Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 59602 | Antibodies to native and denatured collagens in sera of patients with rheumatoid arthritis | 1976 May | A passive hemagglutination assay was used to detect antibodies to native human collagens and to collagen chains in the sera of 110 rheumatoid patients and those of 75 normal controls. The incidence and titer of anticollagen antibodies in rheumatoid arthritis are high, but in controls they are low or in most instances absent. No correlation was found between the stage of RA, or titers of rheumatoid factor, or ANA and the incidence and/or titers of antibody to any given type of collagen. | |
| 602346 | Studies on lymphocytotoxicity in acute and chronic liver disease. | 1977 Dec | The cytotoxicity of lymphocytes from patients with chronic active hepatitis, chronic persistent hepatitis, acute hepatitis B and rheumatoid arthritis as well as from normal controls was studied in a microcytotoxicity assay according to COHEN et al. using 125I-iododeoxyuridine labeled embryonal liver cells and Chang cells as target cells. Unfractionated lymphocytes of the peripheral blood from patients with chronic active hepatitis and rheumatoid arthritis showed a high frequency of cytotoxic activity. The lymphocytotoxicity in chronic active hepatitis was significantly increased in comparison to normal controls at the EC/TC of 10:1 and 100:1. Specificity of the cytotoxic reaction to target cells could not be demonstrated. Addition of autologous serum to the cytotoxic assay blocked the lymphocytotoxicity in patients with chronic active hepatitis. A weak potentiating effect on lymphocytotoxicity was observed in patients with hepatitis B after addition of autologous serum. It is discussed that this reaction is due to the presence of HB-antigen in the serum since addition of HB-antigen from other sources increased also the lymphocytotoxicity in hepatitis B patients. This effect was observed neither in HB-antigen positive nor in HB-antigen negative patients with chronic active hepatitis or chronic persistent hepatisis. | |
| 111678 | A tissue culture model of cartilage breakdown in rheumatoid arthritis. III. Effects of ant | 1979 Aug | The effects of hydrocortisone, indomethacin, and gold thiomalate on proteoglycan release were assessed in bovine nasal cartilage-rheumatoid synovium cocultures. Of the three agents, only hydrocortisone consistently inhibited both basal and synovium-stimulated cartilage breakdown. Hydrocortisone responsivity was a direct function of the degradative capacity of synovial specimens, and this was equally well demonstrated both in patients receiving long-term therapy and those given perioperative glucocorticoid therapy. The data are consistent with significant hydrocortisone inhibition of lysosomal enzyme-mediated degradation of cartilage. | |
| 737907 | Immune complex detection and complement activity in rheumatoid arthritis: a comparative st | 1978 Nov | Paired sera and synovial fluids from forty-nine patients with rheumatoid arthritis and twenty-five with other forms of arthritis were tested for immune complexes by a radioimmunoassay using monoclonal rheumatoid factor and gel diffusion procedures with monoclonal rheumatoid factor and C1q. Synovial fluid hemolytic C4 and C4 adjusted for IgG concentration were determined in both groups of patients. Immune complexes were detected at similar high frequencies in the rheumatoid synovial fluids by precipitin formation with monoclonal rheumatoid factor (68%) and C1q (71%). In contrast, immune complexes in rheumatoid sera were detected in low frequency by precipitin reactions with monoclonal rheumatoid factor (10%) and C1q (0%). Using the monoclonal rheumatoid factor radioimmunoassay, thirty-one (63%) synovial fluids exceeded the mean non-RA binding activity by one standard deviation. Similarly, twenty-four (49%) rheumatoid sera exceeded the mean non-RA binding activity to one standard deviation. Synovial fluid C4 adjusted for IgG as well as IgG alone distinguished between the two groups of patients whereas the C4 values did not. The C4/IgG value showed a strong negative correlation with the monoclonal rheumatoid factor radioimmunoassay and C1q precipitin formation. | |
| 6516555 | [Experiences with Wagner's cup prosthesis]. | 1984 Sep | Surface replacement is an alternative procedure especially in younger patients who absolutely need hip replacement. Accurate diagnosis is imperative and the range of indications is naturally small. A follow up study of 44 patients (range, 10 months to 4 years) showed 2 loosenings (5%); other severe complications were not seen. In 39 (89%) hips was no more pain after operation and there was a distinct improvement of motility in 39 (89%) cases. Avascular necrosis should not be treated by surface replacement. Primary inflammatory diseases (rheumatoid arthritis) seem to have a higher incidence of complications, especially when long time treated with large doses of steroids. Cortisone medication promotes avascular necrosis of the hip and lytic enzymes coming from the pannus might be another reason for loosening. According to our experience the position of the cup according to varus or valgus has no influence on the result of the operation. The Watson-Jones approach seems to be better than the approach recommended by Wagner, because paraarticular calcifications are seldom seen. | |
| 3157529 | HLA antigens and adverse drug reactions to sodium aurothiomalate and D-penicillamine in pa | 1985 Mar | The association between HLA antigens and adverse drug reactions (ADR), (e.g. proteinuria, haematological abnormalities, stomatitis, diarrhoea and dermatitis) in rheumatoid arthritis (RA) to sodium aurothiomalate (gold) and to D-penicillamine (PA) were studied in 32 patients. Thirty-eight RA patients treated with gold and PA, and with no ADR to these drugs, were used as controls. The frequency of HLA B8 was significantly (p less than 0.05) increased among RA patients with ADR compared to plasma donors. DR3 was also significantly increased (p less than 0.05) in RA patients with haematological ADR compared to plasma donors. Haematological ADR occurred significantly (p less than 0.05) more often in DR3 positive patients (55%) than among DR3 negative RA patients (27%). | |
| 4017318 | Significance of the hydrogen ion concentration in synovial fluid in rheumatoid arthritis. | 1985 Apr | The hydrogen ion (H+) concentration and pCO2 were measured in the synovial fluid (SF) from the knee joints of 130 patients with arthritis by an acid-base analyser (ABL2 Acid-Base Laboratory), using a simple technique which prevented contact with air. H+ concentration was significantly higher in SF from 60 RA patients (mean 64.4 n mol/l; range 38-142 n mol/l) compared with patients with OA (mean 44 n mol/l; range 29-56 n mol/l), and 40 with other arthritides (mean 52 n mol/l). The H+ concentration in the SF showed a significant association with other variables of local inflammation-platelet, total leucocyte and polymorph counts, 5-nucleotidase, acid phosphatase and IgA levels in the SF and the clinical knee score, but not with the volume of the effusion. A similar relationship between these variables of inflammatory activity and SF pCO2 was also established. A higher SF H+ concentration was also found in systemically active disease, but no difference in SF pH between seropositive and seronegative patients. Whilst the pH of SF approximated to that of the blood in OA, it was significantly lower in the SF in RA. SF pH is a useful marker of local inflammatory activity, and its measurement is simple, reliable and rapid. It is relevant because changes in pH influence many of the processes involved in inflammation and the pH difference between SF and blood influences the transfer of drugs into the joint. | |
| 7288234 | [[Nitroblue tetrazolium tests of blood and synovial fluid cells in rheumatoid arthritis an | 1981 May | Nitroblue tetrazolium (NBT) test, widely performed to investigate the physiology and function of blood polymorphonuclear leukocytes, was evaluated using blood and synovial fluid cells of 20 patients with rheumatoid arthritis and 19 patients with osteoarthritis. There were no significant differences among two joint diseases and healthy controls in NBT test values on blood polymorphonuclear leukocytes. Seropositive and CRP positive patients with rheumatoid arthritis, however, revealed low values. NBT test value on polymorphonuclear leukocytes of synovial fluids was lower than that of blood in rheumatoid arthritis and was higher than that of blood in osteoarthritis. Negative correlations were seen between NBT test value and nucleated cell count of synovial fluids in these diseases. On the other hand, NBT test by mononuclear cells did not differ from the by polymorphonuclear leukocytes in rheumatoid synovial fluids and these two values correlated well. There was correlation between nucleated cell count and NBT test value on mononuclear cells in osteoarthritic synovial fluids. From these results it was suggested that the severity of joint inflammation might influence the function of not only polymorphonuclear leukocytes but also mononuclear cells of synovial fluids. | |
| 6732962 | Atlanto-axial dislocation with brain atrophy and edema: an autopsy report. | 1984 | We report autopsy findings of the vertical type of atlanto-axial dislocation. Details of the anatomical features in the head and neck are described, with reference to the histological findings of medullary compression. | |
| 7034736 | Clinical trial of penicillamine in rheumatoid arthritis. | 1981 Dec | The medical records of our first 200 consecutive rheumatoid arthritis patients treated with penicillamine were analyzed retrospectively. All but 5 patients (97.5%) had undergone earlier chrysotherapy that resulted in either therapeutic failure or toxicity. Only 57 patients (28.5%) were still receiving penicillamine on January 1, 1981, and the duration of therapy ranged from 23 to 62 months. The dropout rate due to toxicity, therapeutic failure, relapse, or other reasons was very high (71.5%). Toxic effects required permanent discontinuance in 56 patients (28%). Therapy was discontinued for 36 patients (18%) because of no benefit. A striking number (20) had relapse after therapeutic success and while continuing to take penicillamine, and the therapy had to be discontinued, a relapse rate of 10%. Therapy for the remaining 15.5% was discontinued for miscellaneous reasons that were not related to penicillamine per se: patient anxiety (6%), lost to followup (5%), hospitalization for reasons unrelated to penicillamine therapy (2%), lack of cooperation and study protocol (1% each), or pregnancy (0.5%). By our criteria, 142 patients (71%) received benefit (remission or improvement). Therapy results for these patients were as follows: still on penicillamine on January 1, 1981 (28.5%); no longer receiving the drug due to toxicity (19.5%); no longer receiving penicillamine due to relapse while on continuing therapy (10%); no longer receiving penicillamine due to miscellaneous reasons not related to penicillamine therapy (13%). This study shows that penicillamine is a valuable drug in the treatment of rheumatoid arthritis, but its value in clinical practice is limited by a rather high incidence of both toxicity and relapse during treatment. | |
| 7288758 | Longterm follow-up of posterior cervical fusion for atlanto-axial subluxation in rheumatoi | 1981 May | Surgical fusion of the upper cervical spine was used to treat atlanto-axial subluxation in 7 patients with rheumatoid arthritis. Postsurgical follow-up was 3 to 16 yr. Despite progressive and often severe radiological changes in the cervical spine, no patient has had a clinical recurrence of neck symptoms requiring further surgery. These results suggest that surgical fusion is successful in the longterm, despite the often dramatic radiological changes which occur in the cervical spine with the passage of time. | |
| 373651 | A thermographic and clinical comparison of three intra-articular steroid preparations in r | 1979 Feb | We have compared three intra-articular steroid preparations in a double blind study on 30 patients with rheumatoid arthritis and bilateral synovitis of the knees. One knee was injected with 1.0 ml of either prednisolone t-butyl acetate, methyl prednisolone acetate, or triamcinolone hexacetonide, and the patients were followed up for 6 weeks with regular clinical and thermographic assessments. Thermographic improvement was seen with all 3 drugs but was greatest initially and longest lasting with triamcinolone. No significant systemic improvement was seen with any drug after a single injection, though all 3 steroid preparations suppressed endogenous cortisol. | |
| 609877 | [Study of optimal posology of penicillamine in the treatment of common rheumatoid polyarth | 1977 Dec | A comparison of two series of patients with rhe,matic polyarthritis, the one (n = 140) treated with dosage equal to or higher than 900 mg, the other (n = 60) with dosage between 600 and 750 mg, did not reveal significant difference in clinical and biological efficacy. The number of side-effects was not significantly reduced by lower dosage, except for digestive tract disorders. A reduction of dosage does, therefore, not permit less strict supervision and monitoring for side-effects of treatment. | |
| 6212484 | Magnification immersion radiography: better soft tissue visualization in the hands. | 1982 Apr | We have combined microfocal magnification with immersion radiography and mammographic technique to produce superb soft tissue and bone detail in the hand using a single PA exposure. The lateral projections provide excellent demonstration of the flexor and extensor tendons and joint capsules. This method has proved valuable as the primary radiologic examination in the evaluation of soft tissue lesions in the hands, particularly in patients suspected of having rheumatoid arthritis. | |
| 518144 | Effects of corticosteroids and local anaesthetics applied directly to the synovial vascula | 1979 Oct | The effects of intra-articular injection of triamcinolone hexacetonide on the rate of clearance of radioactive xenon (133Xe) was studied in 11 patients with rheumatoid arthritis. No effect of the corticosteroid injection was observed, which suggests that the drug has no immediate effect on synovial blood vessels. | |
| 3872474 | [Diagnosis of the Gougerot-Sjögren syndrome in rheumatology. II--Test strategy]. | 1985 Feb | The diagnostic evaluation of the sicca complex in rheumatology depends, on the one hand, upon performing tests and, on the other hand, upon the specific clinical presentations which lead to these tests. The frequency with which the clinical problem is encountered should be taken into account as well as the probability of whether or not the patient does indeed have the sicca complex, and the necessity of making a precise diagnosis. A labial biopsy should be performed when it is necessary to confirm the diagnosis. Schirmer's test is useful to evaluate the ocular component of the sicca complex, which is the only component requiring therapy. In other cases, one examination can follow another in sequence such as salivary nucleotide scanning followed by biopsy and histological examination. | |
| 6470256 | CT appearances of rheumatoid lung disease. | 1984 Oct | The plain radiography and CT of four patients with rheumatoid lung disease are reviewed. One patient had histologically confirmed rheumatoid nodules. The subpleural location of the nodules and cavitation were more easily diagnosed using CT. Also on CT the nodules were commonly seen in clusters, a finding not previously reported and not visible on plain films. In three patients honeycombing was visible on both plain radiography and CT. However, the areas of cystic destruction visible on CT were larger than those appreciated on the plain films. | |
| 320061 | Diftalone: a new non-steroidal anti-inflammatory agent: comparative study with phenylbutaz | 1977 | A double-blind study was carried out to compare the effectiveness and tolerability of diftalone and phenylbutazone in thirty patients with classical or definite rheumatoid arthritis, randomly distributed between the two treatment groups. Both drugs were administered according to a progressively decreasing daily dosage schedule: 1,000 mg during the 1st week; 750 mg the 2nd week and 500 mg from the 3rd week on for diftalone; 400 mg, 300 mg, and 200 mg daily for the 1st, 2nd and from the 3rd week on respectively for phenylbutazone. The study lasted twelve weeks. The clinical controls and laboratory tests were performed weekly up to the 8th week, while the final evaluation was made at the end of the 3rd month. Twelve patients in the group receiving diftalone and fourteen in the phenylbutazone group completed the trial. Clinical improvement was observed in both groups. Effectiveness was somewhat more evident in the diftalone group. Tolerability was acceptable for both drugs, althoug the diftalone patients showed less frequent and intense side-effects than those treated with phyenylbutazone. No significant differences were found as regards the laboratory parameters, except a significant fall of the E.S.R. (less than 0-05) in the diftalone group. Diftalone seems to be an effective and safe anti-inflammatory agent in the treatment of rheumatoid arthritis. | |
| 6698622 | Cell-mediated immunity in rheumatoid arthritis. Discrimination between specific and non-sp | 1984 | Leucocyte migration inhibition (LMI) by paired samples of autologous serum and synovial fluid IgG as well as homologous IgG and also heat-aggregated forms of all three IgGs was studied for patients with rheumatoid arthritis (RA) and compared with the response to these antigens by leucocytes from healthy individuals. Autologous and homologous serum IgGs did not markedly affect leucocyte migration, whereas synovial fluid IgGs caused occasional pronounced LMI with autologous (rheumatoid) leucocytes. Although aggregated IgG produced LMI in both RA patients and controls, the means of the migration indexes were significantly different between both groups. Peripheral blood mononuclear cells from RA patients and healthy controls were also cultured with both native rheumatoid and normal IgG; only supernatants from RA cells incubated with rheumatoid IgG showed LMI activity, in contrast to the other culture supernatants. These results indicate that LMI to native IgG in RA may represent a form of specific cell-mediated immunity, although LMI to aggregated IgG might be explained by non-specific factors. | |
| 4081787 | Unrecognized staphylococcal pyarthrosis with rheumatoid arthritis. | 1985 Feb | Four patients whose rheumatoid arthritis (RA) was complicated by staphylococcal arthritis were identified. All patients had active, long-standing disease with destructive changes. Affected joints included hip (two patients), knee (one patient), and shoulder (one patient). Pain and loss of motion in the affected joint were prominent, but toxic features of pyogenic infections--hectic fever, chills, sweats, local warmth, or erythema--were conspicuously absent. Two patients had moderate fever and three patients had mild leukocytosis. No patient was leukopenic. When present, fever was attributed to infected decubiti or urinary tract infection and treated with antibiotics. Therapy with corticosteroids and nonsteroidal antiinflammatory drugs (NSAIDs) probably masked symptoms and delayed the correct diagnosis. Purulent synovial effusions were discovered serendipitously--during arthrography (knee), attempted Girdlestone procedure (hip), and aspiration prior to steroid injection (shoulder). Sepsis was included in the preoperative diagnoses only once (hip). Prior instrumentation (aspiration or injection) of the affected joint was not a feature in any patients, although one patient had undergone insertion of a knee prosthesis one year prior to sepsis. Infectious organisms were Staphylococcus aureus in three patients and Staphylococcus epidermidis in one. Severe sequelae ensued in three of four patients: death from recurrent sepsis (one patient), loss of prosthesis leading to knee arthrodesis (one patient), and protracted sepsis with additional pyarthrosis (one patient). The only patient to regain preseptic joint function (shoulder) had not been on long-standing corticosteroids. Pyarthrosis must be considered in RA patients with unusually painful or stiff joints even in the absence of toxic symptoms. |