Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6787855 | Problems in the clinical evaluation of antirheumatic drugs. | 1980 | 1. Subjective. Two of the major deficiencies of drug trials in rheumatoid arthritis are inadequate patient numbers and too brief a duration of study. For the past 5 years we have conducted a continuous programme of patient and drug assessment. Cohorts of patients with classical rheumatoid arthritis are encouraged to select the first-line drug of their own choice. (Within safe limits they are encouraged to vary the dose to suit their own symptoms.) The end point is the day on which the patient feels the drug is either ineffective or produces intolerable side effects. Each cohort comprises 100 patients and the results obtained with a variety of NSAID will be discussed in the context of the placebo response. 2. Objective. We have shown that 99mTc uptake is elevated over inflamed when compared with normal joints an that it may be reduced by first- and second-line treatment of patients with rheumatoid arthritis in proportion to the changes observed with other subjective and objective assessment methods. Results in the 125I-fibrinogen and with radioactive gallium compared with radioactive 99mTc will be presented. | |
| 309126 | Painful joints. Clues to early diagnosis. | 1978 Sep | Many cases of joint pain may be diagnosed from clinical findings alone. A careful history and physical examination are essential. Of all diagnostic laboratory tests for joint disease, none is completely specific. Results of latex fixation tests, antinuclear antibody (ANA) tests, and uric acid tests are all strongly suggestive when positive but do not rule out disease when negative. The most valuable laboratory procedure is examination of the synovial fluid. X-ray examination seldom is helpful in differentiation of early joint disease but may be very helpful in later stages. | |
| 1173777 | [Naproxen, a 'specific" antirheumatic drug?]. | 1975 Feb | Inhibition of endonuclease by d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen) is discussed as a possible therapeutic principle of the antiinflammatory action in polyarthritis. Infections by 'slow viruses" and mycoplasma have to be considered as possible etiologic factors for rheumatoid arthritis. The incorporation of the viral or mycoplasmatic DNA into the genetic material of the host cell depends on the function of endonucleases, which can be inhibited by naproxen. The advantages and the drawbacks of this type of mechanism of action are discussed. | |
| 60013 | [The effect of D-penicillamine on experimental allergic arthritis in rabbits]. | 1976 May | The effect of D-penicillamine on experimental allergic arthritis in rabbits (16 with arthritis and 15 controls) was investigated. After 40 days of treatment with D-penicillamine (intravenous) the arthritis had receded to a large extent. At the same time a maturation inhibition of the hematopoietic marrow had occurred in all the treated arthritic and control animals. The results suggest that D-penicillamine affects fast proliferating cells, to which the precursors of immunologically active cells in the synovial membrane also belong. | |
| 1174636 | Study of the mode of cyclophosphamide action on the rabbit arthritis according to Glynn's | 1975 Feb 10 | A knee joint arthritis is induced in rabbits previously immunized by an intradermal injection of emulsified egg albumin (E.A.) a complete adjuvant, then by an intra-articular injection of E.A. alone. Histologically, the synovium shows at first an Arthus phenomenon and later an immune cellular reaction. Several immunological parameters are studied in these rabbits. Cyclophosphamide (CY), injected intravenously, in a high dose, during a short period from the day of the first immunization, inhibits in the same time the arthritis index, E.A. skin test, humoral and synovial anti-E.A. antibodies and lymphocyte response to P.H.A. Cy, injected I.V., in a low dose, for a long period from the day of the intra-articular immunization, decreases only the arthritis index, but does not modify the various immune reactions to E.A. These results suggest that, according to the timing and the dose, CY inhibits synovial inflammation either by a strict anti-inflammatory action, or by an immunosuppressive effect on the initial phase of the immune reaction inducing subsequently a synovial inflammation. | |
| 7337573 | Medical care and the arthritis sufferer: a survey in outer Melbourne. | 1981 Nov | Chronic rheumatic diseases affect more than 750,000 Australians, who consume medical services at least in proportion to their numbers. A survey in Ringwood, Victoria found consistent accounts by sufferers of unmet expectations and shortcomings in medical care. | |
| 7131458 | Serum sulphydryl levels in early synovitis. | 1982 Jul | The determination of serum sulphydryl levels has been assessed as a diagnostic/prognostic indicator of rheumatoid arthritis in patients attending an early synovitis clinic. This simple assay has been compared with other test systems including C-reactive protein, plasma viscosity, IgM rheumatoid factor and immune complexes. Results show that a low serum sulphydryl at presentation is a useful prognostic indicator for development of persistent synovitis. Patients with normal sulphydryl levels suffered only mild or transient symptoms. These results suggest that, since stimulated phagocytes generate the oxygen-derived species responsible for sulphydryl oxidation, such cells are active before the patient develops persistent symptoms. | |
| 343725 | Radioisotope scanning using a gamma camera. | 1978 Feb | Sixteen outpatients with rheumatoid arthritis took part in a placebo controlled double-blind crossover study. In addition to conventional measurements, a radioactive index was measured using a gamma camera that indicated a radioactive count over the measured joints and a comparable area of normal adjacent bone. This index showed poor correlation with other conventional measurements of change in the clinical trial. | |
| 31004 | The management of inflammation in rheumatic diseases. | 1978 Aug 19 | Drugs used to control inflammation in the rheumatic diseases are extremely diverse. Despite this, the pattern of clinical response and similarities in side-effects allow them to be subdivided into groups. These patterns also provide clues about the mode of action of the drugs. Conversely, studies of the mechanisms of action of drugs used to treat rheumatoid arthritis are beginning to throw light on the pathological process. | |
| 6857123 | [Plasma exchange and rheumatoid polyarthritis with vasculitis. Apropos of 6 case reports]. | 1983 Feb | The authors present six cases of rheumatoid arthritis (RA) complicated by vasculitis of varying clinical presentation: 2 cases of polyneuritis, 5 cases of skin lesions (dry gangrene, ulcers, purpura). The severity of the clinical picture required, in addition to the usual treatment (corticosteroids, immunosuppressants), plasma exchanges. A clinical stabilisation was obtained in every case with good tolerance. The development of a vasculitis would appear to be the prime indication for the use of plasma exchange in rheumatoid arthritis. | |
| 7302464 | Report on a double-blind trial comparing small and large doses of gold in the treatment of | 1981 Nov | A double-blind trial was carried out for one year on 60 patients suffering from rheumatoid disease. A dosage of 10 mg of sodium aurothiomalate weekly was compared to 50 my weekly. The method and regime of the trial are described. Analysis of the results showed no statistical difference in response between the two groups. There was no appreciable difference in the toxic effects between the two groups and those reported were not serious. | |
| 7295485 | Long-term cyclophosphamide treatment in rheumatoid patients: effects on serum sulphydryl l | 1981 Oct | 1 After 12 months cyclophosphamide administration the serum sulphydryl concentrations increased in all of twelve rheumatoid patients treated, and returned towards the normal range in eleven. 2 A decrease was observed in the technetium index, the erythrocyte sedimentation rate, and joint count. 3 Long-term cyclophosphamide-induced serum SH increase may represent a specific change in the process of the rheumatoid disease activity, possibly involving the pathogenic B cells. | |
| 7223083 | [Atlanto-dentoid dislocation in chronic polyarthritis. Correlation of clinical, roentgenol | 1981 Jan | The involvement of the cervical spine in rheumatoid arthritis especially after prolonged steroid medication, is one of the most dangerous symptoms of this disease. 62 patients suffering from rheumatoid arthritis of the cervical spine underwent a critical examination regarding clinical signs and neurological symptoms. According to Larsen Theses of the radiological grading of the severity of rheumatoid arthritis, we tried to develop a classification of the involvement of the upper and the low cervical spine. Clinical and neurological signs are then found especially in stadium III and IV. The bony ankylosis (stadium V) must be considered as a spontaneous healing, for all clinical and neurological signs will have vanished. Electromyographical observations showed characteristic patterns for each stadium. According to this classification the conservative and the operative treatment can be chosen. | |
| 6582274 | Study constraints in African and other epidemiological surveys. | 1983 Nov | Studies on rheumatoid arthritis (RA) in developing countries have suffered from numerous constraints in the application of historical, clinical, radiological, and serological criteria for disease. The Manchester grading for clinical RA turned out to be the best set of criteria in Africa. Erosions on radiographs and a positive rheumatoid factor are of little help as the prevalence of both is high in most African populations. Living at high altitude and hence being void of most tropical parasitic infections apparently increases prevalence figures for RA. More studies are needed from developing countries to determine the magnitude and the determinants of disabling rheumatic conditions. | |
| 1046027 | A coordinated team approach to one health problem. | 1976 May | Rheumatoid arthritis, as a complex and chronic disease, requires the expertise of many disciplines working in a combined fashion with the patient as an active and responsible member of the health team. In-depth knowledge of the disease is vital to the nurse in assisting her in developing an effective and logical plan of care. The nurse must act as the liaison between patient and health team and coordinate the programme of treatment. The most important feature of the delivery of care to the rheumatoid patient at the Rheumatism Foundation Hospital is that the patient is involved in his plan of care from the beginning and has shared responsibility for its being carried out and its effectiveness. It is the cooperative effort between the health team and the patient which is the major feature in this very successful comprehensive approach to caring for the patient with rheumatoid arthritis. | |
| 7373618 | Jaccoud's syndrome. A nosographic entity associated with systemic lupus erythematosus. | 1980 Mar | Six Scandinavian cases of Jaccoud's syndrome, resulting from systemic lupus erythematosus (SLE) are described; 1 patient suffered from both SLE and rheumatoid arthritis (RA). Clinically, the patients showed hand deformities similar to those of RA with pronounced ulnar deviation and swan-neck configuration. Clinically, however, the hands in cases of Jaccoud's syndrome differ from those in RA because the deformities develop more slowly, without much pain, and hand function is well-preserved. Radiologically, subluxation develops in the metacarpophalangeal joints without the typical rheumatoid joint-associated osseous destruction. The presence of erosions and hooks are exceptional and, if present, they are not typical of RA. It is important that Jaccoud's syndrome be recognized and differentiated from RA because an incorrect diagnosis could lead to a choice of therapy inappropriate for patients with SLE. | |
| 537702 | [Possibilities of control of regulation of the function of arteriovenous anastomoses and o | 1979 Dec 15 | Acupuncture was carried out on a patient with rheumatoid arthritis and microangiopathy of the lower limbs. Photoplethysmographic waves appeared at the right inferior limb where before they had been absent; at the left inferior limb normalization of postural reflexes was achieved, suggesting that acupuncture is effective in vasodilatation of capillaries and preterminal arterioles and in the reactivation of the arterio-venous blood flow. | |
| 860606 | [Monoclonal gammopathy in chronic polyarthritis]. | 1977 Mar | Disturbances of immunoglobulin production have often been observed in preclinical multiple myeloma and have led to the question of a pattern of reactive formation of monoclonal gammopathies. In the documented rare case of coincidental Ig-G-myeloma and rheumatoid arthritis some possible similar pathogenetic mechanisms in both diseases are discussed. | |
| 629095 | [Progressive chronic polyarthritis from the viewpoint of individual psychology]. | 1978 Jan | In 106 patients with rheumatoid arthritis it could be shown by Adlerian Psychology that in more than half of the patients both physical over activity before the disease and painful inhibition of movement during the disease were an imaginary solution of the problem. Both are functions of a threatened mental and physical mobility and autonomy. In pointing out this relationship we aim to show lifestyle as a risk factor for the disease and indicate causative therapeutic aspects. | |
| 1266424 | [Influence of knee synovectomy on the disease course in PCP patients]. | 1976 Mar | 72 patients with rheumatoid arthritis undergoing surgical synovectomy of knee joints (102 times) were followed up for five years at yearly intervals for their clinical condition and laboratory parameters (sed. rate, leukocytes, serum iron, rheumatoid factor and others). Findings were documented by use of a questionary. At the end of the study the result of synovectomy was compared with the preoperative disease state by use of the Steinbrocker-Criteria and laboratory findings; in addition influence of synovectomy on the postoperative course was investigated. The following conclusions were drawn. 1) Preoperatively seronegative patients exhibited better local long term recovery than seropositive patients. 2) In most patients synovectomized in stage I the disease did not progress during the study period. 3) Some of the patients showed retardation of immunoserologic disease activity for 2-3 years after synovectomy. |