Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6699052 | Metacarpophalangeal joint implant arthroplasty with a Silastic spacer. | 1984 Mar | We evaluated Silastic implant arthroplasty in the metacarpophalangeal joints of rheumatoid patients by a prospective analysis of the cases of twenty-eight patients. One hundred and fifteen such implants were followed for an average of fifty-four months (range, twenty-four to 125 months). The postoperative active motion of the metacarpophalangeal joint averaged 43 degrees, from 13 degrees of extension to 56 degrees of flexion. The average range of active motion of the metacarpophalangeal joint increased 17 degrees over preoperative values. Ulnar drift recurred in forty-nine fingers (43 per cent), and fracture of the spacer occurred in twenty-four joints (21 per cent). The sites of three spacers became infected, and treatment required the amputation of one finger. Preoperative and postoperative key pinch and grip strengths were unchanged. Patient satisfaction was high; twenty patients (71 per cent) experienced significant pain relief, nineteen patients (68 per cent) felt that they had much better hand function, and twenty-three patients (82 per cent) thought that the cosmetic appearance of the hand was improved. | |
| 6252320 | Comparison of four methods of analysis of 99mTc pyrophosphate uptake in rheumatoid arthrit | 1980 Jul | Knees, hands, forearms and thighs in 22 patients with classical rheumatoid arthritis and 18 controls were imaged with 99mTc pyrophosphate. The uptake of 99Tc pyrophosphate in the joints of the hand and knee was quantitated using a gamma camera interfaced to a computer. Quantitative measurements of joint activity were assessed by analyzing resultant data in a number of ways. Counts per unit area normalized for body weight and dose of radiopharmaceutical was found to be the most satisfactory method of quantitating differences in disease activity. However, the sensitivity of the method was not great enough to clearly distinguish normal and rheumatoid joints. | |
| 6524117 | [Periungual capillary microscopy in patients with chronic polyarthritis and psoriasis arth | 1984 Nov | The aim of this study was to investigate the prevalence of nail bed capillary abnormalities in rheumatoid arthritis and psoriatic arthritis. In 10 per cent of rheumatoid patients the morphological pattern of the nail bed capillaries of the ten fingers was remarkably variable. Long capillaries and a clearly visible subpapillary plexus were the most prominent findings in these patients. The only significant finding observed in patients with psoriatic arthritis was a high subpapillary plexus visibility. Avascular areas and giant loops (typical of scleroderma) were not found in either disorder. | |
| 6335860 | Proportional and functional studies of the infiltrating lymphocytes in the parotid gland o | 1984 Jan | Lymphocyte subpopulations and functions were examined in the salivary (parotid) gland lymphocytes (SGL) obtained as a cell suspension from a patient with Sjögren's syndrome associated with rheumatoid arthritis, in comparison with peripheral blood lymphocytes (PBL). Serial studies on the lymphocyte subsets in PBL using monoclonal antibodies to helper or suppressor T cell subsets (OKT4 or OKT8) demonstrated a decreased proportion of the OKT8 subset (OKT4/OKT8 ratio: 7.1-34.0). Major infiltrating cells in the gland were surface immunoglobulin-bearing B cells, and 23-35% of the SGL were T cells by both the E-rosetting method and OKT3-monoclonal antibody reactivity. Moreover, OKT4/OKT8 ratios were definitely lower in the SGL (1.0 and 1.7) than those in the PBL of the patient. Mitogen-induced lymphocyte proliferative responses of the SGL were markedly diminished, although the possible participation of defective macrophages was considered. The autologous mixed lymphocyte reaction was low in both PBL and SGL. PBL of the patient showed normal proliferative responses to mitogens except for PWM stimulation. Suppressor effects of the SGL for the proliferative responses of autologous and allogeneic PBL were demonstrated. Con A-induced suppressor function was inducible in the SGL, whereas that function could not be demonstrated in the patient's PBL. | |
| 1198011 | Nerve entrapment at the elbow in rheumatoid arthritis. | 1975 Nov | Although there was some delay in the posterior interosseous branch of the radial nerve conduction time in six of the 152 rheumatoid elbows, in no case were there clinical signs attributable to entrapment of this nerve. Some delay in ulnar nerve conduction was recorded in 27 of the 152 elbows; this was marked in 12. These patients tended to be older and to have more severe disease of the elbow. | |
| 4014326 | Rapidly progressive glomerulonephritis in a patient with rheumatoid arthritis during treat | 1985 | A patient with advanced rheumatoid arthritis and severe clinical manifestations of rheumatoid vasculitis died of acute renal failure after 30 months of treatment with high-dosage D-penicillamine. She had had no signs of adverse drug reactions until the terminal illness. Although streptococcal pharyngitis was diagnosed late in her disease, penicillamine-induced immune complex glomerular damage is considered more likely than poststreptococcal glomerulonephritis, because her microscopic hematuria preceded diagnosis of pharyngitis. Postmortem examination disclosed findings suggestive of rapidly progressive glomerulonephritis of immune complex pathogenesis. The short period of microscopic hematuria and the rapidity of development of renal failure before death emphasize the need for frequent monitoring of renal function and prompt discontinuation of D-penicillamine treatment upon detection of otherwise unexplained hematuria. There is urgent need for early immunological evaluation, renal biopsy, and vigorous therapeutic measures. | |
| 6241860 | Helper (OKT4)/suppressor (OKT8) ratios in the peripheral blood and synovial fluid of patie | 1984 Oct | Lymphocyte subsets in the peripheral blood of 10 patients with RA were studied using monoclonal antibodies. The mean percentages of total T, T helper, T suppressor and TAR in the peripheral blood of RA patients were not different from those observed in normal controls. In the synovial fluid the mean percentages of T suppressor cells were present in increased numbers associated with a decreased number of autorosette T cells. We conclude that patients with rheumatoid arthritis present distinct immunoregulatory abnormalities in the synovial fluid not present in the peripheral blood. These changes may be related to the immune abnormalities present and related to the etiology of RA. | |
| 380312 | A combined clinical and immunological assessment of four cyclophosphamide regimes in rheum | 1979 Apr | Four dosage regimes of cyclophosphamide have been compared in patients with late rheumatoid arthritis, in an attempt to separate toxicity from efficacy. Joint inflammation was assessed clinically and objectively by quantitative thermography. Delayed hypersensitivity in vitro was assessed using leucocyte migration inhibition (L.M.T.) to a standard antigen, Streptokinase. There was no significant difference in clinical response or side-effects between a continuous oral regime (1 mg/kg/day) and the same total dose given as an intermittent oral regime. Responders and non-responders were seen in both groups and there was a significant relationship between clinical response and fall in platelet count, suggesting a variable threshold. The same total dose given as an intermittent intravenous regime caused considerable side-effects but these could be avoided by the addition of methylprednisolone. Both intravenous regimes induced a much more rapid fall in the Thermographic Index (T.I.) than the oral regimes. Indeed many patients receiving oral cyclophosphamide showed an increase in joint inflammation in the first three weeks of treatment. Immunological studies demonstrated a corresponding increase in reactivity to Streptokinase over this period. There was a highly significant correlation between changes in L.M.T. and T.I. both early in treatment and, in the oral groups, over a period of six months. | |
| 1188328 | Metacarpophalangeal joint implants. II. Roentgenographic study of the Niebauer--Cutter Met | 1975 | A roentgenographic study was carried out on 41 Niebauer -- Cutter Metacarpophalangeal Joint Prosthesis from 1 to 36 months postoperatively, a total of 105 examinations. The examinations were performed in the AP-projection and in the lateral projection by tomography in maximum active extension and flexion. The tomographic examinations revealed implant damage of three kinds: cracking within the midsection; fragmentation of the midsection; fracture of the hinge. Cracking within the midsection was found in 8 implants between 6 and 12 months postoperatively and in 1 implant later than 12 months. Later examinations revealed fragmentation of the midsection in 2 implants previously showing cracks. Hinge fracture was observed in 22 implants. Implant damage was found in a total frequency of 26/41. Bone reaction was found on the tomograms in all the operated joints, and could not be evaluated on the AP-projections. A bony spur was found to develop on the metacarpal bone volarly at the site of the osteotomy in 35 joints. In 2 of these the bony spur reached the base of the proximal phalanx, causing anchylosis. Bone resorption was found in 23 joints, constantly dorsally in the metacarpal bone and volarly in the proximal phalanx. The mechanism of the implant damage is discussed with respect to the shearing forces in the joint and the two materials of differing elasticity constituting the implant. The bone reaction is discussed with respect to the intended fixation of the intramedullary stems. | |
| 6412793 | Intermittent cyclophosphamide in refractory rheumatoid arthritis. | 1983 Sep 10 | Three patients with refractory rheumatoid arthritis were treated with oral cyclophosphamide; in two cases this was supplemented with pulse treatment with methylprednisolone. Long term remission was induced in all three patients and was sustained until follow up at least nine months after the methylprednisolone was stopped. Leucopenia occurred but resolved when cyclophosphamide was reduced from daily to intermittent dosing. Intermittent treatment with cyclophosphamide, possibly in conjunction with pulses of methylprednisolone, may induce remission in patients with rheumatoid arthritis refractory to other forms of treatment. | |
| 52891 | Isolation and characterization of amyloid-related serum protein SAA as a low molecular wei | 1975 | With direct immunoprecipitation or gel filtration under dissociating conditions, amyloid-related serum protein SAA has been isolated as a low molecular weight protein from the serum of two patients with rheumatoid arthritis but without known amyloidosis. The isolated protein SAA showed antigenic identity and an amino acid composition that was similar, but not identical, with isolated fibril protein AA. Molecular weight estimations suggest that protein SAA is approximately 50% larger than protein AA and has a molecular weight of 14,000-15,000 daltons. Preliminary results indicate that protein SAA from a patient with amyloidosis has a similar small molecular weight subunit. | |
| 6787994 | Proteinuria in rheumatoid arthritis--drug-induced or amyloid? | 1981 Jun | Over a 5-year period 325 patients with rheumatoid arthritis received treatment with gold (162) or D-penicillamine (163). Thirty-eight (11.7%) developed proteinuria, which persisted in 10 patients; renal biopsies in these 10 patients revealed 6 cases of amyloid disease. These 6 cases illustrate the importance of investigation of rheumatoid patients developing proteinuria even when they are receiving potentially nephrotoxic drugs. | |
| 578869 | Rheumatoid pericarditis. Rapid deterioration with evidence of local vasculitis. | 1977 Nov 28 | In a patient with classical rheumatoid arthritis and pericardial involvement, accelerated restriction of cardiac filling resulting from pericardial constriction developed. Pericardiectomy was necessary to relieve this condition. Examination of the synovial and pericardial fluid showed noteworthy decreases in total hemolytic complement (CH50) and C3 levels, while these were normal in the serum. Immunofluorescence staining of the pericardium showed plasma cell infiltration and immune deposit staining of pericardial vessels with IgG, IgM, IgA, or C3. These findings suggest that immune complexes deposition plays an important role in the pathogenesis of this condition. | |
| 55652 | Immunostimulant therapy with levamisole for rheumatoid arthritis. | 1976 Feb 21 | In a controlled study involving thirty-four patients levamisole was shown to be as effective as D-penicillamine and more effective than placebo in the treatment of rheumatoid arthritis. Its action was slow and was accompanied by a reduction in erythrocyte sedimentation-rate, rheumatoid factor, and technetium index. These properties indicate that it has a specific action like that of D-penicillamine. Stimulation of cell-mediated immunity was evident in patients treated with levamisole, and there was a correlation between such changes and pain relief. Animal models confirmed the absence of anti-inflammatory effect and provided some evidence of enhancement of cell-mediated immunity and macrophage stimulation. | |
| 6508861 | D-penicillamine in patients with rheumatoid arthritis. Serum levels, pharmacokinetic aspec | 1984 Dec | After administration of D-penicillamine to patients with rheumatoid arthritis, measurements of serum level and urinary excretion showed half-life times of 1.6 hours in the rapid phase and 4-6 days in the slow phase. The latter evidence suggests that tissue pooling occurs. With a dosage of 750 mg/day, basic serum levels of 100 microM are gradually reached. Serum D-penicillamine levels were shown to be the same for patients who responded well to treatment, those who did not respond, and for patients who had adverse side effects as well as those who had none. Intestinal resorption decreased when D-penicillamine was taken close to meals and was greatly reduced by iron preparations. | |
| 6700838 | [Rheumatoid cardiopathy. Observations on a clinical case]. | 1984 Feb 25 | The occurrence of cardiac involvement in RA is frequent but cardiac lesions are observed more frequently at necroscopy than on clinical examination. The case of a RA patient with a serious mitral valves involvement is reported in which the histological examination of the bioptic tissue obtained during surgical valves replacement showed a typical rheumatoid granulomatous inflammation of the endocardium. | |
| 366142 | A review of the effects of levamisole on erythrocyte sedimentation rate, acute phase prote | 1978 | A statistically significant decrease of erythrocyte sedimentation rate (ESR) is seen in levamisole-treated rheumatoid arthritis (RA) patients. While there is a correlation between ESR decrease and clinical improvement, in a few patients ESR remains unchanged in spite of a good clinical result. A decrease of acute phase proteins and an increase in hemoglobin and hematocrit have also been reported with levamisole. | |
| 6598099 | Histocompatibility antigen combinations in rheumatoid arthritis. | 1983 Jan | The frequencies of HLA-A, -B, -C, DR and MT lymphocyte alloantigens in clinical and serologic subsets of rheumatoid arthritis (RA) were determined in 65 Caucasian patients with definite or classical disease and compared to frequencies observed in normal individuals. The elevation in frequency of several antigens controlled by different genes in the major histocompatibility complex (MHC) suggested that combinations of antigens may be associated with RA. Significant associations were found for HLA-A1-DR4 and A1-MT2 (p less than 0.001), Bw40-DR4 (p less than 0.002) and Cw3-DR4 (p less than 0.001). The results indicate that combinations of genes in the MHC are influential in predisposing to RA. | |
| 1238046 | Effect of intra-articular 90Y resin treatment on the chemical properties of synovial fluid | 1975 Jun | Lyaluronic acid and total protein concentrations in synovial fluid of the knee joint obtained from 48 patients with classical or definite rheumatoid arthritis were determined before, and 1 week, 1 month and 6 months after intra-articular injection of 90Y resin colloid. The concentration ratio of total protein to hyaluronic acid, which is a sensitive index of the abnormality of the synovial fluid, was worse a week after the injection in each group as regards the clinical effect of the 90Y resin injection, but was better 1 month and 6 months after the injection only in the remission group. | |
| 7436640 | Effect of a rheumatology elective on house officers' evaluation of rheumatoid arthritis. | 1980 Nov | To ascertain whether a rheumatology elective (RE) increase the ability of house officers (HOs) to treat patients with rheumatic disease, 109 encounters involving patients with rheumatoid arthritis were audited. This permitted a comparison of 12 HOs who had had an RE with 55 HOs who had not. Results suggested that the RE led to better reporting of history and physical findings and increased the frequency with which relevant laboratory studies were ordered. During the 30-month period of the study, no increase was apparent in audit scores of HOs who had not had the elective, nor was any deterioration noted in scores of HOs who had participated in the elective with increasing length of the interval between the RE and the subsequent encounters. |