Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1022870 | Penicillamine in rheumatoid arthritis. Connective tissue changes and alterations in serum | 1976 Dec | Thirteen patients, aged 27 to 70 years, with definite or classical rheumatoid arthritis were treated with penicillamine for six months. Skin biopsies and blood samples were compared with a clinical evaluation before and after therapy. The analyses of the skin included determinations of total collagen, thermal reaction of collagen, salt soluble collagen, in vitro uptake of 14C-proline and synthesis of 14C-hydroxyproline, as well as determinations of nucleic acids and proteoglycans. Serum concentrations of acute phase reactants, immunoglobulins, complement C3 and C4, rheumatoid factor, and iron, copper, and zinc were also determined. A positive correlation was found between clinical improvement and a fall in the number of granulocytes, a decrease in the concentration of acute phase reactants and serum copper, and an increase in salt soluble collagen of the skin. The total skin collagen decreased during treatment with penicillamine. The changes in skin collagen may reflect a generalized effect of penicillamine on collagen. These alterations may be part of an anti-inflammatory action of penicillamine. | |
| 6847267 | Aorto-atrial fistula in rheumatoid arthritis. | 1983 Apr | A patient with severe deforming rheumatoid arthritis presented with a short history of chest pain. The clinical signs were of an unusual diastolic murmur and profound shock unresponsive to therapy. Post-mortem examination disclosed the unexpected finding of a large aorto-atrial fistula. | |
| 596952 | Thrombocytosis in rheumatoid arthritis. Recurrent arterial thromboembolism and death. | 1977 Dec | A patient with rheumatoid arthritis complicated by excessive thrombocytosis and recurrent thromboembolic events is presented. The platelet count correlated well with disease activity and thrombosis occurred when thrombocytosis was marked. The patient died from massive thrombosis of the aorta despite treatment with anticoagulants, corticosteroids, and azathioprine. | |
| 6475321 | Chiromorphoergometry (a new method for assessment of joint involvement in rheumatoid arthr | 1984 May | The authors suggest a method for "measuring" the morpho-functional damage of hands and wrists. This method analyzes three postural tests: - "Praying hands" (cf. Fig. 1,2) - "Back of the hands opposed" (cf. Fig. 3) - "Phalanges opposed (by their dorsum)" (cf. Fig 4). These tests define for each hand three angles a1, a2, a3. The corresponding indices I1, I2, I3 are obtained by the following formula: Ii = (1 - ai/90 degrees) . 100. One then defines a general index ITOT by the following expression: ITOT = (I1 + I2 + I3)/3 The index ITOT looks very effective in assessing the patient's condition in an objective way and is simple enough to be used in everyday practice. Hence it is also helpful in therapy-monitoring. | |
| 966588 | [Corneal pathology in rheumatoid arthritis and Sjögren-syndrome with special reference to | 1976 Apr | The corneal pathology in rheumatoid arthritis and Sjögren's syndrome is described with emphasis on rheumatic keratomalacia. This particular disorder whether affecting the central and paracentral or the peripheral parts of the cornea is characterized by thinning of the corneal stroma, loss of epithelium, ulceration and eventually by corneal perforation. 7 cases are reported. Reduced tear production and simultaneous corticosteroid treatment seem to be the essential pathogenetic factors of this corneal disease. Therapeutic consequences and differential diagnosis are discussed. | |
| 125562 | Lymphocyte reactivity in rheumatoid arthritis. Mixed lymphocyte culture. | 1975 Jun | Lymphocyte function in rheumatoid arthritis has been assessed by the mixed lymphocyte culture assay. In contrast to previous studies, no difference was found between lymphocytes from healthy volunteers and patients with rheumatoid arthritis. An occasional patient's lymphocytes failed to respond on a given day, but were normal on restudy. All 44 arthritic patient's lymphocytes underwent blast transformation on stimulation with lymphocytes from unrelated donors. By reaction in mixed lymphocyte culture, lymphocytes from patients with rheumatoid arthritis appear to be normal and no different from normal cells studied simultaneously. | |
| 442841 | [The effect of yttrium-90 radio synovectomy on the intra-articular xenon-133 clearance in | 1979 Mar | Nine inflamed knee joints out of eight patients were examined before and after intraarticular injection of yttrium-90 silicate colloid, in order to find out the effect of radiation synovectomy on the perfusion of the joints. These joints and the untreated contralateral knee joints were examined as to the clinical status and the fast component Tf of the xenon-133 clearance was determined as a means of the perfusion of the synovium. A linear correlation exists between the clinical status of the knee joint and the perfusion as determined by Tf measured three months before and after injection of yttrium-90. Also the joints without any radiation synovectomy showed this correlation. Three months after radiation synovectomy with yttrium-90 there was still no therapeutic effect apparent in the majority of the inflamed knee joints (seven out of nine). At this stage there still existed a hyperaemia. Therefore, it seems that on the whole three months are too short a period to judge the therapeutic effect. | |
| 984906 | Seropositive rheumatoid arthritis associated with decreased diffusion capacity of the lung | 1976 Jun | Sixty-two patients with classical or definite rheumatoid arthritis were subjected to lung function analysis. The various parameters--spirography, plethysmography, blood gas analysis, measurement of lung compliance, and diffusion capacity--were correlated with duration and stage of disease, and with rheumatoid factor titres. A statistically significant correlation was found to exist between Rose-Waaler titre and specific diffusion capacity. Similar results between Rose-Waaler titre and lung compliance, however, were not statistically significant. | |
| 335767 | [Richter's syndrome and cervical cancer in the course of a rheumatoid arthritis]. | 1977 Jul | The authors describe a rare case of Richter's syndrome (transition of chronic lymphatic leukaemia into reticulosarcoma) developing during rheumatoid arthritis in a women aged 53 years. Chronic antigenic stimulation and disturbances of interaction between lymphocytes T and B are suggested as a cause of Richter's syndrome. | |
| 4604253 | Complement-fixing granulocyte-specific antinuclear factors in neutropenic cases of rheumat | 1974 Jun | Forty-one sera from patients with rheumatoid arthritis (RA) and accompanying neutropenia, including twenty-one with Felty's syndrome, were studied to investigate the occurrence and determine the titres of granulocyte-specific antinuclear factors (GS-ANF) belonging to the three main immunoglobulin classes. Furthermore complement (C3) fixing GS-ANF and rheumatoid factors were titrated in the sera. Complement-fixing GS-ANF were found in thirty-five of these sera compared with only four out of twenty-eight sera from RA patients without neutropenia. Complement-fixing GS-ANF were similarly detected in all of six sera from non-arthritic patients with severe neutropenia and positive Waaler—Rose tests. Complement-fixing properties of the antibodies were mostly found in sera containing high titres of GS-ANF of the IgG and IgM classes, but the titres of complement-fixing GS-ANF were on the whole markedly lower than the corresponding IgG and IgM antibody titres. A direct autoaggressive activity of complement-fixing GS-ANF on the neutrophilic granulocytes or their precursors is suggested. | |
| 6842470 | Morphometric analysis of peripheral blood and synovial fluid lymphocytes of patients with | 1983 Feb | A morphometric analysis of lymphocytes from the peripheral blood and the synovial fluid (SF) of patients with rheumatoid arthritis (RA) was based on a determination of the nuclear contour index (NCI = perimeter divided by the square root of the area of the nucleus). Use of this method showed that a particular type of lymphocyte, the cerebriform mononuclear cell (CMC), occurred in higher percentages in the SF than in the peripheral blood of patients with RA. The mean NCI of the lymphocytes (non-CMC) was also higher in the SF. These findings indicate that lymphocytes in the inflammatory compartment are morphologically altered, compared to the corresponding cells in the peripheral blood of the same patients, the change probably expressing an alteration in functional status. | |
| 4026084 | Polyarthritis and neutropenia associated with circulating large granular lymphocytes. | 1985 Sep | Five patients with polyarthritis and neutropenia had numerous circulating large granular lymphocytes with a phenotype attributed to immature natural killer cells. All five had splenomegaly and recurrent infections. Arthritis was most prominent at the wrists and hands, and all patients were considered to have atypical cases of Felty's syndrome. Antinuclear antibodies, rheumatoid factor, antineutrophil antibodies, and immune complexes were detected in most patients. Bone marrow biopsies revealed a maturation arrest at the myelocyte stage and lymphoid infiltrates. Large lymphocytes with azurophilic cytoplasmic granules were found on peripheral blood smears and showed a characteristic reactivity pattern with monoclonal antibodies suggesting a natural killer cell lineage. Peripheral blood mononuclear cells showed less than normal natural killer activity against K562 target cells. Increased numbers of large granular lymphocytes with a phenotype of immature natural killer cells may be important in the pathogenesis of neutropenia, humoral immune disturbances, and synovitis in a subset of patients with Felty's syndrome. | |
| 5078408 | Rheumatoid arthritis, rheumatoid factor, and tests for Australia or hepatitis-associated a | 1972 Oct 7 | False-positive results in tests for hepatitis-associated antigen using latex agglutination techniques may be due to rheumatoid factor in the serum. Possibly the use of IgM antibody in preparing the latex particles might diminish the occurrence of such reactions. No evidence was found for a relation between rheumatoid arthritis and a significant incidence of hepatitis-associated antigen detectable by countercurrent immunoelectro-osmophoresis. | |
| 6126710 | Oral contraceptives and rheumatoid arthritis: further evidence for a preventive effect. | 1982 Oct 16 | To investigate a reported negative association between the use of oral contraceptives (OC) and the development of rheumatoid arthritis, a case-control study was undertaken to compare the histories of OC use between 228 women with a diagnosis of probable or definite rheumatoid arthritis and 302 women with the diagnosis of soft-tissue rheumatism and/or osteoarthritis. The use of OCs before the onset of joint complaints was acknowledged by 31.1% of the rheumatoid arthritis patients and by 55.6% of the controls. After adjustment for possible confounding variables, the rate ratio for ever use became 0.42 (95% confidence interval 0.27--0.65), while it was 0.40 (0.22-0.72) for ex-users and 0.45 (0.28-0.75) for current users. These findings confirm the finding from the Royal College of General Practitioners Oral Contraceptive Study that the incidence rate of rheumatoid arthritis among OC users was halved. | |
| 6411587 | Glucocorticoid use in rheumatoid arthritis. | 1983 Sep | Although the early hopes and enthusiasm held for glucocorticoids in rheumatoid arthritis therapy have been greatly modified, there is still a secondary therapeutic role for these drugs, one which has been refined by clinical experience. | |
| 7239501 | A statistical approach to the histopathologic diagnosis of synovitis. | 1981 Apr | Synovial tissue from 393 operations on diseased joints were scored for each of 37 histopathologic variables; the patients fell into 10 clinically defined diagnostic categories. The five most populous of these diagnostic groups provided a data set for calculating diagnoses based on histopathologic findings. For each pair of clinical diagnostic categories we derived a linear discriminant function dependent solely on the histopathologic assessments. The functions gave a numerical score for segregating each case into one of the diagnostic categories. The histopathology based diagnoses agreed with the clinical diagnoses in 54 to 78 per cent of the cases. Illustrations of the application of this technique are presented. | |
| 336322 | [MK-231 (Sulindac) in the treatment of rheumatoid arthritis (author's transl)]. | 1977 Dec 2 | MK-231 (Sulindac), 200-400 mg daily, was given to 25 patients with rheumatoid arthritis. The therapeutic response was good and there were no side effects at all. The drug should be used more frequently than heretofore in the drug treatment of symptoms of rheumatoid arthritis. | |
| 364615 | A comparison of ketoprofen and naproxen in rheumatoid arthritis. | 1978 | Ketoprofen, 50+50+100 mg, was compared to naproxen, 250+250+250 mg, in a double-blind, cross-over twice 4-weeks' study on patients with RA. There was no significant difference in the effect on morning stiffness, pain at rest, joint count, grip strength or ESR. Among 28 patients 10 preferred ketoprofen and 7 naproxen. Two ketoprofen and 1 naproxen periods were interrupted owing to intolerable side-effects. Twenty of the patients experienced some side-effect from at least one drug. The most common complaints were gastrointestinal, seen in 12 patients on ketoprofen and 9 on naproxen. Most side-effects were mild. No abnormality in blood morphology, liver function tests, serum creatinine or fasting blood glucose was observed. No occult bleeding was detected on routine stool examination. | |
| 415670 | Examination of complement C3 metabolism in rheumatoid arthritis using 2-dimensional immuno | 1978 Feb | A previous report that C3 activation products are demonstrable in the plasma of subjects with rheumatoid arthritis was reinvestigated using 2-dimensional immunoelectrophoresis. Initially it seemed that results were in agreement, but the occurrence of similar patterns in normal sera and poor reproducibility of results suggested the findings were artefacts. When calcium and magnesium ions were removed with EDTA, C3 activation products were no longer demonstrable in plasma from normal subjects or from patients with rheumatoid arthritis. The results obtained without EDTA in the buffer showed a greater degree of complement activation in patients with rheumatoid arthritis, suggesting that in this condition the serum may have a greater potential ability to bring about complement activation. | |
| 6882488 | Sustained improvement of intractable rheumatoid arthritis after total lymphoid irradiation | 1983 Aug | Total lymphoid irradiation (TLI) was administered to 11 patients who had intractable rheumatoid arthritis that was unresponsive to conventional medical therapy, including aspirin, multiple nonsteroidal antiinflammatory drugs, gold salts, and D-penicillamine. Total lymphoid irradiation was given as an alternative to cytotoxic drugs such as azathioprine and cyclophosphamide. After radiotherapy, 9 of the 11 patients showed a marked improvement in clinical disease activity as measured by morning stiffness, joint tenderness, joint swelling, and overall functional abilities. The mean improvement of disease activity in all patients ranged from 40-70 percent and has persisted throughout a 13-28 month followup period. This improvement permitted the mean daily steroid dose to be reduced by 54%. Complications included severe fatigue and other constitutional symptoms during radiotherapy, development of Felty's syndrome in 1 patient, and an exacerbation of rheumatoid lung disease in another. After therapy, all patients exhibited a profound T lymphocytopenia, and a reversal in their T suppressor/cytotoxic cell to helper cell ratio. The proliferative responses of peripheral blood mononuclear cells to phytohemagglutinin, concanavalin A, and allogeneic leukocytes (mixed leukocyte reaction) were markedly reduced, as was in vitro immunoglobulin synthesis after stimulation with pokeweed mitogen. Alterations in T cell numbers and function persisted during the entire followup period, except that the mixed leukocyte reaction showed a tendency to return to normal values. |