Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7158085 | Clinical efficacy and adverse effects of tiopronin in rheumatoid arthritis. Report of a fo | 1982 Sep | A follow-up of 15.4 months has been carried out in 50 patients suffering from classical or definite rheumatoid arthritis, treated with tiopronin, a new slow acting sulphydrylant agent. The attention was focused mainly on the frequency of the major side effects needing withdrawal of the drug in 20% of the patients; in other 20% of the cases we have observed the disappearance of the major side effects after reduction of the tiopronin dosage. The most important major side effect was renal toxicity. Five cases of proteinuria and among these four cases of nephrotic syndrome were recorded. These side effects disappeared 2-5 weeks after withdrawal of the tiopronin. From a clinical point of view a positive response was observed in 56% and a complete lack of efficacy in 22% of patients. The clinical benefit and a panel of side effects very close to those of D-penicillamine were confirmed. | |
| 451491 | Skin collagen biosynthesis in patients with rheumatoid arthritis treated with D-penicillam | 1979 | Collagen biosynthesis was measured in skin biopsies taken from 13 patients with rheumatoid arthritis before and after at least 6 months' continuous treatment with D-penicillamine, 1.0 g/day. There was a significant 36% reduction in mean collagen biosynthesis (p less than 0.0125) as assayed by 14C-hydroxyproline formation from 14C-proline during 24 h of tissue culture. The changes in 14C-hydroxyproline formation were correlated with the total doses of D-penicillamine taken (r = 0.71, p less than 0.01) and the falls in ESR (r = 0.72, p less than 0.01). No significant change in general protein syntehsis was observed. 500 microgram/mlD-penicillamine added to skil cultures in vitro inhibited both collagen and general protein synthesis (p less than 0.01). It is suggested that the clinical improvement induced by D-penicillamine could reflect an inhibition of collagen proliferation in the synovium. | |
| 309705 | The prevalence of IgE antinuclear antibodies in rheumatoid arthritis and systemic lupus er | 1978 Oct | Antinuclear antibodies (ANA) of the IgE class were studied in sera from patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and healthy controls. Sixty per cent of 20 RA patients with neutropenia were found to have IgE granulocyte-specific (GS-)ANA, whereas only 16% of RA patients without neutropenia had IgE antibodies of similar specificity. About 5% in each group of RA patients had IgE organ-nonspecific (ON-)ANA. Eleven of 15 patients with active SLE and only 4 of 20 with inactive SLE had IgE ON-ANA. Sera from five patients with lupus nephritis all contained IgE ON-ANA. None of 100 sera from controls showed presence of IgE ANA. IgE ANA titres in RA and SLE patients correlated to the titres of ANA of the other four immunoglobulin classes. Gel filtration studies at neutral and acid pH of RA sera containing high titres of IgE GS-ANA indicated the presence of these antibodies in immune complexes. Studies of serum cryoprecipitates supported this conclusion. IgE ANA production may be of pathogenetic importance in RA and SLE by eliciting type-I reactions. | |
| 424968 | Agranulocytosis in an arthritic patient treated with levamisole. A case report. | 1979 Feb 3 | A case of agranulocytosis in a man with nonspecific seronegative polyarthritis treated with levamisole in the form of a proprietary veterinary anthelmintic is described. At the time of presentation he had a relative monocytosis. Recovery was uneventful and was heralded and paralleled by an increase in monocytes, serum vitamin B12 and total vitamin B12 binding capacity. Levamisole induced agranulocytosis and the significance of monocytosis and serum vitamin B12 binding proteins in neutropenia are briefly reviewed. | |
| 7042364 | Short-term study of indoprofen in comparison with placebo and indomethacin in rheumatoid a | 1981 | The results of a multicentre, double-blind trial are reported, where the effectiveness and safety of indoprofen (IP) were compared with indomethacin (IM) and placebo (PL), in patients with rheumatoid arthritis. After an initial "wash-out" period (3 days), each patient was given each of the three treatments for one week, in randomized sequence. The total dose of indoprofen (tablets) was 800 mg/die and that of indomethacin (capsules) 200 mg/die, in 4 daily doses after the main meals. The evaluation of effectiveness on a cumulative group of 102 cases from 18 centres showed statistically significant differences in favour of both active drugs compared to placebo, based on a series of objectives and subjective criteria. There was no significant difference between IP and IM, but on factorial analysis of correspondences, IP showed a greater difference from placebo. The patient's judgments also suggested that IP (800 mg/die) was slightly more effective than IM (100 mg/die). Adverse reactions were observed in 8.9% of the patients on IM treatment, 3.9% on IP and in 39% on PL. Laboratory variables showed no significant changes in the course of treatment. | |
| 6973185 | [Clinical and radiological study of the manubrio-sternal articulation. Comparison between | 1981 Jun | The manubrio-sternal joint was studied in 168 subjects divided up into two groups : one group of 80 control subjects and one group of 88 patients with chronic inflammatory rheumatism divided up into 3 sub-groups (rheumatoid arthritis 54 ; ankylosing spondylitis 25 ; peripheral psoriatic rheumatism 9). This was a clinical study (search for spontaneous and induced pain) and a radiological study (A.P. and lateral views) with classification in 5 groups : 0 normal appearance, 1 hazy appearance of the joint space, slight narrowing of the joint space, slight osteoporosis and/or subchondral bony condensation ; 2 irregularity of the margins of the joint space, increased osteoporosis and/or condensation, narrowing of the joint space ; 3 increase in the previous signs, erosion, vacuole formation ; 4 partial or total fusion. The results show that only spontaneous pain and the radiological appearances of class II and class III permit one to differentiate in a statistically significant way the control group from the rheumatism group. considering these data one may note a greater frequency of the clinical and radiological signs, together with greater clinical and radiological agreement in ankylosing spondylitis than in rheumatoid arthritis. The interest of a study of the manubrio-sternal joint in the early diagnosis of ankylosing spondylitis is recalled although the involvement of this joint is usually later than the sacro-iliac joint. | |
| 6310780 | [5-year treatment of rheumatoid polyarthritis with D-penicillamine]. | 1983 May 26 | A series of thirty patients with rheumatoid arthritis in whom D-penicillamine therapy was initiated more than five years ago was analyzed. Results were satisfactory in nine patients: two (6.6%) are still taking D-penicillamine and seven (23%) have experienced stabilization of their disease. In nine patients (28%) therapy was discontinued before the end of the third year because of adverse side-effects; no harmful side-effects were recorded after the third year. In ten patients (33%) D-penicillamine was discontinued because of ineffectiveness, either during the first year because of non-responsiveness (3 patients) or after the first two years because of escape phenomenon (7 patients). The authors compare their series to those previously reported in the medical literature. They believe that D-penicillamine should be given in progressive and moderate doses (averaging 600 mg per day). The mean duration of therapy with D-penicillamine was 27 months, lower than that recorded with chrysotherapy or anti-malarials; in 30% of patients, D-penicillamine was discontinued because of adverse side-effects. These findings show that, though D-penicillamine may be useful, it should be considered only after chrysotherapy. | |
| 3981527 | Richard Smith ankle arthroplasty. | 1985 Apr | The indications for ankle joint replacement and the advantages of a 'ball-and-socket' type of prosthesis are examined. The results of 24 Richard Smith ankle replacements of which 18 were followed for an average of 7 years are analysed and the case for abandoning this prosthesis is discussed. | |
| 7019782 | Sustained release indomethacin: a double blind comparison with indomethacin suppositories. | 1981 Apr 22 | A double-blind crossover comparison of sustained release indomethacin capsules and indomethacin suppositories showed no efficacy advantage to either preparation. In other respects the two preparations were found to be comparable. More patients preferred the convenience of the oral route of medication when given the choice after the study was concluded. | |
| 6692626 | Evaluation of outcomes in total joint arthroplasty for rheumatoid arthritis. | 1984 Jan | As the causes of most chronic diseases are multifactorial, so are their outcomes. The first two decades of joint arthroplasty witnessed rapid technologic advances and diffusion. Short-term outcomes measured by traditional clinical parameters show remarkable successes. Long-term results measured traditionally and including patient- and society-oriented outcomes, e.g., health status, cost, and satisfaction, need greater emphasis in the evaluation of surgical management of polyarticular disease. Long-term studies that use standardized outcome measurement are crucial in the future development of the technology and in the refinement of patient selection criteria to achieve optimal outcome. A larger view of the end-results can be measured reliably, but their interpretation and refinement need careful study. | |
| 385874 | The effect of gold salts on the phagocytic activity of synovial macrophages in organ cultu | 1979 | The effect of the gold salt, gold sodium thioglucose, has been studied on the phagocytic activity of tissue macrophages in synovium excised from patients with rheumatoid arthritis (RA) and maintained as explants in organ culture. Specimens of synovial membrane were taken for culture from synovial tissue excised from the knee joints of 22 patients with RA undergoing surgery and 14 menisectomy controls. Glass coverslips coated with yeast were placed on the synovium and the specimens maintained in organ culture. The phagocytic activity was assessed by counting the percentage of macrophages containing yeast on the coverslip removed after 24 hr in culture. The effect of gold salts was assessed by adding gold sodium thioglucose at concentrations of 3 and 30 microgram/ml to the medium, and using sodium thioglucose as an additional control. Results (means %) indicated significantly higher phagocytic activity in RA macrophages (68.6) compared with controls (40.1), p smaller than or equal to 0.001. Gold thioglucose significantly suppressed phagocytosis at 3 microgram/ml (48.0) p smaller than 0.01, and at 30 microgram/ml (47.7) p smaller than 0.02 in RA but had not effect on control synovium. Sodium thioglucose had no significant effect on phagocytosis at either concentration on RA synovium. | |
| 6234391 | HLA antigens and toxic reactions to sodium aurothiomalate in patients with rheumatoid arth | 1984 Jun | HLA typing studies were performed on 60 consecutive patients with seropositive definite or classical rheumatoid arthritis (RA). Patients were treated with gold and were followed for a minimum of 18 months for identification of adverse reactions to gold therapy. HLA-DR3 was increased significantly in patients who developed gold induced rash, proteinuria or thrombocytopenia. On the other hand, the incidence of HLA-DR4 was lower in patients with these adverse reactions. Our results demonstrate that patients with RA carrying DR3 are at a higher risk of developing adverse reactions to gold. The most interesting finding was the low incidence of DR4 in patients who developed adverse reactions to gold, suggesting that DR4 positive patients may have some degree of protection against gold toxicity. | |
| 857744 | Role of ineffective erythropoiesis in the anaemia of rheumatoid arthritis. | 1977 Apr | The importance of inadequate haemoglobin synthesis and ineffective erythropoiesis in the anaemia of rheumatoid arthritis was studied by measuring the incorporation of 15N glycine into haemoglobin haem and early labelled bilirubin in a patient with severe anaemia before and after response to gold therapy. Initially, total erythroid haem turnover was decreased but haem turnover due to ineffective erythropoiesis was markedly increased, accounting for 29% of total erythroid haem turnover. Gold therapy resulted in marked clinical improvement, accompanied by a rise in haemoglobin to normal. Total erythroid haem turnover increased and the percentage ineffective erythropoiesis fell to normal. Ineffective erythropoiesis may thus be an important reversible factor in the production of the anaemia of rheumatoid arthritis. | |
| 322292 | Joint surgery for rheumatoid arthritis. | 1977 Mar | The state of the art in the surgery of rheumatoid joint disease is discussed with emphasis on guidelines for choosing the patients and the types of procedures available. Strong-willed, strong-boned, strong-muscled, and well-informed patients are the best candidates. Synovectomy is particularly useful in the minimally erosive stages of the disease when the active synovitis is not suppressed by one or more steroid injections or other modalities of therapy. Arthrodeses and arthroplasties are midstage procedures that are now being supplanted by total joint replacement. This is especially true of the knee, but new prostheses for elbows, shoulders, wrists, and ankles are on the horizon. | |
| 7102284 | Marmor knee arthroplasty. Clinical results and complications during an observation period | 1982 Aug | During the period October 1975--June 1977, Marmor arthroplasties were performed on 70 knees, 52 of which had rheumatoid arthritis (RA) and 18 osteoarthritis (OA). These patients were followed up in a prospective study. Following arthroplasty, all knees in this material showed primary improvement with respect to pain, walking ability, stability, and extension deficit. The pain in the contralateral knees was studied postoperatively and within 1 year 9 out of 25 RA knees and 6 out of 10 OA knees showed a spontaneous improvement amounting to at least two steps on the pain scale. Four patients died in the course of the observation period and none of them suffered from knee pain. The late complications of the arthroplasties have been analysed separately. During the observation period, which now averages 45 months (36--55), five knees in the RA group and one in the OA group deteriorated to such an extent as to call for reoperation. Of the remaining 60 knee joints 57 have only initial pain or no pain at all, and the other three knees have pain only after physical efforts. | |
| 166646 | DNA polymerase activity of cultured rheumatoid synovial cells. | 1975 May | Cultured synovial cells from 8 patients with rheumatoid arthritis (RA) and 7 subjects without joint disease were assayed and comapred for RNA-directed and DNA-directed DNA polymerase activity. No activity was found in either RA or control specimens using a synthetic RNA template that specificically detects oncornavirus RNA-directed DNA polymerase. The DNA-directed DNA polymerase activity of RA specimens was increased (P less than 0.10) in the high-speed pellet fraction of cell lysates. The possible relationship of these finding to virus infection in RA is disscussed. | |
| 4006384 | Bone mineral loss, bone histomorphometry and vitamin D metabolism in patients with rheumat | 1985 Jun | Long-term glucocorticoid treatment might interfere with the vitamin D metabolism. The serum concentrations of 25-OHD were significantly reduced whereas the circulating levels of 1,25-(OH)2D were normal in 50 patients with rheumatoid arthritis on long-term treatment with small doses of prednisone. The bone mineral content of the forearm was significantly reduced, but the degree of bone loss did not correlate with duration of treatment or dose of prednisone given. Quantitative bone histomorphometry was performed in 18 patients. Apart from a significant correlation between serum 25-OHD and the fractional trabecular bone volume, no relationships were observed between bone histomorphometry and vitamin D metabolites or serum iPTH. The results indicate that the bone loss was due to a decreased osteoblastic activity rather than to an impaired vitamin D metabolism. | |
| 3867280 | Community Surveillance Study--perceived response of rheumatoid arthritis patients to NSAID | 1985 | The perceived effectiveness of nonsteroidal anti-inflammatory drugs was studied in a community population (n=380). The population characteristics of a sample were similar to previous studies. Most patients were on a single NSAID. Rheumatoid arthritis (RA) was found to have a significant impact in terms of disability and lifestyle. Active inflammation was the main incentive to comply with therapy. However, the patients perceptions about the efficacy of the medication, their attitude towards the medication and their motivations for taking it, also affected compliance. A decreased effectiveness of therapy may also be due in part to tolerance to some medications and some evidence of the induction of salicylate metabolism has been reported. Considerable variation in the patients' perception of other forms of therapy for RA were also observed. | |
| 956226 | Stiffness of the proximal interphalangeal joints in rheumatoid arthritis. The role of flex | 1976 Sep | In nineteen hands (seventy-four fingers) of eleven women and one man with rheumatoid arthritis there was restriction of active and passive motion of the proximal interphalangeal joints, with signs of flexor tenosynovitis but no clinical or roentgenographic evidence of involvement of the joint. The nineteen hands were treated by flexor tenosynovectomy (palm only in nine, palm and carpal tunnel in five, both palm and digits in four, and digit, palm, and wrist in one) combined with manipulation of the joint under regional anesthesia. After an average follow-up of twenty-one months (range, six to thirty-six months), the average range of active motion had increased from 40 to 84 degrees and the average range of passive motions, from 57 to 87 degrees. Only three patients had unsatisfactory results, one because of persistent unexplained swelling and two because of recurrence of the tenosynovitis. | |
| 6984570 | [Comprehensive review of the possibilities and limits of drug therapy of rheumatic disease | 1982 Dec 31 | Practically 10-20% of all patients registered with a General Practitioner complains of symptoms in some way associated with rheumatism. Incidences of this disorder are distributed in such a way as to form a pattern whereby 55% is troubled with extra-articulary rheumatism, 38% with arthrosis and spondylarthrosis and 7% with rheumatoid arthritis. It is of most importance that the General Practitioner identifies these patients during the early stages of their disorder, and that he commerces the necessary treatment immediately. With the exception of streptococcus-rheumatism and gout, the pathogenesis of rheumatics eludes us to this day. As far as individual measures are concerned therefore, it is merely a question of selecting some kind of treatment, ranging from the symptomatic to the semi-causal, which can be used alongside the recommended form of therapy. The author describes various kinds of treatment including NSTAR, Glucocorticoids, Antisuppressives and basic therapy such as Chloroquin, gold and D-Penicillamin. |