Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 734376 | Kinetics of 99MTc-pertechnetate uptake in healthy and arthritic knees. | 1978 | 99mPertechnetate (99TcO-4) was injected intravenously in 7 healthy subjects and 30 patients with rheumatoid arthritis (RA). The uptake of isotope (99Tc) in both knee joint regions was traced continuously for 30 min from the time of injection. The isotope showed more rapid accumulation with increasing arthritic involvement of the knee, and the rate of uptake of 99TcO-4 in the knee region tallied with the clinical findings before and after treatment (14 RA patients). The findings indicate that the rate of 99TcO-4 uptake could serve as a useful complement to the more commonly used quantitative uptake of isotope. The two measures may possibly reflect different features of synovial inflammation. | |
| 7426366 | Upper lobe fibrosis and cavitation in rheumatoid disease. | 1980 Jul | Four patients are described with rheumatoid disease with upper lobe fibrosis and cavitation which could not be explained by cavitation of rheumatoid nodules or any other recognized pulmonary manifestation of this disease. | |
| 7230163 | Sarcoidosis presenting as cutaneous ulceration, subcutaneous nodules and chronic arthritis | 1981 Mar | Subcutaneous nodules and cutaneous ulceration are rare accompaniments of chronic sarcoid arthritis. We report a patient with sarcoidosis who presented with the uncommon combination of chronic arthropathy, subcutaneous nodules and cutaneous ulceration who was initially diagnosed as rheumatoid arthritis (RA). Sarcoidosis should be included in the differential diagnosis of articular disorders that may mimic RA. | |
| 7155883 | [Anemia in rheumatoid polyarthritis. Value of serum ferritin for the estimation of iron st | 1982 Dec 18 | Biochemical evaluation of iron depletion due to bleeding is difficult in rheumatoid arthritis (RA) patients with inflammatory anaemia. The authors have tried to assess the usefulness of serum ferritin (SF) level measurements--considered a reliable index of iron stores--by comparing the values obtained with true iron stores, as determined by Perls' test on bone marrow. The study involved 50 RA patients with anaemia and raised erythrocyte sedimentation rate (ESR). The poor correlation (r = 0.51) observed between the two tests in this population was mainly due to differences in ESR. SF levels and Perls' test results correlated better in patients with an ESR above 50 mm/h. (r = 0.69) than in patients with an ESR above 50 mm/h. (r = 0.44). The mean ESR values were higher than those found in patients without inflammatory syndrome. SF levels, therefore, are unreliable in patients with inflammatory syndrome, and no practical conclusion concerning iron stores can be drawn from the finding of a normal SF level. In the present study, only SF levels higher than 250 ng/ml were associated with positive Perls' tests. The behaviour of ferritin in the presence of inflammation may explain the results obtained. | |
| 6730586 | [Diagnostic and prognostic significance of so-called rheumatoid vasculitis]. | 1984 Apr 1 | 23 patients with rheumatoid arthritis and high rheumatic factors (mean titres of rheumatic factors 1 : 1 434) within a prospective study on the diagnostic and prognostic significance of the rheumatoid vasculitis which was performed together with the Research Institute for Rheumatism Moscow underwent examinations for the proof of an extraarticular organ manifestation. In correspondence with the data in literature we found rheumatic nodes (70%) as most frequent extraarticular organ manifestation. In 1 patient each a participation of the lungs and a rheumatic exudate of the pleura, respectively, could be diagnosed. In another patient there were references to a vasculitis at the fundus of the eye. In only 2 patients there was a vasculitis of the digital arteries with necroses, in one of them a generalized vasculitis. 5 of the 13 neurologically examined patients showed polyneuropathic symptoms. Of the biochemical findings the C-reactive protein and the blood sedimentation rate showed clear increases and correlations. | |
| 128019 | Adjuvant arthritis in Lewis and AVN inbred strain of rats. | 1975 | The authors analysed the manifestations of adjuvant arthritis in inbred Lewis and AVN rats and in subsequent generations (F1, F2, B1, B2), using a subjective (scoring system) and an objective criterion (paw volume). The results obtained were in good correlation. Marked variability of the systemic symptoms of the disease was found not only in the parent generation but also in the subsequent generations. | |
| 4087267 | An assessment of the diagnostic value of quantitative measurements of IgA rheumatoid facto | 1985 Oct | IgA rheumatoid factor (RF) was found in a significant number of the normal population. As a consequence, the presence of IgA RF was not more specific for a diagnosis of rheumatoid arthritis than IgM RF. However, further investigation of IgA RF as a prognostic indicator is important. Our results, which show an association between the presence of IgA RF and higher levels of IgM RF, suggest that careful differentiation between the predictive values of the presence of IgA RF and a high level of IgM RF will be necessary. | |
| 225806 | [Chronic constrictive pericarditis complicating an apparently stable rheumatoid arthritis. | 1979 May 8 | The authors report a case of constrictive pericarditis complicating an apparently stable sero-negative rhumatoïd arthritis, a rarely described pathological association. The patient had a serious polyserositis due to an extremely marked and inflammatory pericardial constriction. The rhumatoïd origin was confirmed by pericardial effusion, histological and immunofluorescent studies. The inflammatory pericardial process rendered pericardiectomy virtually impossible and resulted in a fatal outcome. | |
| 7079658 | The demonstration of lymphatic channels on wrist arthrography in rheumatoid disease with p | 1982 May | Delineation of lymphatic vessels is a frequent finding in arthrograms of rheumatoid joints. Arthrography of the rheumatoid wrist when associated with oedema of the upper limb reveals a characteristic pattern consistent with lymphatic obstruction. In our opinion, these findings may be regarded as further evidence in favour of lymphatic obstruction as the cause of peripheral oedema in rheumatoid arthritis. The syndrome appears to be a separate entity from idiopathic oedema of women. | |
| 681405 | Manchester knee arthroplasty. | 1978 Aug | The results of fifty-one Manchester knee arthroplasties in forty-one patients are reviewed and discussed. Excellent and good results were obtained in 85.4 per cent of arthroplasties. Varus and valgus deformity can be corrected and stability preserved or restored. Complications occurred in only twelve patients but resolved in all except one. | |
| 1261892 | Flexor synovectomy in the rheumatoid hand. | 1976 Feb | A review of the types, signs and symptoms of synovitis of the flexor surface of the hand. Indications, contra-indications and the results of surgery are discussed. | |
| 7361061 | [Endoprostheses in surgery of the rheumatoid foot]. | 1980 Feb | On the basis of a series of 100 cases of rheumatoid foot, the author details the present surgical indications. As concerns the big toe, he feels that the installation of a Swanson type implant does not bring a marked improvement compared to the simple arthroplastic resection of the Keller type, since it does not seem that the mobility is improved in the long run. As for the lesions af the external toes, the synovectomy stage is almost always bypassed and he suggests the use of Lelievre realignment. He concludes by insisting on the aims of this surgery, which should basically be an improvement of walking, greater comfort in wearing shoes, and a decrease in pain. | |
| 7100806 | [Rheumatoid polyarthritis and extensive necrotizing vasculitis. Apropos of 2 cases]. | 1982 Apr | The author reports two cases of severe rheumatoid arthritis (RA) where the manifestations of necrosis vasculitis consisted of extensive and bullous gangrene of the lower limbs. In one case, the laboratory picture was that of major complement consumption (CH50 unmeasureable, marked fall in various compounds including C3 and C4) with very high levels of circulating immune complexes. An attempt at treatment by plasmapheresis, immunodepressants and corticosteroids led to moderate stabilisation of the vasculitis (regression of purpura) but remained incapable of resolving the local problem of gangrene. The severity of the lesion led to amputation of both legs. In the other case, there as a fall in CH50 with the presence of circulating immune complexes. Similar treatment led to stabilization of the lesions but final amputation could not be avoided to deal with the residue. Interruption of treatment was followed by an inflammatory exacerbation which was satisfactorily dealt with by further sessions of plasmapheresis. The authors discuss the value of such immunodepressant therapy in severe RA in the light of these cases. | |
| 6099193 | The pronated index finger deformity in the rheumatoid hand. | 1984 Fall | Rotatory deformities of the digits have received little attention in either the anatomical or surgical literature. In developing the flexible hinge silicone arthroplasty method for the metacarpophalangeal joint, we found rotation deformity was a problem that interfered with obtaining an ideal functional result. The study reported here was the result of our interest in improving this arthroplasty method for the rheumatoid patient. | |
| 947172 | Increased incidence of adjuvant arthritis in Wistar rats. | 1976 | The moderate incidence of arthritis in Wistar rats after inoculation of a suspension of Mycobacterium butyricum in oil increased to nearly 100% by two modifications. Inoculation with 4 week- as compared to 1 week-cultured. M. butyricum raised the incidence from 34 to 63%. Inoculation of this more arthritogenic material into the F1-descendants of M. butyricum sensitive parents raised the incidence of 96%. Also the severity of the arthritis in rats selected in that manner was higher than in non-selected rats. Treatment of arthritic rats of either source with phenylbutazone resulted in a comparable dose-related reduction of the diameters of the hind-limbs. Mating of rats with various degrees of arthritic response showed that sensitivity transmission to the F1-descendants was optimal with the most sensitive parents. Although the exact nature of the transmission has not been defined, the uniform and higher sensitivity of thus selected rats is of great value for quantitative pharmacological studies. | |
| 899898 | Functional Queckensted's test in rheumatoid atlanto-axial luxation. | 1977 | Queckenstedt's test was carried out in 15 patients with marked rheumatoid atlanto-axial luxation. The test was done when moving the neck stepwise between flexion and extension, and with the patient in both lateral and sitting positions. The test performed in the sitting position was termed the functional Queckenstedt's test. The flexed position of the neck and the sitting body position, either alone or in combination, were factors contributing to a manometric block. Six more block phenomena were recorded in the sitting compared with the lateral position. As the sensitivity of the test seemed unaffected by body position, this indicated an increased atlanto-axial luxation in the sitting position. This applied to the neutral as well as the flexed position of the neck. There was a fairly good correlation between neurological symptoms and signs and the functional Queckenstedt's test. The use of the test as an aid supplmentary to the clinical and roentgenological findings when deciding on the treatment of patients with rheumatoid atlanto-axial luxation is outlined. | |
| 7419543 | "Hook" erosions in Jaccoud's arthropathy. | 1980 Sep | Jaccoud's aethropathy is a non-erosive deforming arthritis seen in rheumatic fever, systemic lupus crythematosis and ankylosing spondylitis. "Hook" erosions may occur on the radial palmar aspect of the metacarpal heads and can be differentiated from the marginal erosions of rheumatoid arthritis. | |
| 6926967 | [Atypical course of rheumatoid coxarthritis. Clinical and radiographic description of a ca | 1982 Jun | Authors present an unusual case of rheumatoid hip arthritis. Clinical findings, great bone destructions and particular femoral head dislocation are principal characteristics of this case classified as osteolytic rheumatoid hip arthritis. | |
| 941807 | Objective methods to assess the anti-inflammatory activity of antirheumatic compounds. | 1976 Feb | A review is to be made of the methods currently being used in the assessment of anti-inflammatory compounds in man. Many of the current methods suffer from the disadvantage of being subjective or depend on various outside factors. We will review methods such as arthroscopy, histopathology, electron microscopy, joint scintigraphy and enzyme determinations in synovial fluid. Arthroscopy will be described in detail and its application to the course of the disease and the effect of anti-inflammatory drugs. Joint scintigraphy using radioactive technetium and indium will be described, which we find easy and reproducible. Current work using such parameters as skin temperature and enzyme content of synovial fluid will be described. | |
| 7141368 | [Radio-synoviorthesis with yttrium 90 of the knee joint in polyarthritis]. | 1982 Sep 23 | The radio-synoviorthesis with yttrium 90 in the knee-joint in rheumatoid arthritis was performed and controlled in 106 knees of patients with rheumatoid arthritis over a span of time between 6 and 49 months. The results are similar to those of other authors. As compared to synovectomy radio-synoviorthesis seems less successful as far as long-term results are concerned. As local treatment radio-synoviorthesis seems a good supplementory element in the therapeutic plan of rheumatoid arthritis. The indication to alternative procedures has to be considered carefully for each individual case and joint. |