Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7334079 | Serum cryptococcal antigen determination in the presence of rheumatoid factor. | 1981 Dec | Sera from nine patients with cryptococcal infections and from four with rheumatoid arthritis and positive rheumatoid factor were examined for the presence of cryptococcal capsular antigen by the latex agglutination method. Ethylenediaminetetraacetic acid-heat treatment of the sera before testing possibly increased sensitivity as compared with the untreated sera, and the interfering rheumatoid factor activity was eliminated. | |
| 6374835 | Identifying infectious etiologies of chronic disease. | 1984 Mar | Available information regarding possible infectious etiologies of insulin-dependent diabetes mellitus, rheumatoid arthritis, and systemic lupus erythematosus is reviewed. The problems and limitations of classic methods in trying to prove a causal relationship between an infectious agent and a chronic disease are summarized. The authors suggest that these disease occur as a result of persistent infection triggering an immunologic response (which is destructive of host tissue) in genetically susceptible individuals. Prospective studies within families (wherein individuals most at risk for disease can be identified) before the onset or diagnosis of the chronic disease may offer the best approach to elucidating potential infectious etiologies. | |
| 1083615 | [Autoimmune phenomena in D-penicillamine therapy]. | 1975 | In two patients with rheumatoid arthritis, immunoglobuline deposits in the skin were detected during D-penicillamine treatment. One patient presented with drug induced exanthema, the other with pemphigus erythematosus which was confirmed by clinical, histological, and immunofluorescent findings. During the development of the specific side-effect in one patient, an increase of ANA-titre and antibody-binding-capacity versus denaturated DNA was observed. Therefore in a prospective study of another ten patients during four months after onset of treatment with D-penicillamine, antinuclear antibodies and antibody-binding-capacity versus native and denaturated DNA were examined. The latter group of patients - without skin lesions - did not show any changes in the above mentioned parameters. | |
| 6319517 | Serum levels of C1 subunits in rheumatoid arthritis. | 1984 Feb | Modifications of radial immunodiffusion and of hemolytic assays of C1q are described, which enable the results of these assays to be in agreement with those obtained by hydroxyproline assay. Using these assays, we show that C1q serum levels are significantly increased in rheumatoid arthritis (RA) and that the excess C1q levels in this disease are not accompanied by increased levels of C1r and C1s. Active RA is therefore characterized by increased levels of hemolytically active C1q that has a physiologically active stem region unbound to C1r and C1s. | |
| 686867 | Studies on cold insoluble globulin. I Concentrations in citrated plasma in rheumatic disor | 1978 Aug | Cold insoluble globulin (CIG) is a normal glycoprotein of human serum and plasma. The physiological significance of this protein is unknown, but is shows a temperature-dependent relation to fibrinogen and fibrin. It is possible that it represents a substrate for activated fibrin-stabilising factor in the polymerisation of fibrin. CIG is found on the surface of fibroblasts. In the present study CIG was estimated in citrated plasma in 115 patients with rheumatic diseases. Increased amounts were found in patients with systemic lupus erythematosus, secondary amyloidosis in classical and definite rheumatoid arthritis, and in male patients with juvenile rheumatoid arthritis. | |
| 942271 | Immunological reactivity in ankylosing spondylitis. Circulating immunoblasts, autoantibodi | 1976 Apr | Circulating immunoblasts were studied in 39 cases of ankylosing spondylitis. The results were compared with 20 normal subjects and a group of 39 patients with rheumatoid arthritis, Immunoblasts were found to be increased in 11 patients with ankylosing spondylitis and in 22 patients with rheumatoid arthritis in contrast to the controls who were found to have a normal lymphoid cell population in the peripheral blood. Fifteen patients showed raised levels of one or more class of immunoglobulin. Autoantibodies, including antinuclear factors, were negative in all cases. There was a correlation between raised immunoblasts and plasma viscosity but not with clinical assessment of activity. The increase of immunoblasts in the peripheral blood, together with the raised immunoglobulins supports the suggestion of an immunological basis for ankylosing spondylitis. | |
| 1137441 | Chronic monarticular synovitis. Diagnostic and prognostic features. | 1975 Apr | Data have been analysed from a retrospective review of 151 patients with monarthritis of more than 3 months' duration, usually involving the knee joint. The largest group, 49 patients (32%), had synovitis of unknown cause, 44 (29%) had synovitis probably associated with osteoarthrosis and 13 (9%) were diagnosable at presentation as having rheumatoid arthritis according to American Rheumatism Association (1959) criteria, which include serological and histological findings. There was only one case of tuberculous synovitis. Twelve of the thirteen patients diagnosed as rheumatoid arthritis developed involvement in other joints. In most other conditions, however, including synovitis of uknown cause, the prognosis was favourable, with either improvement or complete remission. | |
| 4719210 | Asymptomatic primary biliary cirrhosis. | 1973 Jun | Four asymptomatic patients are described with raised serum alkaline phosphatase values and a positive serum mitochondrial antibody test. In all four needle liver biopsy showed destructive bile duct lesions. Lymphocyte transformation to phytohaemagglutinin was normal in three and impaired in one who also suffered from rheumatoid arthritis. Two patients showed normal skin and serological test responses to dinitrochlorobenzene and haemocyanin. These four patients are believed to be suffering from asymptomatic primary biliary cirrhosis. | |
| 6245108 | Antibody to the rheumatoid arthritis nuclear antigen. Its relationship to in vivo Epstein- | 1980 May | Most patients with seropositive rheumatoid arthritis, and a variable but lesser percentage of normal subjects, have precipitating antibodies to a nuclear antigen, rheumatoid arthritis nuclear antigen, present in Epstein-Barr virus-infected human B lymphoblastoid cells. We have used a sensitive indirect immunofluorescence assay for antibody to rheumatoid arthritis nuclear antigen in a study of patients with infectious mononucleosis and healthy control subjects. Of 110 sera from normal, college-age cadets, 58 were from individuals without prior Epstein-Barr virus infection, as indicated by the lack of antibody to viral capsid antigen. All of these also lacked activity to rheumatoid arthritis nuclear antigen. 52 sera were positive for antibody to viral capsid antigen, and antibody to rheumatoid arthritis nuclear antigen was present in 26 (50%) of these. In 67 sequential sera from 11 college-age students with infectious mononucleosis who became positive for antibody to rheumatoid arthritis nuclear antigen, only 2 were positive during the 1 mo. Thereafter the incidence and titers increased progressively through the 1st yr after infection. This time-course resembled that for the development of antibody to Epstein-Barr nuclear antigen, another transformation antigen in Epstein-Barr virus-infected B lymphocytes. The development of positivity for both was much later than that of antibody to the structural viral capsid antigen, which in the current study was always positive by 1 wk. Thus, antibody to rheumatoid arthritis nuclear antigen is present in a large proportion of normal individuals and can now be clearly ascribed, from both in vivo and in vitro studies, to prior infection with Epstein-Barr virus. | |
| 488790 | Surgical correction of ulnar drift in the rheumatoid hand. | 1979 Jun | A new technique for the correction of ulnar drift is described which has been used by the author in selected cases during the past 5 years. Results of this technique during a 2 year period are compared with those treated by prosthetic joint replacement alone, or a combination of the two methods. | |
| 580742 | The growth kinetics of synovial fibroblastic cells from inflammatory and noninflammatory a | 1978 May | The growth kinetics of subcultured human synovial fibroblasts from 16 patients with inflammatory and noninflammatory arthropathies were studied in antibiotic free media. The experimental design allowed a clear distinction between the growth rates and final saturation densities achieved. The effects of refeeding and of the serum concentration were evaluated for each line. Inflammatory lines achieved significantly higher final saturation densities and growth rates than noninflammatory lines for most protocols, but the differences between rheumatoid and nonrheumatoid groups were less marked. Inflammaroty fibroblasts demonstrated a greater independence to nutritional and growth stimulatory factors in their microenvironment than noninflammatory fibroblasts. | |
| 393102 | Penicillamine in rheumatoid arthritis. | 1979 | Perhaps the most important conclusion is that much remains to be learnt about how to use penicillamine in clinical practice. The results described have been obtained by observing groups of patients on various fixed schedules of dosage. There may be a case for using a more flexible system but this makes comparisons difficult and at this stage predetermined fixed schedules have been preferred. A total daily dose of 1500 mg is clearly excessive and probably unnecessary. There is some suggestion that administration between meals produces better and perhaps more predictable absorption. If used in this way the total daily dose should be lower than the one found most suitable when the drug is given with food. Experience to date favours a daily total of 375 mg given between meals. The late onset of some adverse reactions in patients on low doses suggest that the total cumulative dose may be relevant and that some toxic reactions are liable to occur when a certain total intake has been reached. No mention has been made in this survey of comparisons with other drugs. The main task has been seen to be the exploration of various dosage schedules in the hope of finding an effective dose which does not produce a high incidence of adverse effect. Only when this information has been obtained will it once again become relevant to test the drug under control conditions either against an inactive placebo or some other anti-rheumatoid drug. | |
| 6234248 | Insurance and the disabled. | 1984 | The provision of life insurance for the disabled has been investigated to determine the extent to which the perceived disadvantage expressed by some disabled groups was real and, if real, justified. Life cover for a particular disability is likely to be offered only by the few companies with experience of it; however, the ratings charged appear usually to be a fair reflection of the limited and often poor information available. The response of organizations for the disabled to this problem has been reviewed, and possible strategies to enable the disabled to obtain insurance are suggested. | |
| 7061554 | Early results and complications of surface replacement of the hip. | 1982 Mar | We analyzed the early results and complications of surface replacement arthroplasties of the hip performed at The Hospital for Special Surgery. Fifty-six hips in fifty-one patients were operated on from August 1977 through April 1979. Fifty-five of these hips in fifty patients were available for study after an average follow-up of thirty-six months. Thirty-five hips had an excellent result and thirteen, a good result. Seven arthroplasties were failures, an alarming number in view of the relatively short follow-up. Three of the seven failures were in hips with rheumatoid arthritis, even though only 21 per cent of the hips that had surface replacement were rheumatoid. As a result of this high failure rate, our present attitude toward surface replacement is one of caution, especially in patients with inflammatory arthritis. | |
| 7112162 | The use of unorthodox therapies and marginal practitioners. | 1982 | This study examines the extent of utilization of unorthodox therapies and marginal practitioners among patients with one broad category of chronic disease, rheumatic disorders. Almost all respondents (94%) had tried some unorthodox remedy or practitioner, and several had used 13 different unorthodox remedies or practitioners. There was no relationship between age, sex, race, geographic location and magnitude of usage of treatments. There was no statistically significant relationship between education and income and amount of usage, although there was some variation by income group in which unorthodox remedies were employed. Thus, this study provides evidence that some elements of folk medicine practice continue to exist among most segments of the American population and this issue deserves further research. An important role for medical sociologists is to examine disease and disease treatment from the perspectives of the lay culture, as well as that of the medical community. | |
| 6681148 | IgG-rheumatoid factor in a population of elderly males: relationship to IgM-rheumatoid fac | 1983 Oct | The occurrence of IgG-rheumatoid factor (RF) reacting with rabbit IgG was studied in the sera of 1,105 elderly males from rural areas of Finland. Elevated levels of IgG-RF were found in 12 sera, 11 of which contained also IgM-RF, as measured by conventional agglutination tests and/or by enzyme-linked immunosorbent assay. Subjects with rheumatoid arthritis and those with "false" positive RF reactions did not differ from each other with respect to the occurrence of IgG-RF. | |
| 4026760 | Clinical profile of rheumatic fever in some hospitalised children of Bangladesh. | 1985 Jun | Clinical profile of rheumatic fever (RF) in 100 hospitalised children of Bangladesh were studied. Peak age period of the incidence of the disease was found in the age group of 11-12 years (34 percent) and majority (83.5 percent) of the cases belonged to the middle and poor classes. There was slight preponderance of the male. Carditis was the commonest (64 percent) manifestation followed by poly-arthritis (51 percent). Chorea was present in 6 percent and subcutaneous nodules were in 7 percent cases. Erythema marginatum (EM) was conspicuous by its absence. Amongst the rheumatic heart diseases (RHD), mitral stenosis (MS) and mitral incompetence (MI) comprised the highest (35 percent) incidence and next to it was the MS (13 percent) and MI (9 percent). | |
| 598180 | Wide-track polycentric total knee arthroplasty: one year follow-up study. | 1977 Oct | The use of a peritoneal catheter enhances diagnosis using arthroscopy by affording a clear visibility of the knee joint. The accuracy in diagnosis is significantly enhanced using this method of irrigation. No better method of irrigation is available for cases of acute knee joint injuries. | |
| 652988 | [Arthropathy of sacro-iliac joints in psoriasis (author's transl)]. | 1978 May | Roentgenographic studies of the sacroiliac joints were carried out in 117 psoriatic patients with associated symptoms of joint and/or bone involvement and in eleven psoriatic patients without signs of bone or joint disease. In all patients arthritis of the sacro-iliac joints with varying degree of severity was demonstrated. The sacro-iliac joint space remained open in patients without associated rheumatoid arthritis or ankylosing spondylarthritis. It was shown that the described method in the assessment of the sacro-iliac joints is fully justified. | |
| 7322394 | The Attenborough total knee arthroplasty. | 1981 Dec | A follow-up study was performed on 20 total knee arthroplasties of the Attenborough type in 15 patients. The follow-up term was from one to three years. In 16 cases the knee joint degeneration was caused by rheumatoid arthritis and in four cases by osteoarthrosis. Knee flexion improved from an average preoperative value of 17 degrees to 84 degrees, to an average of 3 degrees to 92 degrees. In one case (5%) a deep infection developed. In another case there was roentgenographic and clinical evidence of prosthetic loosening. Four patients were left with significant patellofemoral pain. With the exception of the infected knee, all patients showed significant improvement in their walking distance. Subjectively, 67% of the patients were satisfied or delighted, 26% felt improved and 7% were dissatisfied. These preliminary results with the Attenborough total knee prosthesis are comparable with the results of other authors; the indications seem limited to patients with restricted physical activity and severe deformity of the knee. |