Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 109915 | Pulmonary infiltrates associated with gold therapy. Report of a case. | 1979 | A case report is presented concerning diffuse pulmonary infiltrates due to sodium aurothiomalate therapy in a 67-year-old woman suffering from rheumatoid arthritis. After the gold treatment was stopped, prednisolone therapy produced complete remission of the pulmonary reaction. | |
| 405283 | Antibodies to pancreatic duct cells in Sjögren's syndrome and rheumatoid arthritis. | 1977 Apr | In the present investigation the occurrence of humoral immunity to pancreatic duct cells (PDC) was studied in 12 patients with Sjögren's syndrome (SS), 31 patients with rheumatoid arthritis (RA), and 64 controls. Four sera of patients with SS and eight of patients with RA produced diffuse cytoplasmic fluorescence of intro- as well as of interlobular PDC of human and rhesus monkey origin. All sera positive with PDC antigens gave also positive staining reaction with parotid, submandibular, and lacrimal duct cells. In absorption studies antibody activity to PDC and salivary duct cells could be absorbed equally well with human or monkey parotid gland or pancreas with almost identical antigen concentrations. These findings point to the presence of common antigenic determinants in the organs studied. Human thyroid microsomes and rat liver homogenate did not reduce antibody activity. The demonstration of antibodies to PDC in addition to the reported mononuclear cell infiltration of the pancreas point to the involvement of autoimmune mechanisms in pathogenesis of the commonly observed subclinical exocrine insufficiency in SS and in some cases of RA. | |
| 3915889 | Rectal administration of tenoxicam for the treatment of rheumatoid arthritis and arthrosis | 1985 | Seventy-nine patients with arthrosis (40) or rheumatoid arthritis (39) were included in an open, non-comparative multicentric study. All the patients were treated by rectal route with a suppository form of tenoxicam (20 mg/day) during 6 weeks (in the first 3 days the dose was increased to 40 mg). The drug was administered once daily at evening. Clinical evaluation was performed before treatment and thereafter every 2 weeks. In the patients with arthrosis the parameters evaluated for efficacy were: pain on movement, pain at rest, tenderness, spontaneous pain, pain after 1 day of normal activity, flexion, functional status, and time to walk 10 metres. For patients with rheumatoid arthritis the parameters were: articular index, duration of morning stiffness, functional status, spontaneous pain and pain when moving. Efficacy was considered excellent or good in 22 patients with rheumatoid arthritis and moderate or poor in 17. In the group of patients with arthrosis the results were excellent or good in 28 and moderate or poor in 12. Side effects occurred in five cases. | |
| 2983389 | Rheumatoid arthritis of the shoulder. Description and standard radiographs. | 1985 Feb | The course of rheumatoid arthritis in the shoulder is evaluated in 143 patients. In a period of 29 years, 630 x-rays were taken of 286 shoulders. In this series 2 or more x-rays per shoulder were taken of 89 patients (29 male, 60 female). The various changes in the glenohumeral and acromioclavicular joints are described. Gross destruction appears to be rare, compared to the more frequently seen minor cystic changes. The progress of the disease is often slow or halting. One or both of the shoulders in some of the patients (15 male and 29 female) did not have any detectable x-ray changes, although some of them were followed up for more than 20 years. During our follow-up it became apparent that the acromioclavicular and glenohumeral joints do not follow the same course neither in time nor in severity of joint destruction. Therefore, we divided the shoulder joint into the acromioclavicular and glenohumeral joint. One normal stage and 5 stages of pathology are recognised to fit into previously published schemes of the other joints. Stage 5 appears to be a new phenomenon of neojoint formation, under the previous humeral head with the inferior glenoid rim. Joint disease in the acromioclavicular joint could be divided only into 3 stages. | |
| 3972299 | [Corium interpositionplasty of the elbow and wrist joint]. | 1985 Jan | The problems involved in the reconstruction of upper extremities, in particular their differentiated movement and the intentionality of the patient concerned are briefly discussed. Three cases presenting typical indications for the interposition of the dermis in the wrist and elbow joints are presented. On the basis of our observations, the indications for implantation of a prosthesis are rare. | |
| 6745994 | IgM-RF prevents complement-mediated inhibition of immune precipitation. | 1984 Jul | Rheumatoid arthritis (RA) serum inhibits complement-mediated inhibition of immune precipitation (solubilization). We have isolated inhibitory activity from RA sera and shown that it is a property of IgM-rheumatoid factor (IgM-RF) and, to a lesser extent, IgG-RF. | |
| 7276495 | Healing of peptic ulcers during continuing anti-inflammatory drug therapy in rheumatoid ar | 1981 Mar | To evaluate the effect of anti-inflammatory drug therapy on ulcer healing, we studied retrospectively patient records listing the dual diagnoses of rheumatoid arthritis and peptic ulcer (1953-1975). Forty-three ulcers (23 gastric and 20 duodenal) occurred in 41 subjects. Evaluation of ulcer healing was possible in 35 patients, 27 of whom had continued on anti-inflammatory drug therapy while being treated for ulcer disease and eight who did not. In 21 of the 27 patients the ulcer healed; in six the ulcer failed to heal, including one who died from gastric carcinoma. Fourteen of the 21 patients whose ulcer healed were taking both aspirin and corticosteroids; in all eight patients who stopped taking anti-inflammatory drugs, the ulcers (eight gastric, one duodenal) healed. In six patients no evaluating was possible because the outcome of ulcer therapy was unknown. The numbers of patients not studied, unlisted or unretrieved are unknown, though probably small, and while no data are available on controls drawn from the same population or on the rates of spontaneous ulcer healing and recurrence in this population, our study nevertheless establishes that ulcer healing does occur in many patients with rheumatoid arthritis despite continued treatment with salicylate, corticosteroid, or other anti-inflammatory drugs. | |
| 6426843 | Review of auranofin, an oral chrysotherapeutic agent. | 1984 Mar | The chemistry, pharmacology, pharmacokinetics, clinical use and efficacy, adverse effects, and dosage of auranofin, an oral chrysotherapeutic agent used in treatment of rheumatoid arthritis, are reviewed. Auranofin is lipid-soluble and is monomeric in solution. It has a modulatory effect on both the humoral and cellular immune systems. Auranofin may be a condition-dependent immunoregulating agent rather than an immunosuppressive agent. It inhibits (1) monocyte-mediated antibody-dependent cellular toxicity, (2) release of enzymes from polymorphonuclear leukocytes that may contribute to the pathogenesis of rheumatoid arthritis, and (3) neutrophil activity. In patients with rheumatoid arthritis, 15-33% of an oral dose of auranofin 6 mg is absorbed. Peak plasma gold concentrations are achieved in one to two hours. Gold is highly protein bound. Elimination occurs through the feces and urine; 73-100% of auranofin gold is excreted. Plasma half-life is three weeks. Patients receiving auranofin 3 mg twice daily for rheumatoid arthritis reported improvement after five weeks of therapy; improvement has also been reported with lower doses. Diarrhea, rashes, and pruritus were the most common adverse effects. Auranofin is safe and effective for short- and long-term treatment of patients with rheumatoid arthritis. Its relative safety and potency compared with injectable gold salts and other drugs need further study. | |
| 155427 | The arthritic in an urban environment. | 1979 Feb | Ninety-five patients with rheumatoid arthritis or osteoarthrosis were interviewed and questioned in their homes, being randomly selected from 354 outpatients with these diseases. The findings were compared with answers from 30 matched able-bodied controls. The handicapped were mainly female and elderly; over half were severely or appreciably handicapped; nearly one-third lived alone. The average weekly income of these households was pound25, at least pound6 a week less than their age-matched counterparts. Very few subjects lived in adapted or specially designed housing, and half the housing had at least 2 steps to street level. A third of the sample could not walk more than 10 yards (9 m), and only half could walk 100 yards (90 m); yet only one-third had a bus stop, one-quarter a local park, and one-third a local shop within this distance. One-third of the patients could not shop for themselves. Powered wheelchairs were not used. Buses were rarely or never used by nearly half these arthritics because of severe disability. Cars were owned by less than a quarter of the sample, and only by those financially better off. Over a third were unable to get a lift when wanted. Cars ameliorated much of the frustration and lack of social contact caused by physical disability. Adequate financing would enable those with severe disability to engage in normal activities. Better designed buses stopping nearer the homes of handicapped would improve independence for those less severely disabled. Correct siting of mobility housing, shops, community facilities, and parks would be greatly appreciated, as would removal of all unnecessary steps and kerbs. | |
| 7154620 | [Clinical significance of circulating immune complexes in patients with metastatic breast | 1982 Dec 1 | In 68 patients with metastatic breast cancer a follow-up study was performed to correlate circulating immune complexes (CIC) as detected by the C1q binding assay and the Raji cell radio immunoassay with the state of disease. Clinical examinations and determinations of CIC were carried out all four to eight weeks over at least six months. 19 patients were positive for CIC in the C1q binding assay and 12 in the Raji cell radioimmunoassay. There was no correlation between the results of both tests. In comparison 26 patients out of 68 with rheumatoid arthritis were positive in the C1q binding assay and 32 in the Raji cell assay. In these patients the results of both tests correlated significantly. There was only in a few cases of metastatic breast cancer a positive correlation between levels of CIC and changes of tumor burden. Furthermore, CIC did not prove to be of prognostic value. | |
| 132936 | Mixed leukocyte reaction in rheumatoid arthritis. | 1976 May | The mixed leukocyte reaction (MLR) responses of 29 patients with classic rheumatoid arthritis (RA) were compared with those of 24 age- and sex-matched healthy controls. Pools of stimulating cells were selected to include the major cross-reacting HL-A specificities. In pooled human serum the MLR response of the RA lymphocytes was significantly enhanced relative to the response controls (P less than 0.05). In autologous serum there was suppression of the MLR response in patients with RA which correlated with disease activity. The data suggest the presence of an intrinsically enhanced cellular reactivity of RA lymphocytes suppressed by serologic factor(s). The mechanisms of this enhancement of suppression are discussed. | |
| 984904 | Detection of IgG rheumatoid factor by concanavalin A treatment and complement fixation wit | 1976 Jun | Concanavalin A (Con A) froms precipitates with carbohydrate-rich protein such as IgM, IgD, IgE, and IgA. Since IgG contains little carbohydrate and does not react with Con A, the activity of IgG-rheumatoid factor (RF) can be measured in the supernate of the Con A-treated serum. When the latex fixation test (LFT) and the sensitized sheep cell agglutination test (SSCA) were perfromed in the supernate for the detection of IgG-RF, LFT was positive in 32-1% of sera, out of 137 sera originally positive for LFT, and SSCA was positive in 18-5% of sera, out of 119 sera originally positive for SSCA. IgG-RF exhibited lower complement fixing ability than IgM-RF and correlated with agglutination titres of IgG-RF, while the CH50 of the original serum did not correlate with haemolytic activities of either IgM-RF or IgG-RF. | |
| 737014 | Involvement of prostaglandins from rheumatoid synovium in inhibition of articular cartilag | 1978 Nov | Short term incubations of articular cartilage in media from cultures of rheumatoid synovial tissue result in marked inhibition of 3H-glycine and Na235SO4 incorporation into trichloroacetic acid (TCA) insoluble macromolecules by the cartilage segments with little effect on degradation of prelabeled cartilage matrix. This inhibition is time dependent and not observed in cartilage segments incubated in media derived from rheumatoid synovia cultured in the presence of indomethacin (a specific inhibitor of prostaglandin synthesis). In addition, no indomethacin-sensitive cartilage inhibitory activity was detectable in media from cultures of normal synovia. The ether solubility of the majority of the inhibitory activity and the indomethacin sensitivity suggest that the inhibitor(s) are prostaglandins. | |
| 3851720 | HLA associations in fibrotic disease. | 1985 | HLA antigens have been associated with a wide variety of human diseases. In general these associations are not absolute in the way that classical genetic disorders are. Thus although the association between ankylosing spondylitis and HLA-B27 has been known for 11 years we are not able to define a closer genetic marker for the disease or indeed to define the mechanism by which B27 is involved with the disease process. This paper indicates the major disease associations with HLA antigens and compares them with those found in fibrotic disease. Some attempt is made to localize the position in the disease process where HLA might play a role. The aim of studies of HLA associations often includes the identification of at-risk groups in the hope of being able to apply selective preventive measures. Some progress along this path has been made and is outlined. | |
| 105739 | Long-term chrysotherapy in rheumatoid arthritis. | 1979 Feb | The efficacy of chrysotherapy appears to increase with prolonged administration. In patients who were followed for 3 years after gold therapy was started, remissions occurred in 73% of those who continued chrysotherapy. Only 6% of those who stopped gold injections during the first 18 months subsequently developed "spontaneous" remissions, although initially both groups had comparable moderately severe rheumatoid arthritis of 6 to 8 years' duration. Therefore, in the absence of definite toxicity, maintenance gold injections should be continued indefinitely. | |
| 785848 | Subpopulations of blood lymphocytes in patients with rheumatoid arthritis. | 1976 Aug | The peripheral blood lymphocyte subpopulations of 18 patients with rheumatoid arthritis were compared with those of 10 healthy donors using minor modifications of the mixed immunofluorescence and rosette test (1), rosette test using human 0 RhD erythrocytes coated with anti-RhD antibodies (2)and the miced rosette test (3). It was found that the percentages of lymphocytes exhibiting both immunoglobulin receptors and receptors for sheep erythrocytes, and lymphocytes with receptors for Fc part of IgG in the rheumatoid patients were increased. A hypothesis for the origin of these subpopulations is discussed. | |
| 6356911 | Overview of efficacy of fenbufen in rheumatoid arthritis and osteoarthritis. | 1983 Oct 31 | Fenbufen (Cinopal) has been evaluated extensively in 155 clinical trials, including 102 in rheumatoid arthritis and 53 in osteoarthritis. Forty-nine of these trials involving 12 protocols have been identified as pivotal. All 12 protocols (six rheumatoid arthritis and six osteoarthritis) were double-blind and controlled, with the duration of treatment ranging from four weeks to one year, and included sufficient patient populations to detect important differences in efficacy between fenbufen and the reference agents. Evaluation of the efficacy results was based on the standard parameters commonly measured for rheumatoid arthritis and osteoarthritis. The primary evaluation point was the end of four weeks of therapy. Results of the 49 studies employing the 12 pivotal protocols, demonstrated that fenbufen, given in divided daily doses of 600 to 1,000 mg, provided significant anti-inflammatory effects. These effects were superior to placebo and comparable to those attained with full therapeutic doses of aspirin, indomethacin, phenylbutazone, and ozyphenbutazone. Long-term trials provided important information as to the relative effectiveness and tolerance of fenbufen in the management of patients with rheumatoid arthritis and osteoarthritis. The proportion of fenbufen-treated patients able to continue long-term therapy was substantially greater than the proportion of aspirin-, indomethacin-, or placebo-treated patients. Results from these trials indicate that fenbufen provides a more favorable ratio of benefit to risk than either aspirin or indomethacin. | |
| 1161815 | Physical therapy management of patients undergoing total hip replacement. | 1975 Sep | Physical therapy management of patients who undergo total prosthetic replacement of the hip at St. Margaret Memorial Hospital is an integral aspect of a multidiscipline process of rehabilitation. Patients requiring total hip replacement have a variety of medical problems and, subsequently, have postoperative conditions which influence the physical therapy plan of care. The scope and pace of our physical therapy program are governed by criteria which emphasize the medical status, individual capability, and motivation of each patient. Arbitrary postoperative time intervals are not considered in the design of our physical therapy program. In addition, physical therapists have responsibility beyond the delivery of quality service which includes collaboration with other members of the rehabilitation team in the development and evaluation of the total surgical program. | |
| 806269 | Antiglobulins in Nigerians with rheumatoid disease. | 1975 Apr | The levels of IgG and IgM antiglobulins in the sera of Nigerian patients with seropositive rheumatoid arthritis, seronegative arthritis, and Reiter's syndrome have been studied using an immunosorbent of glutaraldehyde insolubilized human IgG. No conclusion could be reached in the case of IgM antiglobulins because of the relatively high threshold of detectability in the quantitation procedure, but all groups of patients had significantly higher levels of IgG antiglobulins than did a group of healthy Nigerians. | |
| 1185729 | Variations in collagen, non-collagenous proteins, and hexosamine in menisci derived from o | 1975 Mar | Knee joint menisci from osteoarthritic and rheumatoid knees were analyzed for nitrogen, collagen, non-collagenous proteins (NCP) and hexamine content. Degenerate areas were analyzed separately. The degenerative areas were significantly lower (P less than 0.005) in collagen but NCP and hexosamines were elevated relative to control tissue. The rheumatoid menisci revealed a reduced level of collagen and hexosamine in areas of localized degeneration. However, the collagen and hexosamine content of the remaining tissue was also diminished (P less than 0.025) relative to normal tissue of the same. age. |