffective. In addition, 18 other agents from various classes of therapeutic agents were also tested and found ineffective in each test. These data suggest that the 18-hour arthritis test in rats is highly specific and a more reliable screening procedure than carrageenan-induced edema for detecting potentially useful antiarthritic agents. The practical advantages of this method are also discussed. | |
| 847123 | [Lung and pleural involvement in collagen disease (author's transl)]. | 1977 Jan | Frequency and type of pulmonary and pleural involvement in collagen disease (rheumatoid arthritis, progressive systemic scleroderma, polymyositis-dermatomyositis and lupus erythematodes are analysed on the basis of literature and of own cases with particular regard to the roentgenographic appearance. | |
| 4004958 | When does rheumatoid disease start? | 1985 May | Stored serum specimens collected in connection with a community-oriented epidemiologic study were available from 30 subjects who later developed seropositive rheumatoid arthritis. In 9 of these pre-rheumatoid specimens, the Rose-Waaler test result was positive, and in 16, the latex fixation test was positive. Two-thirds of the samples were positive when the interval between taking the blood specimen and onset of the disease was less than 4 years, and one-third were positive when the interval was greater than or equal to 4 years. The occurrence of rheumatoid factor preceded the onset of clinical disease more often in males than in females. | |
| 6193576 | [The HLA-DR determinants in chronic inflammatory rheumatism]. | 1983 Jun | The authors present a study of the incidence of HLA-DR antigens in 113 controls and in a Breton population suffering from chronic inflammatory rheumatism. They found 80 cases of rheumatoid arthritis and found a significant increase incidence of the DR4 antigen in rheumatoid arthritis (54% compared with 19.5%; pc less than 10(-4); RR = 4.8) and a decreased incidence of the DR2 antigen (12.5% compared with 35%; pc less than 10(-2); RR = 0.27). The increased incidence of DR4 does not seem to be related to the presence of rheumatoid factor. Out of the 95 cases of chronic inflammatory rheumatism treated, 33 cases of drug intolerance (cutaneous and/or renal to gold salts or D-penicillamine) were reported. The authors found a decreased incidence of the DR2 antigen in the patients who presented a drug intolerance, which was partially significant in the group of patients with rheumatoid arthritis (p less than 0.04; pc less than 0.3). This is an important argument in favour of the supposed protective role of this antigen. | |
| 7385159 | [P-pills and rheumatism]. | 1980 Feb 20 | ||
| 136883 | [Studies with the macrophage migration inhibition test in patients with rheumatoid arthrit | 1976 | The authors intended to investigate whether lymphokinins can be verified in rheumatoid arthritis, and if so - to what extent. They used the macrophage-migrations-inhibition test (MMIT). The validity of the experimental model was therefore tested in patients with tuberculosis. In 97 examinations with 76 exactly defined R.A.-patients no significant migrationsinhibitions were present, apart from single findings. Various synovialis extracts and R.A.-synovia were used. The experimental conditions were varied up to a maximum factor of 8. The results obtained were discussed from the point of view of methodical accuracy, unsatisfactory preparation of antigens and possible double inhibition effects. | |
| 6884843 | Extensor tendon rupture over the metacarpal heads. | 1983 Jun | Rupture of the extensor tendons is common in longstanding rheumatoid arthritis of the hand. The tendons commonly involved are those of the ring and little fingers and the common site of rupture is over the dorsal ulna and distal edge of the extensor retinaculum. We are reporting two cases of extensor tendon rupture over the metacarpal head of the middle finger due to prominent osteophytes. | |
| 6085817 | Strong association of rheumatoid arthritis with the presence of a polymorphic Ia epitope d | 1984 | Among individuals with rheumatoid arthritis the presence of the polymorphic Ia antigen epitope detected by the monoclonal antibody 109d6 is more strongly correlated with disease susceptibility than are other specificities, such as HLA DR4, DRw53 (MT3) or the antigenic determinant, defined by the monoclonal antibody 17-3-3S. The cells of 93% of Caucasian and Hispanic patients react with the 109d6 reagent. As was the case in normal individuals, all DR4-positive patients express the 109d6 determinant; however, 26% of those with rheumatoid arthritis have the epitope recognized by antibody 109d6, but lack the specificity DR4. Of these, one-third expresses only HLA DR1 and DQw1 (MT1, MB1) determinants. Studies of family members reveal that here the determinants 109d6, DR1, and DQw1 are encoded by the same unusual haplotype. In certain other individuals with rheumatoid arthritis who express DR4, DRw53, and the 109d6 determinants, family studies show that the 109d6 epitope is encoded not only by the haplotype specifying DR4 but also by the opposite haplotype that does not bear the genes for DR4. This suggests that homozygosity for certain Ia epitopes is relevant to determining the disease-susceptibility state. These studies emphasize the utility of monoclonal antibodies as reagents for the recognition of Ia epitopes that are more closely involved in the determination of disease susceptibility than are allomorphic molecules detected by conventional typing alloantisera. | |
| 6864674 | Local synthesis of IgM and IgM rheumatoid factor in rheumatoid pleuritis. | 1983 Apr | Pleura from 3 patients with rheumatoid pleuritis and from 5 patients with other diseases was examined for its capacity to synthesize IgM and IgM rheumatoid factor (RF). IgM was synthesized by pleura from all 3 patients with rheumatoid pleuritis and IgM RF by 2. Pleura from each of the control patients synthesized less than or equal to 1 ng/mg of IgM and IgM RF. Moreover, pleura from a 4th patient with rheumatoid pleuritis incorporated 3H-leucine into newly synthesized IgM. Simultaneously obtained pleural fluid mononuclear cells (MNL) and pleural tissue from a patient with rheumatoid pleuritis synthesized identical proportions of IgM and IgM RF whereas IgM RF production was not observed with peripheral blood MNL from the same patient. The results support the view that local production of IgM and IgM RF occurs in rheumatoid pleuritis and suggest that local immune events contribute to the pathogenesis of this disorder. | |
| 6414237 | Corneal crystalline deposits in multiple myeloma. A case report. | 1983 Jun | A 70-year-old man with a seronegative rheumatoid arthritis showed some peculiar lamellar crystalline deposits mainly at the Descement/endothelial level in both eyes. Serum protein analysis revealed a monoclonal gammopathy with increased amounts of IgG and K-light chains along with traces of the latter in the urine. Corneal biopsy was not available, but electron microscopy of the conjunctival specimen demonstrated crystalline deposits within the endoplasmic reticulum of plasma cells lying within the connective tissue. This material is supposed to be of protein nature. It seems reasonable that the conjunctival deposits are identical to those seen in the cornea by slit-lamp examination, and it is also suggested that they represents paraprotein aggregates. After treatment with melphalan (Alkeran) and prednisone systemically, the corneal deposits decreased over a period of 9 months with corresponding improvement of the visual acuity. |