Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2858181 | Alcohol consumption in arthritic patients: clinical and laboratory studies. | 1985 Mar | In popular belief patients with chronic arthritis take alcohol for its analgesic effect. To test this we studied by validated questionnaire the past and present alcohol consumption of 103 patients with primary osteoarthritis of the hip (OA), 95 patients with rheumatoid arthritis (RA), and 90 orthopaedic non-arthritic controls. OA men were most likely and RA men least likely to have been heavy drinkers at any time of their lives. Mean red corpuscular volume (MCV), gamma-glutamyltransferase (GGT), and serum uric acid (SUA) levels did not correlate with reported alcohol consumption. Two of 93 OA femoral heads examined had avascular change; both were from heavy drinkers. The abstemiousness of RA men compared with their OA counterparts was due to a striking increase in joint pain after drinking alcohol (p = 0.004), fear of adverse drug reactions with alcohol, and a widespread belief not expressed by OA men that 'alcohol and arthritis do not mix'. | |
| 3160355 | Impaired killer cell generation in the autologous mixed leukocyte reaction by rheumatoid a | 1985 Jul | Natural killer-like cells are generated along with interleukin-2 (IL-2) in the autologous mixed leukocyte reaction (AMLR). Patients with active rheumatoid arthritis (RA), but not those whose disease is in remission, are poor producers of AMLR killer cells. This defect cannot be explained by age, medications, or serum factors. The impaired generation of natural killer-like cells was not influenced by gamma-interferon but could be partially restored by addition of indomethacin to the AMLR culture, or by culturing RA T cells with exogenous IL-2. However, the response of RA T cells to IL-2 was significantly less than that of controls. These results suggest that the defect in the generation of AMLR killer cells in patients with active RA may be due in part to defective production of IL-2 and a lesser sensitivity of RA T cells to IL-2. | |
| 342692 | Treatment of rheumatoid arthritis with L-histidine: a randomized, placebo-controlled, doub | 1977 Winter | A randomized cooperative double-blind trial of oral L-histidine for the treatment of rheumatoid arthritis was carried out. Patients were treated with either L-histidine 4.5 g daily, or placebo, for 30 weeks. None of the clinical measurements showed an advantage of histidine over placebo. A small decrease in rheumatoid factor titer and a small increase in hematocrit were found only in the histidine group. There was suggestive evidence of a beneficial effect of histidine in patients with more active and prolonged disease, based upon subjective doubld-blind evaluations by physicians and patients. No adverse effects of histidine therapy were noted. Histidine cannot be advocated as a therapeutic agent in rheumatoid arthritis, but further studies in certain groups of patients seem justified. | |
| 3933897 | Spontaneous lymphocyte activity in rheumatoid arthritis in a longitudinal study in relatio | 1985 Sep | Spontaneous lymphocyte activity has been measured over 24 weeks in rheumatoid arthritis patients who were receiving placebo, auranofin or gold sodium thiomalate (GST). The results suggest a relationship between a fall in lymphocyte activity and clinical improvement on GST. They also show that the patients with most active disease, as determined by the ESR, had normal levels of lymphocyte activity. We suggest that peripheral lymphocyte activity is secondary to immunological stimulation in the joint capsule, and is not directly related to disease activity. We conclude that spontaneous activity is probably an epiphenomenon and not related directly to disease activity or to disease prognosis. | |
| 6959574 | HLA system and side effects of gold salts and D-penicillamine treatment of rheumatoid arth | 1982 Dec | Among 67 patients with rheumatoid arthritis treated with gold salts (aurothiopropanol sulphonate) a significant correlation (p less than 10(-2)) was noted between gold toxic reactions, whatever their type, and the HLA antigens A1, B8, Cw7, and DR3. Forty-two patients were genotyped, and a correlation was observed between gold side effects and the haplotype A1 Cw7 B8 DR3 (p less than 10(-2), RR = 8.0). In addition 3 out of 4 cases of renal intolerance to D-penicillamine were observed in patients possessing the Cw7 B8 DR3 haplotype. | |
| 6174045 | Sequential gold and penicillamine therapy in rheumatoid arthritis. | 1982 Mar | Ninety patients with rheumatoid arthritis who had received courses of gold followed by penicillamine for their disease were evaluated to determine the predictiveness of a certain response or adverse reaction to gold for the same response or adverse reaction to penicillamine. Most patients who were considered gold-responders also responded to penicillamine, and most patients who did not respond to gold responded to penicillamine as well. Regarding toxicity, gold reactions did not predict reactions to penicillamine except that that patients with gold-induced proteinuria were at a higher risk for development of proteinuria during penicillamine therapy (p less than 0.001), and this usually occurred within the first six months of treatment. Patients with penicillamine-associated mucocutaneous reactions tended to have low gamma globulin levels (p less than 0.05) and were less likely to have subcutaneous nodules (p less than 0.05). | |
| 6871588 | The Cherwell splint: an ankle and foot orthosis for rheumatoid arthritis. | 1983 Aug | Rheumatoid arthritis often gives rise to painful collapse or partial collapse of the foot into valgus under load-bearing conditions, limiting the subject's ability to walk. However, the ankle joint frequently remains unimpaired. Thus, in serious cases a cosmetic splint is required which supports the foot whilst allowing the ankle to plantarflex and dorsiflex. The Cherwell ankle-foot orthosis has been designed and extensively tested in Oxford and elsewhere during the last four years, and can now be prescribed and supplied from three orthopaedic centres to meet this requirement. | |
| 7268083 | [Changes in the atlanto-odontoid articulation in rheumatoid arthritis. Radiologic observat | 1981 Mar | The authors describe the alterations of atlanto-axial joint observed in patients with rheumatoid arthritis: 16 of 86 patients = 18.6% (15 females and 1 male) showed the presence of joint luxation. The authors suggest that a "dynamic" tomographic study in lateral orthostatic projection, with indifferent position and head flexed, is essential for demonstrating the changes of this joint and that examination should be performed in all patients with rheumatoid arthritis, even if they are asymptomatic. | |
| 200034 | [The rhagocyte (author's transl)]. | 1977 | The "rhagocyte" (Delbarre) was defined with the aid of own results and results from the literature as an unity of structure and function of phagocytic cells in synovial fluids. Rhagocytes are an ubiquitous phenomenon in most cases of inflammation in joints detectable with nonspecific methods and are not a specific sign for the diagnosis of rheumatoid arthritis. The inclusion bodies of rhagocytes were demonstrated as immunoglobulin complexes with fixation of complement (IgG/IgM/C) by means of the immunofluorescence technique. In these specific preparations the rhagocyte has an importance as rheumatoid arthritis cell (R.A. cell) as defined by Hollander. --A definition of the rhagocyte and a description of histochemical results is given in a synopsis of characteristical properties of inclusion body cells. Moreover, a representation of the morphogenesis and value of the rhagocytes in a concept of the pathogenesis of rheumatoid arthritis, the in vitro and in vivo reproduction of rhagocytes and its value for the diagnosis in diseases of joints is given. | |
| 1254316 | [A comparison of two tests for rheumatoid factor: latex test and l-agglutination (author's | 1976 Feb | Positive and negative reactions of latex test (LX) and streptococcal L-agglutination (LA) were correlated significantly with one another. However, in approximately 70% of the sera tested only one test was positive, LX at a much higher rate than LA. Postive rheumatoid factor tests were found in 117 patients with rheumatoid arthritis and in 595 patients with other diseases, exclusive of connective tissue diseases. Among the seropositive patients with rheumatoid arthritis, a positive reaction was seen in 85% and 71% by LX or LA respectively. Patients with nonrheumatic diseases showed positive reactions at a rate of 3,1%, with 2,3% and 1,7% in LX or La respectively. This shows that LA is less sensitive, but more specific as compared with LX. With increasing age of the patients, the rate of "nonspecific positive" reactors in patients with nonrheumatic diseases increases, more strongly for LX than for LA. The distribution of positive tests (LX positive, LA positive, or both positive) was analyzed in various groups of patients. The rate of positive reactions in both tests is significantly higher than patients with rheumatoid arthritis; it further increases with the severity of the disease. In cases with positive CRP, the rate of sera positive in both tests is higher, equally in patients with and without rheumatoid arthritis. In patients with nonrheumatic diseases an elevated serum gamma-globulin is associated with positive reactions in both tests and with positive LX. In all other grouping of patients, the rheumatoid factor tests did not yield significant deviations from chance distribution, as determined by chi2 analysis. | |
| 6360455 | Immunologic characteristics of the leukocyte adherence inhibition assay in rheumatoid arth | 1983 | Peripheral blood leukocytes (PBL) from patients with rheumatoid arthritis (RA) when used in the leukocyte adherence inhibition (LAI) assay were capable of distinguishing antigenic differences between RA and osteoarthritic (OA) synovial membrane extracts. Normal PBL from control subjects with nonadherence index (NAI) values of 7 +/- 2 were able to respond positively (NAI values of 31 +/- 6) in the LAI assay if briefly preincubated with IgG obtained from LAI-position RA subjects. The LAI-positive response of PBL from RA patients was negated by preincubating the cells with sera obtained from LAI-nonreactive RA patients. Preincubation of reactive LAI-positive RA cells with urinary protein from 4 LAI-nonreactive RA patients blocked the response of reactive RA leukocytes in the LAI assay (42 +/- 2 to 14 +/- 2). In contrast, preincubation of reactive LAI-positive RA cells with urinary protein from LAI-reactive RA patients or patients with gout had no effect on subsequent LAI reactivity. This study suggests that LAI-nonreactive RA subjects have a 'rheumatoid neoantigen-like material' in their circulation which is excreted in their urine and is capable of being recognized by PBL of reactive, LAI-positive RA patients. | |
| 1107362 | A dual approach to the evaluation of the efficacy of a new rheumatoid arthritic agent--pir | 1976 Jan | Pirprofen was compared to placebo in a double-blind crossover study in 12 rheumatoid arthritis patients. Two approaches--univariate and multivariate--were used to analyze the study results which were in the form of arithmetic changes from pretreatment levels of six efficacy measurements. The univariate analysis failed to permit a single decision to be made regarding the further investigation and use of pirprofen in rheumatoid arthritis. However, the multivariate analysis which treats the efficacy variables simultaneously showed a clear differentation from placebo. Thus, multivariate analysis enabled the clinical pharmacologist to evaluate the new therapeutic agent in a complete and comprehensive manner. It allowed for a single decision to be made regarding the merits of pirprofen compared to placebo. | |
| 1166284 | Effect of an intravenously administered bile acid (chenodeoxycholic acid) on rheumatoid ar | 1975 | On the basis of the earlier observations of an ameliorating effect of jaundice on rheumatoid arthritis, the purpose of the present study was to confirm the influence of bile acids on rheumatoid arthritis. Ten patients were treated with intravenous infusions of chenodeoxycholic acid in single doses of 1-2 g, given over 5-8 hours on 1-4 consecutive days. The concentration of serum bile acids during the infusions were determined. The effect of the treatment was evaluated by means of the subjective experience of the patients, together with the ESR and Lansbury's clinical index. In 6 of the patients, pain relief was obtained for periods of up to 14 days after the last infusion, whereas the symptoms in the remaining 4 patients were unchanged. Where the ESR and the clinical index were concerned, it was characteristic that the course rose and fell, most often with an increase in initial values followed by a cecrease to below the pre-treatment level. In relation to the bile acid infusions, a brief rise, in most cases marked, was observed in the rheuma factors (Waaler-Rose). The serum bile acid concentrations registered during the infusions varied widely. However, no relation was observed between the concentrations and the effect. In all patients, phlebitis occurred in conjunction with each of the infusions. Transient, slight signs of liver injury were recorded in 3 patients, and, in 1 further patient, these signs were more pronounced and accompanied by fever together with deterioration of the joint condition. In all cases, the symptoms had disappeared within 1 week. It is concluded that a certain effect of the bile acid infusions on the clinical condition of rheumatoid arthritis and its related parameters was established. However, the effect was both temporary and inadequate, and especially because of the inevitable occurrence of phlebitis treatment cannot be recommended in tis present form. | |
| 6432402 | Sequential joint scintigraphy in rheumatoid arthritis. | 1983 Mar | In this sequential study joint scintigraphy was compared with clinical and röntgenological evaluation in 19 patients with rheumatoid arthritis. Scintigraphy sometimes preceded clinical and radiological abnormalities and scan results were independent of radiological findings showing no differences when large and small joints were compared. Scan findings in 2 patients with arthralgias only were negative, suggesting that arthritis was unlikely. | |
| 4808814 | Back diffusion of hydrogen ions across gastric mucosa of patients with gastric ulcer and r | 1974 Jan 5 | Ionic permeability of the gastric mucosa was measured in six patients with an acute exacerbation of severe generalized rheumatoid arthritis receiving either aspirin and prednisone or aspirin and indomethacin as therapy. The results were compared with those in four patients with benign gastric ulcer and nine normal subjects. Compared with controls H(+) concentration was decreased and Na(+) concentration increased while corrected H(+) flux out of the lumen and Na(+) flux into the lumen were significantly increased in the patient groups, indicating increased mucosal permeability. Abnormality of the gastric mucosal barrier persisted in two patients despite healing of their ulcers. Mucosal permeability of patients with rheumatoid arthritis and gastric ulcer did not differ significantly from one another. One rheumatoid patient with a gastric ulcer showed no difference in mucosal permeability to that of the other rheumatoid patients. These studies suggest that increased H(+) ion loss contributes to the apparent hyposecretion of acid in patients gastric ulcer; persistence of an abnormal gastric mucosal barrier to H(+) ions may explain the high recurrence rate of gastric ulcers; and an abnormal gastric mucosal barrier may be a precursor to gastric ulceration in rheumatoid arthritis. | |
| 7093867 | Steady-state plasma levels of salicylate in patients with rheumatoid arthritis: effects of | 1982 Aug 15 | Forty patients who were admitted to hospital with rheumatoid arthritis received a total of 3.9 g/d of enteric-coated acetylsalicylic acid (ASA) (Entrophen) according to one of four dosing schedules: group 1 (n = 13), three 325-mg tablets four times daily; group 2 (n = 11), two 650-mg tablets three times daily; group 3 (n = 10), three 650-mg tablets twice daily; and group 4 (n = 6), two 975-mg tablets twice daily. Five to seven days after the start of therapy, when steady-state plasma salicylate levels had been achieved, 10 blood samples, 1 per hour, were collected. Three healthy volunteers who received plain ASA formed a control group. There was little fluctuation in the salicylate levels over the sampling period, regardless of the dosing interval, and no significant difference in the fluctuations between the five groups. Likewise, there was no significant difference in the mean salicylate levels at each sampling time, regardless of the dosing interval or tablet strength. These results suggest that different tablet strengths of enteric-coated ASA and different dosing intervals produce comparable plasma salicylate levels. Less frequent dosing may improve patient acceptance of salicylate therapy in the treatment of arthritis. | |
| 3877166 | D-penicillamine induced suppression of B cell function: in vivo effect of D-penicillamine. | 1985 Aug | We assessed the immunoglobulin secretory capacity of circulating B lymphocytes in 9 patients with classical rheumatoid arthritis (RA) before and after treatment with D-penicillamine. Peripheral blood lymphocytes (PBL) from patients with RA spontaneously synthesized more IgG and IgA than normals. The secretory rate of rheumatoid PBL could not be induced by the polyclonal activator, pokeweed mitogen (PWM). The presence of D-penicillamine in cultures significantly suppressed PWM stimulated immunoglobulin synthesis of control PBL but did not inhibit synthesis of mitogen stimulated RA PBL. After D-penicillamine therapy for 3 months immunoglobulin synthesis by PBL from patients with RA was reduced with or without PWM. The T mu:T gamma ratio was also decreased after therapy. These results support the hypothesis that D-penicillamine selectively impairs helper T cells in vivo, preventing the T dependent expansion and activation of B cells characteristic of RA. | |
| 6614845 | Replacement of the knee in rheumatoid arthritis using the Imperial College London Hospital | 1983 Apr | The Imperial College London Hospital (ICLH) technique and prosthesis for the total replacement of the knee was evolved over the period 1968 to 1977. The results now reported were obtained at The London Hospital on rheumatoid knees operated upon in the period 1977 to 1979. These knees were reviewed and the results published with a one to 2 year follow-up in 1981. In the present paper this review has been extended to 3 to 5 years. We find that in successfully replaced knees the quality of the clinical result has remained unchanged over the extended period of review. Certain further complications have been encountered which are described. These complications have led us to the conclusion that whereas we previously accepted post-operative alignments between one and 10 degrees of valgus, we should now adjust these limits. We now regard a knee having anything less than 5 degrees of valgus post-operatively as having been incorrectly replaced. The limits of valgus can perhaps be extended to 15 degrees. Experience over the period 1977 to 1980 suggested the possibility of further improvements in both the operative technique and the prosthesis. Accordingly the ICLH prosthesis has now been modified. The modified prosthesis (the Freeman-Samuelson prosthesis) is described in this paper but results with it are not reported. | |
| 7247472 | Some in-vitro comparisons of synovial cells dispersed by trypsin from rheumatoid and nonrh | 1981 Jun | Life spans, growth rate, glucose utilisation, response to hydrocortisone, and intracellular activity of lysosomal N-acetyl-beta-glucosaminidase of rheumatoid synovial cells in culture were compared with these properties in nonrheumatoid synovial cells. Except for a small group of RA cells derived from tissue explants, the cells were all isolated by trypsinisation of synovial tissue, either within intact joints or after synovectomy. Cell lines were established by passaging with trypsin. In a study of 56 nonrheumatoid and 24 rheumatoid synovial lines isolated during a 7-year period the latter were found to have a shortened mean life expectancy in culture, though there was wide variation between individual lines. This is in agreement with reported findings from untrypsinised explant-derived synovial lines. However, in the present study mean multiplication rates were identical for nonrheumatoid and rheumatoid synovial cells, and on clear differences could be demonstrated for the other properties studied. No correlation could be found between the life spans of synovial cell lines and the age of the cell donors, whether from rheumatoid or nonrheumatoid sources. Rheumatoid synovial cells isolated from intact joints were notable for especially high proportions of macrophage-like cells and suppression of fibroblasts. In most cases cell lines could not be established from these rheumatoid primary cultures, and in others the lines were short-lived. Early association with relatively high proportions of macrophage-like cells in rheumatoid cultures might thus be important in influencing the establishment and behaviour of synovial cell lines. | |
| 477031 | Electrophoretic behaviour of blood and synovial fluid lymphocytes in rheumatoid arthritis. | 1979 May | Probit analysis of the electrophoretic mobilities of human blood lymphocytes identifies at least three main subpopulations. According to their rate of movement in an electrical field, the subpopulations are referred to as the fast, intermediate and slow cell distributions. Lymphocytes of the fast and intermediate populations appear to be T cells, while the slow cell population includes cells with B cell characteristics. Compared with normal subjects, lymphocytes of intermediate mobility are significantly increased in the blood of rheumatoid patients and comprise a major fraction of the lymphocyte exudate in rheumatoid synovial fluid. |