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Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes

PMID	Title	PublicationDate	abstract
4060139	Gm haplotype sharing by siblings with rheumatoid arthritis.	1985 Aug	Gm haplotype sharing by 9 sibling pairs with rheumatoid arthritis was random. This suggests that the model of a single, uncommon, susceptibility gene linked to Gm which predisposes to RA is unlikely.
7084288	Arthritis in the elderly.	1982	In old age, particularly in those over the age of 75 years, the disease process is operating in a unique setting. The awareness of this uniqueness has been slow in coming to the attention of the medical profession but the weight of clinical experience imposed by demographic change in the population has made this an urgent consideration. Arthritis presents in a setting where there are multiple ageing or degenerative features and it occurs frequently in conjunction with other diseases. Early and accurate diagnosis is of paramount importance in the elderly because of the many interacting factors and the fragile 'milieu interieur'. Judicious use of drugs with close monitoring is essential if the patients's well being is to be improved and the morbidity reduced. Joint disease, osteoarthritis and rheumatoid arthritis make a significant contribution to disability and dependence in the elderly and have certain features which are more common than those found in the younger age groups.
7270374	Pseudo-deep vein thrombosis in rheumatoid arthritis.	1981 Sep	Acute synovial rupture is encountered in several types of arthritis but is most common in rheumatoid arthritis. Chronic synovitis producing tense effusion in the knee may result in a posterior capsular tear. The clinical picture closely mimics acute thrombophlebitis, and failure to recognize the true cause often results in inappropriate anticoagulant therapy, with further deterioration of the leg. Ultrasonography is a useful screening procedure. When operation is undertaken, the posterior capsular defect must be repaired.
4087266	The carpometarcarpal ratio: a useful method for assessing disease progression in rheumatoi	1985 Oct	Determining the progression of anatomic involvement in rheumatoid arthritis (RA) is a well recognized problem. In 1976, Trentham and Masi described the carpometacarpal (CMC) ratio and found it useful for detecting progression of anatomic involvement in RA. Our study attempts to validate the efficacy of this ratio both in a cross sectional (n = 267) and longitudinal (n = 53) sample of patients with rheumatoid arthritis. Our data indicate that the CMC ratio is useful for quantitating anatomic involvement and correlates well with anatomic progression over time.
92110	[ECG changes in chronic polyarthritis compared to a healthy control group].	1979 Jul	ECG from 200 patients with radiologically and clinically definite rheumatoid arthritis were compared with those from a healthy group with the same age and sex distribution. The frequency of pathological changes of the ECG was found to be the same in both groups. Therefore doubt remains whether the pathological changes of the ECG can be attributed to rheumatoid arthritis.
911352	Experimental radiation synovectomy by 165Dy ferric hydroxide macroaggregate.	1977 Sep	The short half-life beta emitter 165Dy coprecipitated as a macroaggregate with ferric hydroxide (FHMA) has been shown to destroy knee synovium in the antigen-induced arthritic rabbit. Using 153Gd as a gamma tracer for leakage studies revealed that the leakage of this system from rabbit knee joints never exceeded 1.2% over 24 hours. This is such less than the leakage rates reported from any human studies or our rabbit studies using 198Au.
147015	Differential binding activity of EA receptor bearing human lymphocyte subpopulations.	1977	Two types of EA rosettes were studied in rheumatoid arthritis patients and control subjects. Heterologous (rabbit) and homologous (anti-D) antibody sensitized human red blood cells (EAr and EAh, respectively) were used for examining the EA binding capacity of human lymphocytes. Both control and rheumatoid arthritis blood samples yielded significantly lower EArRFC levels as compared to the percentage of EArRFCs, the difference being even more expressed with control lymphocytes. No difference, however, was observed in the case of tonsillar lymphocytes, as equal rosette levels were reached in both systems used. Introduction of immunosuppressive therapy resulted in a temporary dissociation of the two rosette values EAr and EAh binding lymphocytes were differently affected by aggregated human IgG, only the latter ones being inhibited, contrasting with the equal inhibitory action of purified Fc fragments. Reducing the density of anti-D antibodies on the surface of erythrocytes, the EAh rosette count dropped to the level of EAr RFCs. The data suggest an activity-depending Fc receptor distribution resulting in different binding capacity for more or less sensitized indicator RBCs.
6332789	Thymulin (FTS-Zn) induced in vitro modulation of T cell subsets markers on lymphocytes fro	1984	Perturbations in T cells and T cell subsets of peripheral blood lymphocytes were looked for, using monoclonal antibodies, in nine patients with rheumatoid arthritis (RA) and four patients with systemic lupus erythematosus (SLE). All SLE patients were in an acute phase of their disease, but had not yet received steroids. Seven of the nine RA patients presented an active illness, recently diagnosed in five cases, and received no steroids nor D-penicillamin. T cell subsets alterations responsible for abnormal values of the OKT4 +/OKT8 + immunoregulatory ratio, were improved by in vitro incubation of the lymphocytes with synthetic thymulin in eight out of nine RA patients. No significant modification occured for SLE patients' lymphocytes. These results support the possible beneficial role of thymulin in the treatment of rheumatoid arthritis.
6677930	[Sideropenic anemia in rheumatoid arthritis: diagnostic usefulness of serum ferritin, unsa	1983 Sep	The various erythrocyte indices, serum iron, unsaturated iron binding capacity, serum ferritin and sideruria after desferrioxamine were measured in a group of 30 patients with active Rheumatoid Arthritis and anemia. The patients were subdivided into two groups of 23 and 7 subjects based on the presence or absence of marrow iron stores, respectively. Significant differences in the mean values of unsaturated iron binding capacity (P less than 0.001), serum ferritin (P less than 0.01) and sideruria after desferrioxamine (P less than 0.001) were observed between the two groups of patients by statistical analysis. Unlike the other indices, the values assessed in the first and the second group of patients as for the above parameters did not overlap. A negative correlation index and a positive one of high significance (P less than 0.001) was found between the values of serum ferritin and those of unsaturated iron binding capacity and sideruria after desferrioxamine, respectively. The above results demonstrate that even in active Rheumatoid Arthritis a concomitant iron deficiency can be diagnosed by means of non-invasive, quantitative and easily reproducible methods.
6638903	Total ankle replacement in rheumatoid arthritis: a preliminary review of 28 arthroplasties	1983	Twenty-eight arthroplasties performed during a period of three and a half years during 1976-1980 were evaluated after an average follow-up period of 21 months. All patients had advanced rheumatoid arthritis. The Richard's prosthesis was used in 22, the ICHL prosthesis in five and St. George prosthesis in one instance. The results were in general satisfactory, particularly as to pain relief, yet there was only limited improvement in the actual range of movement. All ankles were stable: nevertheless loosening could be demonstrated radiologically and clinically in 5 out of 56 prosthetic components. No revisions have been warranted so far. In strictly selected cases, replacement arthropolasty seems a worthwhile alternative to arthrodesis in patients with severe rheumatoid arthritis in many weightbearing joints.
432609	[Evaluation of a new commercial latex test for the study of rheumatoid factors].	1979 Feb 17	A new commercial test of IgG-sensitized latex particle agglutination is compared with a long-established latex test for detection and titration of rheumatoid factors. The comparison was conducted on samples from three groups of patients: 125 with seropositive rheumatoid arthritis (RA), 115 seropositive samples from patients with various diseases except RA, and 100 seronegative samples with varying diagnosis including RA. The new test is very simple to perform. Its sensitivity, however, was lower than that of the Rheins test by about 2.5 dilutions. Its specificity as to the diagnosis of RA was significantly better than that of the Rheins test.
7387219	Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis.	1980 Apr	Two patients with rheumatoid arthritis developed evidence of hepatotoxicity while receiving D-penicillamine. Both recovered after withdrawal of the drug. These cases and a review of the literature suggested that hepatotoxicity, though rare, should be added to the list of adverse reactions to D-penicillamine.
1093076	Pilot study on the effect of New Zealand green mussel on rheumatoid arthritis.	1975 Mar 12	An extract of the New Zealand green mussel did not show any greater effect than a placebo when given to five patients with rheumatoid arthritis in a double-blind crossover trial.
4013812	The temporomandibular joint in rheumatoid arthritis.	1985 May	The temporomandibular joint (TMJ) was investigated clinically and by orthopantomography in 110 patients with rheumatoid arthritis (RA) and in 73 control subjects. Clinical symptoms in the TMJ were established in 34 per cent of the RA patients and in 18 per cent of the controls. Radiographic abnormalities were found in 60 per cent of the RA patients compared with 15 per cent in the controls. No single radiographic abnormality was characteristic of joint involvement by RA. The most common radiologic features in RA patients were changes in the morphology of the condylar head and articular eminentia, marginal irregularities, reduced mobility, and an anterior position of the condylar head. No abnormalities were encountered in the early stage of the disease, which at least in part could be attributed to the inherent limitations of orthopantomography. The incidence of joint lesions increased with duration of the RA.
983356	[The significance of coagulation disorders and the inflammatory reaction in an infectious	1976 Sep	The arthritic activity in the initial phase and during manifestation of experimental erysipelas in rats, an animal model for human rheumatoid arthritis, was studied by plethysmometrical methods. The development of body weight and specific pathologic alterations peculiar to the model such as keratitis, thrombosis of the aorta and gangrene of the tip of the tail served as additional parameters. In the volumetric analysis it could be shown that the first arthritic swelling on both hind legs develops symmetrically up to day 6 post infection in rats with about 200 g of body weight-and in contrast-on the 2nd p.i. in younger animals with about 120 g. The first maximal paw volume was measured on day 9 p. i., the greatest decrease in body weight-a reduction of 25%-on day 10 p. i. In addition the reaction of the animal model following the application of steroid and non-steroid symptomatically as well as cytostatically acting antirheumatic drugs was tested. Daily treatment with acetylsalicylic acid, indomethacine or hydrocortisone provoked more or less significant inhibition of arthritic swelling in the paw. Only at the onset of arthritis acetylsalicylic acid was more effective than the other antiphlogistic drugs. No measurable increase of paw volume during cyclophosphamide treatment could be evaluated. None of the antirheumatics used had a positive effect on body weight developement. In hydrocortisone and also in cyclophosphamide treated rats a greater decrease was obtained than in the infected controls. No thrombosis developed after cytostasis with cyclophosphamide. The advantages of this systemic connective tissue disease with regard to its comparability with human rheumatoid arthritis and due to the course of its arthritic manifestation are discussed, together with the disadvantages specific to the model and the experimental conditions.
737019	Familial deficiency of two subunits of the first component of complement. C1r and C1s asso	1978 Nov	Complete absence of C1r and almost complete absence of C1s were found in 4 of 8 living siblings. Two of the 4 suffer from a syndrome that combines discoid lupus erythematosus and nondeforming rheumatoid-like arthritis; one of the siblings has mild nephritis. The other 2 C1 deficient family members are clinically well. Evidence from this and other families suggests that deficiency of C1 components or C4 is associated with higher risk of developing a lupus-like disease than is deficiency of C2.
6744663	Defective monocyte accessory function due to surface sulphydryl (SH) oxidation in rheumato	1984 Jun	Low serum sulphydryl (SH) levels are a feature of active rheumatoid arthritis (RA). We have investigated whether a similar blockade of membrane SH groups on mononuclear cells modifies the function of these cells in this disease. Using pokeweed mitogen stimulated IgG synthesis as the assay system, we have found that the accessory cell function of peripheral blood monocytes is totally dependent on free SH groups on the cell surface. Monocytes from patients with active RA display poor accessory cell function when compared with healthy monocytes or with cells from patients treated with D-penicillamine. The poor function of the rheumatoid accessory cells may be corrected in vitro by 2-mercaptoethanol (2-ME). Addition of 2-ME to the culture system also enhances IgG synthesis by rheumatoid mononuclear cells to normal levels. We suggest that surface SH-dependent mechanisms are responsible, at least in part, for the depressed mononuclear cell functions of rheumatoid cells in vitro and may explain some effects of D-penicillamine therapy in rheumatoid patients.
7375869	Immunological effects of Biarison in the treatment of rheumatoid arthritis and systemic lu	1980	In two different double-blind studies (Study 1: 27 patients with active rheumatoid arthritis in an early phase, and Study 2: 20 selected patients with rheumatoid arthritis and acute knee effusion) the efficacy of Biarison, a new non-steroidal antiinflammatory agent was compared with that of indomethacin. The daily dose of Biarison was 600-900 mg and that of indomethacin 50-100 mg. Overall clinical improvement was observed in both treatment groups, but the two treatments differ in their effects on the erythrocyte sedimentation rate (ESR) and the immunoglobulin levels in both serum and synovial fluid. In the Biarison group there was a significant decrease in ESR and serum IgG, IgM and IgA. Biarison has also been used in the treatment of active SLE (Study 3), and a good clinical improvement was noticed in 5 out of 8 patients. These preliminary results suggest that Biarison may influence the immunological processes in both rheumatoid arthritis and systemic lupus erythematosus.
488774	Planning treatment of the rheumatoid hand.	1979 Feb	A detailed assessment of the patient as a whole is an essential pre-requisite to the successful planning and execution of surgical treatment of the rheumatoid hand. In particular the decision whether or not to operate must emerge from a careful weighing of the severity of the patient's symptoms, signs and physical disability against the benefits which are likely to accrue from surgical treatment assessed in relation to the patient's own individual requirements. The author presents his personal reflections on the relative merits of the commonly used surgical procedures with reference to their ability to relieve pain, restore function, achieve cosmetic improvement, and prevent further damage, while at the same time carrying minimal risk of further damage to the already impaired function of the hand. Finally, the philosophy which should govern the surgeon - patient relationship during the management of a chronic progressive disease is examined. That it is absolutely essential to establish a sound rapport from early in the surgical programme is strongly emphasised. Some guidelines as to the design of the programme are also provided.
1206670	Decreased concentration of free histidine in serum in rheumatoid arthritis, an isolated am	1975 Dec	The serum concentrations of 12 free amino acids (alanine, arginine, glycine, histidine, isoleucine, leucine, lysine, phenylalanine, serine, threonine, tyrosine, and valine) were measured in 26 patients with rheumatoid arthritis and in 12 control subjects. Patients with rheumatoid arthritis had a low serum histidine concentration (P equals 0.002) but no abnormality of any other amino acid concentration or of the combined concentration of the measured amino acids, excluding histidine. These data and 22 other reported studies provide strong evidence for the presence of hypohistidemia, not associated with generalized hypoaminoacidemia, in patients with rheumatoid arthritis. (J Rheumatol 2: 384-392, 1975).