Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6750154 | Intractable rheumatoid arthritis. Treatment with combined cyclophosphamide, azathioprine, | 1982 Oct 8 | Seventeen patients (15 women, two men) with progressive, erosive seropositive rheumatoid arthritis (RA) refractory to conventional therapy were treated with cyclophosphamide, azathioprine, and hydroxychloroquine sulfate for an average of 27 +/- 19 months (mean +/- SD throughout) (range, five to 60 months). Disease suppression began in 14 patients within three to 16 months (mean, seven months). Five patients achieved complete remission, two had activity in a single joint only, seven had partial disease suppression, and three showed no response. Prednisone dosage was decreased or administration discontinued in nine of ten patients (5.8 +/- 1.2 to 2.7 +/- 3 mg/day). Serial hand roentgenograms showed recortication of erosions in nine patients, with "filling in" of some erosions in three of these. No change was seen in the roentgenograms of five patients, while progressive disease occurred in three instances. Combined therapy with small doses of three drugs, each with proved antirheumatic activity when used separately in larger doses, may provide satisfactory long-term disease control in patients with intractable RA. This regimen is experimental. Proof of efficacy requires a controlled study. Until such data are obtained, this drug combination is not recommended for general use. | |
| 2931914 | [Time-dependent flow behavior and fibrinogen content of synovial fluid]. | 1985 Mar | Normal bovine synovial fluid and synovial effusions in human non-inflammatory joint diseases do not show any decrease of viscosity for a long period of time during imposed shear loading, as is required for thixotropy. This observation is based on two different methods of measurement; the "hysteresis loop" method and the recording of the shear stress-time curve. Inflammatory synovial fluids--particularly from patients with rheumatoid arthritis and a high concentration of fibrinogen--form a visible gel after 6 to 20 hours of rest. Those gels show a hysteresis loop typical for thixotropy and a decrease of viscosity with the duration of shear loading. Due to the shearing in the rheometer precipitation occurs and fibrin clots appear. The appearance of fibrin clots induced by mechanical shear loading not known until now, can be discussed with regard to its possible participation in the symptom of morning stiffness, in the formation of rice bodies and in the destruction of joint cartilage in rheumatoid arthritis. | |
| 6345427 | A double-blind comparison of phenylbutazone and suxibuzone, a prodrug of phenylbutazone, i | 1983 | One hundred and fifty patients with rheumatoid arthritis received suxibuzone (426 mg/day, equivalent to 300 mg of phenylbutazone), a prodrug of phenylbutazone, or phenylbutazone (300 mg/day) in a six-week double-blind comparison study. After six weeks of treatment, morning stiffness, joint symptoms, and grip strength all improved almost equally in both groups. On the other hand, the frequency and severity of side-effects, particularly of gastro-intestinal (GI) disturbances, were markedly and significantly lower in the suxibuzone group. This study indicates that some prodrugs of non-steroid anti-inflammatory drugs are useful because they have fewer side-effects. | |
| 7420331 | Low dose pulse methotrexate therapy in rheumatoid arthritis. | 1980 Jul | Thirty-two patients with definite or classical rheumatoid arthritis were treated with low dose pulse methotrexate (MTX). A therapeutic response was shown in 2/3 of the patients by statistically significant joint changes and improved global response. Greater than one-half of those who improved demonstrated a drop in sedimentation rate. Eight patients discontinued treatment because of inefficacy and 2 because of gastrointestinal distress. One patient died of neoplasm. Five liver biopsies performed in patients with abnormal liver enzymes demonstrated no MTX related changes. We conclude that MTX may be an effective alternative to other more toxic immunosuppressive regimens and should undergo future evaluation. | |
| 406861 | Localization of gold in synovial membrane of rheumatoid arthritis treated with sodium auro | 1977 Jun | The localization of gold in the synovial membrane of rheumatoid arthritis patients treated with sodium aurothiomalate was examined and quantitative analysis of epon-embedded sections was carried out with a wavelength dispersive x-ray microanalyser. Gold was only detected in the lysosomes of synovial lining type A cells and subsynovial mononuclear cells in the form of filamentous deposits and highly electron-dense granules, the latter being few in number. The concentration of gold within the lysosomes containing the characteristic deposits and granules was equivalent to that in epon-embedded standard specimens of freeze-dried albumin in which 2-0-87-4 mg/ml of gold was included. In addition, sulphur was detected in the lysosomes containing the filamentous deposits, but the S/Au x-ray signal ratio was not equal to that detected in sodium aurothiomalate. The significance of the coexistence of gold with sulphur in lysosomes is discussed. | |
| 61951 | A new pyrazolidine derivative - benetazone spofa - in short- and medium-term treatment of | 1976 Jul | The effects of Benetazone Spofa (trimethazone) in a dose of 1000 mg/day with those of phenylbutazone in a dose of 600 mg day in patients with rheumatoid arthritis were tested in a short-term double-blind trial (3 weeks) and in a long-term double-blind trial (12 weeks). The short-term trial failed to disclose a significant superior effect of phenylbutazone, and the continued prolonged therapy showed, on the contrary, the higher effectiveness of the new derivative, but the difference was not statistically significant. The main advantage of Benetazone consisted of its lower toxicity, better tolerance and of the much lower tendency to produce fluid retention compared to phenylbutazone. | |
| 4018948 | Neuromuscular disorders associated with D-penicillamine treatment for rheumatoid arthritis | 1985 | Three cases of D-penicillamine (DPA) induced myasthenia gravis (MG) and one case of DPA-induced polymyositis (PM) are reported among four patients suffering from seropositive rheumatoid arthritis. The cumulative doses responsible for the three DPA-induced MG cases amounted respectively to 73, 117 and 467 g. The cumulative dose responsible for the DPA-induced PM case amounted to 465 g. All the patients were HLA DR1. All four cases healed completely after withdrawal of DPA. The aetiology of the cases is discussed and the literature is reviewed. These cases represent further instances of DPA-induced neuromuscular disorders. | |
| 7341274 | Human pharmacokinetics of indoprofen. | 1981 | The pharmacokinetics of indoprofen were investigated in several studies in healthy volunteers and in rheumatoid arthritis patients. In healthy subjects the drug is rapidly eliminated with a biological half-life of 2.3 h. The drug and its metabolites are almost completely excreted in urine within 24 h from administration. The absorption of indoprofen administered orally to fasting subjects as 100 mg capsules and 200 mg tablets is rapid and complete. The bioavailability of indoprofen tablets is not adversely affected by the presence of food in the gastrointestinal tract. Following administration of 600 mg of indoprofen per day for 7 days, no changes are observed in the drug plasma level profile. There are no substantial differences between healthy subjects and rheumatoid arthritis patients as regards the pharmacokinetics properties of oral indoprofen. | |
| 7223077 | [Safety containers for patients with chronic polyarthritis, how meaningful?]. | 1981 Jan | The problem in handling child-resistant containers for patients suffering from rheumatoid arthritis especially in advanced stage and in the elderly may be underestimated. The negative influence of blister packaging on compliance may be of major importance. The technically insufficient containers of drugs for rheumatoid patients are explained and alternative solutions are briefly discussed. | |
| 337466 | Osmic acid in rheumatoid synovitis. A controlled study. | 1977 | Ninety-nine adult RA patients with knee joint synovitis were randomized into two groups. The knee joints of the first group (52 patients) were treated with osmic acid and those of the second group (47 patients) with a placebo. After 6 months, the incidence of hydrops and pain was statistically less significant in joints treated with osmic acid. the result was better in joints without advanced radiological destruction. It is concluded that osmic acid is still of benefit in the local treatment of rheumatoid knee joint synovitis at an early stage. | |
| 7361064 | [Rheumatic manifestations of erythema elevatum diutinum]. | 1980 Feb | The authors report on a case of erythema elevatum diutinum developing at the same time as a seropositive rheumatoid polyarthritis. Disulone, moderately active on skin lesions, has little influence on the development of arthritis that have reacted well to treatment with D-penicillamine. A review of the literature makes it possible to identify the type of rheumatismal manifestations and immunological disorders accompanying the dermatosis. Three etiological circumstances must be looked for : focal infection, malignant lymphopathy, connectivitis. | |
| 966334 | Systemic lupus erythematosus with a vocal cord granulomatous nodule. | 1976 Aug | Systemic lupus erythematosus (SLE) with subcutaneous granulomatous nodules, joint symptoms, and a positive latex titre for rheumatoid factor may cause diagnostic confusion with rheumatoid arthritis (RA). This has been a subject of renewed interest in recent medical literature, but reports of nodules in SLE outside the subcutis are rare. This report presents a patient with SLE and with a vocal cord granulomatous nodule, arthralgia, and a positive latex titre for rheumatoid factor. The laryngeal manifestations of SLE are discussed. | |
| 309270 | The prevalence and possible significance of IgD granulocyte-specific antinuclear antibodie | 1978 Feb | Sera from 21 rheumatoid arthritis patients with accompanying neutropenia (less than or equal to 2000 neutrophils/microliter) and 45 rheumatoid arthritis patients without neutropenia were studied for the occurrence of IgD granulocyte-specific antinuclear antibodies. Such antibodies were found in 67 per cent of the neutropenic and 18 per cent of the non-neutropenic cases (p less than 0.001). The titres of IgD granulocyte-specific antinuclear antibodies varied independently of the titres of IgD and complement-fixing granulocyte-specific antinuclear antibodies, but showed some covariation with granulocyte-specific antinuclear antibodies of the IgA and IgM classes most probably reflecting a broad polyclonal antibody response to phagocyte nuclear antigens in the serologically highly active neutropenic cases. Gel filtration studies on selected sera containing IgD granulocyte-specific antinuclear antibodies indicated participation of these antibodies in immune complexes. It is thus possible that IgD granulocyte-specific antinuclear antibodies may have some significance for the rheumatoid inflammatory processes. | |
| 6844167 | Shoulder arthritis. Distinguishing among the many causes of inflammation. | 1983 May | Shoulder inflammation occurs in many rheumatic diseases. It is present in about half of the patients with rheumatoid arthritis but in a higher percentage of patients with less common diseases (eg, amyloid arthropathy, polymyalgia rheumatica). Shoulder arthritis, probably more than arthritis involving any other joint, requires prompt diagnosis and treatment to prevent loss of motion and function. For most patients, antiinflammatory medications, range of motion exercises, and instruction in joint protection constitute adequate treatment. A baseline shoulder roentgenogram is usually recommended. Intraarticular corticosteroid therapy may be a helpful adjunct, provided infection has been excluded. | |
| 7130659 | Wrist involvement in rheumatoid swan-neck deformity. | 1982 Sep | Two observations have led to the consideration of another possible factor in the etiology of rheumatoid swan-neck deformity. Distraction of the rheumatoid wrist with correctable carpal collapse and reversible swan-neck deformities resulted in easier initiation of proximal interphalangeal joint flexion, not found in hands with boutonniere deformity or lack of deformity. Review of x-rays of rheumatoid patients with swan-neck deformity indicates that most have evidence of carpal collapse. With carpal collapse and proximal migration of the carpal-hand unit, long or extrinsic motor systems are no longer working at physiological length or optimal efficiency. An imbalance is created, resulting, in effect, in an "extrinsic-minus" phenomena and swan-neck finger deformity. | |
| 6211176 | Immune functions of human synovial cells. Phenotypic and T cell regulatory properties of m | 1982 May | Normal and rheumatoid synovial cells have been analyzed in frozen sections and in suspension. HLA-DR-expressing, macrophage-like cells are demonstrated in normal synovial intima and in rheumatoid tissue. Suspended normal synoviocytes equaled peripheral blood non-T lymphocytes as stimulators of mixed lymphocyte reactions, whereas adherent rheumatoid synovial cells were extremely efficient as such stimulators and in presenting soluble antigens to autologous T lymphocytes. This HLA-DR-dependent T lymphocyte regulation might provide a cellular basis for the HLA-D haplotype-arthritis associations. | |
| 6142648 | Intravenous cyclophosphamide plus methylprednisolone in treatment of systemic rheumatoid v | 1984 Mar | Systemic vasculitis in rheumatoid arthritis shows similarities to polyarteritis nodosa and may require equally aggressive therapy. Forty-five patients with systemic rheumatoid vasculitis were studied during treatment with either cyclophosphamide plus methylprednisolone given by intermittent bolus intravenous injection (21 patients) or a variety of other more conventional drug regimens (24 patients). In this open study, the intravenous treatment group had more severe initial disease, a higher incidence of neuropathy, and more frequent evidence of necrotizing arteritis on biopsy than the other treatment group. Despite this, intravenous cyclophosphamide plus methylprednisolone resulted in more frequent healing of vasculitic lesions including leg ulcers and neuropathy, a lower incidence of relapse, fewer serious complications, and a lower mortality than did other treatments. Toxic effects were similar in both study groups. Intravenous cyclophosphamide plus methylprednisolone is a useful early treatment for systemic rheumatoid vasculitis. | |
| 304045 | A solid-phase radioimmunoassay for IgG and IgM antigammaglobulin factor in rheumatoid arth | 1977 | Rheumatoid factors of IgG and IgM class were detected by means of a solid-phase radioimmunoassay using formalinized sheep erythrocytes sensitized with rabbit anti-sheep erythrocyte serum and 125I-labelled anti-human IgG or anti-human IgM antibody. 28 of 35 sera and all of 7 synovial fluids of patients with rheumatoid arthritis showed positive reaction for both IgG and IgM rheumatoid factor, though the activity of IgM factor was mostly higher than that of IgG factor. However, rheumatoid factor present in synovial fluids of 3 seronegative patients was mainly of IgG class. Of 14 sera of patient with other collagen diseases, 11 showed IgG and 6 showed IgM rheumatoid factor. The IgG rheumatoid factor seemed to be associated with autologous IgG to form macro-molecular complexes which could be dissociated into 7S molecules of IgG rheumatoid factor and IgG by acid treatment. | |
| 3903848 | [Cervical discitis, spondylitis and spondylodiscitis in chronic polyarthritis]. | 1985 Jul | All varieties of inflammatory rheumatoid arthritis may involve the cervical spine. After progressive destruction and narrowing of the intervertebral disks, spondylitis and spondylodiscitis results in subluxation and fusion of vertebral bodies and square anterior corners. These varieties of vertebral body involvements are described. | |
| 20777 | Necrotizing vasculitis of the gallbladder and the appendix. Similarity in the morphology o | 1977 Jun | Two patients with rheumatoid arthritis (RA) and polyarteritis nodosa (PN) presented with abdominal pain. Both revealed necrotizing vasculitis of the gallbladder and the appendix respectively. The controversial role of corticosteroids in the pathogenesis of rheumatoid arteritis, the rarity of rheumatoid arteritis of the gallbladder and the morphologic similarity of the vascular lesion in the gallbladder and appendix are discussed. |