Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 727918 | [A method for the measurement of the collodiaphyseal angle in case of external rotational | 1978 Oct 27 | The authors discuss the objectivity of measurements for the collodiaphyseal angle of the hip fixed in external rotation on the a.p. projection. Since the antetorsion cannot be measured because of the external rotation contracture, an alternative projection is proposed. Several pictures are demonstrated for the determination of the rotation. To find the true value of the distorted collodiaphyseal angle the authors propose a formula for the calculation on theoretical grounds. They consider this formula valuable for clinical use. | |
| 671439 | Talalgia. A review of 30 severe cases. | 1978 Summer | Seronegative spondyloarthritides (Reiter's syndrome, ankylosing spondylitis, or psoriatic arthritis) was diagnosed in 24 of 30 patients with severe heel pain. Most of the patients were carriers of the antigen HLA B27. Talalgia was frequently the first symptom of disease. Heel surgery is contra-indicated during the inflammation phase, since it may cause local aggravation and risk of ankylosis of the talocalcaneal articulation. Other causes of heel pain include tendon chondrocalcinosis, local tuberculous infection, and nodular tendinitis caused by a partial rupture of the tendon. On the other hand, severe talagia was rarely found in rheumatoid arthritis, and no case was related to the presence of tophi or xanthomas of the Achilles tendon. | |
| 6732635 | The painful wrist. | 1984 Feb | Almost certainly, any condition producing pain in the wrist will interfere with the use of the hand. This in turn can cause impaired function of the whole of the limb. | |
| 705270 | Copper in ankylosing spondylitis and rheumatoid arthritis. | 1978 | To study the role of copper in inflammatory rheumatic diseases, serum copper, serum ceruloplasmin concentration, erythrocyte sedimentation rate, and radio-copper studies were performed in 11 male patients with ankylosing spondylitis, in 12 female patients with rheumatoid arthritis and in 7 normal male subjects. The occurrence of elevated serum copper and serum ceruloplasmin levels can be confirmed in our study for patients with ankylosing spondylitis and rheumatoid arthritis when compared with normal controls. A significant correlation was found for these parameters and the inflammatory activity, characterized by the erythrocyte sedimentation rate. If groups with similar inflammatory activity are compared, higher ceruloplasmin concentrations are found in ankylosing spondylitis than in rheumatoid arthritis, the plasma incorporation of radiocopper also being higher in ankylosing spondylitis patients. Therefore, and because of comparable total serum copper concentrations, the non-ceruloplasmin bound copper level is found to be significantly higher in rheumatoid arthritis patients than in the group of ankylosing spondylitis patients. The significant correlation between erythrocyte sedimentation rate and the cumulative 120-hour urine excretion of radiocopper is in good agreement with the chemical finding of an elevated urinary copper excretion found by others, supporting the concept that the elevation of serum and urine copper levels in inflammatory rheumatoid diseases can be considered as an acute phase response. | |
| 659373 | Schizophrenia, rheumatoid arthritis and trytophan metabolism. | 1978 Jun | Rheumatoid arthritis and schizophrenia have been described in early surveys as mutually exclusive disorders. Such claims are seen as especially interesting in view of: (1) indications that both illnesses often follow prodromes of severe psychological stress, (2) theories regarding hypermethylation of indoleamines producing endogenous psychotogens in schizophrenia, and (3) studies of rheumatoid arthritis reporting excessive binding of L-tryptophan to plasma protein, abnormalities of urinary tryptophan metabolites, decreased serotonin binding capacity of thrombocytes, and decreased MAO activity in joint fluid. Further comparative studies of tryptophan metabolism in schizophrenia and rheumatoid arthritis might enhance knowledge of pathogenesis in either or both diseases. | |
| 2934623 | Cytochemical investigation of cathepsin B in rheumatoid synovial membrane and fluid. | 1985 Oct | Cathepsin B was cytochemically investigated in the cells of synovial membranes and in the cell pellet of synovial fluids obtained from 50 patients with rheumatoid arthritis and eight patients with various nonrheumatoid arthropathies. The activity of Cathepsin B was estimated by using the substrate N-alpha-benzoyl-DL-arginine-naphthylamide HCl and diazoic dye Fast Corinth V in phosphate buffer pH 6.0 in the presence of EDTA and cysteine. A significant activity of cathepsin B was shown in lining mesothelial cells, in macrophages of the submesothelial infiltrations, as well as in fibroblasts prominent in the deep areas of rheumatoid synovial membranes. In the cell pellets of synovial fluids the highest activity of cathepsin B was found in the macrophages and polymorphonuclear leukocytes, accompanied by a variable activity in lymphocytes. The considerable activity of cathepsin B, an enzyme with degradative action upon collagen and proteoglycans, in the main cellular populations of rheumatoid synovial membranes and fluids, suggests its involvement in the genesis and maintenance of rheumatoid lesions. | |
| 6439866 | HLA antigens and toxicity to gold and penicillamine in rheumatoid arthritis. | 1984 Oct | One hundred sixty-eight patients with rheumatoid arthritis treated with chloroquine (n = 87), gold salts (n = 133) and/or penicillamine (n = 77) were investigated for possible associations between HLA antigens and toxic reactions. Patients with 2 or more side effects to gold and/or penicillamine had a significantly increased frequency of antigens HLA-B8 and DR3 compared to patients with one or without adverse reactions. Proteinuria to gold or penicillamine was significantly associated with HLA-B8 (relative risk [RR] 4.2) and DR3 (RR 14.0) whereas nonnephrologic side effects to gold or penicillamine were associated with B7 and DR2 (RR 3.5 and 2.8). Patients with skin reactions to gold had a significantly greater frequency of HLA-B7. We found no correlation between chloroquine side effects and any HLA antigen. The results suggest a genetic predisposition to toxic reactions to gold or penicillamine based on an immunologic dysregulation. | |
| 6859066 | Effect of pregnancy on immune complexes and rheumatoid factors in patients with rheumatoid | 1983 Jun | Rheumatoid arthritis is associated with circulating and intra-articular immune complexes and rheumatoid factors. The clinical activity of rheumatoid arthritis improves during pregnancy in the majority of women, with exacerbation following delivery. Concentrations of immune complexes, as detected by the Clq-binding assay, the Clq-solid phase assay, and the monoclonal rheumatoid factor-solid phase assay, decreased during gestation, with elevations following delivery. Concentrations of IgM-rheumatoid factor and IgG-rheumatoid factor, analyzed by radioimmunoassay, changed variably during pregnancy, increasing in some patients and decreasing in others. When examined serially before, during, and following pregnancy, changes in the concentration of circulating immune complexes and/or rheumatoid factors corresponded with the clinical changes in three patients. These observations document the significant effect of gestation on the concentration of circulating immune complexes in patients with rheumatoid arthritis. They also support the role of these laboratory tests in monitoring the clinical course of rheumatoid arthritis. | |
| 6612197 | [The intercapital metatarsal space. Anatomical and pathological aspects]. | 1983 May | The metatarsal intercapital space is located in the forefoot, between two metatarsal heads and above the transverse inter-metatarsal ligament. The 2nd space is the narrowest, the 1st is the widest and the 3rd is the most mobile. It contains a connective tissue bursa which facilitates the sliding of the metatarsal heads. The existence of this bursa was confirmed in two cases of rheumatoid arthritis (at operation). As the bursa hypertrophies, it gradually extends beyond its normal site towards the dorsal or plantar region of the foot. The metatarsal intercapital space, like the metatarso-phalangeal joint, warrants thorough clinical investigation. | |
| 786356 | Phenylbutazone: a clinico-pharmacological study in rheumatoid arthritis. | 1975 Oct | A clinical trial of phenylbutazone in high dose (300 mg daily) and low dose (50 mg daily) is presented. 2. By analysis of the data by different methods, significant differences in clinical efficacy were shown between the two therapeutic regimes. 3. A relationship between the clinical effect and plasma level of phenylbutazone was demonstrated. 4. Some problems in the interpretation of plasma level-clinical effect correlates are discussed. | |
| 6729379 | [Capsulo-synovial lesions of the hip joint at the stage of total prosthesis implantation. | 1984 Apr | The authors have made a systematic study of specimens of synovium and capsule removed during total hip replacement for slowly and rapidly progressive arthritis, rheumatoid coxarthritis and necrosis. Out of 1 120 cases, there were 328 tissue samples suitable for satisfactory morphological interpretation. A number of conclusions are drawn from the detailed analysis of the different types of lesion. The vast majority of cases of common arthritis consist of hyperplastic and degenerative metamorphic lesions often associated with signs of inflammation. The dominant feature at this stage of coxarthritis is the histiocytic macrophage response to foreign bodies of bone and joint cartilage; it is frequent in rapidly progressive arthritis and necrosis. Several cases of synoviocytic and pseudo-tumour histiocytic hyperplasia are identified, as well as myxoid and amyloid degenerative disease of connective tissue and microcrystal formation. | |
| 7400330 | Pinocytosis in human synovial cells in vitro. Evidence for enhanced activity in rheumatoid | 1980 Sep | Human synovial tissue cells in monolayer can be shown to take up and digest a soluble protein, horseradish peroxidase (HRP). Uptake of HRP was linear with increasing concentrations of substrate and cell protein and with time for up to 4 h. Low temperature (4 degrees C), and sodium fluoride, an inhibitor of glycolysis were the most effective metabolic inhibitors of endocytosis. In addition, colchicine, an inhibitor of microtubule assembly, and yeast mannan, an inhibitor of mannose-specific receptors, reduced HRP uptake. Synovial cells from patients with rheumatoid arthritis (RSC) demonstrated a statistically significantly higher rate of endocytosis (247 +/- 107 ng HRP/100 micrograms cell protein per 2 h.) than cells from control, nonrheumatoid patients (NSC) (100 +/- 80 ng HRP/100 micrograms cell protein per 2 h). Thus, it is possible to discriminate RSC from NSC by their quantitatively different rates of endocytosis. Digestion of HRP by synovial cells is statistically significant by 6 h after uptake. A faster initial rate of digestion was seen in RSC. Over the first 6--8 h of incubation 42% of the endocytosed HRP was still cell-associated in RSC and 67% remained in NSC cultures. However, by 24 h 20--30% of endocytosed HRP was found in both types of cultures. These results indicate that endocytosed molecules may accumulate more rapidly in RSC and persist within their lysosomes for a longer time than in NSC. The quantitative determination of enhanced endocytosis by RSC compared with NSC suggests that this increased activity may have a role in the pathological function of synovial tissue in rheumatoid arthritis. | |
| 331687 | [Treatment of rheumatoid arthritis with the immunosuppresive agent, prorezid]. | 1977 | Prorezid treatment was applied to 30 patients with rheumatoid arthritis. It was applied per os with a daily dose of 300 mg to 12 subjects; to 18-intravenous drop infusion with 5 per cent serum glucose--daily dose 400 mg. Oral administration total dose-7-8 g; infusion-10-12 g. Drop infusion administration proved to be more effective and especially the combination of the preparation with salycilates, pirazolon derivatives, minimal doses of corticosteroids and antibiotics. Favourable effect on articular syndrome was obtained in 20 patients (66.6%) about 2-3 and sometimes 4-6 weeks after the onset of the treatment. First the articular pain was attenuated, latter on--the morning stiffness (3-4 week), the movements in the joints involved were improved, the edema decreased towards the 4-6th weeks. A complete normalization of the laboratory indices was observed in none of those patients. In 10 of the patients (33.3%) no clinical improvement was attained in the course of the treatment. In four of them--the improvement developed 4-6 months later, with a longer drug administration. Prorezid preparation is with a low toxicity, with manifestation of transitory side effects in single patients--diarrhoea, mild leukopenia. Alopecia was not observed. Those properties make the drug suitable for application in patients with rheumatoid arthritis whose treatment with the rest applied drugs failed to give results. | |
| 4051592 | Leucocyte function in patients with rheumatoid arthritis: quantitative in-vivo leucocyte m | 1985 Oct | Quantitative leucocyte mobilisation in vivo and the in-vitro random migration, chemotaxis, phagocytosis, and oxidative metabolic activity were studied in 15 patients with rheumatoid arthritis (RA). Patients mobilised leucocytes to chambers covering skin windows to the same degree as control subjects, and the mobilisation correlated with the blood leucocyte numbers and serum concentration of alpha-l-antitrypsin. Peripheral blood leucocytes showed slightly reduced migration in Boyden chambers but increased phagocytosis and increased unstimulated reduction of nitroblue tetrazolium. Exudate leucocytes from patients with RA showed migratory and phagocytic activity which did not differ from that of control subjects, but unstimulated exudate leucocytes reduced nitroblue tetrazolium more actively than leucocytes from control subjects. The observations indicate that leucocyte accumulation at an experimental inflammatory lesion and the function of these exudate leucocytes are not impaired in patients with rheumatoid arthritis. | |
| 539845 | In-vitro reactions of lymphocytes in rheumatoid arthritis and other rheumatic diseases. | 1979 Dec | Various lymphocyte functions and the percentage of different subpopulations have been measured in groups of patients with seropositive rheumatoid arthritis, seronegative ankylosing spondylitis, and psoriatic arthritis, Sjögren's syndrome, sicca complex, and in normal controls. Several abnormal results were found--in the responses to mitogens, in the antibody-dependent cytotoxic test, and in the percentages of EA rosettes (antibody sensitised chick red cells test) and surface immunoglobulin-bearing cells. In the light of these findings cytotoxicity and lymphocyte subpopulations were measured in further groups of rheumatoid arthritis patients in whom the disease was at different stages. The results showed that the changes in cytotoxic potential occurred in patients with active arthritis. Correlation tests showed significant positive associations between the percentage of SE rosette-forming cells (sheep red cells test) and the mitogenic responses to phytohaemagglutinin and concanavalin A, and between the percentage of EA rosette-forming cells and the levels of antibody-dependent cytotoxicity. The results are discussed in the light of our understanding of cellular subpopulations in the immune system. | |
| 1080067 | Routine assay for detection of IgG and IgM antiglobulins in seronegative and seropositive | 1975 Jul 26 | A convenient technique suitable for the routine estimation of IgM and IgG antiglobulins has been devised. The assay involves the binding of antiglobulins (rheumatoid factors) to rabbit immunoglobulin linked to the surface of plastic tubes; the amount of antiglobulin bound is then determined by adding radiolabelled antihuman IgG or IgM. Both antiglobulins were raised in virtually all seropositive rheumatoid arthritics, and 19 out of 22 seronegative patients had raised values for either IgM or IgG rheumatoid factors. The test should prove valuable in diagnosis and the results further emphasize autosensitization to IgG as a dominant immunological characteristic of different forms of rheumatoid arthritis. | |
| 1099507 | Surgical treatment of the swan-neck deformity in rheumatoid arthritis. | 1975 Jul | Swan-neck deformities vary not only in origin but also in the extent of functional loss. Careful examination used to determine the degree of flexion in all positions as well as x-ray examination of the joint has allowed us to group these patients into four types. Various surgical procedures are recommended according to this classification, which has made the treatment of these patients more orderly and rewarding. | |
| 241602 | A comparison of alclofenac and indomethacin in the relief of rheumatoid morning stiffness. | 1975 | In a double-blind within-patient comparison of indomethacin, alclofenac and placebo taken as a single daily dose at bedtime by 29 rheumatoid out-patients, both drugs proved superior to placebo. Seventeen patients expressed a preference for indomethacin and 10 found alclofenac equal or superior in effect. The lower incidence of gastric irritation with alclofenac is confirmed and suggests its use in subjects intolerant of indomethacin. | |
| 324481 | Immunohistochemical localization of prostaglandin E in rheumatoid synovial tissues. | 1977 Apr | Synovial tissues removed at synovectomy from patients with active rheumatoid arthritis (RA) or osteoarthritis (OA) were examined for prostaglandin E (PGE) by immunohistochemical techniques using rabbit antisera specific for PGE. Marked increments of PGE were noted in RA synovia in comparison to OA, with staining concentrated in synovial lining cells, interstitial inflammatory cells, and endothelial cells of blood vessels. A correlation was noted between the degree of synovial lymphocytic infiltrate and the intensity of PGE staining. These studies provide initial cellular localization of PGE in such tissues. | |
| 795021 | Immunotherapy with levamisole in rheumatic diseases. | 1976 | The immuno-modulatory effect of Levamisole in the treatment of rheumatic diseases was studied in an open trial. Nine patients with theumatoid arthritis (RA), 13 with ankylosing spondylitis (AS) and one with Reiter's syndrome (RS) were treated initially with 150 mg Levmisole daily for 4 weeks, then intermittently 3 days a week. Significant clinical improvement was observed in 7 out of 9 patients with RA, in 4 out of 13 patients with AS, and in the one patient with RS. An increased skin sensitivity to a panel of antigens was noted in 3 out of 9 RA patients and in 6 out of 13 AS patients. A fall in rheumatoid factor titre was observed in 2 out of 5 patients with seropositive RA. No development of other auto-antibodies was observed. No significant changes in the absolute lymphocyte counts either of the total counts or of the T, B, and null cell counts, were noted. Drug-related adverse reactions were seen in 13 patients, mostly allergic skin rash which required a short interruption in therapy. Severe leucopenia was observed in 2 patients, whereupon therapy was definitely withdrawn. Levamisole seems to have a definite beneficial effect on RA and a possible effect on AS and RS. Severe adverse reactions, mostly on the haemopoietic system, demonstrated some potential hazardous complications of the drug and required physical and laboratory examinations at short intervals. |